SIRT3-AMP-activated protein kinase activation by nitrite and metformin improves hyperglycemia and normalizes pulmonary hypertension associated with heart failure with preserved ejection fraction
Lai, Yen-Chun, Tabima, Diana M., Dube, John J., Hughan, Kara S., Vanderpool, Rebecca R., Goncharov, Dmitry A., St. Croix, Claudette M., Garcia-Ocaña, Adolfo +4 more·2016·Circulation
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- Heme Protein Metabolism of NO and NitriteDaniel B. Kim‐Shapiro, Mark T. Gladwin · 2017 · Elsevier eBooks
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- Pulmonary Hypertension Associated With Left Heart DiseaseMuhammad Shahzeb Khan, Barry A. Borlaug, Javed Butler, Mardi Gomberg‐Maitland, Marc J.C. Humbert, Carolyn S.P. Lam, Yogesh Reddy, Gregg W. Stone, Faiez M. Zannad, R. Tedford · 2026 · Journal of the American College of Cardiology
- Omics and Extreme Phenotyping Reveal Longitudinal Association Between Left Atrial Size and Pulmonary Vascular Resistance in Group 2 Pulmonary HypertensionNeil J. Kelly, David Newhouse, Himal Chapagain, Ashish B. Patel, Yicheng Tang, Ato Howard, Anna Kirillova, Hee‐Jung J. Kim, Haris Rahman, Wadih El Khoury et al. · 2023 · Journal of the American Heart Association
- Honokiol and Nicotinamide Adenine Dinucleotide Improve Exercise Endurance in Pulmonary Hypertensive Rats Through Increasing SIRT3 Function in Skeletal MuscleMin Li, B.A. McKeon, Sue Gu, Ram Raj Prasad, Hui Zhang, Sushil Kumar, Suzette R. Riddle, David C. Irwin, Kurt R. Stenmark · 2024 · International Journal of Molecular Sciences
- Long‐Term Dipeptidyl Peptidase 4 Inhibition Worsens Hypertension and Renal and Cardiac Abnormalities in Obese Spontaneously Hypertensive Heart Failure RatsEdwin Kerry Jackson, Zaichuan Mi, Delbert G. Gillespie, Dongmei Cheng, Stevan P. Tofovic · 2021 · Journal of the American Heart Association
- Recent advancements in pulmonary arterial hypertension and right heart failure research: overview of selected abstracts from ATS2020 and emerging COVID‐19 researchATS Pulmonary Circulation Early Career Working Group, François Potus, Andrea L. Frump, Soban Umar, Rebecca R. Vanderpool, Imad Al Ghouleh, Yen‐Chun Lai · 2021 · Pulmonary Circulation
- Dynamic evolution and mechanism of myocardial glucose metabolism in different functional phenotypes of diabetic cardiomyopathy — a study based on 18 F-FDG microPET myocardial metabolic imagingXiaoliang Shao, Yaqi Liu, Mingge Zhou, Min Xu, Yuqi Chen, Hongbo Huang, Jianguo Lin, Yuetao Wang · 2023 · Diabetology & Metabolic Syndrome
- Pneumonectomy combined with SU5416 or monocrotaline pyrrole does not cause severe pulmonary hypertension in miceXiao‐Qing Sun, Timothy M. Klouda, Suzanne Barnasconi, Ingrid Schalij, Janne Schwab, Anders Hammer Nielsen-Kudsk, Julie Birkmose Axelsen, Asger Andersen, Jurjan Aman, Frances S. de Man et al. · 2024 · American Journal of Physiology-Lung Cellular and Molecular Physiology
- Apparent Correlations Between AMPK Expression and Brain Inflammatory Response and Neurological Function Factors in Rats with Chronic Renal FailureLi Yang, Nirong Gong, Qin Zhang, Yabin Ma, Hui Zhou · 2019 · Journal of Molecular Neuroscience
