Inhibition of Elevated Ca2+/Calmodulin-Dependent Protein Kinase II Improves Contractility in Human Failing Myocardium

Relation between myocardial function and expression of sarcoplasmic reticulum Ca(2+)-ATPase in failing and nonfailing human myocardium.

Hasenfuss, G. P., Reinecke, H., Studer, R., Meyer, M., Pieske, B. M., Holtz, J., Holubarsch, C., Posival, H., Just, H., & Drexler, H. (1994) · Circulation Research · doi:10.1161/01.res.75.3.434 · Cited by 781

Ca 2+ /Calmodulin–Dependent Protein Kinase Modulates Cardiac Ryanodine Receptor Phosphorylation and Sarcoplasmic Reticulum Ca 2+ Leak in Heart Failure

Ai, X., Curran, J. W., Shannon, T. R., Bers, D. M., & Pogwizd, S. M. (2005) · Circulation Research · doi:10.1161/01.res.0000194329.41863.89 · Cited by 698

Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure.

JBeuckelmann, D., MNäbauer, & EErdmann (1992) · Circulation · Cited by 662

Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure.

Beuckelmann, D. J., Näbauer, M., & Erdmann, E. (1992) · Circulation · doi:10.1161/01.cir.85.3.1046 · Cited by 636

Gene expression of the cardiac Na(+)-Ca2+ exchanger in end-stage human heart failure.

Studer, R., Reinecke, H., Bilger, J., Thomas Eschenhagen, A., Böhm, M., Hasenfuss, G. P., Just, H., Holtz, J., & Drexler, H. (1994) · Circulation Research · doi:10.1161/01.res.75.3.443 · Cited by 633

Ca 2+ /Calmodulin-Dependent Protein Kinase II Phosphorylation Regulates the Cardiac Ryanodine Receptor

Wehrens, X. H. T., Lehnart, S. E., Reiken, S. R., & Marks, A. R. (2004) · Circulation Research · doi:10.1161/01.res.0000125626.33738.e2 · Cited by 622

Calmodulin kinase II inhibition protects against structural heart disease

Zhang, R., Khoo, M. S. C., Wu, Y., Yang, Y., Grueter, C. E., Ni, G., Price, E., Thiel, W. H., Guatimosim, S., Song, L., et al. (2005) · Nature Medicine · doi:10.1038/nm1215 · Cited by 580

The δ C Isoform of CaMKII Is Activated in Cardiac Hypertrophy and Induces Dilated Cardiomyopathy and Heart Failure

Zhang, T., Maier, L. S., Dalton, N. D., Miyamoto, S., Ross, J., Bers, D. M., & Brown, J. H. (2003) · Circulation Research · doi:10.1161/01.res.0000069686.31472.c5 · Cited by 560

Unique phosphorylation site on the cardiac ryanodine receptor regulates calcium channel activity

Witcher, D. R., Kovacs, R. J., Schulman, H., Cefali, D. C., & Jones, L. R. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99140-4 · Cited by 503

Transgenic CaMKIIδ C Overexpression Uniquely Alters Cardiac Myocyte Ca 2+ Handling

Maier, L. S., Zhang, T., Chen, L., DeSantiago, J., Brown, J. H., & Bers, D. M. (2003) · Circulation Research · doi:10.1161/01.res.0000069685.20258.f1 · Cited by 433

The promise of CaMKII inhibition for heart disease: preventing heart failure and arrhythmias

Westenbrink, B. D., Edwards, A. G., McCulloch, A. D., & Brown, J. H. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.809064 · Cited by 28

Sex-dependent alterations of Ca2+cycling in human cardiac hypertrophy and heart failure

Fischer, T. H., Herting, J., Eiringhaus, J., Pabel, S., Hartmann, N., Ellenberger, D., Friedrich, M., Renner, A., Gummert, J. F., Maier, L. S., et al. (2015) · EP Europace · doi:10.1093/europace/euv313 · Cited by 28

Phospholamban ablation rescues the enhanced propensity to arrhythmias of mice with CaMKII‐constitutive phosphorylation of RyR2 at site S2814

Mazzocchi, G., Sommese, L. M., Palomeque, J., Felice, J. I., Carlo, M. N. D., Fainstein, D., Gonzalez, P., Contreras, P., Skapura, D. G., McCauley, M. D., et al. (2015) · The Journal of Physiology · doi:10.1113/jp271622 · Cited by 28

