The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Renal Denervation Prevents Immune Cell Activation and Renal Inflammation in Angiotensin II–Induced Hypertension
Open accessAbstract
Rationale: Inflammation and adaptive immunity play a crucial role in the development of hypertension. Angiotensin II and probably other hypertensive stimuli activate the central nervous system and promote T-cell activation and end-organ damage in peripheral tissues. Objective: To determine if renal sympathetic nerves mediate renal inflammation and T-cell activation in hypertension. Methods and Results: Bilateral renal denervation using phenol application to the renal arteries reduced renal norepinephrine levels and blunted angiotensin II–induced hypertension. Bilateral renal denervation also reduced inflammation, as reflected by decreased accumulation of total leukocytes, T cells, and both CD4 + and CD8 + T cells in the kidney. This was associated with a marked reduction in renal fibrosis, albuminuria, and nephrinuria. Unilateral renal denervation, which partly attenuated blood pressure, only reduced inflammation in the denervated kidney, suggesting that this effect is pressure independent. Angiotensin II also increased immunogenic isoketal-protein adducts in renal dendritic cells (DCs) and increased surface expression of costimulation markers and production of interleukin (IL)-1α, IL-1β, and IL-6 from splenic DCs. Norepinephrine also dose dependently stimulated isoketal formation in cultured DCs. Adoptive transfer of splenic DCs from angiotensin II–treated mice primed T-cell activation and hypertension in recipient mice. Renal denervation prevented these effects of hypertension on DCs. In contrast to these beneficial effects of ablating all renal nerves, renal afferent disruption with capsaicin had no effect on blood pressure or renal inflammation. Conclusions: Renal sympathetic nerves contribute to DC activation, subsequent T-cell infiltration and end-organ damage in the kidney in the development of hypertension.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Multiple preclinical studies have demonstrated that total RDN (TRDN, defined as ablation of the sympathetic efferent and sensory afferent nerves) causes a significant and sustained reduction in mean arterial blood pressure20,69–73.”
From Renal nerves in physiology, pathophysiology and interoception (2025) · cites this paper as [72]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nitric oxide synthases: regulation and function
Forstermann, U., & Sessa, W. C. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr304 · Cited by 4,409
Cellular and Molecular Immunology
Abbas, A. K., Lichtman, A. H., & Pillai, S. S. (1994) · Cited by 3,571
Cellular and Molecular Immunology
Denman, A. M. (1992) · Postgraduate Medical Journal · doi:10.1136/pgmj.68.798.305 · Cited by 2,807
A Controlled Trial of Renal Denervation for Resistant Hypertension
Bhatt, D. L., Kandzari, D. E., O'Neill, W. W., D'Agostino, R., Flack, J. M., Katzen, B. T., Leon, M. B., Liu, M., Mauri, L., Negoita, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1402670 · Cited by 2,186
Role of the T cell in the genesis of angiotensin II–induced hypertension and vascular dysfunction
Guzik, T. J., Hoch, N. E., Brown, K. A., McCann, L. A., Rahman, A., Dikalov, S., Goronzy, J., Weyand, C., & Harrison, D. G. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070657 · Cited by 1,736
Self-citationInflammation, Immunity, and Hypertension
Harrison, D. G., Guzik, T. J., Lob, H. E., Madhur, M. S., Marvar, P. J., Thabet, S., Vinh, A., & Weyand, C. M. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.163576 · Cited by 893
Self-citationJakubzick, C. V., Gautier, E., Gibbings, S. L., Sojka, D. K., Schlitzer, A., Johnson, T. E., Ivanov, S., Duan, Q., Bala, S., Condon, T., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.007 · Cited by 762
Catheter-Based Renal Sympathetic Denervation for Resistant Hypertension
Symplicity HTN-1 Investigators (2011) · Hypertension · doi:10.1161/hypertensionaha.110.163014 · Cited by 743
Predictors of blood pressure response in the SYMPLICITY HTN-3 trial
