A New Era for Treating Enterococcus faecalis Endocarditis: Ampicillin Plus Short-Course Gentamicin or Ampicillin Plus Ceftriaxone: That Is the Question!

Miro, Jose M.; Pericas, Juan M.; del Rio, Ana

doi:10.1161/circulationaha.113.002431

Cited by 46Infective Endocarditis Diagnosis and ManagementStreptococcal Infections and TreatmentsCardiac Valve Diseases and Treatments

A New Era for Treating Enterococcus faecalis Endocarditis: Ampicillin Plus Short-Course Gentamicin or Ampicillin Plus Ceftriaxone: That Is the Question!

Miro, Jose M., Pericas, Juan M., del Rio, Ana·2013·Circulation

DOI 10.1161/circulationaha.113.002431

Open this paper in CoChat — free account

Abstract

E nterococci are the third most common etiologic agent of infective endocarditis worldwide after staphylococci and streptococci and cause 10% to 15% of cases. 1 Enterococcal infections are increasingly relevant, especially among the elderly and patients with comorbid conditions in the healthcare setting.2,3 Approximately 90% of cases of enterococcal endocarditis are caused by Enterococcus faecalis, with <5% caused by E. faecium.2,3 The morbidity and mortality of enterococcal endocarditis are high.The percentage of patients requiring cardiac surgery (42%) and the 1-year mortality rate (29%) have remained almost unchanged for the last 30 years; recent data show that they may even be increasing.3

