Effect of hydroxymethylglutaryl coenzyme-a reductase inhibitors on the long-term progression of rheumatic mitral valve disease
Open accessAbstract
Background— At present, no medical therapy is known to affect the progression of rheumatic mitral stenosis (MS). We sought to assess the effect of statin treatment on long-term progression of MS in a large population. Methods and Results— From our 20-year database, we identified all patients with rheumatic MS with ≥2 echocardiographies ≥1 year apart. Exclusion criteria were previous intervention on the mitral valve, more than moderate aortic regurgitation, or symptoms at first examination. The study sample included 315 patients (mean age, 61±12 years; 224 women); 35 patients (11.1%) were treated with statins, and 280 (88.9%) were not. Mean follow-up period was 6.1±4.0 years (range, 1 to 20). The rate of decrease in mitral valve area was significantly lower in the statin group compared with the untreated group (0.027±0.056 versus 0.067±0.082 cm 2 /y; P =0.005). The annualized change in mean transmitral gradient was lower in statin-treated patients (0.20±0.59 versus 0.58±0.96 mm Hg/y; P =0.023). The prevalence of fast MS progression (annual change in mitral valve area >0.08 cm 2 ) was significantly lower in the statin group ( P =0.008). An increase in systolic pulmonary artery pressure of >10 mm Hg was found in 17% of patients in the statin group versus 40% of untreated patients ( P =0.045). Conclusions— Our study shows a significantly slower progression of rheumatic MS in patients treated with statins. These findings could have an important impact in the early medical therapy of patients with rheumatic heart disease.
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Small observational studies suggest a benefit of statin treatment for rheumatic mitral stenosis and bioprosthetic valves.
“Regarding rheumatic mitral stenosis and bioprosthetic valves, small observational studies suggest a benefit of statin treatment. 381,382”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [381]
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Self-citation
- Authors
- Antonini-Canterin, F., Moura, L. M., Enache, R., Leiballi, E., Pavan, D., Piazza, R., Popescu, B. A., Ginghină, C., Nicolosi, G. L., & Rajamannan, N. M.
- Affiliations
- From the Cardiology ARC, S. Maria degli Angeli Hospital, Pordenone, Italy (F.A.-C., R.E., E.L., D.P., R.P., G.L.N.); Hospital Pedro Hispano, Matosinhos, Portugal (L.M.M.); Carol Davila University of Medicine and Pharmacy, Professor Dr C.C. Iliescu Institute of Cardiovascular Diseases, Bucharest, Romania (B.A.P., C.G.); and Division of Cardiology and Department of Pathology, Feinberg School of Medicine, Chicago, Ill (N.M.R.).
- Carol Davila University of Medicine and Pharmacy (RO)
- Venue
- Circulation
- Published
- 2010-05-18
- Volume
- 121
- Issue
- 19
- Pages
- 2130-2136
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC3263343
- OpenAlex
- W2011272315
- Cited by
- 32
- References
- 53
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 3 · 2021: 1 · 2016: 7 · 2014: 3 · 2013: 4 · 2012: 5
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL085591)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Streptococcal Infections and Treatments
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- rheumatic mitral stenosis, statins, disease progression, mitral valve area, transmitral gradient, pulmonary artery systolic pressure, rheumatic heart disease, long-term follow-up
- MeSH terms
- Aged, Aortic Valve Insufficiency, Echocardiography, Female, Follow-Up Studies, Humans, Male, Middle Aged, Mitral Valve Stenosis, Pulmonary Wedge Pressure, Rheumatic Heart Disease, Multivariate Analysis, Databases, Factual, Treatment Outcome, Disease Progression, Hydroxymethylglutaryl-CoA Reductase Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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