Altered adrenergic response in myocytes bordering a chronic myocardial infarction underlies in vivo triggered activity and repolarization instability

Dries, E., Amoni, M., Vandenberk, B., Johnson, D. M., Gilbert, G., Nagaraju, C. K., Puertas, R. D., Abdesselem, M., Santiago, D. J., Roderick, H. L., et al. (2020) · The Journal of Physiology · doi:10.1113/jp278839 · Cited by 27

Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) in the Heart

Maier, L. S. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-2888-2_30 · Cited by 27

Abnormalities of Calcium Handling Proteins in Skeletal Muscle Mirror Those of the Heart in Humans With Heart Failure: A Shared Mechanism?

Middlekauff, H. R., Vigna, C., Verity, M. A., Fonarow, G. C., Horwich, T. B., Hamilton, M. A., Shieh, P. B., & Tupling, A. R. (2012) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2012.07.005 · Cited by 27

While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in CaMKIIδ-KO mice

Neef, S., Sag, C. M., Daut, M., Bäumer, H., Grefe, C., El‐Armouche, A., DeSantiago, J., Pereira, L., Bers, D. M., Backs, J., et al. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.02.014 · Cited by 26

Role of β-adrenergic signaling in masseter muscle

Ito, A., Ohnuki, Y., Suita, K., Ishikawa, M., Mototani, Y., Shiozawa, K., Kawamura, N., Yagisawa, Y., Nariyama, M., Umeki, D., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0215539 · Cited by 26

Intravenous AAV8 Encoding Urocortin-2 Increases Function of the Failing Heart in Mice

Lai, N. C., Gao, M. H., Giamouridis, D., Suárez, J., Miyanohara, A., Parikh, J., Hightower, S., Guo, T., DILLMANN, W. H., Kim, Y. C., et al. (2015) · Human Gene Therapy · doi:10.1089/hum.2014.157 · Cited by 25

The Ca-calmodulin dependent kinase II: A promising target for future antiarrhythmic therapies?

Fischer, T. H., Neef, S., & Maier, L. S. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.11.003 · Cited by 25

Long-term effects of empagliflozin on excitation-contraction-coupling in human induced pluripotent stem cell cardiomyocytes

Pabel, S., Reetz, F., Dybkova, N., Shomroni, O., Salinas, G., Mustroph, J., Hammer, K. P., Hasenfuss, G. P., Hamdani, N., Maier, L. S., et al. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-01989-6 · Cited by 24

Strain Rate in Children and Young Piglets Mirrors Changes in Contractility and Demonstrates a Force-Frequency Relationship

Alvarez, S. V., Fortin‐Pellerin, É., Alhabdan, M., Serrano-Lomelin, J. A., Kantoch, M. J., Atallah, J., Hornberger, L. K., Coe, J. Y., Cheung, P., Tham, E. B. C., et al. (2017) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2017.04.001 · Cited by 24

Role of protein phosphatase inhibitor-1 in cardiac beta adrenergic pathway

Weber, S., Meyer-Roxlau, S., & El‐Armouche, A. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.09.007 · Cited by 22

CaMKII effects on inotropic but not lusitropic force frequency responses require phospholamban

Wu, Y., Luczak, E. D., Lee, E., Hidalgo, C. G., Yang, J., Gao, Z., Li, J., Wehrens, X. H. T., Granzier, H. L. M., & Anderson, M. E. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.06.019 · Cited by 23

Choice of Anesthetic Combination Determines Ca2+Leak after Ischemia-Reperfusion Injury in the Working Rat Heart

Zaugg, M., Wang, L., Zhang, L., Lou, P., Lucchinetti, E., & Clanachan, A. S. (2012) · Anesthesiology · doi:10.1097/aln.0b013e318247225a · Cited by 23

The small molecule Chicago Sky Blue promotes heart repair following myocardial infarction in mice

Yifa, O., Weisinger, K., Bassat, E., Li, H., Kain, D., Barr, H. M., Kozer, N., Genzelinakh, A., Rajchman, D., Eigler, T., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.128025 · Cited by 24

Caveolae-specific activation loop between CaMKII and L-type Ca2+channel aggravates cardiac hypertrophy in α1-adrenergic stimulation

