The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Human Atrial Ion Channel and Transporter Subunit Gene-Expression Remodeling Associated With Valvular Heart Disease and Atrial Fibrillation
Open accessAbstract
Background— Valvular heart disease (VHD), which often leads to atrial fibrillation (AF), and AF both cause ion-channel remodeling. We evaluated the ion-channel gene expression profile of VHD patients, in permanent AF (AF-VHD) or in sinus rhythm (SR-VHD), in comparison with patients without AF or VHD, respectively. Methods and Results— We used microarrays containing probes for human ion-channel and Ca 2+ -regulator genes to quantify mRNA expression in atrial tissues from 7 SR-VHD patients and 11 AF-VHD patients relative to 11 control patients in SR without structural heart disease (SR-CAD). From the data set, we selected for detailed analysis 59 transcripts expressed in the human heart. SR-VHD patients differentially expressed 24/59 ion-channel and Ca 2+ -regulator transcripts. There was significant overlap between VHD groups, with 66% of genes altered in SR-VHD patients being similarly modified in AF-VHD. Statistical differences between the AF- and SR-VHD groups identified the specific molecular portrait of AF, which involved 12 genes that were further confirmed by real-time reverse transcription–polymerase chain reaction. For example, phospholamban, the β-subunit MinK ( KCNE1 ) and MIRP2 ( KCNE3 ), and the 2-pore potassium channel TWIK-1 were upregulated in AF-VHD compared with SR-VHD, whereas the T-type calcium-channel Cav3.1 and the transient-outward potassium channel Kv4.3 were downregulated. Two-way hierarchical clustering separated SR-VHD from AF-VHD patients. AF-related changes in L-type Ca 2+ -current and inward-rectifier current were confirmed at protein and functional levels. Finally, for 13 selected genes, SR restoration reversed ion-channel remodeling. Conclusions— VHD extensively remodels cardiac ion-channel and transporter expression, and AF alters ion-channel expression in VHD patients.
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Kannel, W. B., Wolf, P. A., Benjamin, E. J., & Levy, D. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00583-9 · Cited by 2,033
Cited by
Pathophysiological mechanisms of atrial fibrillation: a translational appraisal
Schotten, U., Verheule, S., Kirchhof, P., & Goette, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00031.2009 · Cited by 1,273
Atrial Remodeling and Atrial Fibrillation: Mechanisms and Implications
Nattel, S., Burstein, B., & Dobrev, D. (2008) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.107.754564 · Cited by 1,124
Self-citationMolecular Background of Leak K+Currents: Two-Pore Domain Potassium Channels
Enyedi, P., & Czirják, G. (2010) · Physiological Reviews · doi:10.1152/physrev.00029.2009 · Cited by 868
Heijman, J., Voigt, N., Nattel, S., & Dobrev, D. (2014) · Circulation Research · doi:10.1161/circresaha.114.302226 · Cited by 677
Self-citationGaborit, N., Le Bouter, S., Szuts, V., Varro, A., Escande, D., Nattel, S., & Demolombe, S. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2006.126714 · Cited by 522
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Metadata
- Authors
- Gaborit, N., Steenman, M., Lamirault, G., Le Meur, N., Le Bouter, S., Lande, G., Léger, J., Charpentier, F., Christ, T., Dobrev, D., Escande, D., Nattel, S., & Demolombe, S.
- Venue
- Circulation
- Published
- 2005-07-26
- Volume
- 112
- Issue
- 4
- Pages
- 471-481
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2140771305
- Cited by
- 249
- References
- 1
- FWCI
- 9.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gaborit, N., Steenman, M., Lamirault, G., Le Meur, N., Le Bouter, S., Lande, G., Léger, J., Charpentier, F., Christ, T., Dobrev, D., Escande, D., Nattel, S., & Demolombe, S. (2005). Human Atrial Ion Channel and Transporter Subunit Gene-Expression Remodeling Associated With Valvular Heart Disease and Atrial Fibrillation. Circulation. https://doi.org/10.1161/circulationaha.104.506857
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