SIRT3-AMP-activated protein kinase activation by nitrite and metformin improves hyperglycemia and normalizes pulmonary hypertension associated with heart failure with preserved ejection fraction

Lai, Yen-Chun, Tabima, Diana M., Dube, John J., Hughan, Kara S., Vanderpool, Rebecca R., Goncharov, Dmitry A., St. Croix, Claudette M., Garcia-Ocaña, Adolfo +4 more·2016·Circulation

Cited by (270)

Items 201–270 of 270

  1. Heme Protein Metabolism of NO and Nitrite
    Daniel B. Kim‐Shapiro, Mark T. Gladwin · 2017 · Elsevier eBooks
  2. ICS II protects against cardiac hypertrophy by regulating metabolic remodelling, not by inhibiting autophagy
    Dongjian Han, Bo Wang, Xinyue Cui, Weiwei He, Yi zhang, Qingjiao Jiang, Fuhang Wang, Zhiyu Liu, Deliang Shen · 2020 · Journal of Cellular and Molecular Medicine
  3. Atrial Strain Outperforms Ventricular Strain for Detecting Hypertensive HFpEF Using CMR Feature Tracking
    Zhen Wang, Y L Li, Yong Cheng, Peiyang Zheng, Xiaohe Wu, D P Li, Ao Liang, Yongqiang Yu, Ren Zhao, X. Li · 2026 · Hypertension
  4. Pulmonary Hypertension Associated With Left Heart Disease
    Muhammad Shahzeb Khan, Barry A. Borlaug, Javed Butler, Mardi Gomberg‐Maitland, Marc J.C. Humbert, Carolyn S.P. Lam, Yogesh Reddy, Gregg W. Stone, Faiez M. Zannad, R. Tedford · 2026 · Journal of the American College of Cardiology
  5. Omics and Extreme Phenotyping Reveal Longitudinal Association Between Left Atrial Size and Pulmonary Vascular Resistance in Group 2 Pulmonary Hypertension
    Neil J. Kelly, David Newhouse, Himal Chapagain, Ashish B. Patel, Yicheng Tang, Ato Howard, Anna Kirillova, Hee‐Jung J. Kim, Haris Rahman, Wadih El Khoury et al. · 2023 · Journal of the American Heart Association
  6. Honokiol and Nicotinamide Adenine Dinucleotide Improve Exercise Endurance in Pulmonary Hypertensive Rats Through Increasing SIRT3 Function in Skeletal Muscle
    Min Li, B.A. McKeon, Sue Gu, Ram Raj Prasad, Hui Zhang, Sushil Kumar, Suzette R. Riddle, David C. Irwin, Kurt R. Stenmark · 2024 · International Journal of Molecular Sciences
  7. Long‐Term Dipeptidyl Peptidase 4 Inhibition Worsens Hypertension and Renal and Cardiac Abnormalities in Obese Spontaneously Hypertensive Heart Failure Rats
    Edwin Kerry Jackson, Zaichuan Mi, Delbert G. Gillespie, Dongmei Cheng, Stevan P. Tofovic · 2021 · Journal of the American Heart Association
  8. Recent advancements in pulmonary arterial hypertension and right heart failure research: overview of selected abstracts from ATS2020 and emerging COVID‐19 research
    ATS Pulmonary Circulation Early Career Working Group, François Potus, Andrea L. Frump, Soban Umar, Rebecca R. Vanderpool, Imad Al Ghouleh, Yen‐Chun Lai · 2021 · Pulmonary Circulation
