The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
MicroRNA-133 Controls Vascular Smooth Muscle Cell Phenotypic Switch In Vitro and Vascular Remodeling In Vivo
Open accessAbstract
Rationale: MicroRNA (miR)-1 and -133 play a crucial role in skeletal and cardiac muscle biology and pathophysiology. However, their expression and regulation in vascular cell physiology and disease is currently unknown. Objective: The aim of the present study was to evaluate the role, if any, of miR-1 and miR-133 in vascular smooth muscle cell (VSMC) phenotypic switch in vitro and in vivo. Methods and Results: We demonstrate here that miR-133 is robustly expressed in vascular smooth muscle cells (VSMCs) in vitro and in vivo, whereas miR-1 vascular levels are negligible. miR-133 has a potent inhibitory role on VSMC phenotypic switch in vitro and in vivo, whereas miR-1 does not have any relevant effect per se. miR-133 expression is regulated by extracellular signal–regulated kinase 1/2 activation and is inversely correlated with VSMC growth. Indeed, miR-133 decreases when VSMCs are primed to proliferate in vitro and following vascular injury in vivo, whereas it increases when VSMCs are coaxed back to quiescence in vitro and in vivo. miR-133 loss- and gain-of-function experiments show that miR-133 plays a mechanistic role in VSMC growth. Accordingly, adeno-miR-133 reduces but anti-miR-133 exacerbates VSMC proliferation and migration in vitro and in vivo. miR-133 specifically suppresses the transcription factor Sp-1 expression in vitro and in vivo and through Sp-1 repression regulates smooth muscle gene expression. Conclusions: Our data show that miR-133 is a key regulator of vascular smooth muscle cell phenotypic switch in vitro and in vivo, suggesting its potential therapeutic application for vascular diseases.
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Cites
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MicroRNA-133 controls cardiac hypertrophy
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Self-citationFunctional delivery of viral miRNAs via exosomes
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miR-145 and miR-143 regulate smooth muscle cell fate and plasticity
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Cited by
Muscle-specific microRNAs in skeletal muscle development
Horak, M., Novak, J., & Bienertova-Vasku, J. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2015.12.013 · Cited by 478
Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity
Frismantiene, A., Philippova, M., Erne, P., & Resink, T. J. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.08.019 · Cited by 406
Scioli, M. G., Storti, G., D’Amico, F., Rodríguez Guzmán, R., Centofanti, F., Doldo, E., Céspedes Miranda, E. M., & Orlandi, A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061995 · Cited by 281
Mughal, W., Nguyen, L., Pustylnik, S., da Silva Rosa, S. C., Piotrowski, S., Chapman, D., Du, M., Alli, N. S., Grigull, J., Halayko, A. J., et al. (2015) · Cell Death & Disease · doi:10.1038/cddis.2015.306 · Cited by 56
Metadata
- Authors
- Torella, D., Iaconetti, C., Catalucci, D., Ellison, G. M., Leone, A., Waring, C. D., Bochicchio, A., Vicinanza, C., Aquila, I., Curcio, A., Condorelli, G., & Indolfi, C.
- Venue
- Circulation Research
- Published
- 2011-09-30
- Volume
- 109
- Issue
- 8
- Pages
- 880-893
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2171241454
- Cited by
- 293
- References
- 28
- FWCI
- 8.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Torella, D., Iaconetti, C., Catalucci, D., Ellison, G. M., Leone, A., Waring, C. D., Bochicchio, A., Vicinanza, C., Aquila, I., Curcio, A., Condorelli, G., & Indolfi, C. (2011). MicroRNA-133 Controls Vascular Smooth Muscle Cell Phenotypic Switch In Vitro and Vascular Remodeling In Vivo. Circulation Research. https://doi.org/10.1161/circresaha.111.240150
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