CoChat
Sign Up
Cited by 546Infective Endocarditis Diagnosis and ManagementInfectious Diseases and TuberculosisCardiac Valve Diseases and Treatments

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Neurological Complications of Infective Endocarditis: Risk Factors, Outcome, and Impact of Cardiac Surgery: A Multicenter Observational Study

Open access
García-Cabrera, Emilio, Fernández-Hidalgo, Nuria, Almirante, Benito, Ivanova-Georgieva, Radka, Noureddine, Mariam, Plata, Antonio, Lomas, Jose M., Gálvez-Acebal, Juan, Hidalgo-Tenorio, Carmen, Ruíz-Morales, Josefa, Martínez-Marcos, Francisco J., Reguera, Jose M., de la Torre-Lima, Javier, González, Arístides de Alarcón·2013·Circulation
DOI 10.1161/circulationaha.112.000813PMC PMC1700734
Open this paper in CoChat — free accountOpen PDF

Abstract

Background—: The purpose of this study was to assess the incidence of neurological complications in patients with infective endocarditis, the risk factors for their development, their influence on the clinical outcome, and the impact of cardiac surgery. Methods and Results—: This was a retrospective analysis of prospectively collected data on a multicenter cohort of 1345 consecutive episodes of left-sided infective endocarditis from 8 centers in Spain. Cox regression models were developed to analyze variables predictive of neurological complications and associated mortality. Three hundred forty patients (25%) experienced such complications: 192 patients (14%) had ischemic events, 86 (6%) had encephalopathy/meningitis, 60 (4%) had hemorrhages, and 2 (1%) had brain abscesses. Independent risk factors associated with all neurological complications were vegetation size ≥3 cm (hazard ratio [HR] 1.91), Staphylococcus aureus as a cause (HR 2.47), mitral valve involvement (HR 1.29), and anticoagulant therapy (HR 1.31). This last variable was particularly related to a greater incidence of hemorrhagic events (HR 2.71). Overall mortality was 30%, and neurological complications had a negative impact on outcome (45% of deaths versus 24% in patients without these complications; P <0.01), although only moderate to severe ischemic stroke (HR 1.63) and brain hemorrhage (HR 1.73) were significantly associated with a poorer prognosis. Antimicrobial treatment reduced (by 33% to 75%) the risk of neurological complications. In patients with hemorrhage, mortality was higher when surgery was performed within 4 weeks of the hemorrhagic event (75% versus 40% in later surgery). Conclusions—: Moderate to severe ischemic stroke and brain hemorrhage were found to have a significant negative impact on the outcome of infective endocarditis. Early appropriate antimicrobial treatment is critical, and transitory discontinuation of anticoagulant therapy should be considered.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1161/circulationaha.112.000813

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 50 references

Cited by

Sorted by citations

Items 301–400 of 545

Related

See all

Metadata

Authors
García-Cabrera, E., Fernández-Hidalgo, N., Almirante, B., Ivanova-Georgieva, R., Noureddine, M., Plata, A., Lomas, J. M., Gálvez-Acebal, J., Hidalgo-Tenorio, C., Ruíz-Morales, J., Martínez-Marcos, F. J., Reguera, J. M., de la Torre-Lima, J., & González, A. D. A.
Affiliations
  • Red Espanola de Investigacion en Patologia Infecciosa (ES)
  • From the Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain (E.G.-C., N.F.-H., B.A., R.I.-G., M.N., A.P., J.M.L., J.G.-A., C.H.-T., J.R.-M., F.J.M.-M., J.M.R., J.d.l.T.-L., A.d.A.G.); Instituto de Biomedicina de Sevilla (IBIS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain (E.G.-C., A.d.A.G.); Internal Medicine Unit, Hospital Universitario Virgen de la Victoria, Malaga, Spain (R.I.-G.); Diseases Department, Hospital Universitari Vall...
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2013-06-11
Volume
127
Issue
23
Pages
2272-2284
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/circulationaha.112.000813
PMC
PMC1700734
OpenAlex
W1964229213
Semantic Scholar
0f677aa7ff948d305e924c9f32683395e294fad0
Cited by
546
References
50
Citations by year
2026: 33 · 2025: 36 · 2024: 62 · 2023: 69 · 2022: 46 · 2021: 49 · 2020: 38 · 2019: 52 · 2018: 43 · 2017: 27 · 2016: 40 · 2015: 21 · 2014: 23 · 2013: 6
FWCI
21.65
Type
journal article
Language
en
Update notices
correction (2013-07-23)
Open access
Locations
  • Circulation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • RISalud Institutional Health Repository of Andalucía (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Infective Endocarditis Diagnosis and Management
  • Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
Keywords
infective endocarditis, neurological complications, ischemic stroke, cerebral hemorrhage, encephalopathy, meningitis, brain abscess, vegetation size, Staphylococcus aureus, mitral valve, anticoagulation, risk factors, mortality, timing of cardiac surgery, antimicrobial therapy
MeSH terms
Adult, Aged, Anti-Infective Agents, Anticoagulants, Brain Abscess, Intracranial Aneurysm, Cerebral Hemorrhage, Brain Ischemia, Combined Modality Therapy, Encephalitis, Endocarditis, Female, Follow-Up Studies, Humans, Male, Meningitis, Middle Aged, Postoperative Complications, Prognosis, Retrospective Studies, Risk Factors, Spain, Staphylococcal Infections, Ultrasonography, Multicenter Studies as Topic, Comorbidity, Incidence, Proportional Hazards Models, Treatment Outcome, Heart Valve Prosthesis Implantation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review