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/circulationaha.113.002431

Cites

18 of 18 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Clinical Presentation, Etiology, and Outcome of Infective Endocarditis in the 21st Century: The International Collaboration on Endocarditis–Prospective Cohort Study
Murdoch, D. R. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2008.603 · Cited by 2,362 · see citing works
Guidelines on the prevention, diagnosis, and treatment of infective endocarditis (new version 2009)
Endorsed by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and by the International Society of Chemotherapy (ISC) for Infection and Cancer, Habib, G., Hoen, B., Tornos, P., Thuny, F., Prendergast, B., Vilacosta, I., Moreillon, P., de Jesus Antunes, M., Thilen, U., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp285 · Cited by 2,014 · see citing works
Infective Endocarditis: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Statement for Healthcare Professionals From the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, and the Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia, American Heart Association: Endorsed by the Infectious Diseases Society of America
Baddour, L. M., Wilson, W. R., Bayer, A. S., Fowler, V. G., Bolger, A. F., Levison, M. E., Ferrieri, P., Gerber, M. A., Tani, L. Y., Gewitz, M. H., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.165564 · Cited by 1,707 · see citing works
Ampicillin Plus Ceftriaxone Is as Effective as Ampicillin Plus Gentamicin for Treating Enterococcus faecalis Infective Endocarditis
Fernández-Hidalgo, N., Almirante, B., Gavaldà, J., Gurgui, M., Peña, C., de Alarcón, A., Ruiz, J., Vilacosta, I., Montejo, M., Vallejo, N., et al. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit052 · Cited by 311 · see citing works
Brief Communication: Treatment of Enterococcus faecalis Endocarditis with Ampicillin plus Ceftriaxone
Gavaldà, J., Len, O., Miró, J. M., Muñoz, P., Montejo, M., Alarcón, A., de la Torre-Cisneros, J., Peña, C., Martínez-Lacasa, X., Sarria, C., et al. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-8-200704170-00008 · Cited by 202 · see citing works
Enterococcal endocarditis in the beginning of the 21st century: analysis from the International Collaboration on Endocarditis-Prospective Cohort Study
Chirouze, C., Athan, E., Alla, F., Chu, V. H., Ralph Corey, G., Selton-Suty, C., Erpelding, M.-L., Miro, J. M., Olaison, L., & Hoen, B. (2013) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12166 · Cited by 176 · see citing works
Enterococcal endocarditis: 107 cases from the international collaboration on endocarditis merged database
McDonald, J. R., Olaison, L., Anderson, D. J., Hoen, B., Miró, J. M., Eykyn, S. J., Abrutyn, E., Fowler, V. G., Habib, G., Selton‐Suty, C., et al. (2005) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.02.020 · Cited by 167 · see citing works
Enterococcal Endocarditis in Sweden, 1995–1999: Can Shorter Therapy with Aminoglycosides Be Used?
Olaison, L., Schadewitz, K., & Swedish Society of Infectious Diseases Quality Assurance Study Group for Endocarditis (2002) · Clinical Infectious Diseases · doi:10.1086/338233 · Cited by 166 · see citing works
Synergistic effect of amoxicillin and cefotaxime against Enterococcus faecalis
Mainardi, J., Gutmann, L., Acar, J. F., & Goldstein, F. W. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.9.1984 · Cited by 165 · see citing works
Treatment of Streptomycin-Susceptible and Streptomycin-Resistant Enterococcal Endocarditis
WILSON, W. R., WILKOWSKE, C. J., WRIGHT, A. J., SANDE, M. A., & GERACI, J. E. (1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-100-6-816 · Cited by 159 · see citing works
The Combined Action of Penicillin with Streptomycin or Chloromycetin on Enterococci in Vitro
Jawetz, E., Gunnison, J. B., & Coleman, V. R. (1950) · Science · doi:10.1126/science.111.2880.254 · Cited by 144 · see citing works
Efficacy of Ampicillin plus Ceftriaxone in Treatment of Experimental Endocarditis Due to Enterococcus faecalis Strains Highly Resistant to Aminoglycosides
Gavaldà, J., Torres, C., Tenorio, C., López, P., Zaragoza, M., Capdevila, J. A., Almirante, B., Ruiz, F., Borrell, N., Gomis, X., et al. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.3.639 · Cited by 134 · see citing works
Use of streptomycin in the treatment of bacterial endocarditis
Hunter, T. H. (1947) · The American Journal of Medicine · doi:10.1016/0002-9343(47)90088-0 · Cited by 113 · see citing works
Enterococcus faecalis Infective Endocarditis: A Pilot Study of the Relationship Between Duration of Gentamicin Treatment and Outcome
Dahl, A., Rasmussen, R. V., Bundgaard, H., Hassager, C., Bruun, L. E., Lauridsen, T. K., Moser, C., Sogaard, P., Arpi, M., & Bruun, N. E. (2013) · Circulation · doi:10.1161/circulationaha.112.001170 · Cited by 108 · see citing works
Efficacy of ampicillin combined with ceftriaxone and gentamicin in the treatment of experimental endocarditis due to Enterococcus faecalis with no high-level resistance to aminoglycosides
Gavaldà, J. (2003) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkg360 · Cited by 83 · see citing works
Treatment of experimental endocarditis due to Enterococcus faecalis using once-daily dosing regimen of gentamicin plus simulated profiles of ampicillin in human serum
Gavaldà, J., Cardona, P.-J., Almirante, B., Capdevila, J. A., Laguarda, M. V., Pou, L., Crespo, E., Pigrau, C., & Pahissa, A. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.1.173 · Cited by 57 · see citing works
Postantibiotic effect of penicillin plus gentamicin versus Enterococcus faecalis in vitro and in vivo
Hessen, M. T., Pitsakis, P. G., & Levison, M. E. (1989) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.33.5.608 · Cited by 56 · see citing works
In Vitro Antienterococcal Activity Explains Associations between Exposures to Antimicrobial Agents and Risk of Colonization by Multiresistant Enterococci
Rice, L. B., Laktičová, V., Helfand, M. S., & Hutton‐Thomas, R. (2004) · The Journal of Infectious Diseases · doi:10.1086/425580 · Cited by 29 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

