The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Extracellular Cardiac Matrix Biomarkers in Patients With Acute Myocardial Infarction Complicated by Left Ventricular Dysfunction and Heart Failure: Insights From the Eplerenone Post–Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) Study
Abstract
Background— Aldosterone stimulates cardiac collagen synthesis. Circulating biomarkers of collagen turnover provide a useful tool for the assessment of cardiac remodeling in patients with congestive heart failure and left ventricular systolic dysfunction after acute myocardial infarction. Methods and Results— In a substudy of the Eplerenone Post–Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS), which evaluated the effects of the selective aldosterone receptor antagonist eplerenone versus placebo, serum levels of collagen biomarkers were measured in 476 patients with congestive heart failure after acute myocardial infarction complicated with left ventricular systolic dysfunction. The combination of the type I collagen telopeptide and brain natriuretic peptide levels above median at baseline was associated with all-cause mortality and the composite end point of cardiovascular death or heart failure hospitalization, with hazard ratios of 2.49 ( P =0.039) and 3.03 ( P =0.002), respectively. During follow-up, levels of aminoterminal propeptide of type I and type III procollagen were found to be consistently lower in the eplerenone group and significantly lower beginning at 6 months. Conclusions— Changes in biomarkers of collagen synthesis and degradation suggest that extracellular matrix remodeling is an active process in patients with congestive heart failure and left ventricular systolic dysfunction after acute myocardial infarction. High type I collagen telopeptide and high brain natriuretic peptide serum levels are associated with the highest event rate. Eplerenone suppresses post–acute myocardial infarction collagen turnover changes.
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Self-citationMolecular Mechanisms of Myocardial Remodeling
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Self-citationMatrix Metalloproteinases: Regulation and Dysregulation in the Failing Heart
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Regulation of collagen degradation in the rat myocardium after infarction
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Cited by
Eplerenone in patients with systolic heart failure and mild symptoms
Zannad, F., McMurray, J. J. V., Krum, H., van Veldhuisen, D. J., Swedberg, K., Shi, H., Vincent, J., Pocock, S. J., & Pitt, B. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1009492 · Cited by 3,111
Self-citationBraunwald, E. (2013) · JACC: Heart Failure · doi:10.1016/j.jchf.2012.10.002 · Cited by 730
Goetze, J. P., Bruneau, B. G., Ramos, H. R., Ogawa, T., de Bold, M. K., & de Bold, A. J. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0381-0 · Cited by 531
de Boer, R. A., De Keulenaer, G., Bauersachs, J., Brutsaert, D., Cleland, J. G., Diez, J., Du, X.-J., Ford, P., Heinzel, F. R., Lipson, K. E., et al. (2019) · European Journal of Heart Failure · doi:10.1002/ejhf.1406 · Cited by 304
Self-citationAtrial remodeling, fibrosis, and atrial fibrillation
Jalife, J., & Kaur, K. (2015) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2014.12.015 · Cited by 286
Metadata
- Authors
- Iraqi, W., Rossignol, P., Angioi, M., Fay, R., Nuée, J., Ketelslegers, J. M., Vincent, J., Pitt, B., & Zannad, F.
- Venue
- Circulation
- Published
- 2009-05-12
- Volume
- 119
- Issue
- 18
- Pages
- 2471-2479
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1995354197
- Cited by
- 260
- References
- 26
- FWCI
- 15.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Extracellular Cardiac Matrix Biomarkers in Patients With Acute Myocardial Infarction Complicated by Left Ventricular Dysfunction and Heart Failure: Insights From the Eplerenone Post–Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) Study. https://app.cochat.ai/papers/10.1161/circulationaha.108.809194
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- Iraqi, W., Rossignol, P., Angioi, M., Fay, R., Nuée, J., Ketelslegers, J. M., Vincent, J., Pitt, B., & Zannad, F. (2009). Extracellular Cardiac Matrix Biomarkers in Patients With Acute Myocardial Infarction Complicated by Left Ventricular Dysfunction and Heart Failure: Insights From the Eplerenone Post–Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) Study. Circulation. https://doi.org/10.1161/circulationaha.108.809194
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