  9. Dynamic evolution and mechanism of myocardial glucose metabolism in different functional phenotypes of diabetic cardiomyopathy — a study based on 18 F-FDG microPET myocardial metabolic imaging
    Xiaoliang Shao, Yaqi Liu, Mingge Zhou, Min Xu, Yuqi Chen, Hongbo Huang, Jianguo Lin, Yuetao Wang · 2023 · Diabetology & Metabolic Syndrome
  10. Pneumonectomy combined with SU5416 or monocrotaline pyrrole does not cause severe pulmonary hypertension in mice
    Xiao‐Qing Sun, Timothy M. Klouda, Suzanne Barnasconi, Ingrid Schalij, Janne Schwab, Anders Hammer Nielsen-Kudsk, Julie Birkmose Axelsen, Asger Andersen, Jurjan Aman, Frances S. de Man et al. · 2024 · American Journal of Physiology-Lung Cellular and Molecular Physiology
  11. Apparent Correlations Between AMPK Expression and Brain Inflammatory Response and Neurological Function Factors in Rats with Chronic Renal Failure
    Li Yang, Nirong Gong, Qin Zhang, Yabin Ma, Hui Zhou · 2019 · Journal of Molecular Neuroscience
  12. Future perspective in diabetic patients with pre- and post-capillary pulmonary hypertension
    Federico Luongo, Cristiano Miotti, Gianmarco Scoccia, Silvia Papa, Giovanna Manzi, Nadia Cedrone, Federica Toto, Claudia Malerba, Gennaro Papa, Annalisa Caputo et al. · 2022 · Heart Failure Reviews
  13. Chronic nitrite treatment activates adenosine monophosphate-activated protein kinase-endothelial nitric oxide synthase pathway in human aortic endothelial cells
    Yang Liu, Kevin D. Croft, Jonathan M. Hodgson, Trevor Anthony Mori, Natalie C. Ward · 2021 · Journal of Functional Foods
  14. Can Nitrite AMP k Up Sirt -ainty to Treat Heart Failure With Preserved Ejection Fraction?
    Steven Hsu, David A. Kass · 2016 · Circulation
  15. Targeting SIRT3 to Ameliorate Diabetic Cardiomyopathy: Progress in Mechanistic Research and Prospects for Clinical Translation
    Yu-Ting Lin, Kun Yu, J.J. Guo · 2025 · Journal of Diabetes
  16. Impact of metformin on hypertension; current knowledge
    Sina Bakhshaei, Bina Bakhshaei, Setayesh Sotoudehnia Korani, Emad Alamouti-fard, Leila Allamiaghmiouni, Sina Neshat · 2022 · Journal of Renal Endocrinology
  17. xCT/Slc7a11 promotes pulmonary arterial hypertension by disrupting AMPKα suppression of mTOR activation
    Yan Meng, Cuiting Zheng, Xiyu Zhang, Zhenqiang Gao, Hongyu Chen, Kai Li, Kai Li, Fangming Liu, Weiwei Deng, Yuting Wu et al. · 2025 · Biochemical Pharmacology
  18. Letter by Carlström and Lundberg Regarding Article, “SIRT3-AMP–Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction”
    Mattias Carlström, Jon O. Lundberg · 2016 · Circulation
  19. Response by Lai and Gladwin to Letter Regarding Article, “SIRT3-AMP–Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction”