- Future perspective in diabetic patients with pre- and post-capillary pulmonary hypertensionFederico Luongo, Cristiano Miotti, Gianmarco Scoccia, Silvia Papa, Giovanna Manzi, Nadia Cedrone, Federica Toto, Claudia Malerba, Gennaro Papa, Annalisa Caputo et al. · 2022 · Heart Failure Reviews
- Chronic nitrite treatment activates adenosine monophosphate-activated protein kinase-endothelial nitric oxide synthase pathway in human aortic endothelial cellsYang Liu, Kevin D. Croft, Jonathan M. Hodgson, Trevor Anthony Mori, Natalie C. Ward · 2021 · Journal of Functional Foods
- Can Nitrite AMP k Up Sirt -ainty to Treat Heart Failure With Preserved Ejection Fraction?Steven Hsu, David A. Kass · 2016 · Circulation
- Targeting SIRT3 to Ameliorate Diabetic Cardiomyopathy: Progress in Mechanistic Research and Prospects for Clinical TranslationYu-Ting Lin, Kun Yu, J.J. Guo · 2025 · Journal of Diabetes
- Impact of metformin on hypertension; current knowledgeSina Bakhshaei, Bina Bakhshaei, Setayesh Sotoudehnia Korani, Emad Alamouti-fard, Leila Allamiaghmiouni, Sina Neshat · 2022 · Journal of Renal Endocrinology
- xCT/Slc7a11 promotes pulmonary arterial hypertension by disrupting AMPKα suppression of mTOR activationYan Meng, Cuiting Zheng, Xiyu Zhang, Zhenqiang Gao, Hongyu Chen, Kai Li, Kai Li, Fangming Liu, Weiwei Deng, Yuting Wu et al. · 2025 · Biochemical Pharmacology
- Letter by Carlström and Lundberg Regarding Article, “SIRT3-AMP–Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction”Mattias Carlström, Jon O. Lundberg · 2016 · Circulation
- Response by Lai and Gladwin to Letter Regarding Article, “SIRT3-AMP–Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction”Yen‐Chun Lai, Mark T. Gladwin · 2016 · Circulation
- Do BRD(4)S of a Feather Flock Together?Partha Dutta, Delphine A Gomez, Mark T. Gladwin · 2017 · Arteriosclerosis Thrombosis and Vascular Biology
- A preclinical model for phenogroup 3 HFpEFKeyvan Yousefi, Julian C. Dunkley, Lina A. Shehadeh · 2019 · Aging
- New Way to Study Pulmonary Hypertension in HFpEFZhiyu Dai, Edward Benjamin Thorp · 2023 · Circulation Research
- Impact of diabetes mellitus on mortality in pulmonary hypertension: A systematic review and meta-analysisSmitesh Padte, Priyal Dilip Mehta, Vikas Bansal, Niti Singh, Rayyan Rafik Sunasra, Vidhi Goyal, Raunaq B Chaudhary, Yash Junnarkar, Vidhi Shah, Zara Arshad et al. · 2024 · World Journal of Critical Care Medicine
- Sexual dimorphism in animal models of heart failure with preserved ejection fractionMaria Bauer, Mahin Gadkari, Marta Martinez Yus, Lakshmi Santhanam, Jochen Steppan · 2025 · Journal of Applied Physiology
- Prophylactic administration of Kanli granule maintains fatty acid oxidation in the myocardium to prevent heart failure via activating AMPK/PPARα/CPT1A pathway: A network pharmacology-based studyZhejun Zhao, Yuanlong Sun, Meijun Jia, Meixian Jiang, Xiaofen Ruan · 2025 · Fitoterapia
- Cytochrome P450 1A1 influences obesity‐induced pulmonary hypertensionJoshua P. Dignam, Smriti Sharma, Gregor Aitchison, Ayman Gebril, Ioannis A. Stasinopoulos, Sofia Laforest, Chelbi Coyle, Ruth Andrew, Natalie Z M Homer, Sébastien Bonnet et al. · 2025 · British Journal of Pharmacology
- Therapeutic Potential of Metformin in Diabetes Mellitus-Related Cardiovascular ComplicationsHongmei Tan, Jun Tao · 2023 · IntechOpen eBooks
