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Prognostic Utility of Novel Biomarkers of Cardiovascular Stress: The Framingham Heart Study
Open accessAbstract
BACKGROUND: Biomarkers for predicting cardiovascular events in community-based populations have not consistently added information to standard risk factors. A limitation of many previously studied biomarkers is their lack of cardiovascular specificity. METHODS AND RESULTS: To determine the prognostic value of 3 novel biomarkers induced by cardiovascular stress, we measured soluble ST2, growth differentiation factor-15, and high-sensitivity troponin I in 3428 participants (mean age, 59 years; 53% women) in the Framingham Heart Study. We performed multivariable-adjusted proportional hazards models to assess the individual and combined ability of the biomarkers to predict adverse outcomes. We also constructed a "multimarker" score composed of the 3 biomarkers in addition to B-type natriuretic peptide and high-sensitivity C-reactive protein. During a mean follow-up of 11.3 years, there were 488 deaths, 336 major cardiovascular events, 162 heart failure events, and 142 coronary events. In multivariable-adjusted models, the 3 new biomarkers were associated with each end point (P<0.001) except coronary events. Individuals with multimarker scores in the highest quartile had a 3-fold risk of death (adjusted hazard ratio, 3.2; 95% confidence interval, 2.2-4.7; P<0.001), 6-fold risk of heart failure (6.2; 95% confidence interval, 2.6-14.8; P<0.001), and 2-fold risk of cardiovascular events (1.9; 95% confidence interval, 1.3-2.7; P=0.001). Addition of the multimarker score to clinical variables led to significant increases in the c statistic (P=0.005 or lower) and net reclassification improvement (P=0.001 or lower). CONCLUSION: Multiple biomarkers of cardiovascular stress are detectable in ambulatory individuals and add prognostic value to standard risk factors for predicting death, overall cardiovascular events, and heart failure.
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“Elevated serum GDF15 level have also been found in patients with heart failure”
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Cites
Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Regression Models and Life-Tables
Cox, D. R. (1992) · Springer Series in Statistics · doi:10.1007/978-1-4612-4380-9_37 · Cited by 26,297
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Pencina, M. J., D' Agostino, R. B., D' Agostino, R. B., & Vasan, R. S. (2008) · Statistics in Medicine · doi:10.1002/sim.2929 · Cited by 6,493
Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers
Pencina, M. J., D’Agostino, R. B., & Steyerberg, E. W. (2010) · Statistics in Medicine · doi:10.1002/sim.4085 · Cited by 2,483
WRITING COMMITTEE MEMBERS, Hunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M., Konstam, M. A., Mancini, D. M., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.167586 · Cited by 2,251
2010 ACCF/AHA Guideline for Assessment of Cardiovascular Risk in Asymptomatic Adults
Greenland, P., Alpert, J. S., Beller, G. A., Benjamin, E. J., Budoff, M. J., Fayad, Z. A., Foster, E., Hlatky, M. A., Hodgson, J. M., Kushner, F. G., et al. (2010) · Circulation · doi:10.1161/cir.0b013e3182051b4c · Cited by 1,976
AN INVESTIGATION OF CORONARY HEART DISEASE IN FAMILIES
Kannel, W. B., Feinleib, M., McNAMARA, P. M., Garrison, R. J., & Castelli, W. P. (1979) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112813 · Cited by 1,639
Plasma Natriuretic Peptide Levels and the Risk of Cardiovascular Events and Death
Wang, T. J., Larson, M. G., Levy, D. A., Benjamin, E. J., Leip, E. P., Omland, T., Wolf, P. A., & Vasan, R. S. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031994 · Cited by 1,521
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Items 301–400 of 482
Fernandez, C., Rysä, J., Ström, K., Nilsson, J. Å., Engström, G., Orho‐Melander, M., Ruskoaho, H. J., & Melander, O. (2020) · ESC Heart Failure · doi:10.1002/ehf2.12757 · Cited by 13