    Yen‐Chun Lai, Mark T. Gladwin · 2016 · Circulation
  20. Do BRD(4)S of a Feather Flock Together?
    Partha Dutta, Delphine A Gomez, Mark T. Gladwin · 2017 · Arteriosclerosis Thrombosis and Vascular Biology
  21. A preclinical model for phenogroup 3 HFpEF
    Keyvan Yousefi, Julian C. Dunkley, Lina A. Shehadeh · 2019 · Aging
  22. New Way to Study Pulmonary Hypertension in HFpEF
    Zhiyu Dai, Edward Benjamin Thorp · 2023 · Circulation Research
  23. Impact of diabetes mellitus on mortality in pulmonary hypertension: A systematic review and meta-analysis
    Smitesh Padte, Priyal Dilip Mehta, Vikas Bansal, Niti Singh, Rayyan Rafik Sunasra, Vidhi Goyal, Raunaq B Chaudhary, Yash Junnarkar, Vidhi Shah, Zara Arshad et al. · 2024 · World Journal of Critical Care Medicine
  24. Sexual dimorphism in animal models of heart failure with preserved ejection fraction
    Maria Bauer, Mahin Gadkari, Marta Martinez Yus, Lakshmi Santhanam, Jochen Steppan · 2025 · Journal of Applied Physiology
  25. Prophylactic administration of Kanli granule maintains fatty acid oxidation in the myocardium to prevent heart failure via activating AMPK/PPARα/CPT1A pathway: A network pharmacology-based study
    Zhejun Zhao, Yuanlong Sun, Meijun Jia, Meixian Jiang, Xiaofen Ruan · 2025 · Fitoterapia
  26. Cytochrome P450 1A1 influences obesity‐induced pulmonary hypertension
    Joshua P. Dignam, Smriti Sharma, Gregor Aitchison, Ayman Gebril, Ioannis A. Stasinopoulos, Sofia Laforest, Chelbi Coyle, Ruth Andrew, Natalie Z M Homer, Sébastien Bonnet et al. · 2025 · British Journal of Pharmacology
  27. Therapeutic Potential of Metformin in Diabetes Mellitus-Related Cardiovascular Complications
    Hongmei Tan, Jun Tao · 2023 · IntechOpen eBooks
  28. Effects of Short-Term Sodium Nitrate versus Sodium Chloride Supplementation on Energy and Lipid Metabolism during High-Intensity Intermittent Exercise in Athletes
    Larissa Sarah Blau, Jan Gerber, Armin Finkel, Moritz Lützow, Norbert Maassen, Magdalena Aleksandra Röhrich, Erik Hanff, Dimitrios Tsikas, Vladimir Shushakov, Mirja Jantz · 2023 · Applied Sciences
  29. Identifying high risk clinical phenogroups of pulmonary hypertension through a clustering analysis
    Paula K. Rambarat, Emily K. Zern, Dongyu Wang, Athar Roshandelpoor, Shahrooz Zarbafian, Elizabeth E. Liu, Jessica K. Wang, Jenna N. McNeill, Carl T. Andrews, Eugene V. Pomerantsev et al. · 2023 · PLoS ONE
  30. von Willebrand disease: a laboratory approach.
    Sucheta Trasi, Kanjaksha Ghosh, Shrimati Shetty, Dipika Mohanty · 2005 · PubMed
  31. Sirtuin-3 Regulates the Mechanism of Doxorubicin-induced Cardiotoxicity
    Cheng Zhang, Dan Shi, Ping Chang Yang · 2025 · International Heart Journal
  32. FABP4 Inhibitor Improves Right Ventricular Fibrosis in Metabolic Syndrome‐ Related Pulmonary Hypertension due to Left Heart Disease in Mice
    Haihua Qiu, Wenjie Chen, Jingyuan Chen, Jun Luo, Yusi Chen, Yingjie Tan, Tianyu Wang, Jiang Li · 2025 · The FASEB Journal
  33. Cationic microbubble loading hSIRT3 and hTIMP3 optimize cardiac-targeted delivery and myocardial protection in the porcine MI/R model
    Peian Cai, Kegong Chen, Xionghai Qin, Xingpei Jiang, Xuan Jiao, Kexun Liu, Erliang Guo, Zipeng Li, Xianxin Qiu, Chang Liu et al. · 2025 · Materials Today Bio
  34. Association Between Metformin and Other Diabetic Medications and Five-year Onset of New Neovascular Age-related Macular Degeneration Diagnosis
    Christopher M. Maatouk, Max J. Hyman, Arjav Shah, Sean R. Smith, Madeleine Y. Yehia, John T. Moir, Reem Gonnah, Andrea Flores, Seenu M. Hariprasad, Dimitra Skondra · 2026 · Ophthalmic surgery, lasers & imaging retina
