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Vascular Calcification in Chronic Kidney Disease: Diversity in the Vessel Wall

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Extracellular vesicles in cardiovascular calcification: expanding current paradigms

Krohn, J. B., Hutcheson, J. D., Martínez‐Martínez, E., & Aïkawa, E. (2016) · The Journal of Physiology · doi:10.1113/jp271338 · Cited by 119 · see citing works

Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases

Goettsch, C., Kjølby, M., & Aïkawa, E. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.310292 · Cited by 117 · see citing works

Annexin A1–dependent tethering promotes extracellular vesicle aggregation revealed with single–extracellular vesicle analysis

Rogers, M. A., Buffolo, F., Schlotter, F., Atkins, S. K., Lee, L. H., Halu, A., Blaser, M. C., Tsolaki, E., Higashi, H., Luther, K. M., et al. (2020) · Science Advances · doi:10.1126/sciadv.abb1244 · Cited by 115 · see citing works

Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis

Blaser, M. C., Buffolo, F., Halu, A., Turner, M. E., Schlotter, F., Higashi, H., Pantano, L., Clift, C. L., Saddic, L. A., Atkins, S. K., et al. (2023) · Circulation · doi:10.1161/circulationaha.122.063402 · Cited by 114 · see citing works

18 F-Fluoride Signal Amplification Identifies Microcalcifications Associated With Atherosclerotic Plaque Instability in Positron Emission Tomography/Computed Tomography Images

Creager, M. D., Hohl, T., Hutcheson, J. D., Moss, A. J., Schlotter, F., Blaser, M. C., Park, M., Lee, L. H., Singh, S. A., Alcaide-Corral, C. J., et al. (2019) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.118.007835 · Cited by 112 · see citing works

Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis

Blaser, M. C., Kraler, S., Lüscher, T. F., & Aikawa, E. (2021) · Circulation Research · doi:10.1161/circresaha.120.317979 · Cited by 109 · see citing works

Targeted delivery of extracellular vesicles in heart injury

Chen, P., Wang, L., Fan, X., Ning, X., Yu, B., Ou, C., & Chen, M. (2020) · Theranostics · doi:10.7150/thno.51571 · Cited by 107 · see citing works

Roles and Regulation of Extracellular Vesicles in Cardiovascular Mineral Metabolism

Blaser, M. C., & Aïkawa, E. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00187 · Cited by 101 · see citing works

S100A9-RAGE Axis Accelerates Formation of Macrophage-Mediated Extracellular Vesicle Microcalcification in Diabetes Mellitus

Kawakami, R., Katsuki, S., Travers, R. J., Romero, D., BECKER-GREENE, D. R., Passos, L. S. A., Higashi, H., Blaser, M. C., Sukhova, G. K., Buttigieg, J. A., et al. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.314087 · Cited by 100 · see citing works

Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics

van der Valk, D. C., van der Ven, C. F. T., Blaser, M. C., Grolman, J. M., Wu, P.-J., Fenton, O. S., Lee, L. H., Tibbitt, M. W., Andresen, J. L., Wen, J., et al. (2018) · Nanomaterials · doi:10.3390/nano8050296 · Cited by 99 · see citing works

Exosomes: An emerging factor in atherosclerosis

Wang, Y., Xie, Y., Zhang, A., Wang, M., Fang, Z., & Zhang, J. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108951 · Cited by 98 · see citing works

Endoplasmic Reticulum Stress Mediates Vascular Smooth Muscle Cell Calcification via Increased Release of Grp78 (Glucose-Regulated Protein, 78 kDa)-Loaded Extracellular Vesicles

Furmanik, M., van Gorp, R. H., Whitehead, M., Ahmad, S., Bordoloi, J., Kapustin, A. N., Schurgers, L. J., & Shanahan, C. M. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315506 · Cited by 98 · see citing works

