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SIRT3-AMP-activated protein kinase activation by nitrite and metformin improves hyperglycemia and normalizes pulmonary hypertension associated with heart failure with preserved ejection fraction
Open accessAbstract
BACKGROUND: Pulmonary hypertension associated with heart failure with preserved ejection fraction (PH-HFpEF) is an increasingly recognized clinical complication of metabolic syndrome. No adequate animal model of PH-HFpEF is available, and no effective therapies have been identified to date. A recent study suggested that dietary nitrate improves insulin resistance in endothelial nitric oxide synthase null mice, and multiple studies have reported that both nitrate and its active metabolite, nitrite, have therapeutic activity in preclinical models of pulmonary hypertension. METHODS AND RESULTS: To evaluate the efficacy and mechanism of nitrite in metabolic syndrome associated with PH-HFpEF, we developed a 2-hit PH-HFpEF model in rats with multiple features of metabolic syndrome attributable to double-leptin receptor defect (obese ZSF1) with the combined treatment of vascular endothelial growth factor receptor blocker SU5416. Chronic oral nitrite treatment improved hyperglycemia in obese ZSF1 rats by a process that requires skeletal muscle SIRT3-AMPK-GLUT4 signaling. The glucose-lowering effect of nitrite was abolished in SIRT3-deficient human skeletal muscle cells, and in SIRT3 knockout mice fed a high-fat diet, as well. Skeletal muscle biopsies from humans with metabolic syndrome after 12 weeks of oral sodium nitrite and nitrate treatment (IND#115926) displayed increased activation of SIRT3 and AMP-activated protein kinase. Finally, early treatments with nitrite and metformin at the time of SU5416 injection reduced pulmonary pressures and vascular remodeling in the PH-HFpEF model with robust activation of skeletal muscle SIRT3 and AMP-activated protein kinase. CONCLUSIONS: These studies validate a rodent model of metabolic syndrome and PH-HFpEF, suggesting a potential role of nitrite and metformin as a preventative treatment for this disease.
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“For example, obesity, hyperlipidemia, and systemic hypertension are common risk factors for Group I PAH as well as Group II (secondary to left-sided heart failure or PH-heart failure with preserved ejection fraction, HFpEF)[12,15,16], and are also a feature of HIV infection[17,18].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [15]
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“Delivered via intravenous, inhaled, or oral routes, nitrite reduces pulmonary and right heart pressures and prevents or reverses characteristic vascular remodeling and right ventricular hypertrophy (RVH) in several animal models of PAH[15,117,143,146–149].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [15]
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Citations
Cites
AMPK: a nutrient and energy sensor that maintains energy homeostasis
Hardie, D. G., Ross, F. A., & Hawley, S. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3311 · Cited by 4,602
Hawley, S. A., Pan, D. A., Mustard, K. J., Ross, L., Bain, J., Edelman, A. M., Frenguelli, B. G., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.009 · Cited by 1,589
Giaid, A., & Saleh, D. M. (1995) · New England Journal of Medicine · doi:10.1056/nejm199507273330403 · Cited by 1,366
Hawley, S. A., Davison, M., Woods, A., Davies, S. P., Beri, R. K., Carling, D., & Hardie, D. G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.44.27879 · Cited by 1,264
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
Lombard, D. B., Alt, F. W., Cheng, H.-L., Bunkenborg, J., Streeper, R. S., Mostoslavsky, R., Kim, J., Yancopoulos, G., Valenzuela, D., Murphy, A., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01636-07 · Cited by 1,216
Adiponectin and Metabolic Syndrome
Matsuzawa, Y., Funahashi, T., Kihara, S., & Shimomura, I. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000099786.99623.ef · Cited by 1,203
Webb, A. J., Patel, N., Loukogeorgakis, S., Okorie, M., Aboud, Z., Misra, S., Rashid, R., Miall, P., Deanfield, J., Benjamin, N., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.103523 · Cited by 1,078
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
Koo, S., Flechner, L., Qi, L., Zhang, X., Screaton, R. A., Jeffries, S., Hedrick, S. A., Xu, W., Boussouar, F., Brindle, P. K., et al. (2005) · Nature · doi:10.1038/nature03967 · Cited by 1,026
Taraseviciene‐Stewart, L., Kasahara, Y., Alger, L., Hirth, P., Mahon, G. M., Waltenberger, J. L., Voelkel, N. F., & Tuder, R. M. (2001) · The FASEB Journal · doi:10.1096/fj.00-0343com · Cited by 835
Hirschey, M. D., Shimazu, T., Jing, E., Grueter, C. A., Collins, A. M., Aouizerat, B., Stančáková, A., Goetzman, E., Lam, M. M., Schwer, B., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.07.019 · Cited by 787
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- 10.1267/THRO04080413 · DOI
- Pflieger A, Potus F, Malenfant S, Breuils-Bonnet S, Provencher S, Bonnet S. Skeletal muscle metabolism defect in human pulmonary arterial hypertension. Am J Respir Crit Care Med. 2014;189:A2622.
