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Cited by 459

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Right Ventricular Function in Heart Failure With Preserved Ejection Fraction: A Community-Based Study

Open access
Mohammed, Selma F., Hussain, Imad, AbouEzzeddine, Omar F., Takahama, Hiroyuki, Kwon, Susan H., Forfia, Paul, Roger, Véronique L., Redfield, Margaret M.·2014·Circulation
DOI 10.1161/circulationaha.113.008461
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Abstract

Background—: The prevalence and clinical significance of right ventricular (RV) systolic dysfunction (RVD) in patients with heart failure and preserved ejection fraction (HFpEF) are not well characterized. Methods and Results—: Consecutive, prospectively identified HFpEF (Framingham HF criteria, ejection fraction ≥50%) patients (n=562) from Olmsted County, Minnesota, underwent echocardiography at HF diagnosis and follow-up for cause-specific mortality and HF hospitalization. RV function was categorized by tertiles of tricuspid annular plane systolic excursion and by semiquantitative (normal, mild RVD, or moderate to severe RVD) 2-dimensional assessment. Whether RVD was defined by semiquantitative assessment or tricuspid annular plane systolic excursion ≤15 mm, HFpEF patients with RVD were more likely to have atrial fibrillation, pacemakers, and chronic diuretic therapy. At echocardiography, patients with RVD had slightly lower left ventricular ejection fraction, worse diastolic dysfunction, lower blood pressure and cardiac output, higher pulmonary artery systolic pressure, and more severe RV enlargement and tricuspid valve regurgitation. After adjustment for age, sex, pulmonary artery systolic pressure, and comorbidities, the presence of any RVD by semiquantitative assessment was associated with higher all-cause (hazard ratio=1.35; 95% confidence interval, 1.03–1.77; P =0.03) and cardiovascular (hazard ratio=1.85; 95% confidence interval, 1.20–2.80; P =0.006) mortality and higher first (hazard ratio=1.99; 95% confidence interval, 1.35–2.90; P =0.0006) and multiple (hazard ratio=1.81; 95% confidence interval, 1.18–2.78; P =0.007) HF hospitalization rates. RVD defined by tricuspid annular plane systolic excursion values showed similar but weaker associations with mortality and HF hospitalizations. Conclusions—: In the community, RVD is common in HFpEF patients, is associated with clinical and echocardiographic evidence of more advanced HF, and is predictive of poorer outcomes.

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Metadata

Authors
Mohammed, S. F., Hussain, I., AbouEzzeddine, O. F., Takahama, H., Kwon, S. H., Forfia, P., Roger, V. L., & Redfield, M. M.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2014-12
Volume
130
Issue
25
Pages
2310-2320
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/circulationaha.113.008461
OpenAlex
W2620860085
Cited by
459
References
35
FWCI
25.90
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Right Ventricular Function in Heart Failure With Preserved Ejection Fraction: A Community-Based Study. https://app.cochat.ai/papers/10.1161/circulationaha.113.008461
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Mohammed, S. F., Hussain, I., AbouEzzeddine, O. F., Takahama, H., Kwon, S. H., Forfia, P., Roger, V. L., & Redfield, M. M. (2014). Right Ventricular Function in Heart Failure With Preserved Ejection Fraction: A Community-Based Study. Circulation. https://doi.org/10.1161/circulationaha.113.008461

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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