The DOI matches its Crossref record; 219 of the 221 references it cites were found in a registry or an index.
Inflammatory and Biomechanical Drivers of Endothelial-Interstitial Interactions in Calcific Aortic Valve Disease
Open accessAbstract
Calcific aortic valve disease is dramatically increasing in global burden, yet no therapy exists outside of prosthetic replacement. The increasing proportion of younger and more active patients mandates alternative therapies. Studies suggest a window of opportunity for biologically based diagnostics and therapeutics to alleviate or delay calcific aortic valve disease progression. Advancement, however, has been hampered by limited understanding of the complex mechanisms driving calcific aortic valve disease initiation and progression towards clinically relevant interventions.
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“PRRX1 has been shown to orchestrate the transition of stromal fibroblasts to myofibroblasts via TGF-β signaling19, which is a known mechanism taking place in valve interstitial cells in CAVS20.”
From Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation (2024) · cites this paper as [20]
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Cited by
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Lumican promotes calcific aortic valve disease through H3 histone lactylation
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Metadata
- Authors
- Driscoll, K., Cruz, A. D., & Butcher, J. T.
- Affiliations
- Cornell University (US)
- Venue
- Circulation Research
- Published
- 2021-04-30
- Volume
- 128
- Issue
- 9
- Pages
- 1344-1370
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC8519486
- OpenAlex
- W3159358349
- Cited by
- 102
- References
- 221
- Citations by year
- 2026: 23 · 2025: 32 · 2024: 24 · 2023: 12 · 2022: 7 · 2021: 4
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL128745, R01HL151190, R01HL143247)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Aortic Disease and Treatment Approaches
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- calcific aortic valve disease, inflammation, biomechanics
- MeSH terms
- Aortic Valve, Aortic Valve Stenosis, Calcinosis, Homeostasis, Humans, Immune System, Nitric Oxide, Prognosis, Risk Factors, Vasculitis, Cell Adhesion Molecules, Reactive Oxygen Species, Disease Progression, Inflammation Mediators, Endothelial Cells, Nitric Oxide Synthase Type III
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