  35. Prevalence and risk factors of pulmonary hypertension in maintenance hemodialysis patients based on echocardiography
    Jingwen Zhou · 2026 · Medicine
  36. The association between dietary intakes of nitrate and nitrite and odds of metabolic syndrome and its component in adults
    Atieh Mirzababaei, Maryam Mahmoodi, Abbasali Keshtkar, Haleh Ashraf, Fereshteh Pashayee-Khamene, Pardis Khalili, Khadijeh Mirzaei · 2026 · Scientific Reports
  37. Benefits of Dietary Nitrate in Cognitive Decline Associated With Type 2 Diabetes: Pathways and Therapeutic Potential
    João S. Gonçalves, Ana Marcal, João A.N. Laranjinha, Cátia F. Lourenço · 2026 · European Journal of Clinical Investigation
  38. Prevention of Metabolic Impairment by Dietary Nitrate in Overweight Male Mice Improves Stroke Outcome
    Ellen Vercalsteren, Dimitra Karampatsi, Carolina Buizza, Gesine Paul, Jon O. Lundberg, Thomas Nyström, Vladimer Darsalia, Cesare Patrone · 2025 · Nutrients
  39. Metformin and its Potential for Heart Failure with Preserved Ejection Fraction
    Mohapradeep Mohan, Zaid Iskandar, Ify R. Mordi, Casserene Yeow, Alex Neaogoie, Graham Rena, Chew, Samuel, Chim Choy Lang · 2019 · Discovery Research Portal (University of Dundee)
  40. Inorganic nitrite alters mitochondrial dynamics without overt changes in cell death and mitochondrial respiration in cardiomyoblasts under hyperglycemia
    Anand Chellappan Reghuvaran, Bharathan Bhavya, K. Jayakumar, Harikrishnan Vijayakumar Sreelatha, Srinivas Gopala · 2020 · Toxicology in Vitro
  41. Moment on the Lips, a Lifetime on the Lungs?
    Evan L. Brittain, Anna Ryan Hemnes · 2019 · Circulation Research
  42. Type 2 diabetes and exercise unexplained dyspnoea: a new focus under the lens with a long way to go yet
    Marco Guazzi, Ross A Arena · 2022 · European Journal of Preventive Cardiology
  43. Combination of Metformin and Inorganic Nitrate: Effects on Metabolic Disease and Lactic Acidosis
    Arghavan Jahandideh · 2017 · UTUPub (University of Turku)
  44. Reply
    María Valero‐Muñoz, Flora Sam · 2018 · JACC Basic to Translational Science
  45. AMP Kinase Activation Attenuates Cardiac Remodeling in Pulmonary Hypertension due to Heart Failure with Preserved Ejection Fraction; Lung Epithelial Progenitor Cells in Alveolar Regeneration; and Drug Discovery and Novel Therapies for Lung Cancer
    Andrea R. Levine, William Bain, Joseph S. Bednash, Mark T. Gladwin, Bryan J. McVerry · 2018 · American Journal of Respiratory Cell and Molecular Biology
  46. The Effects of Metformin on Obesity-Induced Diabetic Retinas
    Jeesu Kim · 2017 · OakTrust (Texas A&M University Libraries)
  47. Cardiovascular effects of metformin on left ventricular hypertrophy in nondiabetic patients with coronary artery disease
    Mohapradeep Mohan · 2019 · Discovery Research Portal (University of Dundee)
  48. Letter by Komamura Regarding Article, “Treatment With Treprostinil and Metformin Normalizes Hyperglycemia and Improves Cardiac Function in Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction”
    Kazuo Komamura · 2020 · Arteriosclerosis Thrombosis and Vascular Biology
  49. Comprensión actual de los biomarcadores circulantes en la hipertensión pulmonar debida a enfermedad de ventrículo izquierdo
    Noah Todd, Yen‐Chun Lai · 2021 · Kompass Neumología
  50. Right Ventricular Pathobiology
    Vineet Agrawal, Evan L. Brittain, Anna Ryan Hemnes · 2021 · Springer eBooks
  51. AMPK deficiency in smooth muscles causes persistent pulmonary hypertension after birth and premature death