10.1093/cid/R52 · DOI

Sorted by citations

2015 ESC Guidelines for the management of infective endocarditis
Habib, G., Lancellotti, P., Antunes, M. J., Bongiorni, M. G., Casalta, J., Zotti, F. D., Dulgheru, R., Khoury, G. A. E., Erba, P. A., Iung, B., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv319 · Cited by 5,014 · see citing works
Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association
Baddour, L. M., Wilson, W. R., Bayer, A. S., Fowler, V. G., Tleyjeh, I. M., Rybak, M. J., Barsic, B., Lockhart, P. B., Gewitz, M. H., Levison, M. E., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000296 · Cited by 3,232 · see citing works
2023 ESC Guidelines for the management of endocarditis
Delgado, V., Marsan, N. A., de Waha, S., Bonaros, N. E., Brida, M., Burri, H., Caselli, S., Doenst, T., Éderhy, S., Erba, P. A., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad193 · Cited by 1,975 · see citing works
Management Considerations in Infective Endocarditis
Wang, A., Gaca, J. G., & Chu, V. H. Y. (2018) · JAMA · doi:10.1001/jama.2018.7596 · Cited by 372 · see citing works
A Review of Combination Antimicrobial Therapy for Enterococcus faecalis Bloodstream Infections and Infective Endocarditis
Beganovic, M., Luther, M. K., Rice, L. B., Arias, C. A., Rybak, M. J., & LaPlante, K. L. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy064 · Cited by 235 · see citing works
Changes in the treatment of Enterococcus faecalis infective endocarditis in Spain in the last 15 years: from ampicillin plus gentamicin to ampicillin plus ceftriaxone
Pericàs, J. M., Cervera, C., del Rı́o, A., Moreno, A., de la Maria, C. G., Almela, M., Falces, C., Ninot, S. P. I., Castañeda, X., Armero, Y., et al. (2014) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12756 · Cited by 99 · see citing works
Aminoglycosides
Jackson, J., Chen, C., & Buising, K. L. (2013) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000012 · Cited by 71 · see citing works
Defining Daptomycin Resistance Prevention Exposures in Vancomycin-Resistant Enterococcus faecium and E. faecalis
Werth, B. J., Steed, M. E., Ireland, C. E., Tran, T. T., Nonejuie, P., Murray, B. E., Rose, W. E., Sakoulas, G., Pogliano, J., Arias, C. A., et al. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00098-14 · Cited by 68 · see citing works
Enterococcus faecalisinfective endocarditis: focus on clinical aspects
Dahl, A., & Bruun, N. E. (2013) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2013.832482 · Cited by 64 · see citing works
Infectious endocarditis and infection of intracardiac devices in adults. Clinical guidelines 2021
Демин, А. А., Kobalava, Z. D., Skopin, I. I., Tyurin, P. V., Boytsov, S. A., Golukhova, E. Z., Гордеев, М. Л., Gudymovich, V. D., Demchenko, E. A., Дробышева, В. П., et al. (2022) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2022-5233 · Cited by 62 · see citing works
Enterococcal Endocarditis Revisited
Pericàs, J. M., Zboromyrska, Y., Cervera, C., Castañeda, X., Almela, M., García-de-la-Mària, C., Mestres, C. A., Falces, C., Quintana, E., Ninot, S. P. I., et al. (2015) · Future Microbiology · doi:10.2217/fmb.15.46 · Cited by 50 · see citing works
Comparison of Dual β-Lactam therapy to penicillin-aminoglycoside combination in treatment of Enterococcus faecalis infective endocarditis
Rafei, A. E., DeSimone, D. C., Narichania, A. D., Sohail, M. R., Vikram, H. R., Li, Z., Steckelberg, J. M., Wilson, W. R., & Baddour, L. M. (2018) · Journal of Infection · doi:10.1016/j.jinf.2018.06.013 · Cited by 46 · see citing works
Enterococcus Faecalis Endocarditis: What’s Next?
Fernández‐Hidalgo, N., Escolà‐Vergé, L., & Pericàs, J. M. (2020) · Future Microbiology · doi:10.2217/fmb-2019-0247 · Cited by 43 · see citing works
Aminoglycoside-Induced Nephrotoxicity—A Focus on Monitoring
Destache, C. J. (2014) · Journal of Pharmacy Practice · doi:10.1177/0897190014546102 · Cited by 36 · see citing works
Ampicillin Plus Ceftriaxone Regimen against Enterococcus faecalis Endocarditis: A Literature Review
Marıno, A., Munafò, A., Zagami, A., Ceccarelli, M., Mauro, R. D., Cantarella, G., Bernardini, R., Nunnari, G., & Cacopardo, B. S. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10194594 · Cited by 36 · see citing works
Outcome of Enterococcus faecalis infective endocarditis according to the length of antibiotic therapy: Preliminary data from a cohort of 78 patients
Pericàs, J. M., Cervera, C., Moreno, A., García-de-la-Mària, C., Almela, M., Falces, C., Quintana, E., Vidal, B., Llopis, J., Fuster, D., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192387 · Cited by 36 · see citing works
Pathogen influence on epidemiology, diagnostic evaluation and management of infective endocarditis
Talha, K. M., DeSimone, D. C., Sohail, M. R., & Baddour, L. M. (2020) · Heart · doi:10.1136/heartjnl-2020-317034 · Cited by 34 · see citing works
Correction: Outcome of Enterococcus faecalis infective endocarditis according to the length of antibiotic therapy: Preliminary data from a cohort of 78 patients
Pericàs, J. M., Cervera, C., Moreno, A., García-de-la-Mària, C., Almela, M., Falces, C., Quintana, E., Vidal, B., Llopis, J., Fuster, D., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196317 · Cited by 34 · see citing works
Antibacterial Activity of an FtsZ Inhibitor Celastrol and Its Synergistic Effect with Vancomycin against Enterococci In Vitro and In Vivo
Lü, X., Wang, Y., Guo, W., Zhang, Z., Hu, X., Nie, T., Yang, X., Li, C., Wang, X., Li, X., et al. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.03699-22 · Cited by 24 · see citing works
Carbonic Anhydrase Inhibition as a Target for Antibiotic Synergy in Enterococci
Chilambi, G. S., Wang, Y., Wallace, N. R., Obiwuma, C., Evans, K. M., Li, Y., Shalaby, M.-A. W., Flaherty, D. P., Shields, R. K., Doi, Y., et al. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.03963-22 · Cited by 18 · see citing works
Treatment of Enterococcus faecalis infective endocarditis with penicillin G plus ceftriaxone
Suzuki, H., Carlson, J. R., & Matsumoto, E. (2019) · Scandinavian Journal of Infectious Diseases · doi:10.1080/23744235.2019.1672888 · Cited by 17 · see citing works
The catastrophic journey of a retained temporary epicardial pacemaker wire leading toEnterococcus faecalisendocarditis and subsequent stroke
Dyal, H. K., & Sehgal, R. (2015) · BMJ Case Reports · doi:10.1136/bcr-2014-206215 · Cited by 14 · see citing works
Penicillin-Binding Proteins and Alternative Dual-Beta-Lactam Combinations for Serious Enterococcus faecalis Infections with Elevated Penicillin MICs
Cusumano, J. A., Daffinee, K. E., Ugalde‐Silva, P., Peti, W., Arthur, M., Desbonnet, C. R., Rice, L. B., LaPlante, K. L., & Garcia-Solache, M. A. (2023) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00871-22 · Cited by 12 · see citing works