Tonegawa, K., Otsuka, W., Kumagai, S., Matsunami, S., Hayamizu, N., Tanaka, S., Moriwaki, K., Obana, M., Maeda, M., Asahi, M., et al. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00601.2016 · Cited by 22

Mitochondrial and Sarcoplasmic Reticulum Interconnection in Cardiac Arrhythmia

Salazar‐Ramírez, F., Ramos‐Mondragón, R., & García‐Rivas, G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.623381 · Cited by 23

The combined effects of ranolazine and dronedarone on human atrial and ventricular electrophysiology

Hartmann, N., Mason, F. E., Braun, I., Pabel, S., Voigt, N., Schotola, H., Fischer, T. H., Dobrev, D., Danner, B. C., Renner, A., et al. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.03.012 · Cited by 22

Nuclear Calcium/Calmodulin-dependent Protein Kinase II Signaling Enhances Cardiac Progenitor Cell Survival and Cardiac Lineage Commitment

Quijada, P. J., Hariharan, N., Cubillo, J. D., Bala, K. M., Emathinger, J. M., Wang, B. J., Ormachea, L., Bers, D. M., Sussman, M. A., & Poizat, C. I. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.657775 · Cited by 21

The cardiac CaMKII-Nav1.5 relationship: From physiology to pathology

Takla, M., Huang, C. L.-H., & Jeevaratnam, K. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.12.014 · Cited by 21

Functional LTCC-β 2 AR Complex Needs Caveolin-3 and Is Disrupted in Heart Failure

Sanchez‐Alonso, J. L., Fedele, L., Copier, J. S., Lucarelli, C., Mansfield, C. A., Judina, A., Houser, S. R., Brand, T., & Gorelik, J. (2023) · Circulation Research · doi:10.1161/circresaha.123.322508 · Cited by 21

Transient outward potassium channel: a heart failure mediator

He, Q., Feng, Y., & Wang, Y. (2015) · Heart Failure Reviews · doi:10.1007/s10741-015-9474-y · Cited by 22

Calcium and Heart Failure: How Did We Get Here and Where Are We Going?

Siri‐Angkul, N., Dadfar, B., Jaleel, R., Naushad, J., Parambathazhath, J., Doye, A. A., Xie, L., & Gwathmey, J. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147392 · Cited by 20

Mouse Models of Heart Failure

Fiedler, L. R., Maifoshie, E., & Schneider, M. D. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-397920-9.00002-0 · Cited by 20

Catheter Ablation for Atrial Fibrillation in Patients with End-Stage Heart Failure and Eligibility for Heart Transplantation

Sohns, C., MARROUCHE, N. F., Costard‐Jäckle, A., Sossalla, S. T., Bergau, L., Schramm, R., Fuchs, U., Omran, H., Rubarth, K., Dumitrescu, D., et al. (2020) · ESC Heart Failure · doi:10.1002/ehf2.13150 · Cited by 19

New Treatment Options for Late Na Current, Arrhythmias, and Diastolic Dysfunction

Maier, L. S. (2012) · Current Heart Failure Reports · doi:10.1007/s11897-012-0099-3 · Cited by 19

Exercise training reverses myocardial dysfunction induced by CaMKIIδCoverexpression by restoring Ca2+homeostasis

Høydal, M. A., Stølen, T., Kettlewell, S., Maier, L. S., Brown, J. H., Sowa, T., Catalucci, D., Condorelli, G., Kemi, O. J., Smith, G. L., et al. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00188.2016 · Cited by 19

Inhibition of Late Sodium Current as an Innovative Antiarrhythmic Strategy

Bengel, P., Ahmad, S., & Sossalla, S. T. (2017) · Current Heart Failure Reports · doi:10.1007/s11897-017-0333-0 · Cited by 19

A novel mouse model of obstructive sleep apnea by bulking agent-induced tongue enlargement results in left ventricular contractile dysfunction

Lebek, S., Hegner, P., Schach, C., Reuthner, K., Tafelmeier, M., Maier, L. S., Arzt, M. E., & Wagner, S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0243844 · Cited by 20

The Stress-Response MAP Kinase Signaling in Cardiac Arrhythmias

Ai, X., Yan, J., Carrillo, E., & Ding, W. (2016) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2016_8 · Cited by 18

