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CD8 T Lymphocytes and Macrophages Infiltrate Coronary Artery Aneurysms in Acute Kawasaki Disease
Abstract
The pathogenesis of coronary arterial inflammation in acute Kawasaki disease (KD) is unclear. To test the hypothesis that the KD vascular lesion is an activated T lymphocyte-dependent process, immunohistochemical studies were done on coronary artery aneurysms from 8 fatal acute KD cases by using antibodies to CD45RO (activated or memory T lymphocyte), CD8 (cytotoxic T lymphocyte), CD4 (helper T lymphocyte), HAM56 (macrophage), and CD20 (B lymphocyte). Acute KD coronary arteritis was characterized by transmural infiltration of CD45RO T lymphocytes with CD8 T lymphocytes predominating over CD4 T lymphocytes. Macrophages were present primarily in the adventitial layer; B lymphocytes were notably absent. These data lend support to the hypotheses that KD results from infection with an intracellular pathogen, such as a virus, whose antigens are presented by major histocompatibility complex class I molecules, and that CD8 T lymphocytes and macrophages are important in the pathogenesis of KD coronary aneurysms.
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Citations
Cited by
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Kobayashi, T., Inoue, Y., Takeuchi, K., Okada, Y., Tamura, K., Tomomasa, T., Kobayashi, T., & Morikawa, A. (2006) · Circulation · doi:10.1161/circulationaha.105.592865 · Cited by 889
Kavey, R.-E. W., Allada, V., Daniels, S. R., Hayman, L. L., McCrindle, B. W., Newburger, J. W., Parekh, R. S., & Steinberger, J. (2006) · Circulation · doi:10.1161/circulationaha.106.179568 · Cited by 707
Kobayashi, T., Saji, T., Otani, T., Takeuchi, K., Nakamura, T., Arakawa, H., Kato, T., Hara, T., Hamaoka, K., Ogawa, S., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61930-2 · Cited by 676
Newburger, J. W., Takahashi, M., & Burns, J. C. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.12.073 · Cited by 586
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Metadata
- Authors
- Brown, T. J., Crawford, S. E., Cornwall, M. L., Garcia, F., Shulman, S. T., & Rowley, A. H.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-10
- Volume
- 184
- Issue
- 7
- Pages
- 940-943
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2098627447
- Cited by
- 271
- References
- 0
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- Brown, T. J., Crawford, S. E., Cornwall, M. L., Garcia, F., Shulman, S. T., & Rowley, A. H. (2001). CD8 T Lymphocytes and Macrophages Infiltrate Coronary Artery Aneurysms in Acute Kawasaki Disease. The Journal of Infectious Diseases. https://doi.org/10.1086/323155
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