Cited by 1,785Peripheral Artery Disease ManagementHealthcare Systems and Public HealthVascular Procedures and Complications

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Epidemiology of Peripheral Artery Disease

Criqui, Michael H., Aboyans, Victor·2015·Circulation Research

DOI 10.1161/circresaha.116.303849

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Abstract

New data on the epidemiology of peripheral artery disease (PAD) are available, and they should be integrated with previous data. We provide an updated, integrated overview of the epidemiology of PAD, a focused literature review was conducted on the epidemiology of PAD. The PAD results were grouped into symptoms, diagnosis, prevalence, and incidence both in the United States and globally, risk factors, progression, coprevalence with other atherosclerotic disease, and association with incident cardiovascular morbidity and mortality. The most common symptom of PAD is intermittent claudication, but noninvasive measures, such as the ankle-brachial index, show that asymptomatic PAD is several times more common in the population than intermittent claudication. PAD prevalence and incidence are both sharply age-related, rising >10% among patients in their 60s and 70s. With aging of the global population, it seems likely that PAD will be increasingly common in the future. Prevalence seems to be higher among men than women for more severe or symptomatic disease. The major risk factors for PAD are similar to those for coronary and cerebrovascular disease, with some differences in the relative importance of factors. Smoking is a particularly strong risk factor for PAD, as is diabetes mellitus, and several newer risk markers have shown independent associations with PAD. PAD is strongly associated with concomitant coronary and cerebrovascular diseases. After adjustment for known cardiovascular disease risk factors, PAD is associated with an increased risk of incident coronary and cerebrovascular disease morbidity and mortality.

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Authors: Criqui, M. H., & Aboyans, V.
Affiliations: Inserm (FR)
ORCID: Criqui, Michael H.
Aboyans, Victor
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2015-04-24
Volume: 116
Issue: 9
Pages: 1509-1526
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/circresaha.116.303849
OpenAlex: W2148374679
Cited by: 1,785
References: 160
Citations by year: 2026: 149 · 2025: 172 · 2024: 195 · 2023: 179 · 2022: 203 · 2021: 223 · 2020: 196 · 2019: 169 · 2018: 131 · 2017: 107 · 2016: 52 · 2015: 9
FWCI: 100.46
Type: journal article
Language: en
Update notices: correction (2015-06-19)
Open access: closed
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Health Sciences › Medicine › Surgery › Peripheral Artery Disease Management
Health Sciences › Medicine › Epidemiology › Healthcare Systems and Public Health
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vascular Procedures and Complications
Keywords: peripheral arterial disease, epidemiology, intermittent claudication, asymptomatic peripheral artery disease, ankle-brachial index, prevalence, incidence, risk factors, smoking, diabetes mellitus, atherosclerosis, cardiovascular morbidity, cardiovascular mortality, population aging
MeSH terms: Humans, Intermittent Claudication, Prognosis, Risk Factors, United States, Global Health, Incidence, Prevalence, Ankle Brachial Index, Peripheral Arterial Disease

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