Kandzari, D. E., Bhatt, D. L., Brar, S. K., Devireddy, C. M., Esler, M., Fahy, M. P., Flack, J. M., Katzen, B. T., Lea, J. P., Lee, D. P., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu441 · Cited by 552
DC isoketal-modified proteins activate T cells and promote hypertension
Kirabo, A., Fontana, V., de Faria, A. P., Loperena, R., Galindo, C. L., Wu, J., Bikineyeva, A. T., Dikalov, S., Xiao, L., Chen, W., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74084 · Cited by 549
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–231 of 231
Renal Nerves: Roles in Homeostasis and Pathophysiology
Tyshynsky, R., Vulchanova, L., & Osborn, J. W. (2023) · Springer eBooks · doi:10.1007/978-3-031-38934-4_1 · Cited by 1
Self-citationThe Influence of Celery (Apium graveolens) Juice on Hypertension
Illes, J. D., & Rodrigues, J. (2024) · Reference series in phytochemistry · doi:10.1007/978-3-031-38663-3_72 · Cited by 1
Inflammation and Immunity in Hypertension
Harrison, D. G., Bernstein, K. E., & Guzik, T. J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-88369-6.00007-4 · Cited by 1
Self-citationKossmann, S., & Wenzel, P. (2018) · Hypertension · doi:10.1161/hypertensionaha.117.10216 · Cited by 1
Circulation Research “In This Issue” Anthology
Williams, R. R. E., & Editors, T. (2016) · Circulation Research · doi:10.1161/res.0000000000000108 · Cited by 1
Denervation Aggravates Renal Ischemia Reperfusion Injury via BMAL1-mediated Nrf2/ARE pathwayPreprint
Sun, Q., WANG, Y., Tang, Q., ZENG, C., Du, L., & Dong, C. (2022) · Research Square · doi:10.21203/rs.3.rs-2017001/v1 · Cited by 1
Hoyer-Kimura, C. H., Huentelman, M. J., & Hay, M. (2026) · medRxiv · doi:10.64898/2026.05.06.26352482 · Cited by 1
Diseases, C., & Ablation, H. (2016) · Interventional Cardiology Journal · doi:10.21767/2471-8157.100025
Pathophysiological Insights in Resistant Hypertension
Burlacu, A., & Covic, A. C. (2017) · Springer eBooks · doi:10.1007/978-3-319-56827-0_7
Investigating the role of kidney mononuclear phagocytes in immune complex-induced inflammation.
Richoz, N. (2019) · Apollo (University of Cambridge) · doi:10.17863/cam.50696
Gigliotti, J. C., Le, T. H., & McDonough, A. A. (2020) · Nephrology Self-Assessment Program · doi:10.1681/nsap.2020.19.1.5
Renal Denervation: Physiology, Scope, and Current Evidence
Kiuchi, M. G., & Schlaich, M. P. (2020) · Springer eBooks · doi:10.1007/978-3-030-45414-2_21
SGK1, influenced by salt and IL-17A, promotes hypertension and end-organ damage
Norlander, A. E. (2017)
Chade, A. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733456824.793552578
Editorial: Inflammation in hypertensive disorders
Itani, H. A., & Evans, L. C. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2022.1085856
Self-citationRenal Denervation for Chronic Kidney Disease
Kiuchi, M. G., Carnagarin, R., Lugo‐Gavidia, L. M., Hering, D., & Schlaich, M. P. (2023) · Springer eBooks · doi:10.1007/978-3-031-38934-4_9
Renal denervation for Diabetes and Metabolic syndrome
Carnagarin, R., Kiuchi, M. G., Lugo‐Gavidia, L. M., & Schlaich, M. P. (2023) · Springer eBooks · doi:10.1007/978-3-031-38934-4_8
Nistor, M., Schmidt, M., Klingner, C. M., Klingner, C. C., Matziolis, G., Shayganfar, S., & Schiffner, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042041
Vasoactive Substances as Mediators of Renal Injury
Caceres, P. S., & Rossi, N. F. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00105-4
Cortinovis, M., Perico, N., & Remuzzi, G. (2025) · Updates in hypertension and cardiovascular protection · doi:10.1007/978-3-031-81292-7_10
Renal Denervation for Treating Refractory Hypertension
Katsurada, K., & Kario, K. (2024) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.113.703
18F-DOPA uptake illustration acts as an indicator for renal sympathetic activity
Wu, R. J., Shi, S., Huang, Y., Tian, F., Hou, J.-Q., Kong, X., Sheng, L., Zhang, T., Tang, L., & Sun, W. Y. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1569699
Zhuo, C., Chen, L., Sun, X., Chen, T., Cai, H., & Hu, X. (2026) · Global Heart · doi:10.5334/gh.1526
Neural control of renal function
Grisk, O., Johns, E. J., & Kopp, U. C. (2026) · Elsevier eBooks · doi:10.1016/b978-0-12-815389-5.00031-9
Recent update on renal denervation: where do we stand now?
