The cardiac pacemaker current

The Structure of the Potassium Channel: Molecular Basis of K + Conduction and Selectivity

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Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes

Kehat, I., Kenyagin‐Karsenti, D., Snir, M., Segev, H., Amit, M., Gepstein, A., Livne, E., Binah, O., Itskovitz‐Eldor, J., & Gepstein, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12131 · Cited by 1,814 · see citing works

Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes

Kehat, I., Kenyagin‐Karsenti, D., Snir, M., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112131 · Cited by 1,536 · see citing works

Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial

Fox, K., Ford, I., Steg, P. G., Tendera, M., & Ferrari, R. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61170-8 · Cited by 1,099 · see citing works

Differentiation of Human Embryonic Stem Cells to Cardiomyocytes: Role of Coculture With Visceral Endoderm-Like Cells

Mummery, C., Ward-van Oostwaard, D., Doevendans, P., Spijker, R., van den Brink, S., Hassink, R., van der Heyden, M., Opthof, T., Pera, M., de la Riviere, A. B., et al. (2003) · Circulation · doi:10.1161/01.cir.0000068356.38592.68 · Cited by 1,001 · see citing works

Voltage Sensor of Kv1.2: Structural Basis of Electromechanical Coupling

Long, S. B., Campbell, E. B., & MacKinnon, R. (2005) · Science · doi:10.1126/science.1116270 · Cited by 982 · see citing works

Electromechanical integration of cardiomyocytes derived from human embryonic stem cells

Kehat, I., Khimovich, L., Caspi, O., Gepstein, A., Shofti, R., Arbel, G., Huber, I., Satin, J., Itskovitz‐Eldor, J., & Gepstein, L. (2004) · Nature Biotechnology · doi:10.1038/nbt1014 · Cited by 875 · see citing works

Pacemaker Mechanisms in Cardiac Tissue

DiFrancesco, D. (1993) · Annual Review of Physiology · doi:10.1146/annurev.ph.55.030193.002323 · Cited by 853 · see citing works

Direct activation of cardiac pacemaker channels by intracellular cyclic AMP

DiFrancesco, D., & Tortora, P. (1991) · Nature · doi:10.1038/351145a0 · Cited by 850 · see citing works

Human Embryonic Stem Cells Develop Into Multiple Types of Cardiac Myocytes: Action Potential Characterization

He, J.-Q., Ma, Y., Lee, Y., Thomson, J. A., & Kamp, T. J. (2003) · Circulation Research · doi:10.1161/01.res.0000080317.92718.99 · Cited by 800 · see citing works

Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomised controlled trial

Fox, K., Ford, I., Steg, P. G., Tendera, M., Robertson, M., & Ferrari, R. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61171-x · Cited by 789 · see citing works

Genesis and Regulation of the Heart Automaticity

Mangoni, M. E., & Nargeot, J. (2008) · Physiological Reviews · doi:10.1152/physrev.00018.2007 · Cited by 602 · see citing works

Structural basis for modulation and agonist specificity of HCN pacemaker channels

Zagotta, W. N., Olivier, N. B., Black, K. D., Young, E. C., Olson, R., & Gouaux, E. (2003) · Nature · doi:10.1038/nature01922 · Cited by 589 · see citing works

How does adrenaline accelerate the heart?

Brown, H. F., DiFrancesco, D., & Noble, S. J. (1979) · Nature · doi:10.1038/280235a0 · Cited by 585 · see citing works

Efficacy of ivabradine, a new selective If inhibitor, compared with atenolol in patients with chronic stable angina

Tardif, J., Ford, I., Tendera, M., Bourassa, M. G., & Fox, K. M. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi586 · Cited by 580 · see citing works

Molecular mechanism of cAMP modulation of HCN pacemaker channels

Wainger, B. J., DeGennaro, M., Santoro, B., Siegelbaum, S. A., & Tibbs, G. R. (2001) · Nature · doi:10.1038/35081088 · Cited by 520 · see citing works

Regional and tissue specific transcript signatures of ion channel genes in the non‐diseased human heart

