The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Cardiac Metabolism and its Interactions With Contraction, Growth, and Survival of Cardiomyocytes
Open accessAbstract
The network for cardiac fuel metabolism contains intricate sets of interacting pathways that result in both ATP-producing and non–ATP-producing end points for each class of energy substrates. The most salient feature of the network is the metabolic flexibility demonstrated in response to various stimuli, including developmental changes and nutritional status. The heart is also capable of remodeling the metabolic pathways in chronic pathophysiological conditions, which results in modulations of myocardial energetics and contractile function. In a quest to understand the complexity of the cardiac metabolic network, pharmacological and genetic tools have been engaged to manipulate cardiac metabolism in a variety of research models. In concert, a host of therapeutic interventions have been tested clinically to target substrate preference, insulin sensitivity, and mitochondrial function. In addition, the contribution of cellular metabolism to growth, survival, and other signaling pathways through the production of metabolic intermediates has been increasingly noted. In this review, we provide an overview of the cardiac metabolic network and highlight alterations observed in cardiac pathologies as well as strategies used as metabolic therapies in heart failure. Lastly, the ability of metabolic derivatives to intersect growth and survival are also discussed.
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Cited by
Guidelines for experimental models of myocardial ischemia and infarction
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Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes
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Contractile work contributes to maturation of energy metabolism in hiPSC-derived cardiomyocytes
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Lipoxidation in cardiovascular diseases
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Metadata
- Authors
- Kolwicz, S. C., Purohit, S., & Tian, R.
- Venue
- Circulation Research
- Published
- 2013-08-16
- Volume
- 113
- Issue
- 5
- Pages
- 603-616
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W1968550558
- Cited by
- 813
- References
- 31
- FWCI
- 21.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Kolwicz, S. C., Purohit, S., & Tian, R. (2013). Cardiac Metabolism and its Interactions With Contraction, Growth, and Survival of Cardiomyocytes. Circulation Research. https://doi.org/10.1161/circresaha.113.302095
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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