The DOI matches its Crossref record; 211 of the 211 references it cites were found in a registry or an index.
Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension
Open accessAbstract
This review summarizes an expanding body of knowledge indicating that failure to resolve inflammation and altered immune processes underlie the development of pulmonary arterial hypertension. The chemokines and cytokines implicated in pulmonary arterial hypertension that could form a biomarker platform are discussed. Pre-clinical studies that provide the basis for dysregulated immunity in animal models of the disease are reviewed. In addition, we present therapies that target inflammatory/immune mechanisms that are currently enrolling patients, and discuss others in development. We show how genetic and metabolic abnormalities are inextricably linked to dysregulated immunity and adverse remodeling in the pulmonary arteries.
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“Inflammation is a prominent feature of PH that may be mediated by the host-microbe interaction[314,315].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [314]
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Bosentan Therapy for Pulmonary Arterial Hypertension
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Autophagy and inflammation in chronic respiratory disease
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Hypoxia-inducible factor signaling in pulmonary hypertension
Pullamsetti, S. S., Mamazhakypov, A., Weissmann, N., Seeger, W., & Savai, R. (2020) · Journal of Clinical Investigation · doi:10.1172/jci137558 · Cited by 234
Koch, C. D., Gladwin, M. T., Freeman, B. A., Lundberg, J. O., Weitzberg, E., & Morris, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.015 · Cited by 186
Pulmonary arterial hypertension and the Enigma code of smouldering inflammation
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Metadata
- Authors
- Rabinovitch, M., Guignabert, C., Humbert, M., & Nicolls, M. R.
- Affiliations
- Université Paris-Sud (FR)
- Venue
- Circulation Research
- Published
- 2014-06-20
- Volume
- 115
- Issue
- 1
- Pages
- 165-175
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC4097142
- OpenAlex
- W2132001965
- Cited by
- 1,029
- References
- 211
- Citations by year
- 2026: 78 · 2025: 84 · 2024: 114 · 2023: 84 · 2022: 102 · 2021: 141 · 2020: 92 · 2019: 101 · 2018: 68 · 2017: 60 · 2016: 62 · 2015: 34 · 2014: 6
- FWCI
- 43.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-12-JSV1-0004)
- National Institutes of Health (5r01hl074186-17, 5p01hl108797-10)
- National Heart, Lung, and Blood Institute (HL082662, R01-HL074186, R01HL095686, R56HL082662, R01HL082662, P01-HL-108797)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Rheumatology › Systemic Sclerosis and Related Diseases
- Keywords
- pulmonary arterial hypertension, inflammation, immune dysregulation, chemokines, cytokines, biomarkers, animal models, anti-inflammatory therapy, pulmonary vascular remodeling, genetic abnormalities, metabolic abnormalities
- MeSH terms
- Animals, Dendritic Cells, T-Lymphocytes, Helper-Inducer, Humans, Hypertension, Pulmonary, Immunity, Inflammation, Lymphocytes, Macrophages, Biomarkers, Cytokines, Chemokines, Familial Primary Pulmonary Hypertension
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