Cited by
Sorted by citations
Items 101–200 of 270
Bahadoran, Z., Mirmiran, P., Ghasemi, A., Carlström, M., Azizi, F., & Hadaegh, F. (2017) · Nitric Oxide · doi:10.1016/j.niox.2016.11.005 · Cited by 32
Pulmonary vascular disease in the setting of heart failure with preserved ejection fraction
Levine, A. R., Simon, M. A. M., & Gladwin, M. T. (2018) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2018.08.005 · Cited by 31
Leopold, J. A., Kawut, S. M., Aldred, M. A., Archer, S. L., Benza, R. L., Bristow, M. R., Brittain, E. L., Chesler, N. C., DeMan, F. S., ERZURUM, S. C., et al. (2021) · Circulation Heart Failure · doi:10.1161/circheartfailure.120.007975 · Cited by 32
Insights into the pulmonary vascular complications of heart failure with preserved ejection fraction
Lai, Y., Wang, L., & Gladwin, M. T. (2018) · The Journal of Physiology · doi:10.1113/jp275858 · Cited by 30
Oghbaei, H., Alipour, M. R., Hamidian, G., Ahmadi, M., Ghorbanzadeh, V., & Keyhanmanesh, . (2018) · Experimental Physiology · doi:10.1113/ep087198 · Cited by 31
Joshi, S. R., Atabay, E. K., Liu, J., Ding, Y., Briscoe, S. D., Alexander, M. J., André, P., Kumar, R., & Li, G. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1064290 · Cited by 31
Keulenaer, G. W. D., Segers, V. F. M., Zannad, F. M., & Brutsaert, D. L. (2017) · European Journal of Heart Failure · doi:10.1002/ejhf.735 · Cited by 31
Bhaswant, M., Brown, L., McAinch, A. J., & Mathai, M. L. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700478 · Cited by 30
Emerging therapeutics in pulmonary hypertension
Hensley, M. K., Levine, A. R., Gladwin, M. T., & Lai, Y. (2018) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00259.2017 · Cited by 30
Pulmonary vascular dysfunction in metabolic syndrome
Willson, C., Watanabe, M., Tsuji‐Hosokawa, A., & Makino, A. (2018) · The Journal of Physiology · doi:10.1113/jp275856 · Cited by 30
Rezaei, M., Keshtzar, E., Khodayar, M. J., & Javadipour, M. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.10.025 · Cited by 31
Rana, U., Callan, E., Entringer, B., Michalkiewicz, T., Joshi, A., Parchur, A. K., Teng, R., & Konduri, G. G. (2020) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0275oc · Cited by 29
Lteif, C., Ataya, A., & Duarte, J. D. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.020633 · Cited by 29
Ameri, P., Mercurio, V., Pollesello, P., Anker, M. S., Backs, J., Bayés‐Genís, A., Borlaug, B. A., Burkhoff, D., Caravita, S., Chan, S. Y., et al. (2024) · European Journal of Heart Failure · doi:10.1002/ejhf.3236 · Cited by 28
Skeletal muscle abnormalities in heart failure with preserved ejection fraction
Anderson, M., Parrott, C. F., Haykowsky, M. J., Brubaker, P. H., Fan Ye, M. D., & Upadhya, B. (2022) · Heart Failure Reviews · doi:10.1007/s10741-022-10219-9 · Cited by 28
Ntessalen, M., Procter, N. E. K., Schwarz, K., Loudon, B. L., Minnion, M., Fernandez, B. O., Vassiliou, V. S., Vauzour, D., Madhani, M., Constantin‐Teodosiu, D., et al. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz245 · Cited by 28
Cordero‐Herrera, I., Guimarães, D. D., Moretti, C. H., Zhuge, Z., Han, H., Haworth, S. M., Gonzalez, A. E. U., Andersson, D. C., Weitzberg, E., Lundberg, J. O., et al. (2020) · Nitric Oxide · doi:10.1016/j.niox.2020.01.013 · Cited by 28