New insight into the association between bile infection and clinically relevant pancreatic fistula in patients undergoing pancreatoduodenectomy
Nakamura, K., Sho, M., Kinoshita, S., Akahori, T., Nagai, M., Nakagawa, K., Takagi, T., & Ikeda, N. (2020) · Journal of Hepato-Biliary-Pancreatic Sciences · doi:10.1002/jhbp.781 · Cited by 12 · see citing works
A new pharmacodynamic approach to study antibiotic combinations against enterococci in vivo: Application to ampicillin plus ceftriaxone
Jimenez-Toro, I. E., Rodríguez, C. A., Zuluaga, A. F., Otalvaro, J. D., & Vesga, Ó. (2020) · PLoS ONE · doi:10.1371/journal.pone.0243365 · Cited by 11 · see citing works
Consensus Report on Diagnosis, Treatment and Prevention of Infective Endocarditis by Turkish Society of Cardiovascular Surgery (TSCVS), Turkish Society of Clinical Microbiology and Infectious Diseases (KLIMIK), Turkish Society of Cardiology (TSC), Turkish Society of Nuclear Medicine (TSNM), Turkish Society of Radiology (TSR), Turkish Dental Association (TDA) and Federation of Turkish Pathology Societies (TURKPATH) Cardiovascular System Study Group
Yavuz, S. Ş. (2020) · Turkish Journal of Thoracic and Cardiovascular Surgery · doi:10.5606/tgkdc.dergisi.2020.01954 · Cited by 10 · see citing works
Which trial do we need? Aminopenicillin-gentamicin versus aminopenicillin-ceftriaxone for Enterococcus faecalis endocarditis
Paz, D. L., Cuervo, G., Miró, J. M., & Tattevin, P. (2023) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2023.02.023 · Cited by 8 · see citing works
Evaluation of penicillin‐gentamicin and dual beta-lactam therapies in Enterococcus faecalis infective endocarditis
Freeman, L., Milkovits, A. E., McDaniel, L. F., & Everson, N. A. (2022) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2022.106522 · Cited by 7 · see citing works
Eficacia de las combinaciones antimicrobianas para el tratamiento de infecciones enterocócicas: una revisión crítica
Jimenez-Toro, I. E., Rodríguez, C. A., & Zuluaga, A. F. (2019) · Revista chilena de infectología · doi:10.4067/s0716-10182019000500556 · Cited by 6 · see citing works
Tedizolid as Step-Down Therapy following Daptomycin versus Continuation of Daptomycin against Enterococci and Methicillin- and Vancomycin-Resistant Staphylococcus aureus in a Rat Endocarditis Model
Singh, K. V., Arias, C. A., & Murray, B. E. (2020) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02303-19 · Cited by 6 · see citing works
Ampicillin plus ceftriaxone therapy against Enterococcus faecalis endocarditis: A case report, guidelines considerations, and literature review
Marıno, A., Munafò, A., Zagami, A., Ceccarelli, M., Campanella, E., Cosentino, F., Moscatt, V., Cantarella, G., Mauro, R. D., Bernardini, R., et al. (2022) · IDCases · doi:10.1016/j.idcr.2022.e01462 · Cited by 6 · see citing works
Meropenem plus Ceftaroline Is Active against Enterococcus faecalis in an In Vitro Pharmacodynamic Model Using Humanized Dosing Simulations
Cusumano, J. A., Daffinee, K. E., Piehl, E. C., Garcia-Solache, M. A., Desbonnet, C. R., Rice, L. B., & LaPlante, K. L. (2022) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00426-22 · Cited by 5 · see citing works
Efficacy of Telavancin Alone and in Combination with Ampicillin in a Rat Model of Enterococcus faecalis Endocarditis
Tran, T. T., Tam, V. H., Murray, B. E., Arias, C. A., & Singh, K. V. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02489-16 · Cited by 4 · see citing works
Infective endocarditis – can we treat it more effectively?
Guzek, A., Braksator, W., Gąsior, Z., Kuśmierczyk, M., Różański, J., & Rybicki, Z. (2020) · Polish Journal of Cardio-Thoracic Surgery · doi:10.5114/kitp.2020.94184 · Cited by 4 · see citing works
Rejuvenating aminoglycosides usage in geriatric patients with gram-negative infections
Pagani, L. (2014) · European Geriatric Medicine · doi:10.1016/j.eurger.2014.01.006 · Cited by 3 · see citing works
History, Virulence Genes, Identification and Antimicrobial Resistance of Enterococcus faecalis Isolated from Diabetic Foot Patients
Bloushy, A. A., & Elbehiry, A. (2018) · International Journal of Current Microbiology and Applied Sciences · doi:10.20546/ijcmas.2018.701.258 · Cited by 2 · see citing works
Bacterial α-CAs: a biochemical and structural overview
Vivenzio, V. M., Esposito, D., Monti, S. M., & Simone, G. D. (2024) · The Enzymes · doi:10.1016/bs.enz.2024.07.001 · Cited by 2 · see citing works
Isolated Pulmonary Valve Endocarditis Caused by Enterococcus faecalis—Facing the Unpredictable
Vâţă, A., Loghin, I. I., Miftode, R.-Ş., Crișu, D., Luca, C. M., Vasilescu, A. M., Onofrei, M. I., Părângă, T. G., & Miftode, I.-L. (2025) · Antibiotics · doi:10.3390/antibiotics14030220 · Cited by 2 · see citing works
Adjunctive Therapy in Enterococcus Faecalis Endocarditis Treatment: Maybe Less Is Not Enough
Danneels, P., Hamel, J., & Dubée, V. (2024) · Clinical Infectious Diseases · doi:10.1093/cid/ciae459 · Cited by 1 · see citing works
Changing antimicrobial prescribing patterns, and laboratory reporting in Enterococcus faecalis infective endocarditis at a tertiary Australian centre
Vigneswaran, N., Chua, K. Y. L., Khan, S. F., Korman, T. M., Rogers, B. A., & Robson, C. (2025) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-025-05331-1 · Cited by 1 · see citing works
Insights into the mechanisms underlying cell wall-active agents and gentamicin bactericidal synergism against Enterococcus faecalis
Silva, P. U., Desbonnet, C. R., Rice, L. B., & Garcia-Solache, M. A. (2026) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkag210 · Cited by 1 · see citing works
Early antimicrobial therapy and clinical outcomes of left-sided Enterococcus faecalis endocarditis: a NIDUS registry study
Ståhl, A., Østergaard, L., Hadji-Turdeghal, K., Graversen, P. L., Knudsen, I. H. J., Sørensen, L. M., Dahl, A., Møller, J. E., Bruun, N. E., Povlsen, J. A., et al. (2026) · Infection · doi:10.1007/s15010-026-02974-w · Cited by 1 · see citing works
Combined Antimicrobial Therapy for Infective Endocarditis
Gomez-Villegas, S. I., Miller, W. R., & Arias, C. A. (2024) · Springer eBooks · doi:10.1007/978-3-031-65839-6_16
Treatment of infective endocarditis caused by Enterococcus faecalis with a combination of penicillin G and ceftriaxone: a case report and literature review
Jiang, L., Lin, Z., Wu, S., & Chen, T. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1539372
2025 Clinical practice guidelines for Infectious endocarditis and infection of intracardiac devices
Кобалава, Ж. Д., Демин, А. А., Titov, D. A., Kozlov, R. S., Artyukhina, Е. А., Boytsov, S. A., Golukhova, E. Z., Гордеев, М. Л., Gudymovich, V. D., А., Д. Е., et al. (2026) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2026-6853

