The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Circulating Nitrite Contributes to Cardioprotection by Remote Ischemic Preconditioning
Abstract
Rationale: Remote ischemic preconditioning (rIPC) with short episodes of ischemia/reperfusion (I/R) of an organ remote from the heart is a powerful approach to protect against myocardial I/R injury. The signal transduction pathways for the cross talk between the remote site and the heart remain unclear in detail. Objective: To elucidate the role of circulating nitrite in cardioprotection by rIPC. Methods and Results: Mice were subjected to 4 cycles of no-flow ischemia with subsequent reactive hyperemia within the femoral region and underwent in vivo myocardial I/R (30 minutes/5 minutes or 24 hours). The mouse experiments were conducted using genetic and pharmacological approaches. Shear stress–dependent stimulation of endothelial nitric oxide synthase within the femoral artery during reactive hyperemia yielded substantial release of nitric oxide, subsequently oxidized to nitrite and transferred humorally to the myocardium. Within the heart, reduction of nitrite to nitric oxide by cardiac myoglobin and subsequent S -nitrosation of mitochondrial membrane proteins reduced mitochondrial respiration, reactive oxygen species formation, and myocardial infarct size. Pharmacological and genetic inhibition of nitric oxide/nitrite generation by endothelial nitric oxide synthase at the remote site or nitrite bioactivation by myoglobin within the target organ abrogated the cardioprotection by rIPC. Transfer experiments of plasma from healthy volunteers subjected to rIPC of the arm identified plasma nitrite as a cardioprotective agent in isolated Langendorff mouse heart preparations exposed to I/R. Conclusions: Circulating nitrite derived from shear stress–dependent stimulation of endothelial nitric oxide synthase at the remote site of rIPC contributes to cardioprotection during I/R. Clinical Trial Registration—: URL: http://www.clinicaltrials.gov . Unique identifier: NCT01259739.
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Citations
Cites
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
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Bøtker, H. E., Kharbanda, R., Schmidt, M. R., Bøttcher, M., Kaltoft, A. K., Terkelsen, C. J., Munk, K., Andersen, N. H., Hansen, T. M., Trautner, S., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(09)62001-8 · Cited by 989
Dietary Inorganic Nitrate Improves Mitochondrial Efficiency in Humans
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“As demonstrated by us and others, circulating nitrite levels in the investigated species range at ≈20 to 50 nmol/L in humans and ≈300 to 500 nmol/L in mice.(36,37) Considering that after 40 minutes (ie, 4 cycles of ischemia and 4 cycles of reperfusion of each 5-minute duration) most nitrite will escape the circulation…”
BackgroundHausenloy, D. J., Mwamure, P. K., Venugopal, V., Harris, J., Barnard, M., Grundy, E., Ashley, E., Vichare, S., Di Salvo, C., Kolvekar, S., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61296-3 · Cited by 680
Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver
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Furchgott, R. F., & Bhadrakom, S. (1953) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)05163-8 · Cited by 655
Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I
Chouchani, E. T., Methner, C., Nadtochiy, S. M., Logan, A., Pell, V. R., Ding, S., James, A. M., Cochemé, H. M., Reinhold, J., Lilley, K. S., et al. (2013) · Nature Medicine · doi:10.1038/nm.3212 · Cited by 619 · cited 2×
“function by S-nitrosation, recently emerging as a key event for cardioprotection.(29,31,49,50) A potential effect on I/R-induced mitochondrial damage or turnover would also be an important aspect, and future studies are needed.”
BackgroundMyocardial Protection by Brief Ischemia in Noncardiac Tissue
Gho, B. C. G., Schoemaker, R. G., van den Doel, M. A., Duncker, D. J., & Verdouw, P. D. (1996) · Circulation · doi:10.1161/01.cir.94.9.2193 · Cited by 618
Nitrate and nitrite in biology, nutrition and therapeutics
Lundberg, J. O., Gladwin, M. T., Ahluwalia, A., Benjamin, N., Bryan, N. S., Butler, A., Cabrales, P., Fago, A., Feelisch, M., Ford, P. C., et al. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.260 · Cited by 617
Self-citation
Cited by
Nitric oxide signalling in cardiovascular health and disease
Farah, C., Michel, L. Y. M., & Balligand, J.-L. (2018) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.224 · Cited by 779
Strategies to increase nitric oxide signalling in cardiovascular disease
Lundberg, J. O., Gladwin, M. T., & Weitzberg, E. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4623 · Cited by 576
Ischaemic conditioning and reperfusion injury
Hausenloy, D. J., & Yellon, D. M. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.5 · Cited by 579
Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541
Self-citationIschaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery
Hausenloy, D. J., Barrabes, J. A., Bøtker, H. E., Davidson, S. M., Di Lisa, F., Downey, J., Engstrom, T., Ferdinandy, P., Carbrera-Fuentes, H. A., Heusch, G., et al. (2016) · Basic Research in Cardiology · doi:10.1007/s00395-016-0588-8 · Cited by 308
Self-citation
Metadata
- Authors
- Rassaf, T., Totzeck, M., Hendgen-Cotta, U. B., Shiva, S., Heusch, G., & Kelm, M.
- Venue
- Circulation Research
- Published
- 2014-05-09
- Volume
- 114
- Issue
- 10
- Pages
- 1601-1610
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2098329072
- Cited by
- 344
- References
- 48
- FWCI
- 34.24
- Type
- journal article
- Language
- en
- Open access
- closed
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