The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Avoidance of Transient Cardiomyopathy in Cardiomyocyte-Targeted Tamoxifen-Induced MerCreMer Gene Deletion Models
Open accessAbstract
Cardiac myocyte targeted MerCreMer transgenic mice expressing tamoxifen-inducible Cre driven by the α-myosin heavy chain promoter are increasingly used to control gene expression in the adult heart. Here, we show tamoxifen-mediated MerCreMer (MCM) nuclear translocation can induce severe transient dilated cardiomyopathy in mice with or without loxP transgenes. The cardiomyopathy is accompanied by marked reduction of energy/metabolism and calcium-handling gene expression (eg, PGC1-α, peroxisome proliferator-activated α, SERCA2A), all fully normalized with recovery. MCM-negative/flox-positive controls display no dysfunction with tamoxifen. Nuclear Cre translocation and equally effective gene knockdown without cardiomyopathy is achievable with raloxifene, suggesting toxicity is not simply from Cre. Careful attention to controls, reduced tamoxifen dosing and/or use of raloxifene is advised with this model.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Current issues in mouse genome engineering
Glaser, S., Anastassiadis, K., & Stewart, A. F. (2005) · Nature Genetics · doi:10.1038/ng1668 · Cited by 160
Cited by
Hippo pathway deficiency reverses systolic heart failure after infarction
Leach, J. P., Heallen, T., Zhang, M., Rahmani, M., Morikawa, Y., Hill, M. C., Segura, A., Willerson, J. T., & Martin, J. F. (2017) · Nature · doi:10.1038/nature24045 · Cited by 422
Self-citationLoffredo, F. S., Steinhauser, M. L., Gannon, J., & Lee, R. T. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.02.002 · Cited by 385
Metabolic stress–induced activation of FoxO1 triggers diabetic cardiomyopathy in mice
Battiprolu, P. K., Hojayev, B., Jiang, N., Wang, Z. V., Luo, X., Iglewski, M., Shelton, J. M., Gerard, R. D., Rothermel, B. A., Gillette, T. G., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60329 · Cited by 345
Koitabashi, N., Danner, T., Zaiman, A. L., Pinto, Y. M., Rowell, J., Mankowski, J., Zhang, D., Nakamura, T., Takimoto, E., & Kass, D. A. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44824 · Cited by 334
Self-citationCre‐lox P‐Mediated Recombination: General Principles and Experimental Considerations
McLellan, M. A., Rosenthal, N. A., & Pinto, A. R. (2017) · Current Protocols in Mouse Biology · doi:10.1002/cpmo.22 · Cited by 172
Metadata
- Authors
- Koitabashi, N., Bedja, D., Zaiman, A. L., Pinto, Y. M., Zhang, M., Gabrielson, K. L., Takimoto, E., & Kass, D. A.
- Venue
- Circulation Research
- Published
- 2009-07-02
- Volume
- 105
- Issue
- 1
- Pages
- 12-15
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2137654131
- Cited by
- 203
- References
- 1
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Avoidance of Transient Cardiomyopathy in Cardiomyocyte-Targeted Tamoxifen-Induced MerCreMer Gene Deletion Models. https://app.cochat.ai/papers/10.1161/circresaha.109.198416
- The paper
- Koitabashi, N., Bedja, D., Zaiman, A. L., Pinto, Y. M., Zhang, M., Gabrielson, K. L., Takimoto, E., & Kass, D. A. (2009). Avoidance of Transient Cardiomyopathy in Cardiomyocyte-Targeted Tamoxifen-Induced MerCreMer Gene Deletion Models. Circulation Research. https://doi.org/10.1161/circresaha.109.198416
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
