The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Molecular Architecture of the Human Sinus Node: Insights Into the Function of the Cardiac Pacemaker
Open accessAbstract
Background— Although we know much about the molecular makeup of the sinus node (SN) in small mammals, little is known about it in humans. The aims of the present study were to investigate the expression of ion channels in the human SN and to use the data to predict electrical activity. Methods and Results— Quantitative polymerase chain reaction, in situ hybridization, and immunofluorescence were used to analyze 6 human tissue samples. Messenger RNA (mRNA) for 120 ion channels (and some related proteins) was measured in the SN, a novel paranodal area, and the right atrium (RA). The results showed, for example, that in the SN compared with the RA, there was a lower expression of Na v 1.5, K v 4.3, K v 1.5, ERG, K ir 2.1, K ir 6.2, RyR2, SERCA2a, Cx40, and Cx43 mRNAs but a higher expression of Ca v 1.3, Ca v 3.1, HCN1, and HCN4 mRNAs. The expression pattern of many ion channels in the paranodal area was intermediate between that of the SN and RA; however, compared with the SN and RA, the paranodal area showed greater expression of K v 4.2, K ir 6.1, TASK1, SK2, and MiRP2. Expression of ion channel proteins was in agreement with expression of the corresponding mRNAs. The levels of mRNA in the SN, as a percentage of those in the RA, were used to estimate conductances of key ionic currents as a percentage of those in a mathematical model of human atrial action potential. The resulting SN model successfully produced pacemaking. Conclusions— Ion channels show a complex and heterogeneous pattern of expression in the SN, paranodal area, and RA in humans, and the expression pattern is appropriate to explain pacemaking.
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Cites
Courtemanche, M., Ramirez, R. J., & Nattel, S. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.275.1.h301 · Cited by 1,218
Pacemaker Mechanisms in Cardiac Tissue
DiFrancesco, D. (1993) · Annual Review of Physiology · doi:10.1146/annurev.ph.55.030193.002323 · Cited by 862
Self-citationKrapivinsky, G., Gordon, E. A., Wickman, K., Velimirović, B., Krapivinsky, L., & Clapham, D. E. (1995) · Nature · doi:10.1038/374135a0 · Cited by 847
The sinoatrial node, a heterogeneous pacemaker structure
Boyett, M. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00135-8 · Cited by 698
Self-citationGaborit, N., Le Bouter, S., Szuts, V., Varro, A., Escande, D., Nattel, S., & Demolombe, S. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2006.126714 · Cited by 522
Functional role of L-type Ca v 1.3 Ca 2+ channels in cardiac pacemaker activity
Mangoni, M. E., Couette, B., Bourinet, E., Platzer, J., Reimer, D., Striessnig, J., & Nargeot, J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0935295100 · Cited by 467
Stieber, J., Herrmann, S., Feil, S., Löster, J., Feil, R., Biel, M., Hofmann, F., & Ludwig, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2434235100 · Cited by 456
New Insights Into Pacemaker Activity: Promoting Understanding of Sick Sinus Syndrome
Dobrzynski, H., Boyett, M. R., & Anderson, R. H. (2007) · Circulation · doi:10.1161/circulationaha.106.616011 · Cited by 429
Self-citationBiological pacemaker created by gene transfer
Miake, J., Marbán, E., & Nuss, H. B. (2002) · Nature · doi:10.1038/419132b · Cited by 421
Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria
Hoogaars, W. M. H., Engel, A., Brons, J. F., Verkerk, A. O., de Lange, F. J., Wong, L. Y. E., Bakker, M. L., Clout, D. E., Wakker, V., Barnett, P., et al. (2007) · Genes & Development · doi:10.1101/gad.416007 · Cited by 409
Cited by
The Role of the Funny Current in Pacemaker Activity
DiFrancesco, D. (2010) · Circulation Research · doi:10.1161/circresaha.109.208041 · Cited by 587
Self-citationSpatially resolved multiomics of human cardiac niches
Kanemaru, K., Cranley, J., Muraro, D., Miranda, A. M. A., Ho, S. Y., Wilbrey-Clark, A., Patrick Pett, J., Polanski, K., Richardson, L., Litvinukova, M., et al. (2023) · Nature · doi:10.1038/s41586-023-06311-1 · Cited by 425
The Cardiomyocyte Circadian Clock: Emerging Roles in Health and Disease
Durgan, D. J., & Young, M. E. (2010) · Circulation Research · doi:10.1161/circresaha.109.209957 · Cited by 277
Zhu, W.-Z., Xie, Y., Moyes, K. W., Gold, J. D., Askari, B., & Laflamme, M. A. (2010) · Circulation Research · doi:10.1161/circresaha.110.223917 · Cited by 228
Baruscotti, M., Barbuti, A., & Bucchi, A. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.06.019 · Cited by 149
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Metadata
- Authors
- Chandler, N. J., Greener, I. D., Tellez, J. O., Inada, S., Musa, H., Molenaar, P., DiFrancesco, D., Baruscotti, M., Longhi, R., Anderson, R. H., Billeter, R., Sharma, V., Sigg, D. C., Boyett, M. R., & Dobrzynski, H.
- Venue
- Circulation
- Published
- 2009-03-31
- Volume
- 119
- Issue
- 12
- Pages
- 1562-1575
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2084874490
- Cited by
- 396
- References
- 32
- FWCI
- 17.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chandler, N. J., Greener, I. D., Tellez, J. O., Inada, S., Musa, H., Molenaar, P., DiFrancesco, D., Baruscotti, M., Longhi, R., Anderson, R. H., Billeter, R., Sharma, V., Sigg, D. C., Boyett, M. R., & Dobrzynski, H. (2009). Molecular Architecture of the Human Sinus Node: Insights Into the Function of the Cardiac Pacemaker. Circulation. https://doi.org/10.1161/circulationaha.108.804369
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