Regulation of gastrointestinal motility by Ca2+/calmodulin-stimulated protein kinase II

Perrino, B. A. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.03.009 · Cited by 18

Synthetic Phosphopeptides Enable Quantitation of the Content and Function of the Four Phosphorylation States of Phospholamban in Cardiac Muscle

Ablorh, N.-A. D., Dong, X., James, Z. M., Xiong, Q., Zhang, J. J., Thomas, D. D., & Karim, C. B. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.556621 · Cited by 17

CaMKII at the crossroads: calcium dysregulation, and post‐translational modifications driving cell death

MATTIAZZI, A. R., Giusti, C. J. D., & Valverde, C. A. (2025) · The Journal of Physiology · doi:10.1113/jp285941 · Cited by 17

Ca2+/calmodulin-dependent protein kinase II is essential in hyperacute pressure overload

Baier, M. J., Klatt, S., Hammer, K. P., Maier, L. S., & Rokita, A. G. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.12.002 · Cited by 17

CaMKII-dependent myofilament Ca2+ desensitization contributes to the frequency-dependent acceleration of relaxation

Guilbert, A., Lim, H. J., Cheng, J., & Wang, Y. (2015) · Cell Calcium · doi:10.1016/j.ceca.2015.08.001 · Cited by 16

Review of novel therapeutic targets for improving heart failure treatment based on experimental and clinical studies

Bonsu, K. O., Owusu, I. K., Buabeng, K. O., Reidpath, D. D., & Kadirvelu, A. (2016) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s106065 · Cited by 16

Caveolae-Specific CaMKII Signaling in the Regulation of Voltage-Dependent Calcium Channel and Cardiac Hypertrophy

Tanaka, S., Fujio, Y., & Nakayama, H. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01081 · Cited by 16

Loss of Myeloid Differentiation Protein 1 Promotes Atrial Fibrillation in Heart Failure with Preserved Ejection Fraction

Shuai, W., Kong, B., Yang, H., Fu, H. Q., & Huang, H. (2020) · ESC Heart Failure · doi:10.1002/ehf2.12620 · Cited by 16

Over-expression of microRNA-145 drives alterations in β-adrenergic signaling and attenuates cardiac remodeling in heart failure post myocardial infarction

Liu, Z., Tao, B., Fan, S., Cui, S., Pu, Y., Qiu, L., Xia, H., & Xu, L. (2020) · Aging · doi:10.18632/aging.103320 · Cited by 17

Repolarizing cardiac potassium channels: Multiple sites and mechanisms for CaMKII-mediated regulation

Nerbonne, J. M. (2011) · Heart Rhythm · doi:10.1016/j.hrthm.2011.01.018 · Cited by 16

Effects of Ranolazine on Torsades de Pointes Tachycardias in a Healthy Isolated Rabbit Heart Model

Sossalla, S. T., Wallisch, N., Toischer, K., Sohns, C., Vollmann, D., Seegers, J., Lüthje, L., Maier, L. S., & Zabel, M. (2014) · Cardiovascular Therapeutics · doi:10.1111/1755-5922.12078 · Cited by 16

Ca2+/Calmodulin‐Dependent Protein Kinase II Regulation by Inhibitor of RIPK3 Protects against Cardiac Hypertrophy

Zhang, J., Qian, J., Cao, J., Wang, X. B., Zhang, W., & Gu, X. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/7941374 · Cited by 15

Blockade of CaMKII depresses conduction preferentially in the right ventricular outflow tract and promotes ischemic ventricular fibrillation in the rabbit heart

Warren, M. D., Sciuto, K. J., Taylor, T. G., Garg, V., Torres, N. S., Shibayama, J., Spitzer, K. W., & Зайцев, А. В. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00347.2016 · Cited by 15

Antioxidant defense and protection against cardiac arrhythmias: lessons from a mammalian hibernator (the woodchuck)

Zhao, Z., Kudej, R. K., Wen, H., Fefelova, N., Yan, L., Vatner, D. E., Vatner, S. F., & Xie, L. (2018) · The FASEB Journal · doi:10.1096/fj.201701516r · Cited by 15

Tiotropium bromide, a long acting muscarinic receptor antagonist triggers intracellular calcium signalling in the heart