- Effects of Short-Term Sodium Nitrate versus Sodium Chloride Supplementation on Energy and Lipid Metabolism during High-Intensity Intermittent Exercise in AthletesLarissa Sarah Blau, Jan Gerber, Armin Finkel, Moritz Lützow, Norbert Maassen, Magdalena Aleksandra Röhrich, Erik Hanff, Dimitrios Tsikas, Vladimir Shushakov, Mirja Jantz · 2023 · Applied Sciences
- Identifying high risk clinical phenogroups of pulmonary hypertension through a clustering analysisPaula K. Rambarat, Emily K. Zern, Dongyu Wang, Athar Roshandelpoor, Shahrooz Zarbafian, Elizabeth E. Liu, Jessica K. Wang, Jenna N. McNeill, Carl T. Andrews, Eugene V. Pomerantsev et al. · 2023 · PLoS ONE
- von Willebrand disease: a laboratory approach.Sucheta Trasi, Kanjaksha Ghosh, Shrimati Shetty, Dipika Mohanty · 2005 · PubMed
- Sirtuin-3 Regulates the Mechanism of Doxorubicin-induced CardiotoxicityCheng Zhang, Dan Shi, Ping Chang Yang · 2025 · International Heart Journal
- FABP4 Inhibitor Improves Right Ventricular Fibrosis in Metabolic Syndrome‐ Related Pulmonary Hypertension due to Left Heart Disease in MiceHaihua Qiu, Wenjie Chen, Jingyuan Chen, Jun Luo, Yusi Chen, Yingjie Tan, Tianyu Wang, Jiang Li · 2025 · The FASEB Journal
- Cationic microbubble loading hSIRT3 and hTIMP3 optimize cardiac-targeted delivery and myocardial protection in the porcine MI/R modelPeian Cai, Kegong Chen, Xionghai Qin, Xingpei Jiang, Xuan Jiao, Kexun Liu, Erliang Guo, Zipeng Li, Xianxin Qiu, Chang Liu et al. · 2025 · Materials Today Bio
- Association Between Metformin and Other Diabetic Medications and Five-year Onset of New Neovascular Age-related Macular Degeneration DiagnosisChristopher M. Maatouk, Max J. Hyman, Arjav Shah, Sean R. Smith, Madeleine Y. Yehia, John T. Moir, Reem Gonnah, Andrea Flores, Seenu M. Hariprasad, Dimitra Skondra · 2026 · Ophthalmic surgery, lasers & imaging retina
- Prevalence and risk factors of pulmonary hypertension in maintenance hemodialysis patients based on echocardiographyJingwen Zhou · 2026 · Medicine
- The association between dietary intakes of nitrate and nitrite and odds of metabolic syndrome and its component in adultsAtieh Mirzababaei, Maryam Mahmoodi, Abbasali Keshtkar, Haleh Ashraf, Fereshteh Pashayee-Khamene, Pardis Khalili, Khadijeh Mirzaei · 2026 · Scientific Reports
- Benefits of Dietary Nitrate in Cognitive Decline Associated With Type 2 Diabetes: Pathways and Therapeutic PotentialJoão S. Gonçalves, Ana Marcal, João A.N. Laranjinha, Cátia F. Lourenço · 2026 · European Journal of Clinical Investigation
- Prevention of Metabolic Impairment by Dietary Nitrate in Overweight Male Mice Improves Stroke OutcomeEllen Vercalsteren, Dimitra Karampatsi, Carolina Buizza, Gesine Paul, Jon O. Lundberg, Thomas Nyström, Vladimer Darsalia, Cesare Patrone · 2025 · Nutrients
- Metformin and its Potential for Heart Failure with Preserved Ejection FractionMohapradeep Mohan, Zaid Iskandar, Ify R. Mordi, Casserene Yeow, Alex Neaogoie, Graham Rena, Chew, Samuel, Chim Choy Lang · 2019 · Discovery Research Portal (University of Dundee)
- Inorganic nitrite alters mitochondrial dynamics without overt changes in cell death and mitochondrial respiration in cardiomyoblasts under hyperglycemiaAnand Chellappan Reghuvaran, Bharathan Bhavya, K. Jayakumar, Harikrishnan Vijayakumar Sreelatha, Srinivas Gopala · 2020 · Toxicology in Vitro
