The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart
Open accessAbstract
MicroRNAs (miRNAs) modulate gene expression by inhibiting mRNA translation and promoting mRNA degradation, but little is known of their potential roles in organ formation or function. miR-133a-1 and miR-133a-2 are identical, muscle-specific miRNAs that are regulated during muscle development by the SRF transcription factor. We show that mice lacking either miR-133a-1 or miR-133a-2 are normal, whereas deletion of both miRNAs causes lethal ventricular-septal defects in approximately half of double-mutant embryos or neonates; miR-133a double-mutant mice that survive to adulthood succumb to dilated cardiomyopathy and heart failure. The absence of miR-133a expression results in ectopic expression of smooth muscle genes in the heart and aberrant cardiomyocyte proliferation. These abnormalities can be attributed, at least in part, to elevated expression of SRF and cyclin D2, which are targets for repression by miR-133a. These findings reveal essential and redundant roles for miR-133a-1 and miR-133a-2 in orchestrating cardiac development, gene expression, and function and point to these miRNAs as critical components of an SRF-dependent myogenic transcriptional circuit.
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Cites
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“Because miRNAs typically diminish the expression of their mRNA targets (Baek et al. 2008; Selbach et al. 2008), we focused on those mRNAs that were up-regulated in dKO hearts, a subset of which would be expected to be direct targets of miR-133a.”
BackgroundControl of translation and mRNA degradation by miRNAs and siRNAs: Table 1.
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Cited by
Bartel, D. P. (2018) · Cell · doi:10.1016/j.cell.2018.03.006 · Cited by 3,751
MicroRNAs in Stress Signaling and Human Disease
Mendell, J. T., & Olson, E. N. (2012) · Cell · doi:10.1016/j.cell.2012.02.005 · Cited by 1,673
Self-citationPervasive roles of microRNAs in cardiovascular biology
Small, E. M., & Olson, E. N. (2011) · Nature · doi:10.1038/nature09783 · Cited by 1,180
Self-citationFunctional screening identifies miRNAs inducing cardiac regeneration
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Linking actin dynamics and gene transcription to drive cellular motile functions
Olson, E. N., & Nordheim, A. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2890 · Cited by 958
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Metadata
- Authors
- Liu, N., Bezprozvannaya, S., Williams, A. H., Qi, X., Richardson, J. A., Bassel-Duby, R., & Olson, E. N.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2008-11-17
- Volume
- 22
- Issue
- 23
- Pages
- 3242-3254
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2156322485
- Cited by
- 790
- References
- 7
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Liu, N., Bezprozvannaya, S., Williams, A. H., Qi, X., Richardson, J. A., Bassel-Duby, R., & Olson, E. N. (2008). microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes & Development. https://doi.org/10.1101/gad.1738708
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