Cassambai, S., Mee, C., Renshaw, D. W., & Hussain, A. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.114778 · Cited by 14

β2‐adrenergic stimulation potentiates spontaneous calcium release by increasing signal mass and co‐activation of ryanodine receptor clusters

Nolla-Colomer, C., Casabella-Ramón, S., Jiménez-Sábado, V., Vallmitjana, A., Tarifa, C., Herraiz‐Martínez, A., Llach, A., Taurón, M., Montiel, J., Juan Cinca, A., et al. (2021) · Acta Physiologica · doi:10.1111/apha.13736 · Cited by 14

The Effect of Gender and Sex Hormones on Cardiovascular Disease, Heart Failure, Diabetes, and Atrial Fibrillation in Sleep Apnea

Hegner, P., Lebek, S., Maier, L. S., Arzt, M. E., & Wagner, S. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.741896 · Cited by 17

Impact of SGLT2 Inhibitors on Cardiovascular Risk Scores, Metabolic Parameters, and Laboratory Profiles in Type 2 Diabetes

Yalçın, N., Aktaş, S., Uyar, S., & Koca, N. (2025) · Life · doi:10.3390/life15050722 · Cited by 15

Wenxin Keli for the Treatment of Arrhythmia—Systems Pharmacology and In Vivo Pharmacological Assessment

Li, X., Tian, G., Xu, L., Sun, L., Tao, R., Zhang, S., Cong, Z., Deng, F., Chen, J., Yu, Y., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.704622 · Cited by 13

New Insights Into Diastolic Dysfunction and Heart Failure With Preserved Ejection Fraction

Gelzinis, T. A. (2013) · Seminars in Cardiothoracic and Vascular Anesthesia · doi:10.1177/1089253213510748 · Cited by 13

Influence of Mild Metabolic Acidosis on Cardiac Contractility and Isoprenaline Response in Isolated Ovine Myocardium: INFLUENCE OF ACIDOSIS ON CARDIAC CONTRACTILITY

Schotola, H., Sossalla, S., Rajab, T. K., Toischer, K., Quintel, M., Bauer, M., & Schmitto, J. D. (2011) · Artificial Organs · doi:10.1111/j.1525-1594.2011.01390.x · Cited by 12

The Regulatory Effect of Receptor-Interacting Protein Kinase 3 on CaMKIIδ in TAC-Induced Myocardial Hypertrophy

Qian, J., Zhang, J., Cao, J., Wang, X. B., Zhang, W., & Chen, X. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914529 · Cited by 12

Ruxolitinib as a CaMKII inhibitor for treatment of cardiac arrhythmias: Applications and prospects

Guo, Q., Huo, Y., Liu, Q., Zhou, S., & Xiao, Y. (2024) · Heart Rhythm · doi:10.1016/j.hrthm.2024.07.118 · Cited by 12

Recombinant Klotho administration after myocardial infarction reduces ischaemic injury and arrhythmias by blocking intracellular calcium mishandling and CaMKII activation

Vázquez‐Sánchez, S., Blasco, A., Corredoira, P. M. F., Cantolla, P., Mercado‐García, E., Rodríguez‐Sánchez, E., González‐Lafuente, L., Poveda, J., González‐Moreno, D., Muñoz, A. M., et al. (2025) · The Journal of Pathology · doi:10.1002/path.6388 · Cited by 12

SR calcium handling dysfunction, stress-response signaling pathways, and atrial fibrillation

Ai, X. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00046 · Cited by 12

Nuclear Calcium in Cardiac (Patho)Physiology: Small Compartment, Big Impact

Kießling, M., Djalinac, N., Voglhuber, J., & Ljubojević-Holzer, S. (2023) · Biomedicines · doi:10.3390/biomedicines11030960 · Cited by 11

Ca2+/Calmodulin-Dependent Kinase IIδC-Induced Chronic Heart Failure Does Not Depend on Sarcoplasmic Reticulum Ca2+ Leak

Dewenter, M., Seitz, T., Steinbrecher, J. H., Westenbrink, B. D., Ling, H., Lehnart, S. E., Wehrens, X. H. T., Backs, J., Brown, J. H., Maier, L. S., et al. (2024) · ESC Heart Failure · doi:10.1002/ehf2.14772 · Cited by 11

Loss of ATP-Sensitive Potassium Channel Surface Expression in Heart Failure Underlies Dysregulation of Action Potential Duration and Myocardial Vulnerability to Injury

Gao, Z., Sierra, A., Zhu, Z., Koganti, S. R. K., Subbotina, E., Maheshwari, A., Anderson, M. E., Zingman, L. V., & Hodgson‐Zingman, D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151337 · Cited by 11

The Significance of the Late Na + Current for Arrhythmia Induction and the Therapeutic Antiarrhythmic Potential of Ranolazine

Mason, F. E., & Sossalla, S. T. (2016) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248416644989 · Cited by 10

Will Secretoneurin Be the Next Big Thing?

