Cited by 123Cardiac Valve Diseases and TreatmentsAortic Disease and Treatment ApproachesAtherosclerosis and Cardiovascular Diseases

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Inflammatory and Biomechanical Drivers of Endothelial-Interstitial Interactions in Calcific Aortic Valve Disease

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Driscoll, Katherine, Cruz, Alexander D., Butcher, Jonathan T.·2021·Circulation Research

DOI 10.1161/circresaha.121.318011PMC PMC8519486

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Abstract

Calcific aortic valve disease is dramatically increasing in global burden, yet no therapy exists outside of prosthetic replacement. The increasing proportion of younger and more active patients mandates alternative therapies. Studies suggest a window of opportunity for biologically based diagnostics and therapeutics to alleviate or delay calcific aortic valve disease progression. Advancement, however, has been hampered by limited understanding of the complex mechanisms driving calcific aortic valve disease initiation and progression towards clinically relevant interventions.

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Additional file 19 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606473
Additional file 23 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
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Additional file 9 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606443
Additional file 8 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606440
Additional file 6 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606431
Additional file 13 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J. T., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606455
Additional file 1 of Screening of immune-related secretory proteins linking chronic kidney disease with calcific aortic valve disease based on comprehensive bioinformatics analysis and machine learning
Zhu, E., Shu, X., Xu, Z. J., Peng, Y., Xiang, Y., Liu, Y., Guan, H., Zhong, M., Li, J., Zhang, L.-Z., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26593280
Additional file 22 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606494
Additional file 14 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J. T., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606458
Additional file 18 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606470
Additional file 5 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606428
Additional file 4 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606425
Additional file 24 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606500
Additional file 1 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606416
Additional file 21 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606485
Additional file 17 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606467
Additional file 10 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606446
Additional file 20 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606479
Additional file 16 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J. T., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606464
Additional file 26 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606506

Authors: Driscoll, K., Cruz, A. D., & Butcher, J. T.
Affiliations: Cornell University (US)
ORCID: Driscoll, Katherine
Cruz, Alexander D.
Butcher, Jonathan T.
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2021-04-30
Volume: 128
Issue: 9
Pages: 1344-1370
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/circresaha.121.318011
PMC: PMC8519486
OpenAlex: W3159358349
Cited by: 102
References: 221
Citations by year: 2026: 23 · 2025: 32 · 2024: 24 · 2023: 12 · 2022: 7 · 2021: 4
FWCI: 3.32
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL128745, R01HL151190, R01HL143247)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Aortic Disease and Treatment Approaches
Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords: calcific aortic valve disease, inflammation, biomechanics
MeSH terms: Aortic Valve, Aortic Valve Stenosis, Calcinosis, Homeostasis, Humans, Immune System, Nitric Oxide, Prognosis, Risk Factors, Vasculitis, Cell Adhesion Molecules, Reactive Oxygen Species, Disease Progression, Inflammation Mediators, Endothelial Cells, Nitric Oxide Synthase Type III

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