The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Air Versus Oxygen in ST-Segment–Elevation Myocardial Infarction
Open accessAbstract
Background—: Oxygen is commonly administered to patients with ST-elevation–myocardial infarction despite previous studies suggesting a possible increase in myocardial injury as a result of coronary vasoconstriction and heightened oxidative stress. Methods and Results—: We conducted a multicenter, prospective, randomized, controlled trial comparing oxygen (8 L/min) with no supplemental oxygen in patients with ST-elevation–myocardial infarction diagnosed on paramedic 12-lead ECG. Of 638 patients randomized, 441 patients had confirmed ST-elevation–myocardial infarction and underwent primary end-point analysis. The primary end point was myocardial infarct size as assessed by cardiac enzymes, troponin I, and creatine kinase. Secondary end points included recurrent myocardial infarction, cardiac arrhythmia, and myocardial infarct size assessed by cardiac magnetic resonance imaging at 6 months. Mean peak troponin was similar in the oxygen and no oxygen groups (57.4 versus 48.0 μg/L; ratio, 1.20; 95% confidence interval, 0.92–1.56; P =0.18). There was a significant increase in mean peak creatine kinase in the oxygen group compared with the no oxygen group (1948 versus 1543 U/L; means ratio, 1.27; 95% confidence interval, 1.04–1.52; P =0.01). There was an increase in the rate of recurrent myocardial infarction in the oxygen group compared with the no oxygen group (5.5% versus 0.9%; P =0.006) and an increase in frequency of cardiac arrhythmia (40.4% versus 31.4%; P =0.05). At 6 months, the oxygen group had an increase in myocardial infarct size on cardiac magnetic resonance (n=139; 20.3 versus 13.1 g; P =0.04). Conclusion—: Supplemental oxygen therapy in patients with ST-elevation–myocardial infarction but without hypoxia may increase early myocardial injury and was associated with larger myocardial infarct size assessed at 6 months. Clinical Trial Registration—: URL: http://www.clinicaltrials.gov . Unique identifier: NCT01272713.
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Cites
Multiple imputation using chained equations: Issues and guidance for practice
White, I. R., Royston, P., & Wood, A. M. (2011) · Statistics in Medicine · doi:10.1002/sim.4067 · Cited by 9,792
WRITING COMMITTEE MEMBERS*, O’Gara, P. T., Kushner, F. G., Ascheim, D. D., Casey, D. E., Chung, M. K., de Lemos, J. A., Ettinger, S. M., Fang, J. C., Fesmire, F. M., et al. (2013) · Circulation · doi:10.1161/cir.0b013e3182742cf6 · Cited by 4,725
Multiple imputation in health‐are databases: An overview and some applications
Rubin, D. B., & Schenker, N. (1991) · Statistics in Medicine · doi:10.1002/sim.4780100410 · Cited by 1,550
Bøtker, H. E., Kharbanda, R., Schmidt, M. R., Bøttcher, M., Kaltoft, A. K., Terkelsen, C. J., Munk, K., Andersen, N. H., Hansen, T. M., Trautner, S., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(09)62001-8 · Cited by 989
BTS guideline for emergency oxygen use in adult patients
O'Driscoll, B. R., Howard, L. S., Davison, A. G., & on behalf of the British Thoracic Society (2008) · Thorax · doi:10.1136/thx.2008.102947 · Cited by 729
Prehospital Ticagrelor in ST-Segment Elevation Myocardial Infarction
Montalescot, G., van 't Hof, A. W., Lapostolle, F., Silvain, J., Lassen, J. F., Bolognese, L., Cantor, W. J., Cequier, Á., Chettibi, M., Goodman, S. G., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1407024 · Cited by 661
Shahzad, A., Kemp, I., Mars, C., Wilson, K., Roome, C., Cooper, R., Andron, M., Appleby, C., Fisher, M., Khand, A., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60924-7 · Cited by 543
Systematic review of studies of the effect of hyperoxia on coronary blood flow
Farquhar, H., Weatherall, M., Wijesinghe, M., Perrin, K., Ranchord, A., Simmonds, M., & Beasley, R. (2009) · American Heart Journal · doi:10.1016/j.ahj.2009.05.037 · Cited by 257
Controlled trial of oxygen in uncomplicated myocardial infarction.
Rawles, J. M., & Kenmure, A. C. (1976) · BMJ · doi:10.1136/bmj.1.6018.1121 · Cited by 242
Chia, S., Senatore, F., Raffel, O., Lee, H., Wackers, F. J. T., & Jang, I. (2008) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2008.04.010 · Cited by 228
Cited by
Ibanez, B., James, S., Agewall, S., Antunes, M. J., Bucciarelli-Ducci, C., Bueno, H., Caforio, A. L. P., Crea, F., Goudevenos, J. A., Halvorsen, S., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehx393 · Cited by 9,728
Roffi, M., Patrono, C., Collet, J.-P., Mueller, C., Valgimigli, M., Andreotti, F., Bax, J. J., Borger, M. A., Brotons, C., Chew, D. P., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv320 · Cited by 8,261
2023 ESC Guidelines for the management of acute coronary syndromes
Byrne, R. A., Rossello, X., Coughlan, J. J., Barbato, E., Berry, C., Chieffo, A., Claeys, M. J., Dan, G.-A., Dweck, M. R., Galbraith, M., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad191 · Cited by 5,333
Nolan, J. P., Soar, J., Cariou, A., Cronberg, T., Moulaert, V. R. M., Deakin, C. D., Bottiger, B. W., Friberg, H., Sunde, K., & Sandroni, C. (2015) · Resuscitation · doi:10.1016/j.resuscitation.2015.07.018 · Cited by 1,116
Field, J. M., Hazinski, M. F., Sayre, M. R., Chameides, L., Schexnayder, S. M., Hemphill, R., Samson, R. A., Kattwinkel, J., Berg, R. A., Bhanji, F., et al. (2010) · Circulation · doi:10.1161/circulationaha.110.970889 · Cited by 1,050
Metadata
- Authors
- Stub, D., Smith, K., Bernard, S., Nehme, Z., Stephenson, M., Bray, J. E., Cameron, P., Barger, B., Ellims, A. H., Taylor, A. J., Meredith, I. T., & Kaye, D. M.
- Venue
- Circulation
- Published
- 2015-06-16
- Volume
- 131
- Issue
- 24
- Pages
- 2143-2150
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2110625603
- Cited by
- 537
- References
- 25
- FWCI
- 53.54
- Type
- journal article
- Language
- en
- Open access
- green
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- Stub, D., Smith, K., Bernard, S., Nehme, Z., Stephenson, M., Bray, J. E., Cameron, P., Barger, B., Ellims, A. H., Taylor, A. J., Meredith, I. T., & Kaye, D. M. (2015). Air Versus Oxygen in ST-Segment–Elevation Myocardial Infarction. Circulation. https://doi.org/10.1161/circulationaha.114.014494
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