The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Deficiency of the Long Pentraxin PTX3 Promotes Vascular Inflammation and Atherosclerosis
Open accessAbstract
Background— Immune responses participate in several phases of atherosclerosis; there is, in fact, increasing evidence that both adaptive immunity and innate immunity tightly regulate atherogenesis. Pentraxins are a superfamily of acute-phase proteins that includes short pentraxins such as C-reactive protein or long pentraxins such as PTX3, a molecule acting as the humoral arm of innate immunity. To address the potential role of PTX3 in atherogenesis, we first investigated the expression of PTX3 during atherogenesis, generated double-knockout mice lacking PTX3 and apolipoprotein E, and then studied the effect of murine PTX3 deficiency on plasma lipids, atherosclerosis development, and gene expression pattern in the vascular wall. Methods and Results— PTX3 expression increases in the vascular wall of apolipoprotein E–knockout mice from 3 up to 18 months of age. Double-knockout mice lacking PTX3 and apolipoprotein E were fed an atherogenic diet for 16 weeks. Aortic lesions were significantly increased in double-knockout mice and mice heterozygous for PTX3 compared with apolipoprotein E–knockout mice. Mice lacking PTX3 showed a more pronounced inflammatory profile in the vascular wall as detected by cDNA microarray and quantitative polymerase chain reaction analysis and an increased macrophage accumulation within the plaque. Finally, lesion size correlated with the number of bone marrow monocytes. Conclusion— PTX3 has atheroprotective effects in mice, which, in light of the cardioprotective effects recently reported, suggests a cardiovascular protective function of the long pentraxin 3 through the modulation of the immunoinflammatory balance in the cardiovascular system.
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Cites
Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E
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The immune response in atherosclerosis: a double-edged sword
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Self-citationNon-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response
Garlanda, C., Hirsch, E., Bozza, S., Salustri, A., De Acetis, M., Nota, R., Maccagno, A., Riva, F., Bottazzi, B., Peri, G., et al. (2002) · Nature · doi:10.1038/nature01195 · Cited by 669
Self-citationCombadière, C., Potteaux, S., Rodero, M., Simon, T., Pezard, A., Esposito, B., Merval, R., Proudfoot, A., Tedgui, A., & Mallat, Z. (2008) · Circulation · doi:10.1161/circulationaha.107.745091 · Cited by 663
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Self-citationPrognostic Significance of the Long Pentraxin PTX3 in Acute Myocardial Infarction
Latini, R., Maggioni, A. P., Peri, G., Gonzini, L., Lucci, D., Mocarelli, P., Vago, L., Pasqualini, F., Signorini, S., Soldateschi, D., et al. (2004) · Circulation · doi:10.1161/01.cir.0000145167.30987.2e · Cited by 431
Self-citationAnti-Inflammatory Mechanisms in the Vascular Wall
Tedgui, A., & Mallat, Z. (2001) · Circulation Research · doi:10.1161/hh0901.090440 · Cited by 422
Cited by
The immunology of atherosclerosis
Gisterå, A., & Hansson, G. K. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.51 · Cited by 982
Phetsouphanh, C., Darley, D. R., Wilson, D. B., Howe, A., Munier, C. M. L., Patel, S. K., Juno, J. A., Burrell, L. M., Kent, S. J., Dore, G. J., et al. (2022) · Nature Immunology · doi:10.1038/s41590-021-01113-x · Cited by 1,015
Macrophage Diversity and Polarization in Atherosclerosis: A Question of Balance
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Self-citationPTX3 Is an Extrinsic Oncosuppressor Regulating Complement-Dependent Inflammation in Cancer
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Self-citationInflammation in End-Stage Renal Disease-What Have We Learned in 10 Years?
Carrero, J. J., & Stenvinkel, P. (2010) · Seminars in Dialysis · doi:10.1111/j.1525-139x.2010.00784.x · Cited by 354
Metadata
- Authors
- Norata, G. D., Marchesi, P., Pulakazhi Venu, V. K., Pasqualini, F., Anselmo, A., Moalli, F., Pizzitola, I., Garlanda, C., Mantovani, A., & Catapano, A. L.
- Venue
- Circulation
- Published
- 2009-08-25
- Volume
- 120
- Issue
- 8
- Pages
- 699-708
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1976315388
- Cited by
- 277
- References
- 47
- FWCI
- 8.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Norata, G. D., Marchesi, P., Pulakazhi Venu, V. K., Pasqualini, F., Anselmo, A., Moalli, F., Pizzitola, I., Garlanda, C., Mantovani, A., & Catapano, A. L. (2009). Deficiency of the Long Pentraxin PTX3 Promotes Vascular Inflammation and Atherosclerosis. Circulation. https://doi.org/10.1161/circulationaha.108.806547
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