Calcifications in atherosclerotic plaques and impact on plaque biomechanics

Barrett, H. E., der Heiden, K. V., Farrell, E., Gijsen, F. J. H., & Akyildiz, A. C. (2019) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2019.03.005 · Cited by 97 · see citing works

Pathophysiology of Aortic Stenosis and Future Perspectives for Medical Therapy

Zheng, K. H., Tzolos, E., & Dweck, M. R. (2019) · Cardiology Clinics · doi:10.1016/j.ccl.2019.09.010 · Cited by 97 · see citing works

Rheumatic heart disease in the modern era: recent developments and current challenges

Leal, M. T. B. C., Passos, L. S. A., Guarçoni, F. V., AGUIAR, J. P. S. D., da Silva, R. B. R., de Paula, T. M. N., Santos, R. F. D., Nassif, M. C. L., Gomes, N. F. A., Tan, T. C., et al. (2019) · Revista da Sociedade Brasileira de Medicina Tropical · doi:10.1590/0037-8682-0041-2019 · Cited by 96 · see citing works

Vascular smooth muscle cell phenotypic switching in atherosclerosis

Yu, Y., Cai, Y., Yang, F., Yang, Y., Cui, Z., Shi, D., & Bai, R. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e37727 · Cited by 96 · see citing works

The Interplay of Hypoxia Signaling on Mitochondrial Dysfunction and Inflammation in Cardiovascular Diseases and Cancer: From Molecular Mechanisms to Therapeutic Approaches

Bouhamida, E., Morciano, G., Perrone, M., Kahsay, A. E., Della Sala, M., Wieckowski, M. R., Fiorica, F., Pinton, P., Giorgi, C., & Patergnani, S. (2022) · Biology · doi:10.3390/biology11020300 · Cited by 87 · see citing works

Potential Causality and Emerging Medical Therapies for Lipoprotein(a) and Its Associated Oxidized Phospholipids in Calcific Aortic Valve Stenosis

Tsimikas, S. (2019) · Circulation Research · doi:10.1161/circresaha.118.313864 · Cited by 87 · see citing works

Poly(ADP-Ribose) Links the DNA Damage Response and Biomineralization

Müller, K. H., Hayward, R., Rajan, R., Whitehead, M., Cobb, A. M., Ahmad, S., Sun, M., Goldberga, I., Li, R., Bashtanova, U., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.038 · Cited by 87 · see citing works

Calciprotein Particles

Kutikhin, A. G., Feenstra, L., Kostyunin, A. E., Yuzhalin, A. E., Hillebrands, J., & Krenning, G. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315697 · Cited by 87 · see citing works

Role of Extracellular Vesicles in the Pathogenesis of Vascular Damage

Buffolo, F., Monticone, S., Camussi, G., & Aïkawa, E. (2022) · Hypertension · doi:10.1161/hypertensionaha.121.17957 · Cited by 86 · see citing works

Autophagic LC3 + calcified extracellular vesicles initiate cartilage calcification in osteoarthritis

Yan, J., Shen, M., Sui, B., Lu, W., Han, X., Wan, Q., Liu, Y., Kang, J., Qin, W., Zhang, Z., et al. (2022) · Science Advances · doi:10.1126/sciadv.abn1556 · Cited by 81 · see citing works

A novel fluorescent probe-based flow cytometric assay for mineral-containing nanoparticles in serum

Smith, E. R., Hewitson, T. D., Cai, M. M., Aghagolzadeh, P., Bachtler, M., Pasch, A., & Holt, S. G. (2017) · Scientific Reports · doi:10.1038/s41598-017-05474-y · Cited by 81 · see citing works

Biologics May Prevent Cardiovascular Events in Rheumatoid Arthritis by Inhibiting Coronary Plaque Formation and Stabilizing High‐Risk Lesions

Karpouzas, G. A., Ormseth, S. R., Hernández, E., & Budoff, M. J. (2020) · Arthritis & Rheumatology · doi:10.1002/art.41293 · Cited by 79 · see citing works