NOVA Score to Predict Endocarditis in Patients With Enterococcal Bacteremia: Sticking to Valves or to Scores?
Stryjewski, M. E., & Corey, G. R. (2016)
Enterococcus Faecalis in Endocarditis: Second Most Common Endocarditis Pathogen on the Rise? Data from the Brandenburg Endocarditis Registry
Ostovar, R., Schröter, F., Kühnel, R., Braun, C., Seifi, Z., Fritzsche, D., Minden, H. H., Ritter, O., Dörr, G., & Albes, J. M. (2024) · The Thoracic and Cardiovascular Surgeon · doi:10.1055/s-0044-1780563
Enterococcus faecalis Infective Endocarditis
Dunny, G. M., Schlievert, P. M., Mccormick, J. K., Hirt, H., Waters, C. M., Dunny, G. M., Patrick, & Schlievert, M. (2001)
Native aortic valve enterococcal endocarditis with myocardial paravalvular abscess
Mieszczanska, H. Z., Janicka, A., Cunha, B. A., & Lazar, J. (2003) · Heart & Lung · doi:10.1016/s0147-9563(03)00076-1
Endocarditis infecciosa por Enterococcus faecalis
Fernández, D. A., Rayek, J. N., Velez-Pintado, M., & Soto, R. (2019) · Anales Médicos de la Asociación Médica del Centro Médico ABC · Cited by 1 · see citing works

