The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
Neuregulin in Cardiovascular Development and Disease
Open accessAbstract
Studies in genetically modified mice have demonstrated that neuregulin-1 (NRG-1), along with the erythroblastic leukemia viral oncogene homolog (ErbB) 2, 3, and 4 receptor tyrosine kinases, is necessary for multiple aspects of cardiovascular development. These observations stimulated in vitro and in vivo animal studies, implicating NRG-1/ErbB signaling in the regulation of cardiac cell biology throughout life. Cardiovascular effects of ErbB2-targeted cancer therapies provide evidence in humans that ErbB signaling plays a role in the maintenance of cardiac function. These and other studies suggest a conceptual model in which a key function of NRG-1/ErbB signaling is to mediate adaptations of the heart to physiological and pathological stimuli through activation of intracellular kinase cascades that regulate tissue plasticity. Recent work implicates NRG-1/ErbB signaling in the regulation of multiple aspects of cardiovascular biology, including angiogenesis, blood pressure, and skeletal muscle responses to exercise. The therapeutic potential of recombinant NRG-1 as a potential treatment for heart failure has been demonstrated in animal models and is now being explored in clinical studies. NRG-1 is found in human serum and plasma, and it correlates with some clinical parameters, suggesting that it may have value as an indicator of prognosis. In this review, we bring together this growing literature on NRG-1 and its significance in cardiovascular development and disease.
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Untangling the ErbB signalling network
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Multiple essential functions of neuregulin in development
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Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor
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Neuregulin1/ErbB4 Signaling Induces Cardiomyocyte Proliferation and Repair of Heart Injury
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ErbB2 is essential in the prevention of dilated cardiomyopathy
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Cited by
D’Uva, G., Aharonov, A., Lauriola, M., Kain, D., Yahalom-Ronen, Y., Carvalho, S., Weisinger, K., Bassat, E., Rajchman, D., Yifa, O., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3149 · Cited by 657
MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy
Halkein, J., Tabruyn, S. P., Ricke-Hoch, M., Haghikia, A., Nguyen, N.-Q.-N., Scherr, M., Castermans, K., Malvaux, L., Lambert, V., Thiry, M., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64365 · Cited by 499
Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure
Koenig, A. L., Shchukina, I., Amrute, J., Andhey, P. S., Zaitsev, K., Lai, L., Bajpai, G., Bredemeyer, A., Smith, G., Jones, C., et al. (2022) · Nature Cardiovascular Research · doi:10.1038/s44161-022-00028-6 · Cited by 482
Paik, D. T., Tian, L., Williams, I. M., Rhee, S., Zhang, H., Liu, C., Mishra, R., Wu, S. M., Red-Horse, K., & Wu, J. C. (2020) · Circulation · doi:10.1161/circulationaha.119.041433 · Cited by 281
Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails.
Fu, Y., Huang, C., Xu, X., Gu, H., Ye, Y., Jiang, C., Qiu, Z., & Xie, X. (2015) · Cell Research · doi:10.1038/cr.2015.99 · Cited by 248
Metadata
- Authors
- Odiete, O., Hill, M. F., & Sawyer, D. B.
- Venue
- Circulation Research
- Published
- 2012-10-26
- Volume
- 111
- Issue
- 10
- Pages
- 1376-1385
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2120636426
- Cited by
- 294
- References
- 90
- FWCI
- 7.95
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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