Innate and adaptive immunity in cardiovascular calcification

Passos, L. S. A., Lupieri, A., BECKER-GREENE, D. R., & Aïkawa, E. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.02.016 · Cited by 77 · see citing works

Unraveling the Mechanisms of Valvular Heart Disease to Identify Medical Therapy Targets: A Scientific Statement From the American Heart Association

Small, A., Yutzey, K. E., Binstadt, B. A., Key, K. V., Bouatia‐Naji, N., Milan, D., Aïkawa, E., Otto, C. M., & Hilaire, C. S. (2024) · Circulation · doi:10.1161/cir.0000000000001254 · Cited by 75 · see citing works

Usefulness of C-reactive protein-triglyceride glucose index in detecting prevalent coronary heart disease: findings from the National Health and Nutrition Examination Survey 1999–2018

Xu, M., Zhang, L., Xu, D., Shi, W., & Zhang, W. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1485538 · Cited by 75 · see citing works

Bioengineered H-Ferritin Nanocages for Quantitative Imaging of Vulnerable Plaques in Atherosclerosis

Liang, M., Tan, H., Zhou, J., Wang, T., Duan, D., Fan, K., He, J., Cheng, D., Shi, H., Choi, H. S., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b04158 · Cited by 74 · see citing works

How To Build a Bone: PHOSPHO1, Biomineralization, and Beyond

Dillon, S., Staines, K. A., Millán, J. L., & Farquharson, C. (2019) · JBMR Plus · doi:10.1002/jbm4.10202 · Cited by 74 · see citing works

Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-β Signaling

Krohn, J. B., Hutcheson, J. D., Martínez‐Martínez, E., Irvin, W. S., Bouten, C. V. C., Bertazzo, S., Bendeck, M. P., & Aïkawa, E. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.307009 · Cited by 72 · see citing works

Giving Calcification Its Due: Recognition of a Diverse Disease

Hutcheson, J. D., Blaser, M. C., & Aïkawa, E. (2017) · Circulation Research · doi:10.1161/circresaha.116.310060 · Cited by 72 · see citing works

Cell-Matrix Interactions and Matricrine Signaling in the Pathogenesis of Vascular Calcification

Ngai, D., Lino, M., & Bendeck, M. P. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00174 · Cited by 68 · see citing works

Plaque Calcification

Akers, E. J., Nicholls, S. J., & Bartolo, B. A. D. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.311574 · Cited by 68 · see citing works

KLF2 Mediates the Suppressive Effect of Laminar Flow on Vascular Calcification by Inhibiting Endothelial BMP/SMAD1/5 Signaling

Huang, J., Pu, Y., Zhang, H., Xie, L., He, L., Zhang, C., Cheng, C. K., Huo, Y., Wan, S., Chen, S., et al. (2021) · Circulation Research · doi:10.1161/circresaha.120.318690 · Cited by 67 · see citing works

A Rock and a Hard Place

Aïkawa, E., & Libby, P. (2017) · Circulation · doi:10.1161/circulationaha.117.027776 · Cited by 67 · see citing works

Mud in the blood: the role of protein-mineral complexes and extracellular vesicles in biomineralisation and calcification

Jahnen‐Dechent, W., Büscher, A., Köppert, S., Heiss, A., Kuro‐o, M., & Smith, E. R. (2020) · Journal of Structural Biology · doi:10.1016/j.jsb.2020.107577 · Cited by 66 · see citing works

Imaging of coronary atherosclerosis — evolution towards new treatment strategies

Dweck, M. R., Doris, M. K., Motwani, M., Adamson, P. D., Slomka, P. J., Dey, D., Fayad, Z. A., Newby, D. E., & Berman, D. S. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.79 · Cited by 62 · see citing works