Huang, Q., Monzel, A. S., Rausser, S., Haahr, R., Indik, C. E., Savin, M. J., Bobba‐Alves, N., Liu, C. C., Devine, J., Thompson, E., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.19.590241 · Cited by 16
Tun, B., Ehrbar, R. Q., Short, M. I., Cheng, S. C., Vasan, R. S., & Xanthakis, V. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.120.016762 · Cited by 12
deFilippi, C. R., Tran, H., Gattani, R., Daniels, L. B., Shah, P. M., Ilkhanoff, L., Christenson, R. H., Lima, J. A. C., & Seliger, S. L. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1104715 · Cited by 12
Alhathlool, R., Aldaghri, O. A., Ibnaouf, K. H., Alqarni, L. S., Modwi, A. K., Taha, K. K., & Bououdina, M. (2024) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2024.112477 · Cited by 12
Mo, Q., Zhuo, L., Liao, Z., Li, R., Chen, Y., & Geng, J. (2022) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/10760296211063875 · Cited by 12
The current status of heart failure diagnostic biomarkers
Zhang, X., Schulz, B. L., & Punyadeera, C. (2016) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2016.1144474 · Cited by 14
Zhu, K., Hung, J., Divitini, M., Murray, K., Lim, E. M., John, A. S., Walsh, J. P., & Knuiman, M. W. (2018) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2018.05.003 · Cited by 12
Monzo, L., Kobayashi, M., Ferreira, J. P., Lamiral, Z., Delles, C., Clark, A. L., Edelmann, F., González, A., Heymans, S. R. B., Pellicori, P., et al. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-02609-8 · Cited by 11
Gottdiener, J. S., Seliger, S. L., deFilippi, C. R., Christenson, R. H., Baldridge, A. S., Kizer, J. R., Psaty, B. M., & Shah, S. J. (2020) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2020.09.013 · Cited by 11
Soluble ST2 in Ventricular Dysfunction
Lupu, S., & Agoşton-Coldea, L. (2015) · Advances in clinical chemistry · doi:10.1016/bs.acc.2014.12.005 · Cited by 11
Kaess, B. M., Gala, T. D. L. H., Zierer, A., Meisinger, C., Wahl, S., Peters, A., Todd, J., Herder, C., Huth, C., Thorand, B., et al. (2017) · European Journal of Epidemiology · doi:10.1007/s10654-017-0266-7 · Cited by 11
Liu, H., Lyu, Y., Li, D., Cui, Y., Huang, Y., Dai, W., & Li, Y. (2019) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0823-3 · Cited by 11
Parker, D. M., Owens, S. L., Ramkumar, N., Likosky, D. S., DiScipio, A. W., Malenka, D. J., MacKenzie, T. A., & Brown, J. R. (2019) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2019.05.072 · Cited by 11
Watson, C. J., Tea, I., O'Connell, E., Glezeva, N., Zhou, S., James, S., Gallagher, J., Snider, J., Januzzi, J. L., Ledwidge, M. T., et al. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15004 · Cited by 11
Wang, W., Song, X., Chen, Y., Yuan, F., Xu, F., Zhang, M., Tan, K., Yang, X.-S., Yu, X., Cui, K., et al. (2020) · PubMed Central · doi:10.11909/j.issn.1671-5411.2020.04.004 · Cited by 11
Highly sensitive troponins knocking at the door of primary prevention
Giannitsis, E., & Katus, H. A. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht479 · Cited by 11
Yang, P., Wang, S., Zhong, C., Yin, J., Yang, J., Wang, A., Xu, T., & Zhang, Y. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.031010 · Cited by 10
Huang, X., Mu, M., Wang, B., Zhang, H., Liu, Y., Yu, L., Zhou, M., Ma, J., Wang, D., & Chen, W. (2024) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-024-02062-2 · Cited by 10
Lyu, L., Xv, C., Xu, J., Liu, Z., Yan-ru, H., Zhu, W., Lin, L., Yang, Q., Wei, Y., Wang, J., et al. (2024) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-024-03019-5 · Cited by 10
Cardiac biomarkers and CT coronary angiography for the assessment of coronary heart disease
Myrmel, G. M. S., Wereski, R., Karaji, I., Saeed, N., Aakre, K. M., Mills, N. L., & Pedersen, E. R. (2024) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2024.110857 · Cited by 11
Huet, F., Dupuy, A., Duflos, C., Reis, C. A., Kuster, N., Aguilhon, S., Cristol, J., & Roubille, F. (2021) · Future Science OA · doi:10.2144/fsoa-2020-0197 · Cited by 10
