The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Acute Kidney Injury After Cardiac Surgery: Focus on Modifiable Risk Factors
Abstract
Background— Acute kidney injury (AKI) after cardiac surgery is a major health issue. Lacking effective therapies, risk factor modification may offer a means of preventing this complication. The objective of the present study was to identify and determine the prognostic importance of such risk factors. Methods and Results— Data from a multicenter cohort of 3500 adult patients who underwent cardiac surgery at 7 hospitals during 2004 were analyzed (using multivariable logistic regression modeling) to determine the independent relationships between 3 thresholds of AKI (>25%, >50%, and >75% decrease in estimated glomerular filtration rate within 1 week of surgery or need for postoperative dialysis) with death rates, as well as to identify modifiable risk factors for AKI. The 3 thresholds of AKI occurred in 24% (n=829), 7% (n=228), and 3% (n=119) of the cohort, respectively. All 3 thresholds were independently associated with a >4-fold increase in the odds of death and could be predicted with several perioperative variables, including preoperative intra-aortic balloon pump use, urgent surgery, and prolonged cardiopulmonary bypass. In particular, 3 potentially modifiable variables were also independently and strongly associated with AKI. These were preoperative anemia, perioperative red blood cell transfusions, and surgical reexploration. Conclusions— AKI after cardiac surgery is highly prevalent and prognostically important. Therapies aimed at mitigating preoperative anemia, perioperative red blood cell transfusions, and surgical reexploration may offer protection against this complication.
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Cites
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Duration of Red-Cell Storage and Complications after Cardiac Surgery
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A Comparison of Aprotinin and Lysine Analogues in High-Risk Cardiac Surgery
Fergusson, D. A., Hébert, P. C., Mazer, C. D., Fremes, S., MacAdams, C., Murkin, J. M., Teoh, K., Duke, P. C., Arellano, R., Blajchman, M. A., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802395 · Cited by 1,152
Self-citationChronic Hypoxia and Tubulointerstitial Injury: A Final Common Pathway to End-Stage Renal Failure
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Acute Kidney Injury Associated with Cardiac Surgery
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Cited by
Bagur, R., Webb, J. G., Nietlispach, F., Dumont, E., De Larochelliere, R., Doyle, D., Masson, J.-B., Gutierrez, M. J., Clavel, M.-A., Bertrand, O. F., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehp552 · Cited by 477
Parolari, A., Pesce, L. L., Pacini, D., Mazzanti, V., Salis, S., Sciacovelli, C., Rossi, F., & Alamanni, F. (2012) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2011.09.073 · Cited by 270
Cardioprotection during cardiac surgery.
Hausenloy, D. J., Boston-Griffiths, E., & Yellon, D. M. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs131 · Cited by 152
Metadata
- Authors
- Karkouti, K., Wijeysundera, D. N., Yau, T. M., Callum, J. L., Cheng, D. C., Crowther, M., Dupuis, J.-Y., Fremes, S. E., Kent, B., Laflamme, C., Lamy, A., Legare, J.-F., Mazer, C. D., McCluskey, S. A., Rubens, F. D., Sawchuk, C., & Beattie, W. S.
- Venue
- Circulation
- Published
- 2009-02-03
- Volume
- 119
- Issue
- 4
- Pages
- 495-502
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2077447212
- Cited by
- 732
- References
- 42
- FWCI
- 26.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Karkouti, K., Wijeysundera, D. N., Yau, T. M., Callum, J. L., Cheng, D. C., Crowther, M., Dupuis, J.-Y., Fremes, S. E., Kent, B., Laflamme, C., Lamy, A., Legare, J.-F., Mazer, C. D., McCluskey, S. A., Rubens, F. D., Sawchuk, C., & Beattie, W. S. (2009). Acute Kidney Injury After Cardiac Surgery: Focus on Modifiable Risk Factors. Circulation. https://doi.org/10.1161/circulationaha.108.786913
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