- Moment on the Lips, a Lifetime on the Lungs?Evan L. Brittain, Anna Ryan Hemnes · 2019 · Circulation Research
- Type 2 diabetes and exercise unexplained dyspnoea: a new focus under the lens with a long way to go yetMarco Guazzi, Ross A Arena · 2022 · European Journal of Preventive Cardiology
- Combination of Metformin and Inorganic Nitrate: Effects on Metabolic Disease and Lactic AcidosisArghavan Jahandideh · 2017 · UTUPub (University of Turku)
- ReplyMaría Valero‐Muñoz, Flora Sam · 2018 · JACC Basic to Translational Science
- AMP Kinase Activation Attenuates Cardiac Remodeling in Pulmonary Hypertension due to Heart Failure with Preserved Ejection Fraction; Lung Epithelial Progenitor Cells in Alveolar Regeneration; and Drug Discovery and Novel Therapies for Lung CancerAndrea R. Levine, William Bain, Joseph S. Bednash, Mark T. Gladwin, Bryan J. McVerry · 2018 · American Journal of Respiratory Cell and Molecular Biology
- The Effects of Metformin on Obesity-Induced Diabetic RetinasJeesu Kim · 2017 · OakTrust (Texas A&M University Libraries)
- Cardiovascular effects of metformin on left ventricular hypertrophy in nondiabetic patients with coronary artery diseaseMohapradeep Mohan · 2019 · Discovery Research Portal (University of Dundee)
- Letter by Komamura Regarding Article, “Treatment With Treprostinil and Metformin Normalizes Hyperglycemia and Improves Cardiac Function in Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction”Kazuo Komamura · 2020 · Arteriosclerosis Thrombosis and Vascular Biology
- Comprensión actual de los biomarcadores circulantes en la hipertensión pulmonar debida a enfermedad de ventrículo izquierdoNoah Todd, Yen‐Chun Lai · 2021 · Kompass Neumología
- Right Ventricular PathobiologyVineet Agrawal, Evan L. Brittain, Anna Ryan Hemnes · 2021 · Springer eBooks
- AMPK deficiency in smooth muscles causes persistent pulmonary hypertension after birth and premature deathJavier Moral‐Sanz, Sophronia A. Lewis, Sandy MacMillan, Marco Meloni, Heather McClafferty, Benoı̂t Viollet, Marc Foretz, Jorge Del‐Pozo, A. Mark Evans · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- AMPK Activation Protects Against Pulmonary Hypertension in Rats and Relaxes Isolated Human Pulmonary ArteryHeba Abdelazeem, Ly Tu, Raphaël Thuillet, Mina Ottaviani, Achraf Boulfrad, Amira M. Senbel, Salma Mani, Yves Castier, Alice Guyard, Alexy Tran‐Dinh et al. · 2022 · SSRN Electronic Journal
- Nitrate, Nitrite and Type 2 DiabetesZahra Bahadoran, Parvin Mirmiran, Khosrow Kashfi, Asghar Ghasemi · 2022 · BENTHAM SCIENCE PUBLISHERS eBooks
- Myeloid Cell Derived IL1β Contributes to Pulmonary Vascular Remodeling in Heart Failure with Preserved Ejection FractionVineet Agrawal, Jonathan A. Kropski, Jason J. Gokey, Elizabeth Kobeck, Matthew Murphy, Katherine T. Murray, Niki L. Fortune, Christy S. Moore, David F. Meoli, Ken Monahan et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Evaluating the impact of metformin targets on the risk of heart failure: a Mendelian randomization studyPan He, Ziqiang Guo, Yanyan Han, Anping Deng, Haiwei Chen, Junjie Yang, Qi Wang · 2023 · Research Square