Galassi, A., Ciceri, P., Bono, V., Magagnoli, L., Sala, M., Artioli, L., Rovito, R., Hadla, M., Yellenki, V., Monforte, A. D., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10123251 · Cited by 10
Conventional Biomarkers for Predicting Clinical Outcomes in Patients with Heart Disease
Mănescu, I. B., Pál, K., Lupu, S., & Dobreanu, M. (2022) · Life · doi:10.3390/life12122112 · Cited by 10
Candidate biomarkers in heart failure with reduced and preserved ejection fraction
Sinning, C., Zengin, E., Zeller, T., Schnabel, R. B., Blankenberg, S., & Westermann, D. (2015) · Biomarkers · doi:10.3109/1354750x.2015.1068856 · Cited by 10
Treatment Strategies for the Prevention of Heart Failure
Grodin, J. L., & Tang, W. H. W. (2013) · Current Heart Failure Reports · doi:10.1007/s11897-013-0154-8 · Cited by 10
New Risk Markers for Cardiovascular Prevention
Backer, G. D. (2014) · Current Atherosclerosis Reports · doi:10.1007/s11883-014-0427-z · Cited by 11
Skranes, J. B., Einvik, G., Namtvedt, S. K., Randby, A., Hrubos‐Strøm, H., Brynildsen, J., Hagve, T., Somers, V. K., Røsjø, H. R., & Omland, T. (2016) · BMC Cardiovascular Disorders · doi:10.1186/s12872-016-0407-z · Cited by 10
Sponder, M., Lichtenauer, M., Wernly, B., Paar, V., Hoppe, U. C., Emich, M., Fritzer‐Szekeres, M., Litschauer, B., & Strametz‐Juranek, J. (2018) · Journal of Investigative Medicine · doi:10.1136/jim-2018-000913 · Cited by 10
The concentration of interleukin-33 in heart failure with reduced ejection fraction
Segiet, O. A. (2019) · The Anatolian Journal of Cardiology · doi:10.14744/anatoljcardiol.2019.64614 · Cited by 10
Puleo, C. W., Ayers, C. R., Garg, S., Neeland, I. J., Lewis, A., Pandey, A., Drazner, M. H., & de Lemos, J. A. (2021) · Biomarkers in Medicine · doi:10.2217/bmm-2021-0055 · Cited by 10
Yan, X., Guo, Y., Li, L., Wang, Z., & Li, Z. (2022) · Journal of Thoracic Disease · doi:10.21037/jtd-22-470 · Cited by 10
van der Linden, N., Tieland, M., Klinkenberg, L. J. J., Verdijk, L. B., de Groot, C. P. G. M., van Loon, L. J. C., van Dieijen‐Visser, M. P., & Meex, S. J. R. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.05.017 · Cited by 10
Combined Effect of Serum Gamma-glutamyltransferase and Uric Acid on Framingham Risk Score
Lee, D.-J., Choi, J. S., Kim, K., Joo, N., Lee, S. H., & Kim, K.-N. (2014) · Archives of Medical Research · doi:10.1016/j.arcmed.2014.04.004 · Cited by 10
Role of Soluble ST2 as a Marker for Rejection after Heart Transplant
Lee, G. Y., Choi, J.-O., Ju, E., Lee, Y., & Jeon, E. (2016) · Korean Circulation Journal · doi:10.4070/kcj.2016.46.6.811 · Cited by 10
Li, Y., Pei, H., & Zhou, C. (2019) · Biomarkers · doi:10.1080/1354750x.2019.1606277 · Cited by 10
Short-Term Prognosis Value of sST2 for an Unfavorable Outcome in Hypertensive Patients
Fărcaș, A. D., Mocan, M., Anton, F. P., Hognogi, L. D. M., Chiorescu, R. M., Stoia, M. A., Vonica, C. L., Goidescu, C. M., & Vida-Simiti, L. A. (2020) · Disease Markers · doi:10.1155/2020/8143737 · Cited by 10
Heart Failure, the Inflammasome, and Interleukin-1β
Everett, B. M., & Siddiqi, H. K. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.01.005 · Cited by 10
Prognostic indicators of new onset atrial fibrillation in patients with acute coronary syndrome
Zhang, H., Dong, P., Yang, X., Du, L., Wang, K., Yan, P., Zhang, H., Wang, T., Zhao, X., & Guo, T. (2020) · Clinical Cardiology · doi:10.1002/clc.23363 · Cited by 9
Heart Failure: Recent Advances and Breakthroughs
Sebastian, S. A., Co, E. L., Mahtani, A. U., Padda, I., Anam, M., Mathew, S. S., Shahzadi, A., Niazi, M., Pawar, S., & Johal, G. (2023) · Disease-a-Month · doi:10.1016/j.disamonth.2023.101634 · Cited by 9
Adela, R., Mohammed, S. A., Kanwal, A., Vishwakarma, G., Reddy, P. N., & Banerjee, S. (2016) · Personalized Medicine · doi:10.2217/pme-2016-0030 · Cited by 9
Jin, S., Li, X., Wang, Y., Zhang, Y., Wu, Q., Zhang, L., Zuo, X.-B., Gao, J., & Li, J. (2019) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000159 · Cited by 9
Cardiovascular Risk Assessment for Noncardiac Surgery: Are We Ready for Biomarkers?