Shin, J., & Yoon, Y.-W. (2026) · Clinical Hypertension · doi:10.5646/ch.2026.32.e26
Recent Advances in the Pathophysiology of Hypertension
Montezano, A. C. I., Sarafian, R. D., Rios, F. J. O., Blaikie, Z., Camargo, L. L., Rasouli, M., & Touyz, R. M. (2026) · Physiology · doi:10.1152/physiol.00019.2023
Yang, Y., Xue, J., Wang, L. H., Tao, L., & Tian, L. (2026) · Medicine · doi:10.1097/md.0000000000048842
Tong, X., Wang, B., Gao, F., Zhong, A., Fan, W., Zhang, Y., & Huang, W.-Y. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118382
Renal denervation for hypertension management: past, current evidence, and future directions
Hassan, S., Rendon, I. H., Spilias, N., Bredel, L., Chatzizisis, Y. S., & Delgado-Lelievre, M. C. (2026) · American Journal of Hypertension · doi:10.1093/ajh/hpag112
The role of immuno-inflammatory biomarkers in the pathogenesis of hypertension
Mordovin, V. F., Rudenko, V. V., Zyubanova, I. V., Lichikaki, V. A., Manukyan, M. A., Хунхинова, С. А., Цой, Е. И., Popova, A. A., Вторушина, А. А., Garganeeva, E. S., et al. (2026) · Arterial’naya Gipertenziya (Arterial Hypertension) · doi:10.18705/1607-419x-2026-2593
Викторович, Ж. В., Михайлович, Е. Е., Teplova, N. V., Ob, K., & Владимировна, С. М. (2026) · Nephrology (Saint-Petersburg) · doi:10.36485/1561-6274-2026-30-3-75-85
Metadata
- Authors
- Xiao, L., Kirabo, A., Wu, J., Saleh, M. A., Zhu, L., Wang, F., Takahashi, T., Loperena, R., Foss, J. D., Mernaugh, R. L., Chen, W., Roberts, J., Osborn, J. W., Itani, H. A., & Harrison, D. G.
- Affiliations
- University of Minnesota (US)
- ORCID
- Venue
- Circulation Research
- Published
- 2015-08-28
- Volume
- 117
- Issue
- 6
- Pages
- 547-557
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC4629828
- OpenAlex
- W2166852030
- Cited by
- 233
- References
- 42
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 19 · 2023: 18 · 2022: 23 · 2021: 19 · 2020: 30 · 2019: 25 · 2018: 22 · 2017: 23 · 2016: 20 · 2015: 6
- FWCI
- 17.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Vanderbilt University
- Vanderbilt University Medical Center
- National Heart, Lung, and Blood Institute (R01HL039006, R01HL108701, K01HL130497, P01 HL58000, R01HL116476, F32HL124972, P01HL058000, HL039006, P01HL095070, R01HL105294, R01HL125865)
- National Institute of General Medical Sciences (GM015431, P50GM015431, P01GM015431, R25GM062459, T32GM007569)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK079341)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Nephrology › Renal and Vascular Pathologies
- Keywords
- renal denervation, angiotensin II-induced hypertension, renal inflammation, T cell activation, renal sympathetic nerves, dendritic cells, norepinephrine, renal fibrosis, albuminuria, renal afferent nerves, capsaicin, adaptive immunity, interleukins
- MeSH terms
- Angiotensin II, Animals, Hypertension, Immunity, Cellular, Kidney, Mice, Inbred C57BL, Random Allocation, Sympathectomy, Mice, Knockout, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
