The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Prediction of Intravenous Immunoglobulin Unresponsiveness in Patients With Kawasaki Disease
Abstract
Background— In the present study, we developed models to predict unresponsiveness to intravenous immunoglobulin (IVIG) in Kawasaki disease (KD). Methods and Results— We reviewed clinical records of 546 consecutive KD patients (development dataset) and 204 subsequent KD patients (validation dataset). All received IVIG for treatment of KD. IVIG nonresponders were defined by fever persisting beyond 24 hours or recrudescent fever associated with KD symptoms after an afebrile period. A 7-variable logistic model was constructed, including day of illness at initial treatment, age in months, percentage of white blood cells representing neutrophils, platelet count, and serum aspartate aminotransferase, sodium, and C-reactive protein, which generated an area under the receiver-operating-characteristics curve of 0.84 and 0.90 for the development and validation datasets, respectively. Using both datasets, the 7 variables were used to generate a simple scoring model that gave an area under the receiver-operating-characteristics curve of 0.85. For a cutoff of 0.15 or more in the logistic regression model and 4 points or more in the simple scoring model, sensitivity and specificity were 86% and 67% in the logistic model and 86% and 68% in the simple scoring model. The kappa statistic is 0.67, indicating good agreement between the logistic and simple scoring models. Conclusions— Our predictive models showed high sensitivity and specificity in identifying IVIG nonresponders among KD patients.
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A REVIEW OF GOODNESS OF FIT STATISTICS FOR USE IN THE DEVELOPMENT OF LOGISTIC REGRESSION MODELS1
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The Treatment of Kawasaki Syndrome with Intravenous Gamma Globulin
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CD8 T Lymphocytes and Macrophages Infiltrate Coronary Artery Aneurysms in Acute Kawasaki Disease
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Cited by
Kobayashi, T., Saji, T., Otani, T., Takeuchi, K., Nakamura, T., Arakawa, H., Kato, T., Hara, T., Hamaoka, K., Ogawa, S., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61930-2 · Cited by 676
Self-citationUpdate on the use of immunoglobulin in human disease: A review of evidence
Perez, E. E., Orange, J. S., Bonilla, F., Chinen, J., Chinn, I. K., Dorsey, M., El-Gamal, Y., Harville, T. O., Hossny, E., Mazer, B., et al. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.09.023 · Cited by 666
Randomized Trial of Pulsed Corticosteroid Therapy for Primary Treatment of Kawasaki Disease
Newburger, J. W., Sleeper, L. A., McCrindle, B. W., Minich, L. L., Gersony, W., Vetter, V. L., Atz, A. M., Li, J. S., Takahashi, M., Baker, A. L., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa061235 · Cited by 451
Metadata
- Authors
- Kobayashi, T., Inoue, Y., Takeuchi, K., Okada, Y., Tamura, K., Tomomasa, T., Kobayashi, T., & Morikawa, A.
- Venue
- Circulation
- Published
- 2006-06-06
- Volume
- 113
- Issue
- 22
- Pages
- 2606-2612
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2071347890
- Cited by
- 889
- References
- 14
- FWCI
- 9.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kobayashi, T., Inoue, Y., Takeuchi, K., Okada, Y., Tamura, K., Tomomasa, T., Kobayashi, T., & Morikawa, A. (2006). Prediction of Intravenous Immunoglobulin Unresponsiveness in Patients With Kawasaki Disease. Circulation. https://doi.org/10.1161/circulationaha.105.592865
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