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Cited by 287

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Anemia and Change in Hemoglobin Over Time Related to Mortality and Morbidity in Patients With Chronic Heart Failure: Results From Val-HeFT

Anand, Inder S., Kuskowski, Michael A., Rector, Thomas S., Florea, Viorel G., Glazer, Robert D., Hester, Allen, Chiang, Yann Tong, Aknay, Nora, Maggioni, Aldo P., Opasich, Cristina, Latini, Roberto, Cohn, Jay N.·2005·Circulation
DOI 10.1161/circulationaha.104.512988
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Abstract

Background— Anemia is known to be a prognostic marker for patients with heart failure. However, little is known about the prognostic value of changes in hemoglobin (Hgb) over time or about the causes of anemia. Methods and Results— Retrospective analysis of Valsartan Heart Failure Trial data indicated that the quartile of patients with the biggest average decrease in Hgb over 12 months (from 14.2 to 12.6 g/dL) had significantly ( P ≤0.01) increased risk of subsequent hospitalization (hazard ratio [HR], 1.47), morbid events (HR, 1.41), and death (HR, 1.6) compared with the quartile that exhibited little change in Hgb over 12 months (from 13.7 to 13.8 g/dL). Increasing Hgb was significantly associated with lower mortality in patients with (HR, 0.78) and without (HR, 0.79) anemia at baseline. Anemia at baseline and the changes in Hgb were independently associated with serum albumin, blood pressure, glomerular filtration rate, B-type natriuretic peptide, and C-reactive protein. Lack of anemia at baseline and increases in Hgb over 12 months were not associated with smaller left ventricular diameters or higher ejection fractions. Conclusions— Changes in Hgb over 12 months were inversely associated with subsequent risk of mortality and morbidity, independently of the effects of baseline anemia and other important predictors. Several factors were independently related to anemia at baseline and changes in Hgb, suggesting multiple causes of anemia in patients with heart failure. These findings raise important questions about the optimal level of Hgb in patients with moderate to severe heart failure and how to achieve them.

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Show all 7 references

Research works printed but not linked: 20

  1. 10.1136/heart.87.4.377 · doi:10.1136/heart.87.4.377
  2. 10.1016/j.cardfail.2004.05.004 · DOI
  3. 10.1136/hrt.70.4.357 · DOI · Paper page
  4. 10.1007/s11936-001-0070-1 · DOI
  5. 10.1016/S0735-1097(01)01248-7 · DOI · Paper page
  6. 10.1161/01.cir.0000044914.42696.6a · DOI · Paper page
  7. 10.1016/0735-1097(95)00007-Q · DOI · Paper page
  8. 10.1016/S1470-2045(03)01163-X · DOI · Paper page
  9. 10.1161/01.cir.0000054164.99881.00 · DOI · Paper page
  10. 10.1016/j.cardfail.2004.01.003 · DOI
  11. 10.1046/j.1523-1755.1998.00084.x · DOI
  12. 10.1093/ndt/13.5.1206 · doi:10.1093/ndt/13.5.1206
  13. 10.1161/circ.96.2.526 · doi:10.1161/circ.96.2.526
  14. 10.1161/01.cir.0000052623.16194.80 · DOI · Paper page
  15. 10.1016/S0735-1097(02)02667-0 · doi:10.1016/s0735-1097(02)02667-0
  16. Olivetti G, Quaini F, Lagrasta C, Ricci R, Tiberti G, Capasso JM, Anversa P. Myocyte cellular hypertrophy and hyperplasia contribute to ventricular wall remodeling in anemia-induced cardiac hypertrophy in rats. Am J Pathol. 1992; 141: 227–239.
  17. 10.1161/01.cir.0000134279.79571.73 · DOI · Paper page
  18. 10.1073/pnas.97.21.11609 · DOI · Paper page
  19. 10.1016/0002-9149(94)90905-9 · DOI
  20. 10.1097/00007890-200108150-00035 · DOI

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Metadata

Authors
Anand, I. S., Kuskowski, M. A., Rector, T. S., Florea, V. G., Glazer, R. D., Hester, A., Chiang, Y. T., Aknay, N., Maggioni, A. P., Opasich, C., Latini, R., & Cohn, J. N.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2005-08-23
Volume
112
Issue
8
Pages
1121-1127
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/circulationaha.104.512988
OpenAlex
W2142441226
Cited by
287
References
7
FWCI
11.42
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Anemia and Change in Hemoglobin Over Time Related to Mortality and Morbidity in Patients With Chronic Heart Failure: Results From Val-HeFT. https://app.cochat.ai/papers/10.1161/circulationaha.104.512988
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Anand, I. S., Kuskowski, M. A., Rector, T. S., Florea, V. G., Glazer, R. D., Hester, A., Chiang, Y. T., Aknay, N., Maggioni, A. P., Opasich, C., Latini, R., & Cohn, J. N. (2005). Anemia and Change in Hemoglobin Over Time Related to Mortality and Morbidity in Patients With Chronic Heart Failure: Results From Val-HeFT. Circulation. https://doi.org/10.1161/circulationaha.104.512988

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.