- Simple model of pulmonary hypertension secondary to left heart pressure overload induced by partial intravascular occlusion of the ascending aortaMilan Chovanec, Jana Ďurišová, Olga Vajnerová, Alena Baňasová, M Vízek, Marie Žaloudíková, Jir̆ı́ Uhlı́k, Kryštof Krása, Jan Herget, Václav Hampl · 2024 · American Journal of Physiology-Lung Cellular and Molecular Physiology
- Endothelial MICU1 protects against vascular inflammation and atherosclerosis by inhibiting mitochondrial calcium uptakeLu Sun, Rui‐Xue Leng, Qingze He, Meiming Su, Zhidan Zhang, Zhenghong Liu, Zhihua Wang, Hui Jiang, Monan Liu, Li Wang et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- TAZ and RUNX2 awareness in pulmonary hypertension due to left heart diseaseVinicio de Jesús Pérez, Yen‐Chun Lai · 2024 · European Respiratory Journal
- Obesity’s Impact on Pulmonary Hypertension Progression: A Cohort Study of Body Composition Metrics in UAE PopulationHassa Iftikhar · 2024 · medRxiv
- Knockdown of THBS3 inhibits mitochondrial dysfunction through the PI3K/AKT/eNOS signaling pathway and improves doxorubicin-induced cardiac injury in elderly miceYao Chen, Wentao Cao · 2025 · Molecular & Cellular Toxicology
- Additional file 1 of SS-31 alleviated nociceptive responses and restored mitochondrial function in a headache mouse model via Sirt3/Pgc-1α positive feedback loopZhengming Shan, Wang, Yajuan, Qiu, Tao, Yanjie Zhou, Zhang, Yu, Luyu Hu, Zhang, Lili, Liang, Jingjing, Man Ding, Fan, Shanghua et al. · 2024 · Figshare
- Additional file 1 of Dynamic evolution and mechanism of myocardial glucose metabolism in different functional phenotypes of diabetic cardiomyopathy — a study based on 18 F-FDG microPET myocardial metabolic imagingShao, Xiaoliang, Liu, Yaqi, Zhou, Mingge, Xu, Min, Chen, Yuqi, Huang, Hongbo, Lin, Jianguo, Wang, Yuetao · 2024 · Figshare
- Decreased AMP-kinase function in pulmonary artery smooth muscle cells contributes to pulmonary artery remodeling in persistent pulmonary hypertension of the newbornEmily A. Mooers, Ujala Rana, Chintamani N Joshi, Adeleye James Afolayan, Ru‐Jeng Teng, Girija Ganesh Konduri · 2026 · American Journal of Physiology-Lung Cellular and Molecular Physiology
- Metformin attenuates HSV-1-induced neuropathic pain by restoring Sirt3-mediated mitophagyYuanyuan Fang, Mengqiu Deng, Kesheng Huang, Honghao Song, Yan Chu, Huawei Wei, Dashuang Chen, Yutong Yang, Chaofeng Han, Hongbin Yuan · 2026 · Cell Communication and Signaling
- Iron deficiency drives pathological cardiac remodeling and diastolic dysfunction associated with inhibition of AMPK-mTORC1 signalingDehui Li, Haichu Wen, Bokang Qiao, Yuan Wang, Lei Wang, Lixin Jia, Jie Du · 2026 · Cardiovascular Pathology
- AMP-activated protein kinase independent mechanisms of pulmonary artery banding-induced right ventricular failureElizabeth A Straight, Sharanya Satyanarayana Bettadapura, Zackery S. Fullerton, Sydney M. Polson, Danielle R. Bruns · 2026 · Translational Medicine of Aging
- Association of Antidiabetic Medication Classes With Survival Outcomes in Pulmonary Hypertension Patients With DiabetesAaron W. Trammell, Divya Verma, ALYSSA CRUSE, Xiangqin Cui, Matthew Ryan Smith, C. Michael Hart · 2026 · Pulmonary Circulation
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