Dhir, S., & Dhir, A. K. (2019) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2019.10.014 · Cited by 9
Hinton, J., Gabara, L., & Curzen, N. P. (2020) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2020.1828063 · Cited by 9
Hammer, F., Genser, B., Dieplinger, B., Egger, M., Müller, T. M., Drechsler, C., März, W., Störk, S., Wanner, C., & Krane, V. (2022) · Clinical Kidney Journal · doi:10.1093/ckj/sfac142 · Cited by 9
Clinical Course After a First Episode of Heart Failure: Insights from the Framingham Heart Study
Velagaleti, R. S., Larson, M. G., Enserro, D. M., Song, R. J., & Vasan, R. S. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1918 · Cited by 9
Zhou, Y., Wang, X., Yuan, H., Wu, L., Zhang, B., Chen, X., & Zhang, Y. (2023) · Scientific Reports · doi:10.1038/s41598-023-48125-1 · Cited by 8
Huang, S., Yu, L.-J., Sun, G., & Zhang, Z. (2025) · BMC Cardiovascular Disorders · doi:10.1186/s12872-025-04488-z · Cited by 8
Lorenz, E. C., Smith, B. H., Liang, Y., Park, W. D., Bentall, A., Dhala, A. F., Waterman, A. D., Kennedy, C. C., Hickson, L. J., Rule, A. D., et al. (2024) · Transplantation · doi:10.1097/tp.0000000000005103 · Cited by 8
Milwidsky, A. (2014) · Journal of Metabolic Syndrome · doi:10.4172/2167-0943.1000151 · Cited by 8
Stabler, M. E., Rezaee, M. E., Parker, D. M., MacKenzie, T. A., Bohm, A. R., DiScipio, A. W., Malenka, D. J., & Brown, J. R. (2018) · Biomarkers · doi:10.1080/1354750x.2018.1556338 · Cited by 8
Sahle, B. W., Owen, A. J., Wing, L. M. H., Nelson, M. R., Jennings, G., & Reid, C. M. (2016) · American Journal of Hypertension · doi:10.1093/ajh/hpw119 · Cited by 8
Song, L., Söderholm, M., Svensson, E. H., Borné, Y., & Engström, G. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.664010 · Cited by 8
Improving the prediction of long‐term readmission and mortality using a novel biomarker panel
Brown, J. R., Parker, D. M., Stabler, M. E., Jacobs, M. L., Jacobs, J. P., Everett, A. D., Lobdell, K. W., von Ballmoos, M. C. W., Thiessen‐Philbrook, H., Parikh, C. R., et al. (2021) · Journal of Cardiac Surgery · doi:10.1111/jocs.15954 · Cited by 8
Obesity and Survival With Heart Failure
deFilippi, C. R., & Seliger, S. L. (2016) · JACC Heart Failure · doi:10.1016/j.jchf.2016.11.011 · Cited by 8
Webber, K., Patel, S., Kizer, J. R., Eastell, R., Psaty, B. M., Newman, A. B., & Cummings, S. R. (2024) · medRxiv · doi:10.1101/2024.08.07.24311629 · Cited by 8
Heart failure risk estimation based on novel biomarkers
Ataklte, F., & Vasan, R. S. (2021) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2021.1933446 · Cited by 7
Making Sense of High Sensitivity Troponin Assays and their Role in Clinical Care
Daniels, L. B. (2014) · Current Cardiology Reports · doi:10.1007/s11886-014-0471-x · Cited by 7
Biomarkers for Heart Failure Prediction and Prevention
Kotta, P. A., Nambi, V., & Bozkurt, B. (2023) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd10120488 · Cited by 7
GDF-15, soluble ST2 and Troponin-I: Biomarkers of Subclinical Vascular Disease?