    Javier Moral‐Sanz, Sophronia A. Lewis, Sandy MacMillan, Marco Meloni, Heather McClafferty, Benoı̂t Viollet, Marc Foretz, Jorge Del‐Pozo, A. Mark Evans · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  52. AMPK Activation Protects Against Pulmonary Hypertension in Rats and Relaxes Isolated Human Pulmonary Artery
    Heba Abdelazeem, Ly Tu, Raphaël Thuillet, Mina Ottaviani, Achraf Boulfrad, Amira M. Senbel, Salma Mani, Yves Castier, Alice Guyard, Alexy Tran‐Dinh et al. · 2022 · SSRN Electronic Journal
  53. Nitrate, Nitrite and Type 2 Diabetes
    Zahra Bahadoran, Parvin Mirmiran, Khosrow Kashfi, Asghar Ghasemi · 2022 · BENTHAM SCIENCE PUBLISHERS eBooks
  54. Myeloid Cell Derived IL1β Contributes to Pulmonary Vascular Remodeling in Heart Failure with Preserved Ejection Fraction
    Vineet Agrawal, Jonathan A. Kropski, Jason J. Gokey, Elizabeth Kobeck, Matthew Murphy, Katherine T. Murray, Niki L. Fortune, Christy S. Moore, David F. Meoli, Ken Monahan et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  55. Evaluating the impact of metformin targets on the risk of heart failure: a Mendelian randomization study
    Pan He, Ziqiang Guo, Yanyan Han, Anping Deng, Haiwei Chen, Junjie Yang, Qi Wang · 2023 · Research Square
  56. Simple model of pulmonary hypertension secondary to left heart pressure overload induced by partial intravascular occlusion of the ascending aorta
    Milan Chovanec, Jana Ďurišová, Olga Vajnerová, Alena Baňasová, M Vízek, Marie Žaloudíková, Jir̆ı́ Uhlı́k, Kryštof Krása, Jan Herget, Václav Hampl · 2024 · American Journal of Physiology-Lung Cellular and Molecular Physiology
  57. Endothelial MICU1 protects against vascular inflammation and atherosclerosis by inhibiting mitochondrial calcium uptake
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  58. TAZ and RUNX2 awareness in pulmonary hypertension due to left heart disease
    Vinicio de Jesús Pérez, Yen‐Chun Lai · 2024 · European Respiratory Journal
  59. Obesity’s Impact on Pulmonary Hypertension Progression: A Cohort Study of Body Composition Metrics in UAE Population
    Hassa Iftikhar · 2024 · medRxiv
  60. Knockdown of THBS3 inhibits mitochondrial dysfunction through the PI3K/AKT/eNOS signaling pathway and improves doxorubicin-induced cardiac injury in elderly mice
    Yao Chen, Wentao Cao · 2025 · Molecular & Cellular Toxicology
  61. Additional file 1 of SS-31 alleviated nociceptive responses and restored mitochondrial function in a headache mouse model via Sirt3/Pgc-1α positive feedback loop
    Zhengming Shan, Wang, Yajuan, Qiu, Tao, Yanjie Zhou, Zhang, Yu, Luyu Hu, Zhang, Lili, Liang, Jingjing, Man Ding, Fan, Shanghua et al. · 2024 · Figshare
  62. Additional file 1 of Dynamic evolution and mechanism of myocardial glucose metabolism in different functional phenotypes of diabetic cardiomyopathy — a study based on 18 F-FDG microPET myocardial metabolic imaging
    Shao, Xiaoliang, Liu, Yaqi, Zhou, Mingge, Xu, Min, Chen, Yuqi, Huang, Hongbo, Lin, Jianguo, Wang, Yuetao · 2024 · Figshare
  63. Decreased AMP-kinase function in pulmonary artery smooth muscle cells contributes to pulmonary artery remodeling in persistent pulmonary hypertension of the newborn
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  65. Iron deficiency drives pathological cardiac remodeling and diastolic dysfunction associated with inhibition of AMPK-mTORC1 signaling
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  66. AMP-activated protein kinase independent mechanisms of pulmonary artery banding-induced right ventricular failure
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  68. Pitfalls of Therapies Targeting the Nitric Oxide Signaling Pathway in Heart Failure With Preserved Ejection Fraction
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