Gaborit, N., Bouter, S. L., Szüts, V., Varró, A., Escande, D., Nattel, S., & Demolombe, S. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2006.126714 · Cited by 518 · see citing works

Effect of current flow on the membrane potential of cardiac muscle

Weidmann, S. (1951) · The Journal of Physiology · doi:10.1113/jphysiol.1951.sp004667 · Cited by 487 · see citing works

Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinusnodal, atrial and ventricular cell types

Maltsev, V. A., Rohwedel, J., Hescheler, J., & Wobus, A. M. (1993) · Mechanisms of Development · doi:10.1016/0925-4773(93)90015-p · Cited by 483 · see citing works

Functional Integration of Electrically Active Cardiac Derivatives From Genetically Engineered Human Embryonic Stem Cells With Quiescent Recipient Ventricular Cardiomyocytes: Insights Into the Development of Cell-Based Pacemakers

Xue, T., Cho, H. C., Akar, F. G., Tsang, S.-Y., Jones, S. P., Marbán, E., Tomaselli, G. F., & Li, R. A. (2005) · Circulation · doi:10.1161/01.cir.0000151313.18547.a2 · Cited by 480 · see citing works

Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiac-specific genes and ionic currents.

Maltsev, V. A., Wobus, A. M., Rohwedel, J., Bäder, M., & Hescheler, J. (1994) · Circulation Research · doi:10.1161/01.res.75.2.233 · Cited by 476 · see citing works

Antianginal and Antiischemic Effects of Ivabradine, an I f Inhibitor, in Stable Angina

BORER, J. S., Fox, K. M., Jaillon, P., & Lerebours, G. (2003) · Circulation · doi:10.1161/01.cir.0000048143.25023.87 · Cited by 474 · see citing works

Properties of the hyperpolarizing‐activated current (if) in cells isolated from the rabbit sino‐atrial node.

DiFrancesco, D., Ferroni, A., Mazzanti, M., & Tromba, C. (1986) · The Journal of Physiology · doi:10.1113/jphysiol.1986.sp016177 · Cited by 471 · see citing works

The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart

Stieber, J., Herrmann, S., Feil, S. C., Löster, J., Feil, R., Biel, M., Hofmann, F. B., & Ludwig, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2434235100 · Cited by 456 · see citing works

HCN channels: Structure, cellular regulation and physiological function

Wahl‐Schott, C., & Biel, M. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8525-0 · Cited by 438 · see citing works

Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate

Suh, B., & Hille, B. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.05.005 · Cited by 436 · see citing works

CNG AND HCN CHANNELS: Two Peas, One Pod

Craven, K. B., & Zagotta, W. N. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040104.134728 · Cited by 434 · see citing works

Properties of Hyperpolarization-Activated Pacemaker Current Defined by Coassembly of Hcn1 and Hcn2 Subunits and Basal Modulation by Cyclic Nucleotide

Chen, S., Wang, J., & Siegelbaum, S. A. (2001) · The Journal of General Physiology · doi:10.1085/jgp.117.5.491 · Cited by 416 · see citing works

Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues

Moosmang, S., Stieber, J., Zong, X., Biel, M., Hofmann, F. B., & Ludwig, A. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02036.x · Cited by 415 · see citing works

Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria

Hoogaars, W. M. H., Engel, A., Brons, J. F., Verkerk, A. O., de Lange, F. J., Wong, L. Y. E., Bakker, M. L., Clout, D. E., Wakker, V., Barnett, P., et al. (2007) · Genes & Development · doi:10.1101/gad.416007 · Cited by 409 · see citing works

Familial Sinus Bradycardia Associated with a Mutation in the Cardiac Pacemaker Channel

Milanesi, R., Baruscotti, M., Gnecchi‐Ruscone, T., & DiFrancesco, D. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052475 · Cited by 401 · see citing works

A new interpretation of the pace‐maker current in calf Purkinje fibres.

