The DOI matches its Crossref record; 166 of the 166 references it cites were found in a registry or an index.
Induced Pluripotent Stem Cells 10 Years Later: For Cardiac Applications
Abstract
Induced pluripotent stem cells (iPSCs) are reprogrammed cells that have features similar to embryonic stem cells, such as the capacity of self-renewal and differentiation into many types of cells, including cardiac myocytes. Although initially the reprogramming efficiency was low, several improvements in reprogramming methods have achieved robust and efficient generation of iPSCs without genomic insertion of transgenes. iPSCs display clonal variations in epigenetic and genomic profiles and cellular behavior in differentiation. iPSC-derived cardiac myocytes (iPSC cardiac myocytes) recapitulate phenotypic differences caused by genetic variations, making them attractive human disease models, and are useful for drug discovery and toxicology testing. In addition, iPSC cardiac myocytes can help with patient stratification in regard to drug responsiveness. Furthermore, they can be used as source cells for cardiac regeneration in animal models. Here, we review recent progress in iPSC technology and its applications to cardiac diseases.
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Cited by
Functional isolation, culture and cryopreservation of adult human primary cardiomyocytes
Zhou, B., Shi, X., Tang, X., Zhao, Q., Wang, L., Yao, F., Hou, Y., Wang, X., Feng, W., Wang, L., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01044-5 · Cited by 46
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Metadata
- Authors
- Yoshida, Y., & Yamanaka, S.
- Venue
- Circulation Research
- Published
- 2017-06-09
- Volume
- 120
- Issue
- 12
- Pages
- 1958-1968
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2622073064
- Cited by
- 264
- References
- 166
- FWCI
- 10.19
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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