Clinical and Angiographic Risk Stratification and Differential Impact on Treatment Outcomes in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Trial
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Background—: The Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial assigned patients with type 2 diabetes mellitus to prompt coronary revascularization plus intensive medical therapy versus intensive medical therapy alone and reported no significant difference in mortality. Among patients selected for coronary artery bypass graft surgery, prompt coronary revascularization was associated with a significant reduction in death/myocardial infarction/stroke compared with intensive medical therapy. We hypothesized that clinical and angiographic risk stratification would affect the effectiveness of the treatments overall and within revascularization strata. Methods and Results—: An angiographic risk score was developed from variables assessed at randomization; independent prognostic factors were myocardial jeopardy index, total number of coronary lesions, prior coronary revascularization, and left ventricular ejection fraction. The Framingham Risk Score for patients with coronary disease was used to summarize clinical risk. Cardiovascular event rates were compared by assigned treatment within high-risk and low-risk subgroups. Overall, no outcome differences between the intensive medical therapy and prompt coronary revascularization groups were seen in any risk stratum. The 5-year risk of death/myocardial infarction/stroke was 36.8% for intensive medical therapy compared with 24.8% for prompt coronary revascularization among the 381 coronary artery bypass graft surgery–selected patients in the highest angiographic risk tertile ( P =0.005); this treatment effect was amplified in patients with both high angiographic and high Framingham risk (47.3% intensive medical therapy versus 27.1% prompt coronary revascularization; P =0.010; hazard ratio=2.10; P =0.009). Treatment group differences were not significant in other clinical-angiographic risk groups within the coronary artery bypass graft surgery stratum, or in any subgroups within the percutaneous coronary intervention stratum. Conclusion—: Among patients with diabetes mellitus and stable ischemic heart disease, a strategy of prompt coronary artery bypass graft surgery significantly reduces the rate of death/myocardial infarction MI/stroke in those with extensive coronary artery disease or impaired left ventricular function. Clinical Trial Registration—: URL: http://www.clinicaltrials.gov . Unique identifier: NCT00006305.
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When coronary anatomy is more extensive and complex, especially with large ischemic burden or frequent angina, adding revascularization to optimized medical therapy provides benefit.
“However, as coronary anatomic burden and complexity increase, particularly among those with large ischemic burden or frequent angina, the benefit of revascularization combined with OMT becomes manifest.263,265–267”
From Clinical management of stable coronary artery disease in patients with type 2 diabetes mellitus: a scientific statement from the American Heart Association (2020) · cites this paper as [265]
Greater vascular disease burden and progressive coronary disease in type 2 diabetes increase the likelihood of ischemic events in target and nontarget vessels after revascularization, especially in patients with more advanced diabetes as indicated by insulin use.
“In particular, the increased vascular disease burden and progressive nature of CAD in patients with T2DM lead to an increased propensity toward postrevascularization target and nontarget vessel ischemic events, especially in those with more advanced T2DM as reflected by insulin requirements.265,297”
From Clinical management of stable coronary artery disease in patients with type 2 diabetes mellitus: a scientific statement from the American Heart Association (2020) · cites this paper as [265]
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- Authors
- Brooks, M. M., Chaitman, B. R., Nesto, R. W., Hardison, R. M., Feit, F., Gersh, B. J., Krone, R. J., Sako, E. Y., Rogers, W. J., Garber, A. J., King, S. B., Davidson, C. J., Ikeno, F., & Frye, R. L.
- Affiliations
- Lahey Hospital and Medical Center (US)
- ORCID
- Venue
- Circulation
- Published
- 2012-10-23
- Volume
- 126
- Issue
- 17
- Pages
- 2115-2124
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC4104411
- OpenAlex
- W2161418914
- Cited by
- 70
- References
- 28
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 7 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 9 · 2016: 5 · 2015: 6 · 2014: 9 · 2013: 10
- FWCI
- 8.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (U01HL063804, U01HL061748, U01HL061744, R21HL121495, U01HL061746)
- Topics
- Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Surgery › Cardiac and Coronary Surgery Techniques
- Keywords
- type 2 diabetes, coronary artery bypass grafting, percutaneous coronary intervention, coronary revascularization, risk stratification, Framingham risk score, intensive medical therapy, stable coronary artery disease, cardiovascular mortality, myocardial infarction, stroke, left ventricular ejection fraction, BARI 2D trial
- MeSH terms
- Aged, Coronary Artery Bypass, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Risk Factors, Angioplasty, Balloon, Coronary, Treatment Outcome, Coronary Angiography, Percutaneous Coronary Intervention
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