Exosomes, the message transporters in vascular calcification

Zhang, C., Zhang, K., Huang, F., Feng, W., Chen, J., Zhang, H., Wang, J., Luo, P., & Huang, H. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13692 · Cited by 61 · see citing works

Extracellular vesicle signalling in atherosclerosis

Charla, E., Mercer, J. R., Maffia, P., & Nicklin, S. A. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109751 · Cited by 61 · see citing works

Microparticles (Exosomes) and Atherosclerosis

Chen, Y.-T., Yuan, H., Ou, Z., & Ou, J. (2020) · Current Atherosclerosis Reports · doi:10.1007/s11883-020-00841-z · Cited by 60 · see citing works

Macrophage death in atherosclerosis: potential role in calcification

Neels, J. G., Gollentz, C., & Chinetti, G. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1215612 · Cited by 60 · see citing works

Pathological Mineralization: The Potential of Mineralomics

Tsolaki, E., & Bertazzo, S. (2019) · Materials · doi:10.3390/ma12193126 · Cited by 60 · see citing works

Correlative imaging reveals physiochemical heterogeneity of microcalcifications in human breast carcinomas

Kunitake, J. A. M. R., Choi, S., Nguyen, K. X., Lee, M. M., He, F., Sudilovsky, D., Morris, P. G., Jochelson, M. S., Hudis, C. A., Muller, D. A., et al. (2017) · Journal of Structural Biology · doi:10.1016/j.jsb.2017.12.002 · Cited by 59 · see citing works

Serum Sortilin Associates With Aortic Calcification and Cardiovascular Risk in Men

Goettsch, C., Iwata, H., Hutcheson, J. D., O’Donnell, C. J., Chapurlat, R. D., Cook, N. R., Aikawa, M., Szulc, P., & Aïkawa, E. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.308932 · Cited by 58 · see citing works

Sorting through the extensive and confusing roles of sortilin in metabolic disease

Mitok, K. A., Keller, M. P., & Attie, A. (2022) · Journal of Lipid Research · doi:10.1016/j.jlr.2022.100243 · Cited by 57 · see citing works

Cell-matrix mechanics and pattern formation in inflammatory cardiovascular calcification

Hsu, J. J., Lim, J., Tintut, Y., & Demer, L. L. (2016) · Heart · doi:10.1136/heartjnl-2016-309667 · Cited by 57 · see citing works

Regulatory Role of Sex Hormones in Cardiovascular Calcification

Woodward, H. J., Zhu, D., Hadoke, P. W. F., & MacRae, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094620 · Cited by 56 · see citing works

Two-faced Janus: the dual role of macrophages in atherosclerotic calcification

Waring, O. J., Skenteris, N. T., Biessen, E. A. L., & Donners, M. M. P. C. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab301 · Cited by 56 · see citing works

Senescence in Vascular Smooth Muscle Cells and Atherosclerosis

Zha, Y., Zhuang, W., Yang, Y., Zhou, Y., Li, H., & Liang, J. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.910580 · Cited by 55 · see citing works

Phosphate in Cardiovascular Disease: From New Insights Into Molecular Mechanisms to Clinical Implications

Turner, M. E., Beck, L., Hill Gallant, K. M., Chen, Y., Moe, O. W., Kuro-o, M., Moe, S. M., & Aikawa, E. (2024) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.123.319198 · Cited by 54 · see citing works

Effects of glycine on metabolic syndrome components: a review

Imenshahidi, M., & Hossenzadeh, H. (2022) · Journal of Endocrinological Investigation · doi:10.1007/s40618-021-01720-3 · Cited by 54 · see citing works

Coronary Artery Microcalcification: Imaging and Clinical Implications

Vancheri, F., Longo, G., Vancheri, S., Danial, J. S. H., & Henein, M. (2019) · Diagnostics · doi:10.3390/diagnostics9040125 · Cited by 54 · see citing works

The Paradox Effect of Calcification in Carotid Atherosclerosis: Microcalcification Is Correlated with Plaque Instability