Anderson, M. E. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.11.028 · Cited by 10

Cardiac Calmodulin Kinase: A Potential Target for Drug Design

Bányász, T., Szentandrássy, N., Tóth, A. J., Nánási, P. P., Magyar, J., & Chen‐Izu, Y. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711796642409 · Cited by 9

SGLT2 inhibitors: a new pillar of the heart failure regimen

DeSa, T. B., & Gong, T. (2021) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2204133 · Cited by 10

CaMKII-δ9 Induces Cardiomyocyte Death to Promote Cardiomyopathy and Heart Failure

Zhang, M., Zhang, J., Zhang, W., Hu, Q., Li, J., Xie, P., Zheng, W., Shang, H., & Zhang, Y. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.820416 · Cited by 9

CaMKII Inhibition

Dominic, P. S., & Anderson, M. E. (2011) · Circulation · doi:10.1161/circulationaha.111.031682 · Cited by 9

Crosstalk between myocardial autophagy and sterile inflammation in the development of heart failure

Tang, J., Tam, E., Song, E., Xu, A., & Sweeney, G. (2024) · Autophagy Reports · doi:10.1080/27694127.2024.2320605 · Cited by 7

High inborn aerobic capacity does not protect the heart following myocardial infarction

Høydal, M. A., Kaurstad, G., Rolim, N. P. L., Johnsen, A. B., Alves, M. N. M., Koch, L. G., Britton, S. L., Stølen, T., Smith, G. L., & Wisløff, U. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00312.2013 · Cited by 8

The Neonatal But Not the Mature Heart Adapts to Acute Tachycardia by Beneficial Modification of the Force–Frequency Relationship

Schmidt, M. R., White, P. A., Khambadkone, S., Gross, G. J., Bøtker, H. E., Vogel, M., Hjortdal, V. E., Sørensen, K. E., & Redington, A. N. (2011) · Pediatric Cardiology · doi:10.1007/s00246-011-9899-6 · Cited by 8

Calcium-Dependent Signaling in Cardiac Myocytes

Ko, C. Y., Smith, C. E. R., & Grandi, E. (2022) · Springer eBooks · doi:10.1007/978-3-031-08309-9_1 · Cited by 7

Tetramethylpyrazine Protects Against Chronic Hypobaric Hypoxia-Induced Cardiac Dysfunction by Inhibiting CaMKII Activation in a Mouse Model Study

Zhang, P., Deng, H., Lan, X., Shen, P., Bai, Z., Huangfu, C., Wang, N., Xiao, C., Gao, Y., Sun, Y., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms26010054 · Cited by 7

CrossTalk opposing view: The late sodium current is not an important player in the development of diastolic heart failure (heart failure with a preserved ejection fraction)

Papp, Z., Borbély, A., & Paulus, W. J. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.264242 · Cited by 7

Electrical storm and calcium signaling: a review

Tsuji, Y. (2011) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2011.07.022 · Cited by 7

The Role of CaMKII Overexpression and Oxidation in Atrial Fibrillation—A Simulation Study

Wang, W. J., Shen, W., Zhang, S., Luo, G., Wang, K., Xu, Y. D., & Zhang, H. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.607809 · Cited by 7

Stress-driven cardiac calcium mishandling via a kinase-to-kinase crosstalk

McKee, C., Bare, D. J., & Ai, X. (2021) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-021-02533-2 · Cited by 7

Chronic Ca2+/Calmodulin-Dependent Protein Kinase II Inhibition Rescues Advanced Heart Failure

Liu, Y., Shao, Q., Cheng, H.-J., Li, T., Zhang, X., Callahan, M. F., Herrington, D. M., Kitzman, D. W., Zhao, D. X.-M., & Cheng, C. (2021) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.000361 · Cited by 7

