The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Antiplatelet Therapy and Stent Thrombosis After Sirolimus-Eluting Stent Implantation
Abstract
Background— The influences of antiplatelet therapy discontinuation on the risk of stent thrombosis and long-term clinical outcomes after drug-eluting stent implantation have not yet been addressed adequately. Methods and Results— In an observational study in Japan, 2-year outcomes were assessed in 10 778 patients undergoing sirolimus-eluting stent implantation. Data on status of antiplatelet therapy during follow-up were collected prospectively. Incidences of definite stent thrombosis were 0.34% at 30 days, 0.54% at 1 year, and 0.77% at 2 years. Thienopyridine use was maintained in 97%, 62%, and 50% of patients at 30 days, 1 year, and 2 years, respectively. Patients who discontinued both thienopyridine and aspirin had a significantly higher rate of stent thrombosis than those who continued both in the intervals of 31 to 180 days, 181 to 365 days, and 366 to 548 days after stent implantation (1.76% versus 0.1%, P <0.001; 0.72% versus 0.07%, P =0.02; and 2.1% versus 0.14%, P =0.004, respectively). When discontinuation of aspirin was taken into account, patients who discontinued thienopyridine only did not have an excess of stent thrombosis in any of the time intervals studied. Adjusted rates of death or myocardial infarction at 24 months were 4.1% for patients taking thienopyridine and 4.1% for patients not taking thienopyridine ( P =0.99) in the 6-month landmark analysis. Conclusions— Discontinuation of both thienopyridine and aspirin, but not discontinuation of thienopyridine therapy only, was associated with an increased risk of stent thrombosis. Landmark analysis did not suggest an apparent clinical benefit of thienopyridine use beyond 6 months after sirolimus-eluting stent implantation.
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Clopidogrel and Aspirin versus Aspirin Alone for the Prevention of Atherothrombotic Events
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A Clinical Trial Comparing Three Antithrombotic-Drug Regimens after Coronary-Artery Stenting
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Stent Thrombosis in Randomized Clinical Trials of Drug-Eluting Stents
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Late thrombosis in drug-eluting coronary stents after discontinuation of antiplatelet therapy
McFadden, E. P., Stabile, E., Regar, E., Cheneau, E., Ong, A. T., Kinnaird, T., Suddath, W. O., Weissman, N. J., Torguson, R., Kent, K. M., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17275-9 · Cited by 1,436
Cited by
Urban, P., Mehran, R., Colleran, R., Angiolillo, D. J., Byrne, R. A., Capodanno, D., Cuisset, T., Cutlip, D., Eerdmans, P., Eikelboom, J., et al. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz372 · Cited by 621
Self-citationGwon, H.-C., Hahn, J.-Y., Park, K. W., Song, Y. B., Chae, I.-H., Lim, D.-S., Han, K.-R., Choi, J.-H., Choi, S.-H., Kang, H.-J., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.059022 · Cited by 614
Duration of Dual Antiplatelet Therapy after Implantation of Drug-Eluting Stents
Park, S.-J., Park, D.-W., Kim, Y.-H., Kang, S.-J., Lee, S.-W., Lee, C. W., Han, K.-H., Park, S.-W., Yun, S.-C., Lee, S.-G., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1001266 · Cited by 511
Garg, S., & Serruys, P. W. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.06.007 · Cited by 501
Holmes, D. R., Kereiakes, D. J., Garg, S., Serruys, P. W., Dehmer, G. J., Ellis, S. G., Williams, D. O., Kimura, T., & Moliterno, D. J. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.07.016 · Cited by 367
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Metadata
- Authors
- Kimura, T., Morimoto, T., Nakagawa, Y., Tamura, T., Kadota, K., Yasumoto, H., Nishikawa, H., Hiasa, Y., Muramatsu, T., Meguro, T., Inoue, N., Honda, H., Hayashi, Y., Miyazaki, S., Oshima, S., Honda, T., Shiode, N., Namura, M., Sone, T., Nobuyoshi, M., Kita, T., & Mitsudo, K.
- Venue
- Circulation
- Published
- 2009-02-24
- Volume
- 119
- Issue
- 7
- Pages
- 987-995
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2065132155
- Cited by
- 358
- References
- 21
- FWCI
- 37.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kimura, T., Morimoto, T., Nakagawa, Y., Tamura, T., Kadota, K., Yasumoto, H., Nishikawa, H., Hiasa, Y., Muramatsu, T., Meguro, T., Inoue, N., Honda, H., Hayashi, Y., Miyazaki, S., Oshima, S., Honda, T., Shiode, N., Namura, M., Sone, T., . . . Mitsudo, K. (2009). Antiplatelet Therapy and Stent Thrombosis After Sirolimus-Eluting Stent Implantation. Circulation. https://doi.org/10.1161/circulationaha.108.808311
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