The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Cardiac Angiography in Renally Impaired Patients (CARE) Study: A Randomized Double-Blind Trial of Contrast-Induced Nephropathy in Patients With Chronic Kidney Disease
Abstract
Background— No direct comparisons exist of the renal tolerability of the low-osmolality contrast medium iopamidol with that of the iso-osmolality contrast medium iodixanol in high-risk patients. Methods and Results— The present study is a multicenter, randomized, double-blind comparison of iopamidol and iodixanol in patients with chronic kidney disease (estimated glomerular filtration rate, 20 to 59 mL/min) who underwent cardiac angiography or percutaneous coronary interventions. Serum creatinine (SCr) levels and estimated glomerular filtration rate were assessed at baseline and 2 to 5 days after receiving medications. The primary outcome was a postdose SCr increase ≥0.5 mg/dL (44.2 μmol/L) over baseline. Secondary outcomes were a postdose SCr increase ≥25%, a postdose estimated glomerular filtration rate decrease of ≥25%, and the mean peak change in SCr. In 414 patients, contrast volume, presence of diabetes mellitus, use of N-acetylcysteine, mean baseline SCr, and estimated glomerular filtration rate were comparable in the 2 groups. SCr increases ≥0.5 mg/dL occurred in 4.4% (9 of 204 patients) after iopamidol and 6.7% (14 of 210 patients) after iodixanol ( P =0.39), whereas rates of SCr increases ≥25% were 9.8% and 12.4%, respectively ( P =0.44). In patients with diabetes, SCr increases ≥0.5 mg/dL were 5.1% (4 of 78 patients) with iopamidol and 13.0% (12 of 92 patients) with iodixanol ( P =0.11), whereas SCr increases ≥25% were 10.3% and 15.2%, respectively ( P =0.37). Mean post-SCr increases were significantly less with iopamidol (all patients: 0.07 versus 0.12 mg/dL, 6.2 versus 10.6 μmol/L, P =0.03; patients with diabetes: 0.07 versus 0.16 mg/dL, 6.2 versus 14.1 μmol/L, P =0.01). Conclusions— The rate of contrast-induced nephropathy, defined by multiple end points, is not statistically different after the intraarterial administration of iopamidol or iodixanol to high-risk patients, with or without diabetes mellitus. Any true difference between the agents is small and not likely to be clinically significant.
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Cites
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Hospital-acquired renal insufficiency
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Goodpasture syndrome during the course of a Schönlein-Henoch purpura
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Nephrotoxic Effects in High-Risk Patients Undergoing Angiography
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Contrast-induced nephropathy: Definition, epidemiology, and patients at risk
Mehran, R., & Nikolsky, E. (2006) · Kidney International · doi:10.1038/sj.ki.5000368 · Cited by 891
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Jo, S.-H., Youn, T.-J., Koo, B.-K., Park, J.-S., Kang, H.-J., Cho, Y.-S., Chung, W.-Y., Joo, G.-W., Chae, I.-H., Choi, D.-J., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.06.047 · Cited by 288
Cited by
Roffi, M., Patrono, C., Collet, J.-P., Mueller, C., Valgimigli, M., Andreotti, F., Bax, J. J., Borger, M. A., Brotons, C., Chew, D. P., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv320 · Cited by 8,261
2018 ESC/EACTS guidelines on myocardial revascularization
Neumann, F.-J., Sousa-Uva, M., Ahlsson, A., Alfonso, F., Banning, A. P., Benedetto, U., Byrne, R. A., Collet, J.-P., Falk, V., Head, S. J., et al. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehy394 · Cited by 7,167
2023 ESC Guidelines for the management of acute coronary syndromes
Byrne, R. A., Rossello, X., Coughlan, J. J., Barbato, E., Berry, C., Chieffo, A., Claeys, M. J., Dan, G.-A., Dweck, M. R., Galbraith, M., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad191 · Cited by 5,333
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Kushner, F. G., Hand, M., Smith, S. C., King, S. B., Anderson, J. L., Antman, E. M., Bailey, S. R., Bates, E. R., Blankenship, J. C., Casey, D. E., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.10.015 · Cited by 1,911
Metadata
- Authors
- Solomon, R. J., Natarajan, M. K., Doucet, S., Sharma, S. K., Staniloae, C. S., Katholi, R. E., Gelormini, J. L., Labinaz, M., Moreyra, A. E., & the Investigators of the CARE Study
- Venue
- Circulation
- Published
- 2007-06-26
- Volume
- 115
- Issue
- 25
- Pages
- 3189-3196
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2138153676
- Cited by
- 346
- References
- 13
- FWCI
- 26.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Solomon, R. J., Natarajan, M. K., Doucet, S., Sharma, S. K., Staniloae, C. S., Katholi, R. E., Gelormini, J. L., Labinaz, M., Moreyra, A. E., & the Investigators of the CARE Study. (2007). Cardiac Angiography in Renally Impaired Patients (CARE) Study: A Randomized Double-Blind Trial of Contrast-Induced Nephropathy in Patients With Chronic Kidney Disease. Circulation. https://doi.org/10.1161/circulationaha.106.671644
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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