DiFrancesco, D. (1981) · The Journal of Physiology · doi:10.1113/jphysiol.1981.sp013713 · Cited by 400 · see citing works

Molecular Architecture of the Human Sinus Node

Chandler, N. J., Greener, I. D., Tellez, J. O., Inada, S., Musa, H., Molenaar, P., DiFrancesco, D., Baruscotti, M., Longhi, R., Anderson, R. H., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.804369 · Cited by 400 · see citing works

Distribution and Prevalence of Hyperpolarization-Activated Cation Channel (HCN) mRNA Expression in Cardiac Tissues

Shi, W., Wymore, R. S., Yu, H., Wu, J.-Y., Wymore, R. T., Pan, Z., Robinson, R. B., Dixon, J. E., McKinnon, D. H., & Cohen, I. S. (1999) · Circulation Research · doi:10.1161/01.res.85.1.e1 · Cited by 382 · see citing works

The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart.

Hoogaars, W. M., Tessari, A., Moorman, A., de Boer, P. D., Hagoort, J., Soufan, A., Campione, M., & Christoffels, V. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.01.030 · Cited by 378 · see citing works

Developmental Changes in Cardiomyocytes Differentiated from Human Embryonic Stem Cells: A Molecular and Electrophysiological Approach

Sartiani, L., Bettiol, E., Stillitano, F., Mugelli, A., Cerbai, E., & Jaconi, M. E. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0466 · Cited by 370 · see citing works

Embryonic stem cells: a model to study structural and functional properties in cardiomyogenesis

Hescheler, J. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00193-4 · Cited by 366 · see citing works

Pacemaker channel dysfunction in a patient with sinus node disease

Schulze‐Bahr, E., Neu, A. D., Friederich, P., Kaupp, U. B., Breithardt, G., Pongs, O., & Isbrandt, D. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16387 · Cited by 364 · see citing works

Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart

Marionneau, C., Couette, B., Liu, J., Li, H., Mangoni, M. E., Nargeot, J., Lei, M., Escande, D., & Demolombe, S. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.074047 · Cited by 347 · see citing works

A study of the ionic nature of the pace‐maker current in calf Purkinje fibres.

DiFrancesco, D. (1981) · The Journal of Physiology · doi:10.1113/jphysiol.1981.sp013714 · Cited by 344 · see citing works

Physiology and pharmacology of the cardiac pacemaker (“funny”) current

Baruscotti, M., Bucchi, A., & DiFrancesco, D. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.01.005 · Cited by 338 · see citing works

Inhibitory actions of ZENECA ZD7288 on whole‐cell hyperpolarization activated inward current (If) in guinea‐pig dissociated sinoatrial node cells

BoSmith, R. E., Briggs, I., & Sturgess, N. C. (1993) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1993.tb13815.x · Cited by 313 · see citing works

Pacemaker channel dysfunction in a patient with sinus node disease

Schulze‐Bahr, E., Neu, A. D., Friederich, P., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200316387 · Cited by 311 · see citing works

Mode of action of bradycardic agent, S 16257, on ionic currents of rabbit sinoatrial node cells

Bois, P., Bescond, J., Renaudon, B., & Lenfant, J. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15505.x · Cited by 297 · see citing works

What keeps us ticking: a funny current, a calcium clock, or both?

Lakatta, E. G., & DiFrancesco, D. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.03.022 · Cited by 292 · see citing works

Current-dependent Block of Rabbit Sino-Atrial Node If Channels by Ivabradine

Bucchi, A., Baruscotti, M., & DiFrancesco, D. (2002) · The Journal of General Physiology · doi:10.1085/jgp.20028593 · Cited by 288 · see citing works

Human Mesenchymal Stem Cells as a Gene Delivery System to Create Cardiac Pacemakers

Potapova, I. A., Plotnikov, A. N., Lu, Z., Danilo, P., Valiūnas, V., Qu, J., Doronin, S. V., Zuckerman, J., Shlapakova, I. N., Gao, J., et al. (2004) · Circulation Research · doi:10.1161/01.res.0000123827.60210.72 · Cited by 285 · see citing works

Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyocytes

Satin, J., Kehat, I., Caspi, O., Huber, I., Arbel, G., Itzhaki, I., Magyar, J., Schroder, E. A., Perlman, I., & Gepstein, L. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.068213 · Cited by 283 · see citing works

Molecular Characterization of the Hyperpolarization-activated Cation Channel in Rabbit Heart Sinoatrial Node

Ishii, T. M., Takano, M., Xie, L.-H., Noma, A., & Ohmori, H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.18.12835 · Cited by 276 · see citing works

MinK-Related Peptide 1

Yu, H., Wu, J., Potapova, I. A., Wymore, R. T., Holmes, B., Zuckerman, J. J., Pan, Z., Wang, H. Q., Shi, W., Robinson, R., et al. (2001) · Circulation Research · doi:10.1161/hh1201.093511 · Cited by 254 · see citing works

Expression and Function of a Biological Pacemaker in Canine Heart

Qu, J., Plotnikov, A. N., Danilo, P., Shlapakova, I. N., Cohen, I. S., Robinson, R. B., & Rosen, M. R. (2003) · Circulation · doi:10.1161/01.cir.0000059939.97249.2c · Cited by 243 · see citing works

Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5

Espinoza-Lewis, R. A., Yu, L., He, F.-L., Liu, H.-B., Tang, R.-H., Shi, J., Sun, X., Martin, J. F., Wang, D.-Z., Yang, J., et al. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2008.12.028 · Cited by 240 · see citing works

Electrophysiological effects of S 16257, a novel sino‐atrial node modulator, on rabbit and guinea‐pig cardiac preparations: comparison with UL‐FS 49

Thollon, C., Cambarrat, C., Vian, J., Prost, J.-F. F., Peglion, J. L., & Vilaine, J. P. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb13025.x · Cited by 236 · see citing works

Functional Characterization of a Trafficking-defective HCN4 Mutation, D553N, Associated with Cardiac Arrhythmia

Ueda, K., Nakamura, K., Hayashi, T., Inagaki, N., Takahashi, M., Arimura, T., Morita, H., Higashiuesato, Y., Hirano, Y., Yasunami, M., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311953200 · Cited by 225 · see citing works

HCN4 provides a ‘depolarization reserve’ and is not required for heart rate acceleration in mice

Herrmann, S., Stieber, J., Stöckl, G., Hofmann, F. B., & Ludwig, A. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601868 · Cited by 222 · see citing works

Heteromeric HCN1–HCN4 Channels: A Comparison with Native Pacemaker Channels from the Rabbit Sinoatrial Node

Altomare, C., Terragni, B., Brioschi, C., Milanesi, R., Pagliuca, C., Viscomi, C. F., Moroni, A., Baruscotti, M., & DiFrancesco, D. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.027698 · Cited by 218 · see citing works

Functional Heteromerization of HCN1 and HCN2 Pacemaker Channels

Ulens, C., & Tytgat, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000738200 · Cited by 217 · see citing works

From Funny Current to HCN Channels: 20 Years of Excitation

Accili, E. A., Proenza, C., Baruscotti, M., & DiFrancesco, D. (2002) · Physiology · doi:10.1152/physiologyonline.2002.17.1.32 · Cited by 212 · see citing works

Biological Pacemaker Implanted in Canine Left Bundle Branch Provides Ventricular Escape Rhythms That Have Physiologically Acceptable Rates

Plotnikov, A. N., Sosunov, E. A., Qu, J., Shlapakova, I. N., Anyukhovsky, E. P., Liu, L., Janse, M. J., Brink, P. R., Cohen, I. S., Robinson, R. B., et al. (2004) · Circulation · doi:10.1161/01.cir.0000114527.10764.cc · Cited by 202 · see citing works

Modulation of single hyperpolarization‐activated channels (i(f)) by cAMP in the rabbit sino‐atrial node.