Ca2+/Calmodulin-dependent protein kinase II (CaMKII)-targeted drug discovery: Challenges and strategies

Tian, X., Wang, X., Chen, S., Sun, X., Shao, D., Zhang, K., Gao, Q., & Hao, L. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102886 · Cited by 7

The role of calcium metabolism dysregulation in the pathogenesis of cardiovascular diseases

Майлян, Д. Э., & Kolomiets, V. V. (2019) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2019-9-78-85 · Cited by 6

Enhanced Cardiac CaMKII Oxidation and CaMKII-Dependent SR Ca Leak in Patients with Sleep-Disordered Breathing

Arzt, M., Drzymalski, M. A., Ripfel, S., Meindl, S., Biedermann, A., Durczok, M., Keller, K., Mustroph, J., Katz, S., Tafelmeier, M., et al. (2022) · Antioxidants · doi:10.3390/antiox11020331 · Cited by 6

How arrhythmias weaken the ventricle: an often underestimated vicious cycle

Körtl, T., Schach, C., & Sossalla, S. T. (2023) · Herz · doi:10.1007/s00059-022-05158-y · Cited by 6

Physiology and pathology of cardiac CaMKII

Bussey, C. T., & Erickson, J. (2017) · Current Opinion in Physiology · doi:10.1016/j.cophys.2017.07.003 · Cited by 6

Ellagic Acid Prevents Ca2+ Dysregulation and Improves Functional Abnormalities of Ventricular Myocytes via Attenuation of Oxidative Stress in Pathological Cardiac Hypertrophy

Yamasan, B. E., Mercan, T., Erkan, O., & Özdemir, S. (2021) · Cardiovascular Toxicology · doi:10.1007/s12012-021-09654-1 · Cited by 6

Large Animal Models of Ischemic Cardiomyopathy: Are They Enough to Bridge the Translational Gap?

Nguyen, P. K. P., & Wu, J. C. (2015) · Journal of Nuclear Cardiology · doi:10.1007/s12350-015-0078-7 · Cited by 7

Inhibition of CaMKII Does Not Attenuate Cardiac Hypertrophy in Mice with Dysfunctional Ryanodine Receptor

Chakraborty, A., Pasek, D. A., Huang, T. Q., Gomez, A. C., Yamaguchi, N., Anderson, M. E., & Meissner, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104338 · Cited by 6

The reduced myofilament responsiveness to calcium contributes to the negative force-frequency relationship in rat cardiomyocytes: role of reactive oxygen species and p-38 map kinase

Espejo, M. S., Aiello, I., Sepúlveda, M., Petroff, M. V., Aiello, E. A., & Giusti, V. C. D. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-2058-z · Cited by 6

Protein kinase signaling at the crossroads of myocyte life and death in ischemic heart disease

Vagnozzi, R. J., Hoffman, N. E., Elrod, J. W., Madesh, M., & Force, T. L. (2012) · Drug Discovery Today Therapeutic Strategies · doi:10.1016/j.ddstr.2013.12.001 · Cited by 5

Calm down when the heart is stressed: Inhibiting calmodulin-dependent protein kinase II for antiarrhythmias

Duan, D. D. (2015) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2015.01.016 · Cited by 5

Compromised cardiovascular function in aged rats corresponds with increased expression and activity of calcium/calmodulin dependent protein kinase IIδ in aortic endothelium

McCluskey, C., Mooney, L., Paul, A., & Currie, S. (2019) · Vascular Pharmacology · doi:10.1016/j.vph.2019.04.002 · Cited by 5

CaMKII in the Heart: From Homeostasis to Pathology

Mattiazzi, A. R., & Bers, D. M. (2026) · Annual Review of Physiology · doi:10.1146/annurev-physiol-043024-114759 · Cited by 6

Increased CaMKII activation and contrast changes of cardiac β1-and β3-Adrenergic signaling pathways in a humanized angiotensinogen model of hypertension

Sun, X., Cao, J., Chen, Z., Liu, Y., VonCannon, J. L., Cheng, H.-J., Ferrario, C. M., & Cheng, C. P. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e17851 · Cited by 3