Tomaschitz, A., Pilz, S., & März, W. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.02.008 · Cited by 7
Application of Differential Network Enrichment Analysis for Deciphering Metabolic Alterations
Iyer, G. R., Wigginton, J. E., Duren, W. L., Meijer, J. L., Brandenburg, M. D., Burant, C., Michailidis, G. C., & Karnovsky, A. (2020) · Metabolites · doi:10.3390/metabo10120479 · Cited by 8
Soluble ST2 as a Potential Biomarker in Pericardial Fluid of Coronary Artery Patients
Dikme, R., Padak, M., Işık, M., Koyuncu, İ., Temiz, E., Aydın, M. S., & Göç, Ö. (2020) · Brazilian Journal of Cardiovascular Surgery · doi:10.21470/1678-9741-2020-0317 · Cited by 7
Spanos, M., Gokulnath, P., Li, G., Hutchins, E. D., Meechoovet, B., Sheng, Q., Chatterjee, E., Sharma, R., Carnel-Amar, N., Lin, C., et al. (2024) · medRxiv · doi:10.1101/2024.09.19.24314009 · Cited by 7
Cardiac markers and cardiovascular disease in chronic kidney disease
Chen, Y.-J., Chen, C.-C., & Er, T. (2023) · Advances in clinical chemistry · doi:10.1016/bs.acc.2023.03.001 · Cited by 6
m6A epitranscriptomic modification of inflammation in cardiovascular disease
Zhang, Y.-S., Liu, Z., Liu, Z., Lin, L.-C., Chen, Q., Zhao, J., & Tao, H. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112222 · Cited by 6
Natriuretic Peptides and Primary Prevention
Felker, G. M., & Ahmad, T. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.06.009 · Cited by 6
Negishi, K., Hoshide, S., Shimpo, M., & Kario, K. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.660317 · Cited by 6
Balonov, I., Kurlbaum, M., Koschker, A., Stier, C. K., Faßnacht, M., & Dischinger, U. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032354 · Cited by 6
He, G., Ji, R., Huo, X., Su, X., Ge, J., Li, W., Lei, L., Pu, B., Tian, A., Liu, J., et al. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s387534 · Cited by 6
Robbertse, P. S., Doubell, A. F., Esterhuizen, T. M., & Herbst, P. G. (2023) · ESC Heart Failure · doi:10.1002/ehf2.14603 · Cited by 6
The Role of Biomarkers in Predicting Cognitive Impairment in Elderly Patients with Heart Failure
Arslan, A. (2024) · Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology · doi:10.5543/tkda.2024.97143 · Cited by 5
Butler, J., Khan, M. S., Ferreira, J. P., Girerd, N., Gulati, M., Lala, A., Petrie, M. C., Stockbridge, N., Vaduganathan, M., & Zannad, F. M. (2026) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2025.12.029 · Cited by 5
Cardiovascular Toxicity Biomarkers
Zoltani, C. K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814655-2.00012-8 · Cited by 5
Screening for Heart Failure: Biomarkers to Detect Heightened Risk in the General Population
Kosyakovsky, L. B., de Boer, R. A., & Ho, J. E. (2024) · Current Heart Failure Reports · doi:10.1007/s11897-024-00686-6 · Cited by 6
Prognostic value of sst2 in long-term mortality in acute heart failure
Matyar, S., Açıkalın, A., Dişel, N. R., Avcı, A., Çağlayan, Ç. E., Yıldırım, A., & Akpınar, O. (2024) · Acta cardiologica. Supplementum · doi:10.1080/00015385.2024.2406683 · Cited by 5
Peterson, T. E., Landon, C., Haberlen, S., Bhondoekhan, F., Plankey, M. W., Palella, F. J., Piggott, D. A., Margolick, J. B., Brown, T. T., Post, W. S., et al. (2022) · BMC Cardiovascular Disorders · doi:10.1186/s12872-022-02835-y · Cited by 5
Clinical risk factors and blood protein biomarkers of 10-year pneumonia risk
Lee, M.-M., Zuo, Y., Steiling, K. A., Mizgerd, J. P., Kalesan, B., & Walkey, A. J. (2024) · PLoS ONE · doi:10.1371/journal.pone.0296139 · Cited by 5
Alvi, R. M., Zanni, M. V., Neilan, A. M., Hassan, M. Z. O., Tariq, N., Zhang, L., Afshar, M., Banerji, D., Mulligan, C. P., Rokicki, A., et al. (2019) · Clinical Infectious Diseases · doi:10.1093/cid/ciz958 · Cited by 5
Can soluble ST2 be a new marker in heart failure?
