The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Arterial and Aortic Valve Calcification Abolished by Elastolytic Cathepsin S Deficiency in Chronic Renal Disease
Open accessAbstract
Background— Clinical studies have demonstrated that 50% of individuals with chronic renal disease (CRD) die of cardiovascular causes, including advanced calcific arterial and valvular disease; however, the mechanisms of accelerated calcification in CRD remain obscure, and no therapies can prevent disease progression. We recently demonstrated in vivo that inflammation triggers cardiovascular calcification. In vitro evidence also indicates that elastin degradation products may promote osteogenesis. Here, we used genetically modified mice and molecular imaging to test the hypothesis in vivo that cathepsin S (catS), a potent elastolytic proteinase, accelerates calcification in atherosclerotic mice with CRD induced by 5/6 nephrectomy. Methods and Results— Apolipoprotein-deficient (apoE −/− )/catS +/+ (n=24) and apoE −/− /catS −/− (n=24) mice were assigned to CRD and control groups. CRD mice had significantly higher serum phosphate, creatinine, and cystatin C levels than those without CRD. To visualize catS activity and osteogenesis in vivo, we coadministered catS-activatable and calcification-targeted molecular imaging agents 10 weeks after nephrectomy. Imaging coregistered increased catS and osteogenic activities in the CRD apoE −/− /catS +/+ cohort, whereas CRD apoE −/− /catS −/− mice exhibited less calcification. Quantitative histology demonstrated greater catS-associated elastin fragmentation and calcification in CRD apoE −/− /catS +/+ than CRD apoE −/− /catS −/− aortas and aortic valves. Notably, catS deletion did not cause compensatory increases in RNA levels of other elastolytic cathepsins or matrix metalloproteinases. Elastin peptide and recombinant catS significantly increased calcification in smooth muscle cells in vitro, a process further amplified in phosphate-enriched culture medium. Conclusions— The present study provides direct in vivo evidence that catS-induced elastolysis accelerates arterial and aortic valve calcification in CRD, providing new insight into the pathophysiology of cardiovascular calcification.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Goodman, W. G., Goldin, J., Kuizon, B. D., Yoon, C., Gales, B., Sider, D., Wang, Y., Chung, J., Emerick, A., Greaser, L., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005183422003 · Cited by 2,509
Pathology of the Vulnerable Plaque
Virmani, R., Burke, A. P., Farb, A., & Kolodgie, F. D. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.10.065 · Cited by 2,315
Oodman, W. I. G. G., Oldin, J. O. G., Uizon, D. K., Oon, C. H. Y., Ales, B. A. G., Ider, D. O. S., Ang, W. C., Oanie, J., Hung, C., Merick, A. L. E., et al. (2000) · Cited by 2,191
Intensive Lipid Lowering with Simvastatin and Ezetimibe in Aortic Stenosis
Rossebø, A. B., Pedersen, T. R., Boman, K., Brudi, P., Chambers, J. B., Egstrup, K., Gerdts, E., Gohlke-Bärwolf, C., Holme, I., Kesäniemi, Y. A., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0804602 · Cited by 1,644
Chronic Kidney Disease: Effects on the Cardiovascular System
Schiffrin, E. L., Lipman, M. L., & Mann, J. F. E. (2007) · Circulation · doi:10.1161/circulationaha.106.678342 · Cited by 1,448
Vascular Calcification: Pathobiology of a Multifaceted Disease
Demer, L. L., & Tintut, Y. (2008) · Circulation · doi:10.1161/circulationaha.107.743161 · Cited by 1,065
Vascular Calcification: Pathobiological Mechanisms and Clinical Implications
Johnson, R. C., Leopold, J. A., & Loscalzo, J. (2006) · Circulation Research · doi:10.1161/01.res.0000249379.55535.21 · Cited by 944
Reynolds, J. L., Joannides, A. J., Skepper, J. N., McNair, R., Schurgers, L. J., Proudfoot, D., Jahnen-Dechent, W., Weissberg, P. L., & Shanahan, C. M. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000141960.01035.28 · Cited by 911
Vascular Calcification: Mechanisms and Clinical Ramifications
Abedin, M., Tintut, Y., & Demer, L. L. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000133194.94939.42 · Cited by 863
Kielty, C. M., Sherratt, M. J., & Shuttleworth, C. A. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.14.2817 · Cited by 841
Cited by
Lindman, B. R., Clavel, M.-A., Mathieu, P., Iung, B., Lancellotti, P., Otto, C. M., & Pibarot, P. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.6 · Cited by 982
New, S. E. P., Goettsch, C., Aikawa, M., Marchini, J. F., Shibasaki, M., Yabusaki, K., Libby, P., Shanahan, C. M., Croce, K., & Aikawa, E. (2013) · Circulation Research · doi:10.1161/circresaha.113.301036 · Cited by 451
Self-citationGenesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques
Hutcheson, J. D., Goettsch, C., Bertazzo, S., Maldonado, N., Ruiz, J. L., Goh, W., Yabusaki, K., Faits, T., Bouten, C., Franck, G., et al. (2016) · Nature Materials · doi:10.1038/nmat4519 · Cited by 419
Self-citationYutzey, K. E., Demer, L. L., Body, S. C., Huggins, G. S., Towler, D. A., Giachelli, C. M., Hofmann-Bowman, M. A., Mortlock, D. P., Rogers, M. B., Sadeghi, M. M., et al. (2014) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.114.302523 · Cited by 371
Self-citationCalcific aortic valve disease: mechanisms, prevention and treatment
Moncla, L.-H. M., Briend, M., Bossé, Y., & Mathieu, P. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00845-7 · Cited by 306
Metadata
- Authors
- Aikawa, E., Aikawa, M., Libby, P., Figueiredo, J.-L., Rusanescu, G., Iwamoto, Y., Fukuda, D., Kohler, R. H., Shi, G.-P., Jaffer, F. A., & Weissleder, R.
- Venue
- Circulation
- Published
- 2009-04-07
- Volume
- 119
- Issue
- 13
- Pages
- 1785-1794
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1971540719
- Cited by
- 310
- References
- 45
- FWCI
- 17.93
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Arterial and Aortic Valve Calcification Abolished by Elastolytic Cathepsin S Deficiency in Chronic Renal Disease. https://app.cochat.ai/papers/10.1161/circulationaha.108.827972
- The paper
- Aikawa, E., Aikawa, M., Libby, P., Figueiredo, J.-L., Rusanescu, G., Iwamoto, Y., Fukuda, D., Kohler, R. H., Shi, G.-P., Jaffer, F. A., & Weissleder, R. (2009). Arterial and Aortic Valve Calcification Abolished by Elastolytic Cathepsin S Deficiency in Chronic Renal Disease. Circulation. https://doi.org/10.1161/circulationaha.108.827972
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
