The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Bone Marrow-Derived Cell Therapy Stimulates Endogenous Cardiomyocyte Progenitors and Promotes Cardiac Repair
Open accessAbstract
SUMMARY Cell therapy can improve cardiac function in animals and humans after injury, but the mechanism is unclear. We performed cell therapy experiments in genetically engineered mice that permanently express green fluorescent protein (GFP) only in cardiomyocytes after a pulse of 4-OH-tamoxifen. Myocardial infarction diluted the GFP+ cardiomyocyte pool, indicating refreshment by non-GFP+ progenitors. Cell therapy with bone marrow-derived c-kit+ cells, but not mesenchymal stem cells, further diluted the GFP+ pool, consistent with c-kit+ cell-mediated augmentation of cardiomyocyte progenitor activity. This effect could not be explained by transdifferentiation to cardiomyocytes by exogenously delivered c-kit+ cells or by cell fusion. Therapy with c-kit+ cells but not mesenchymal stem cells improved cardiac function. These findings suggest that stimulation of endogenous cardiogenic progenitor activity is a critical mechanism of cardiac cell therapy.
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Bone marrow cells regenerate infarcted myocardium
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Adult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration
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Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
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Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors
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Self-citation
Cited by
Mammalian heart renewal by pre-existing cardiomyocytes
Senyo, S. E., Steinhauser, M. L., Pizzimenti, C. L., Yang, V. K., Cai, L., Wang, M., Wu, T.-D., Guerquin-Kern, J.-L., Lechene, C. P., & Lee, R. T. (2013) · Nature · doi:10.1038/nature11682 · Cited by 1,343
Self-citationHeart repair by reprogramming non-myocytes with cardiac transcription factors
Song, K., Nam, Y.-J., Luo, X., Qi, X., Tan, W., Huang, G. N., Acharya, A., Smith, C. L., Tallquist, M. D., Neilson, E. G., et al. (2012) · Nature · doi:10.1038/nature11139 · Cited by 1,147
Williams, A. R., & Hare, J. M. (2011) · Circulation Research · doi:10.1161/circresaha.111.243147 · Cited by 886
Burridge, P. W., Keller, G., Gold, J. D., & Wu, J. C. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2011.12.013 · Cited by 670
Zangi, L., Lui, K. O., von Gise, A., Ma, Q., Ebina, W., Ptaszek, L. M., Später, D., Xu, H., Tabebordbar, M., Gorbatov, R., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2682 · Cited by 646
Metadata
- Authors
- Loffredo, F. S., Steinhauser, M. L., Gannon, J., & Lee, R. T.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 8
- Issue
- 4
- Pages
- 389-398
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W1983517713
- Cited by
- 385
- References
- 29
- FWCI
- 23.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Loffredo, F. S., Steinhauser, M. L., Gannon, J., & Lee, R. T. (2011). Bone Marrow-Derived Cell Therapy Stimulates Endogenous Cardiomyocyte Progenitors and Promotes Cardiac Repair. Cell Stem Cell. https://doi.org/10.1016/j.stem.2011.02.002
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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