Konukoğlu, D. (2017) · International journal of medical biochemistry/International journal of medical biochemistry : · doi:10.14744/ijmb.2017.36844 · Cited by 5
de Bakker, M., Gordon, B., Shah, A. S. V., Boersma, E. H., & Kimenai, D. M. (2025) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaf764 · Cited by 6
Hsieh, M., Yeh, J., Huang, Y., Ho, M.-Y., Chen, D., Lee, C., Wang, C., Chang, S., Chen, C., & Hsieh, I.-C. (2024) · IJC Heart & Vasculature · doi:10.1016/j.ijcha.2024.101521 · Cited by 4
Wimalanathan, T., Paus, M. F., Skranes, J. B., Berge, T., Tveit, A., Røsjø, H. R., Omland, T., Lyngbakken, M. N., & Heck, S. L. (2024) · The Journal of Applied Laboratory Medicine · doi:10.1093/jalm/jfae145 · Cited by 4
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Valina, C. M., Amann, M., Stratz, C., Trenk, D., Löffelhardt, N., Ferenc, M., Neumann, F., & Hochholzer, W. (2016) · EuroIntervention · doi:10.4244/eijv12i3a53 · Cited by 4
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Metadata
- Authors
- Wang, T. J., Wollert, K. C., Larson, M. G., Coglianese, E., McCabe, E. L., Cheng, S., Ho, J. E., Fradley, M. G., Ghorbani, A., Xanthakis, V., Kempf, T., Benjamin, E. J., Levy, D., Vasan, R. S., & Januzzi, J. L.
- Affiliations
- Boston University (US)
- ORCID
- Venue
- Circulation
- Published
- 2012-09-25
- Volume
- 126
- Issue
- 13
- Pages
- 1596-1604
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC3656719
- OpenAlex
- W2163917890
- Cited by
- 482
- References
- 65
- Citations by year
- 2026: 16 · 2025: 16 · 2024: 29 · 2023: 33 · 2022: 25 · 2021: 32 · 2020: 40 · 2019: 42 · 2018: 31 · 2017: 42 · 2016: 45 · 2015: 38 · 2014: 44 · 2013: 43 · 2012: 6
- FWCI
- 32.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01hc25195-41-0-1)
- National Heart, Lung, and Blood Institute (R01HL086875, N01‐HC25195, K99HL107642, R01-HL-08675, N01-HC-025195)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › GDF15 and Related Biomarkers
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Keywords
- soluble ST2, growth differentiation factor 15, high-sensitivity troponin I, cardiovascular mortality, heart failure, major cardiovascular events, brain natriuretic peptide, C-reactive protein, prognostic value, Framingham Heart Study
- MeSH terms
- Interleukin-1 Receptor-Like 1 Protein, Aged, C-Reactive Protein, Cardiovascular Diseases, Follow-Up Studies, Heart Failure, Humans, Male, Middle Aged, Prognosis, Receptors, Cell Surface, Retrospective Studies, Risk Factors, Biomarkers, Proportional Hazards Models, Troponin I, Natriuretic Peptide, Brain, Growth Differentiation Factor 15
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