The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Predictors of Ischemic Stroke in the Territory of a Symptomatic Intracranial Arterial Stenosis
Abstract
Background— Antithrombotic therapy for intracranial arterial stenosis was recently evaluated in the Warfarin versus Aspirin for Symptomatic Intracranial Disease (WASID) trial. A prespecified aim of WASID was to identify patients at highest risk for stroke in the territory of the stenotic artery who would be the target group for a subsequent trial comparing intracranial stenting with medical therapy. Methods and Results— WASID was a randomized, double-blinded, multicenter trial involving 569 patients with transient ischemic attack or ischemic stroke due to 50% to 99% stenosis of a major intracranial artery. Median time from qualifying event to randomization was 17 days, and mean follow-up was 1.8 years. Multivariable Cox proportional hazards models were used to identify factors associated with subsequent ischemic stroke in the territory of the stenotic artery. Subsequent ischemic stroke occurred in 106 patients (19.0%); 77 (73%) of these strokes were in the territory of the stenotic artery. Risk of stroke in the territory of the stenotic artery was highest with severe stenosis ≥70% (hazard ratio 2.03; 95% confidence interval 1.29 to 3.22; P =0.0025) and in patients enrolled early (≤17 days) after the qualifying event (hazard ratio 1.69; 95% confidence interval 1.06 to 2.72; P =0.028). Women were also at increased risk, although this was of borderline significance (hazard ratio 1.59; 95% confidence interval 1.00 to 2.55; P =0.051). Location of stenosis, type of qualifying event, and prior use of antithrombotic medications were not associated with increased risk. Conclusions— Among patients with symptomatic intracranial stenosis, the risk of subsequent stroke in the territory of the stenotic artery is greatest with stenosis ≥70%, after recent symptoms, and in women.
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Cites
Beneficial Effect of Carotid Endarterectomy in Symptomatic Patients with High-Grade Carotid Stenosis
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Armitage, P. (1955) · Biometrics · doi:10.2307/3001775 · Cited by 2,071
Comparison of Warfarin and Aspirin for Symptomatic Intracranial Arterial Stenosis
Chimowitz, M. I., Lynn, M. J., Howlett-Smith, H., Stern, B. J., Hertzberg, V. S., Frankel, M. R., Levine, S. R., Chaturvedi, S., Kasner, S. E., Benesch, C. G., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043033 · Cited by 1,744
Self-citationRothwell, P., Eliasziw, M., Gutnikov, S., Warlow, C., & Barnett, H. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15785-1 · Cited by 1,556
Short-term Prognosis After Emergency Department Diagnosis of TIA
Johnston, S. C. (2000) · JAMA · doi:10.1001/jama.284.22.2901 · Cited by 1,300
Sacco, R. L., Kargman, D. E., Gu, Q., & Zamanillo, M. C. (1995) · Stroke · doi:10.1161/01.str.26.1.14 · Cited by 974
The Warfarin-Aspirin Symptomatic Intracranial Disease Study
Chimowitz, M. I., Kokkinos, J., Strong, J., Brown, M. B., Levine, S. R., Silliman, S., Pessin, M. S., Weichel, E., Sila, C. A., Furlan, A. J., et al. (1995) · Neurology · doi:10.1212/wnl.45.8.1488 · Cited by 621
Self-citationThe SSYLVIA Study Investigators (2004) · Stroke · doi:10.1161/01.str.0000128708.86762.d6 · Cited by 604
Race, sex and occlusive cerebrovascular disease: a review.
Caplan, L. R., Gorelick, P. B., & Hier, D. B. (1986) · Stroke · doi:10.1161/01.str.17.4.648 · Cited by 553
Race and Sex Differences in the Distribution of Cerebral Atherosclerosis
Wityk, R. J., Lehman, D., Klag, M., Coresh, J., Ahn, H., & Litt, B. (1996) · Stroke · doi:10.1161/01.str.27.11.1974 · Cited by 518
Cited by
Kernan, W. N., Ovbiagele, B., Black, H. R., Bravata, D. M., Chimowitz, M. I., Ezekowitz, M. D., Fang, M. C., Fisher, M., Furie, K. L., Heck, D. V., et al. (2014) · Stroke · doi:10.1161/str.0000000000000024 · Cited by 5,170
Self-citationKleindorfer, D. O., Towfighi, A., Chaturvedi, S., Cockroft, K. M., Gutierrez, J., Lombardi-Hill, D., Kamel, H., Kernan, W. N., Kittner, S. J., Leira, E. C., et al. (2021) · Stroke · doi:10.1161/str.0000000000000375 · Cited by 3,237
Self-citationBrott, T. G., Halperin, J. L., Abbara, S., Bacharach, J. M., Barr, J. D., Bush, R. L., Cates, C. U., Creager, M. A., Fowler, S. B., Friday, G., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.11.006 · Cited by 447
Self-citationFiorella, D., Levy, E. I., Turk, A. S., Albuquerque, F. C., Niemann, D. B., Aagaard-Kienitz, B., Hanel, R. A., Woo, H., Rasmussen, P. A., Hopkins, L. N., et al. (2007) · Stroke · doi:10.1161/01.str.0000257963.65728.e8 · Cited by 337
Antithrombotic and Thrombolytic Therapy for Ischemic Stroke
Albers, G. W., Amarenco, P., Easton, J. D., Sacco, R. L., & Teal, P. (2008) · Chest · doi:10.1378/chest.08-0720 · Cited by 320
Metadata
- Authors
- Kasner, S. E., Chimowitz, M. I., Lynn, M. J., Howlett-Smith, H., Stern, B. J., Hertzberg, V. S., Frankel, M. R., Levine, S. R., Chaturvedi, S., Benesch, C. G., Sila, C. A., Jovin, T. G., Romano, J. G., & Cloft, H. J.
- Venue
- Circulation
- Published
- 2006-01-31
- Volume
- 113
- Issue
- 4
- Pages
- 555-563
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2133963928
- Cited by
- 759
- References
- 23
- FWCI
- 33.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kasner, S. E., Chimowitz, M. I., Lynn, M. J., Howlett-Smith, H., Stern, B. J., Hertzberg, V. S., Frankel, M. R., Levine, S. R., Chaturvedi, S., Benesch, C. G., Sila, C. A., Jovin, T. G., Romano, J. G., & Cloft, H. J. (2006). Predictors of Ischemic Stroke in the Territory of a Symptomatic Intracranial Arterial Stenosis. Circulation. https://doi.org/10.1161/circulationaha.105.578229
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