Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs

Furchgott, Robert F.; Bhadrakom, Suchin

doi:10.1016/s0022-3565(25)05163-8

Cited by 655Receptor Mechanisms and SignalingCardiovascular, Neuropeptides, and Oxidative Stress ResearchNitric Oxide and Endothelin Effects

Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs

Furchgott, Robert F., Bhadrakom, Suchin·1953·The Journal of Pharmacology and Experimental Therapeutics

DOI 10.1016/s0022-3565(25)05163-8

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Furchgott and Bhadrakhom demonstrated that nitrite relaxes pre-constricted aortic vessels, but the concentrations used were substantially higher than physiological.
“In 1952 Furchgott and Bhadrakhom demonstrated the ability of nitrite to effect relaxation of pre-constricted aortic vessels, but the concentrations used where substantially higher than that found in physiological conditions (100 μM compared to normal levels of tens to hundreds of nanomolar) [27].”
From Mechanisms of nitrite bioactivation (2014) · cites this paper as [27]

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“These strips were discarded since they would not respond to any stimulus.(17)”
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More answers to the still unresolved question of nitrate tolerance
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Method
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BackgroundMethod
Characterization of postsynaptic α‐adrenoceptors in rat aortic strips and portal veins
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Background
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Background
A New, Long-Lasting Competitive Inhibitor of Angiotensin
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“This enzyme can produce both O 2 and hydrogen peroxide during its metabolism of purines.242–244 This enzyme, as discussed above, belongs to the major endogenous pathways contributing to the reduction in inorganic nitrate/nitrite to NO.”
BackgroundInfluential
Influence of papaverine, D 600, and nifedipine on the effects of noradrenaline and calcium on the isolated aorta and mesenteric artery of the rabbit
Sch�mann, H. J., G�rlitz, B. D., & Wagner, J. (1975) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00508414 · Cited by 85 · see citing works
“Thereafter the thoracic aorta and the mesenterie artery were prepared according to Furchgott and Bhadrakom (1953). After removing the connective tissue the vessels were cut into spiral strips and mounted in an organ bath of 40 ml of Tyrode solution.”
Method
Plasma Renin Activity in Acute Tubular Necrosis and Other Renal Diseases Associated with Hypertension
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Authors: Furchgott, R. F., & Bhadrakom, S.
Affiliations: Washington University in St. Louis (US)
Venue: The Journal of Pharmacology and Experimental Therapeutics
Publisher: Elsevier BV
Published: 1953-06
Volume: 108
Issue: 2
Pages: 129-143
ISSN: 0022-3565 (ISSN-L)
DOI: 10.1016/s0022-3565(25)05163-8
OpenAlex: W2302863210
Cited by: 655
References: 0
Citations by year: 2026: 1 · 2025: 4 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 8 · 2018: 6 · 2017: 6 · 2016: 9 · 2015: 9 · 2014: 13 · 2013: 7 · 2012: 9
FWCI: 2.01
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
PubMed (publishedVersion)
PubMed
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords: rabbit aorta, epinephrine, isoproterenol, sodium nitrite, norepinephrine, histamine, acetylcholine, vascular smooth muscle contraction, drug sensitivity, drug antagonism
MeSH terms: Animals, Aorta, Epinephrine, Isoproterenol, Norepinephrine, Rabbits, Sodium Nitrite

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Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs

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