The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Circulating Long Noncoding RNA, LIPCAR, Predicts Survival in Patients With Heart Failure
Open accessAbstract
Rationale: Long noncoding RNAs represent a novel class of molecules regulating gene expression. Long noncoding RNAs are present in body fluids, but their potential as biomarkers was never investigated in cardiovascular disease. Objective: To study the role of long noncoding RNAs as potential biomarkers in heart disease. Methods and Results: Global transcriptomic analyses were done in plasma RNA from patients with or without left ventricular remodeling after myocardial infarction. Regulated candidates were validated in 3 independent patient cohorts developing cardiac remodeling and heart failure (788 patients). The mitochondrial long noncoding RNA uc022bqs.1 (LIPCAR) was downregulated early after myocardial infarction but upregulated during later stages. LIPCAR levels identified patients developing cardiac remodeling and were independently to other risk markers associated with future cardiovascular deaths. Conclusions: LIPCAR is a novel biomarker of cardiac remodeling and predicts future death in patients with heart failure.
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Cites
Long Noncoding RNAs: Cellular Address Codes in Development and Disease
Batista, P. J., & Chang, H. Y. (2013) · Cell · doi:10.1016/j.cell.2013.02.012 · Cited by 2,531
Cited by
Tham, Y. K., Bernardo, B. C., Ooi, J. Y. Y., Weeks, K. L., & McMullen, J. R. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1477-x · Cited by 708
Long non-coding RNAs and complex diseases: from experimental results to computational models
Chen, X., Yan, C. C., Zhang, X., & You, Z.-H. (2016) · Briefings in Bioinformatics · doi:10.1093/bib/bbw060 · Cited by 567
Long non-coding RNAs: From disease code to drug role
Chen, Y., Li, Z., Chen, X., & Zhang, S. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.10.001 · Cited by 503
Targeting mitochondria-located circrna scar alleviates nash via reducing mros output
Zhao, Q., Liu, J., Deng, H., Ma, R., Liao, J.-Y., Liang, H., Hu, J., Li, J., Guo, Z., Cai, J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.009 · Cited by 469
The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy
Wang, Z., Zhang, X.-J., Ji, Y.-X., Zhang, P., Deng, K.-Q., Gong, J., Ren, S., Wang, X., Chen, I., Wang, H., et al. (2016) · Nature Medicine · doi:10.1038/nm.4179 · Cited by 386
Metadata
- Authors
- Kumarswamy, R., Bauters, C., Volkmann, I., Maury, F., Fetisch, J., Holzmann, A., Lemesle, G., de Groote, P., Pinet, F., & Thum, T.
- Venue
- Circulation Research
- Published
- 2014-05-09
- Volume
- 114
- Issue
- 10
- Pages
- 1569-1575
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2137854396
- Cited by
- 625
- References
- 1
- FWCI
- 39.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Circulating Long Noncoding RNA, LIPCAR, Predicts Survival in Patients With Heart Failure. https://app.cochat.ai/papers/10.1161/circresaha.114.303915
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- Kumarswamy, R., Bauters, C., Volkmann, I., Maury, F., Fetisch, J., Holzmann, A., Lemesle, G., de Groote, P., Pinet, F., & Thum, T. (2014). Circulating Long Noncoding RNA, LIPCAR, Predicts Survival in Patients With Heart Failure. Circulation Research. https://doi.org/10.1161/circresaha.114.303915
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