DiFrancesco, D., & Mangoni, M. E. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020038 · Cited by 201 · see citing works

Analysis of cardiac pacemaker potential using a "voltage clamp" technique

Vassalle, M. (1966) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1966.210.6.1335 · Cited by 197 · see citing works

Antianginal Efficacy and Safety of Ivabradine Compared with Amlodipine in Patients with Stable Effort Angina Pectoris

Rużyłło, W., Tendera, M., Ford, I., & Fox, K. M. (2007) · Drugs · doi:10.2165/00003495-200767030-00005 · Cited by 192 · see citing works

Hyperpolarization-Activated Inward Current in Ventricular Myocytes From Normal and Failing Human Hearts

Hoppe, U. C., Jansen, E., Südkamp, M., & Beuckelmann, D. J. (1998) · Circulation · doi:10.1161/01.cir.97.1.55 · Cited by 187 · see citing works

Characterization of the Hyperpolarization-Activated Current, I f , in Ventricular Myocytes From Human Failing Heart

Cerbai, E., Pino, R., Porciatti, F., Sani, G., Toscano, M., Maccherini, M., Giunti, G., & Mugelli, A. (1997) · Circulation · doi:10.1161/01.cir.95.3.568 · Cited by 184 · see citing works

Role of Subunit Heteromerization and N-Linked Glycosylation in the Formation of Functional Hyperpolarization-activated Cyclic Nucleotide-gated Channels

Much, B., Wahl‐Schott, C., Zong, X., Schneider, A., Baumann, L., Moosmang, S., Ludwig, A., & Biel, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306958200 · Cited by 183 · see citing works

Point Mutation in the HCN4 Cardiac Ion Channel Pore Affecting Synthesis, Trafficking, and Functional Expression Is Associated With Familial Asymptomatic Sinus Bradycardia

Nof, E., Luria, D. M., Brass, D., Marek, D., Lahat, H., Reznik-Wolf, H., Pras, E., Dascal, N., Eldar, M., & Glikson, M. (2007) · Circulation · doi:10.1161/circulationaha.107.706887 · Cited by 178 · see citing works

Molecular basis of funny current (If) in normal and failing human heart.

Stillitano, F., Lonardo, G., Zicha, S., Varró, A., Cerbai, E., Mugelli, A., & Nattel, S. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.04.013 · Cited by 178 · see citing works

Properties of the hyperpolarization-activated current (If) in isolated mouse sino-atrial cells

Mangoni, M. E. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00370-4 · Cited by 176 · see citing works

Properties of ivabradine‐induced block of HCN1 and HCN4 pacemaker channels

Bucchi, A., Tognati, A., Milanesi, R., Baruscotti, M., & DiFrancesco, D. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.100776 · Cited by 175 · see citing works

Sinus node dysfunction and hyperpolarization-activated (HCN) channel subunit remodeling in a canine heart failure model

Zicha, S., Fernández‐Velasco, M., Lonardo, G., L’Heureux, N., & Nattel, S. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.02.011 · Cited by 171 · see citing works

Regulation of Gating and Rundown of HCN Hyperpolarization-activated Channels by Exogenous and Endogenous PIP2

Pian, P., Bucchi, A., Robinson, R. B., & Siegelbaum, S. A. (2006) · The Journal of General Physiology · doi:10.1085/jgp.200609648 · Cited by 167 · see citing works

Location of pacemaker in chick embryo heart at the time of initiation of heartbeat

Mierop, L. V. (1967) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1967.212.2.407 · Cited by 167 · see citing works

Blocker State Dependence and Trapping in Hyperpolarization-Activated Cation Channels

Shin, K. S., Rothberg, B. S., & Yellen, G. (2001) · The Journal of General Physiology · doi:10.1085/jgp.117.2.91 · Cited by 165 · see citing works

Occurrence and Properties of the Hyperpolarization-Activated Current I f in Ventricular Myocytes From Normotensive and Hypertensive Rats During Aging

Cerbai, E., Barbieri, M., & Mugelli, A. (1996) · Circulation · doi:10.1161/01.cir.94.7.1674 · Cited by 165 · see citing works

Site of Origin and Molecular Substrate of Atrioventricular Junctional Rhythm in the Rabbit Heart

