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Utility of Doppler Echocardiography and Tissue Doppler Imaging in the Estimation of Diastolic Function in Heart Failure With Normal Ejection Fraction: A Comparative Doppler-Conductance Catheterization Study

Kasner, Mario, Westermann, Dirk, Steendijk, Paul, Gaub, Regina, Wilkenshoff, Ursula, Weitmann, Kerstin, Hoffmann, Wolfgang, Poller, Wolfgang, Schultheiss, Heinz-Peter, Pauschinger, Matthias, Tschöpe, Carsten·2007·Circulation

Abstract

Background— Various conventional and tissue Doppler echocardiographic indexes were compared with pressure–volume loop analysis to assess their accuracy in detecting left ventricular (LV) diastolic dysfunction in patients with heart failure with normal ejection fraction (HFNEF). Methods and Results— Diastolic dysfunction was confirmed by pressure–volume loop analysis obtained by conductance catheter in 43 patients (19 men) with HFNEF. Their Doppler indexes were compared with those of 12 control patients without heart failure symptoms and with normal ejection fraction. Invasively measured indexes for diastolic relaxation (τ, dP/dt min ), LV end-diastolic pressure, and LV end-diastolic pressure–volume relationship (stiffness, b [dP/dV], and stiffness constant, β) were correlated with several conventional mitral flow and tissue Doppler imaging indexes. Conventional Doppler indexes correlated moderately with the degree of LV relaxation index, τ (E/A: r =−0.36, P =0.013; isovolumic relaxation time: r =0.31, P =0.040) and b (deceleration time: r =0.39, P =0.012) but not with β, in contrast to the tissue Doppler imaging indexes E’/A’ lateral ( r =−0.37, P =0.008) and E/E’ lateral ( r =0.53, P <0.001). Diastolic dysfunction was detected in 70% of the HFNEF patients by mitral flow Doppler but in 81% and 86% by E’/A’ lateral , and E/E’ lateral , respectively. Conclusions— Of all echocardiographic parameters investigated, the LV filling index E/E’ lateral was identified as the best index to detect diastolic dysfunction in HFNEF in which the diagnosis of diastolic dysfunction was confirmed by conductance catheter analysis. We recommend its use as an essential tool for noninvasive diagnostics of diastolic function in patients with HFNEF.

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Crossref · 10.1161/circulationaha.106.661983

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Metadata

Authors
Kasner, M., Westermann, D., Steendijk, P., Gaub, R., Wilkenshoff, U., Weitmann, K., Hoffmann, W., Poller, W., Schultheiss, H.-P., Pauschinger, M., & Tschöpe, C.
Venue
Circulation
Published
2007-08-07
Volume
116
Issue
6
Pages
637-647
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
OpenAlex
W2148405482
Cited by
565
References
45
FWCI
27.65
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Utility of Doppler Echocardiography and Tissue Doppler Imaging in the Estimation of Diastolic Function in Heart Failure With Normal Ejection Fraction: A Comparative Doppler-Conductance Catheterization Study. https://app.cochat.ai/papers/10.1161/circulationaha.106.661983
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Kasner, M., Westermann, D., Steendijk, P., Gaub, R., Wilkenshoff, U., Weitmann, K., Hoffmann, W., Poller, W., Schultheiss, H.-P., Pauschinger, M., & Tschöpe, C. (2007). Utility of Doppler Echocardiography and Tissue Doppler Imaging in the Estimation of Diastolic Function in Heart Failure With Normal Ejection Fraction: A Comparative Doppler-Conductance Catheterization Study. Circulation. https://doi.org/10.1161/circulationaha.106.661983

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