The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Evaluation of Dose-Related Effects of Aspirin on Platelet Function: Results From the Aspirin-Induced Platelet Effect (ASPECT) Study
Open accessAbstract
Background— The antiplatelet effect of aspirin is attributed to platelet cyclooxygenase-1 inhibition. Controversy exists on the prevalence of platelet resistance to aspirin in patients with coronary artery disease and effects of aspirin dose on inhibition. Our primary aim was to determine the degree of platelet aspirin responsiveness in patients, as measured by commonly used methods, and to study the relation of aspirin dose to platelet inhibition. Methods and Results— We prospectively studied the effect of aspirin dosing on platelet function in 125 stable outpatients with coronary artery disease randomized in a double-blind, double-crossover investigation (81, 162, and 325 mg/d for 4 weeks each over a 12-week period). At all doses of aspirin, platelet function was low as indicated by arachidonic acid (AA)-induced light transmittance aggregation, thrombelastography, and VerifyNow. At any 1 dose, resistance to aspirin was 0% to 6% in the overall group when AA was used as the agonist, whereas it was 1% to 27% by other methods [collagen and ADP-induced light transmittance aggregation, platelet function analyzer (PFA-100)]. Platelet response to aspirin as measured by collagen-induced light transmittance aggregation, ADP-induced light transmittance aggregation, PFA-100 (81 mg versus 162 mg, P ≤0.05), and urinary 11-dehydrothromboxane B 2 was dose-related (81 mg versus 325 mg, P =0.003). No carryover effects were observed. Conclusions— The assessment of aspirin resistance is highly assay-dependent; aspirin is an effective blocker of AA-induced platelet function at all doses, whereas higher estimates of resistance were observed with methods that do not use AA as the stimulus. The observation of dose-dependent effects despite nearly complete inhibition of AA-induced aggregation suggests that aspirin may exert antiplatelet properties through non–cyclooxygenase-1 pathways and deserves further investigation.
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Cites
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The way I see it: House officers need formal career development
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Profile and prevalence of aspirin resistance in patients with cardiovascular disease
Gum, P. A., Kottke-Marchant, K., Poggio, E. D., Gurm, H., Welsh, P. A., Brooks, L., Sapp, S. K., & Topol, E. J. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)01631-9 · Cited by 820
Platelet-Active Drugs: The Relationships Among Dose, Effectiveness, and Side Effects
Patrono, C., Coller, B., FitzGerald, G. A., Hirsh, J., & Roth, G. (2004) · Chest · doi:10.1378/chest.126.3_suppl.234s · Cited by 671
Platelet Reactivity in Patients and Recurrent Events Post-Stenting
Gurbel, P. A., Bliden, K. P., Guyer, K., Cho, P. W., Zaman, K. A., Kreutz, R. P., Bassi, A. K., & Tantry, U. S. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.07.041 · Cited by 644
Self-citationDesign and Analysis of Cross-Over Trials
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Cited by
Gurbel, P. A., Bliden, K. P., Butler, K., Tantry, U. S., Gesheff, T., Wei, C., Teng, R., Antonino, M. J., Patil, S. B., Karunakaran, A., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.912550 · Cited by 1,159
Self-citationWeitz, J. I., Eikelboom, J. W., & Samama, M. M. (2012) · Chest · doi:10.1378/chest.11-2294 · Cited by 527
Guthikonda, S., Alviar, C. L., Vaduganathan, M., Arikan, M., Tellez, A., DeLao, T., Granada, J. F., Dong, J.-F., Kleiman, N. S., & Lev, E. I. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.05.031 · Cited by 337
Diabetes and Antiplatelet Therapy in Acute Coronary Syndrome
Ferreiro, J. L., & Angiolillo, D. J. (2011) · Circulation · doi:10.1161/circulationaha.109.913376 · Cited by 333
Duzenli, M. A., Ozdemir, K., Aygul, N., Soylu, A., & Tokac, M. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.03.074 · Cited by 20
Metadata
- Authors
- Gurbel, P. A., Bliden, K. P., DiChiara, J., Newcomer, J., Weng, W., Neerchal, N. K., Gesheff, T., Chaganti, S. K., Etherington, A., & Tantry, U. S.
- Venue
- Circulation
- Published
- 2007-06-26
- Volume
- 115
- Issue
- 25
- Pages
- 3156-3164
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2072518791
- Cited by
- 417
- References
- 26
- FWCI
- 29.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Evaluation of Dose-Related Effects of Aspirin on Platelet Function: Results From the Aspirin-Induced Platelet Effect (ASPECT) Study. https://app.cochat.ai/papers/10.1161/circulationaha.106.675587
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- Gurbel, P. A., Bliden, K. P., DiChiara, J., Newcomer, J., Weng, W., Neerchal, N. K., Gesheff, T., Chaganti, S. K., Etherington, A., & Tantry, U. S. (2007). Evaluation of Dose-Related Effects of Aspirin on Platelet Function: Results From the Aspirin-Induced Platelet Effect (ASPECT) Study. Circulation. https://doi.org/10.1161/circulationaha.106.675587
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