Inhibition of CaMKII Attenuates Progressing Disruption of C a2+ Homeostasis Upon Left Ventricular Assist Device Implantation in Human Heart Failure

Fischer, T. H., Kleinwächter, A., Herting, J., Eiringhaus, J., Hartmann, N., Renner, A., Gummert, J. F., Haverich, A., Schmitto, J. D., & Sossalla, S. T. (2016) · Artificial Organs · doi:10.1111/aor.12677 · Cited by 4

A Tale of Two Leaks

Venetucci, L. A., Sankaranarayanan, R., & Eisner, D. A. (2013) · Circulation · doi:10.1161/circulationaha.113.004713 · Cited by 4

Protein Kinase Inhibitors in Heart Failure: Mechanistic Insights and Therapeutic Prospects.

Ahmad, R., Frishman, W., & Aronow, W. (2025) · Cardiology in Review · doi:10.1097/crd.0000000000001038 · Cited by 4

Schlüsselrolle des Ca2+ in der Herzinsuffizienz und mögliche neue therapeutische Ansatzpunkte

Fischer, T. H., Rokita, A. G., & Maier, L. S. (2011) · Der Kardiologe · doi:10.1007/s12181-011-0325-3 · Cited by 3

Two polymorphic gene loci associated with treprostinil dose in pulmonary arterial hypertension

Thomeas-McEwing, V., Psotka, M. A., Gamazon, E. R., Friedman, P., Konkashbaev, A., Kubo, M., Nakamura, Y., Ratain, M. J., Benza, R. L., Cox, N. J., et al. (2022) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0000000000000463 · Cited by 3

Calcium Handling Remodeling Underlies Impaired Sympathetic Stress Response in Ventricular Myocardium from Cacna1c Haploinsufficient Rats

Fender, H., Kim, W., Kiper, A. K., Plačkić, J., Kisko, T. M., Braun, M. D., Schwarting, R. K. W., Rohrbach, S., Wöhr, M., Decher, N., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129795 · Cited by 3

The ryanodine receptor microdomain in cardiomyocytes

Dries, E., Gilbert, G., Roderick, H. L., & Sipido, K. R. (2023) · Cell Calcium · doi:10.1016/j.ceca.2023.102769 · Cited by 3

Sarcoplasmic Reticulum Ca Homeostasis and Heart Failure

Zima, A. V., & Terentyev, D. A. (2013) · Biological and medical physics series · doi:10.1007/978-1-4614-7678-8_2 · Cited by 3

Differential diagnosis and clinical management of diastolic heart failure: current best practice

Gelzinis, T. A., & Tawil, J. N. (2016) · Research Reports in Clinical Cardiology · doi:10.2147/rrcc.s80291 · Cited by 3

Molecular mechanisms of heart failure progression associated with implantable cardioverter‐defibrillator shocks for ventricular tachyarrhythmias

Tsuji, Y., Ishikawa, T., & Makita, N. (2014) · Journal of Arrhythmia · doi:10.1016/j.joa.2014.04.003 · Cited by 3

Inhibtion der Ca2+/Calmodulin-abhängigen Proteinkinase (CaMKII) verbessert die Kontratilität von terminal insuffizientem Myokard des Menschen

Fluschnik, N. (2011) · doi:10.53846/goediss-1131

CaMKII Inhibition in Heart Failure Makes Jump to Human

Bers, D. M. (2010) · Circulation Research · doi:10.1161/circresaha.110.231902 · Cited by 29

CaMKII Activity in Heart Failure and Functional Molecular Targets

Bers, D. M. (2016)

Ca2+/Calmodulin-Dependent Protein Kinase II Equally Induces Sarcoplasmic Reticulum Ca2+ Leak in Human Ischaemic and Dilated Cardiomyopathy

Fischer, T. H., Eiringhaus, J., Dybkova, N., Förster, A., Herting, J., Kleinwächter, A., Ljubojević-Holzer, S., Schmitto, J. D., Streckfuß‐Bömeke, K., Renner, A., et al. (2014) · European Journal of Heart Failure · doi:10.1002/ejhf.163 · Cited by 66

CaMKII inhibition in heart failure, beneficial, harmful, or both

Cheng, J., Xu, L., Lai, D., Guilbert, A., Lim, H. J., Keskanokwong, T., & Wang, Y. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00812.2011 · Cited by 45