Montanaro, M., Scimeca, M., Anemona, L., Servadei, F., Giacobbi, E., Bonfiglio, R., Bonanno, E., Urbano, N., Ippoliti, A., Santeusanio, G., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22010395 · Cited by 54 · see citing works

Extracellular vesicles in cardiovascular homeostasis and disease

Hutcheson, J. D., & Aïkawa, E. (2018) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000510 · Cited by 53 · see citing works

Zooming in on the genesis of atherosclerotic plaque microcalcifications

Ruiz, J., Weinbaum, S., Aïkawa, E., & Hutcheson, J. D. (2016) · The Journal of Physiology · doi:10.1113/jp271339 · Cited by 52 · see citing works

Lumenal calcification and microvasculopathy in fetuin-A-deficient mice lead to multiple organ morbidity

Herrmann, M., Babler, A., Moshkova, I., Gremse, F., Kiessling, F. M., Kusebauch, U., Nelea, V., Kramann, R., Moritz, R. L., McKee, M. D., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0228503 · Cited by 52 · see citing works

Role of Inflammation in Arterial Calcification

Lee, H., Lim, S., & Park, S. (2021) · Korean Circulation Journal · doi:10.4070/kcj.2020.0517 · Cited by 51 · see citing works

Nano-Hydroxyapatite Stimulation of Gene Expression Requires Fgf Receptor, Phosphate Transporter, and Erk1/2 Signaling

Ha, S., Park, J., Habib, M. M., & Beck, G. R. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b12029 · Cited by 51 · see citing works

Extracellular vesicles in vascular calcification

Yang, W., Zou, B., Hou, Y., Yan, W., Chen, T., & Qu, S.-L. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.09.002 · Cited by 51 · see citing works

Extracellular vesicles in vascular remodeling

Ye, C., Zheng, F., Wu, N., Zhu, G., & Li, X. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00846-7 · Cited by 49 · see citing works

Role of Extracellular Vesicles as Potential Diagnostic and/or Therapeutic Biomarkers in Chronic Cardiovascular Diseases

Martı́n-Ventura, J. L., Roncal, C., Orbe, J., & Blanco‐Colio, L. M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.813885 · Cited by 49 · see citing works

Effects of Curcumin on Mitochondrial Function, Endoplasmic Reticulum Stress, and Mitochondria-Associated Endoplasmic Reticulum Membranes in the Jejunum of Oxidative Stress Piglets

Li, X., Zhu, J., Lin, Q., Yu, M., Lu, J., Feng, J., & Hu, C. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c02824 · Cited by 49 · see citing works

Zooming in on the genesis of atherosclerotic plaque microcalcifications

Ruiz, J., Weinbaum, S., Aïkawa, E., & Hutcheson, J. D. (2016) · The Journal of Physiology · doi:10.1113/jp271339 · Cited by 52 · see citing works

Abstract 648: Visualizing the Genesis of Microcalcifications via Matrix Vesicle Aggregation: Novel Implications for Plaque Vulnerability

Hutcheson, J. D., Goettsch, C., Ricchiuto, P., Bertazzo, S., Maldonado, N., Aikawa, M., Singh, S. A., & Aïkawa, E. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvb.34.suppl_1.648

Tissue-engineered models to unravel the role of microcalcifications in atherosclerotic plaque rupture

Jansen, I. (2026) · EUR Research Repository (Erasmus University Rotterdam)

Extracellular vesicles in cardiovascular disease: focus on vascular calcification

Aïkawa, E. (2016) · The Journal of Physiology · doi:10.1113/jp272112 · Cited by 32 · see citing works

Abstract 15888: Scamc-1 is a Novel Extracellular Vesicle Protein Linked to Vascular Calcification

Hutcheson, J. D., Goettsch, C., Maldonado, N., Ricchiuto, P., Singh, S. A., & Aïkawa, E. (2014) · Circulation