Authors: Miro, J. M., Pericas, J. M., & del Rio, A.
Affiliations: From the Infectious Diseases Service, Hospital Clinic–IDIBAPS, University of Barcelona, Barcelona, Spain.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2013-04-30
Volume: 127
Issue: 17
Pages: 1763-1766
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/circulationaha.113.002431
OpenAlex: W2130478228
Semantic Scholar: f1b691f3aadca2114cdb66b070096792c9ae6983
Cited by: 46
References: 18
Citations by year: 2026: 3 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 1 · 2020: 7 · 2019: 2 · 2018: 6 · 2017: 1 · 2015: 4 · 2014: 4 · 2013: 2
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Funders: Universitat de Barcelona
Centre Hospitalier Universitaire de Rennes
Instituto de Salud Carlos III
Topics: Health Sciences › Medicine › Epidemiology › Infective Endocarditis Diagnosis and Management
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Streptococcal Infections and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
Keywords: Enterococcus faecalis, infective endocarditis, enterococcal endocarditis, Enterococcus faecium, antibiotic therapy, mortality, cardiac surgery, elderly patients, comorbidities
MeSH terms: Anti-Bacterial Agents, Endocarditis, Bacterial, Female, Gentamicins, Humans, Male, Enterococcus faecalis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A New Era for Treating Enterococcus faecalis Endocarditis: Ampicillin Plus Short-Course Gentamicin or Ampicillin Plus Ceftriaxone: That Is the Question!

Abstract

Integrity signals

Claims the paper makes

Self-check

Cites

Cited by

Related

Record

About these checks