Dobrzynski, H., Nikolski, V. P., Sambelashvili, A. T., Greener, I. D., 山本, 充., Boyett, M. R., & Efimov, I. R. (2003) · Circulation Research · doi:10.1161/01.res.0000101913.95604.b9 · Cited by 163 · see citing works

Pacemaking by HCN Channels Requires Interaction with Phosphoinositides

Zolles, G., Klöcker, N., Wenzel, D., Weisser-Thomas, J., Fleischmann, B. K., Roeper, J., & Fakler, B. (2006) · Neuron · doi:10.1016/j.neuron.2006.12.005 · Cited by 162 · see citing works

Functional Expression of the Human HCN3 Channel

Stieber, J., Stöckl, G., Herrmann, S., Haßfurth, B., & Hofmann, F. B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502508200 · Cited by 161 · see citing works

Pacemaker current (If) in the human sinoatrial node

Verkerk, A. O., Wilders, R., van Borren, M. M. G. J., Peters, R. J. G., Broekhuis, E., Lam, K. Y., Coronel, R., de Bakker, J. M. T., & Tan, H. L. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm339 · Cited by 159 · see citing works

I f Current and Spontaneous Activity in Mouse Embryonic Ventricular Myocytes

Yasui, K., Liu, W., Tobias Opthof, A., Kada, K., Lee, J., Kamiya, K., & Kodama, I. (2001) · Circulation Research · doi:10.1161/01.res.88.5.536 · Cited by 158 · see citing works

Differential Expression of Ion Channel Transcripts in Atrial Muscle and Sinoatrial Node in Rabbit

Tellez, J. O., Dobrzynski, H., Greener, I. D., Graham, G. M., Laing, E., Honjo, H., Hubbard, S. J., Boyett, M. R., & Billeter, R. (2006) · Circulation Research · doi:10.1161/01.res.0000251717.98379.69 · Cited by 156 · see citing works

Organisation of the mouse sinoatrial node: structure and expression of HCN channels

Liu, J., Dobrzynski, H., Yanni, J., Boyett, M. R., & Lei, M. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.11.016 · Cited by 156 · see citing works

Bioartificial Sinus Node Constructed via In Vivo Gene Transfer of an Engineered Pacemaker HCN Channel Reduces the Dependence on Electronic Pacemaker in a Sick-Sinus Syndrome Model

Tse, H., Xue, T., Lau, C., Siu, C., Wang, K., Zhang, Q.-Y., Tomaselli, G. F., Akar, F. G., & Li, R. A. (2006) · Circulation · doi:10.1161/circulationaha.106.615385 · Cited by 155 · see citing works

The S4–S5 linker couples voltage sensing and activation of pacemaker channels

Chen, J., Mitcheson, J. S., Tristani‐Firouzi, M., Lin, M. J.-Y., & Sanguinetti, M. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.201250598 · Cited by 154 · see citing works

Salt Bridges and Gating in the COOH-terminal Region of HCN2 and CNGA1 Channels

Craven, K. B., & Zagotta, W. N. (2004) · The Journal of General Physiology · doi:10.1085/jgp.200409178 · Cited by 153 · see citing works

Lowe Syndrome, a deficiency of a phosphatidyl-inositol 4,5-bisphosphate 5-phosphatase in the Golgi apparatus

Suchy, S. F., Olivos-Glander, I. M., & Nussbaum, R. L. (1995) · Human Molecular Genetics · doi:10.1093/hmg/4.12.2245 · Cited by 143 · see citing works

Localization of Pacemaker Channels in Lipid Rafts Regulates Channel Kinetics

Barbuti, A., Gravante, B., Riolfo, M., Milanesi, R., Terragni, B., & DiFrancesco, D. (2004) · Circulation Research · doi:10.1161/01.res.0000127621.54132.ae · Cited by 142 · see citing works

HCN2 Overexpression in Newborn and Adult Ventricular Myocytes

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Wild-Type and Mutant HCN Channels in a Tandem Biological-Electronic Cardiac Pacemaker

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