Inorganic Nitrate in Angina Study: A Randomized Double‐Blind Placebo‐Controlled Trial
Schwarz, K., Singh, S., Parasuraman, S. K., Rudd, A. E., Shepstone, L., Feelisch, M., Minnion, M., Ahmad, S., Madhani, M., Horowitz, J. D., et al. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.006478 · Cited by 27
Jheng, J.-R., Bai, Y., Noda, K., Huot, J. R., Cook, T. G., Fisher, A. J., Chen, Y.-Y., Goncharov, D. A., Goncharova, E. A., Simon, M. A. M., et al. (2024) · Circulation · doi:10.1161/circulationaha.124.068624 · Cited by 26
Mitochondrial NOS1 suppresses apoptosis in colon cancer cells through increasing SIRT3 activity
Wang, Q., Ye, S., Chen, X., Xu, P., Li, K., Zeng, S., Huang, M., Gao, W., Chen, J., Zhang, Q., et al. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.05.114 · Cited by 26
Alterations in platelet bioenergetics in Group 2 PH-HFpEF patients
Nguyen, Q. L., Wang, Y., Helbling, N. L., Simon, M. A. M., & Shiva, S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0220490 · Cited by 26
Gomes, P., Leal, H., Mendes, A. F., Reis, F., & Cavadas, C. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2019.09.003 · Cited by 27
Zhang, D., Gao, T., Xu, R., Sun, L., Zhang, C., Bai, L., Chen, W., Liu, K.-Y., Zhou, Y., Jiao, X., et al. (2020) · Rejuvenation Research · doi:10.1089/rej.2019.2260 · Cited by 26
Exosomal miR-211 contributes to pulmonary hypertension via attenuating CaMK1/PPAR-γaxis
Zhang, S., Liu, J., Zheng, K., Chen, L., Sun, Y., Yao, Z., Sun, Y., Lin, Y., Lin, K., & Yuan, L. (2020) · Vascular Pharmacology · doi:10.1016/j.vph.2020.106820 · Cited by 26
Models and Molecular Mechanisms of World Health Organization Group 2 to 4 Pulmonary Hypertension
Xiong, P. Y., Potus, F., Chan, W. W. Y., & Archer, S. L. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.08824 · Cited by 27
Mercurio, V., Bianco, A., Campi, G., Cuomo, A., Diab, N., Mancini, A., Parrella, P., Petretta, M., Hassoun, P. M., & Bonaduce, D. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180201095743 · Cited by 25
What Is Cardiometabolic HFpEF and How Can We Study it Preclinically?
Daou, D., Tong, D., Schiattarella, G. G., Gillette, T. G., & Hill, J. A. (2025) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2025.04.009 · Cited by 32
Proteomic and phosphoproteomic profiling in heart failure with preserved ejection fraction (HFpEF)
Valero‐Muñoz, M., Saw, E. L., Hekman, R. M., Blum, B. C., Hourani, Z., Granzier, H. L. M., Emili, A., & Sam, F. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.966968 · Cited by 27
Kelly, N. J., Radder, J. E., Baust, J., Burton, C. L., Lai, Y., Potoka, K. C., Agostini, B., Wood, J. P., Bachman, T. N., Vanderpool, R. R., et al. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0176oc · Cited by 23
Gorman, S., & Weller, R. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.616527 · Cited by 23
Alamri, A., Burzangi, A. S., Coats, P., & Watson, D. G. (2018) · Metabolites · doi:10.3390/metabo8040087 · Cited by 23
Shan, Z., Wang, Y., Qiu, T., Zhou, Y., Zhang, Y., Hu, L., Zhang, L., Liang, J., Ding, M., Fan, S., et al. (2023) · The Journal of Headache and Pain · doi:10.1186/s10194-023-01600-6 · Cited by 22
Varzandi, T., Abdollahifar, M., Rohani, S. A. H., Piryaei, A., Zadeh–Vakili, A., Jeddi, S., & Ghasemi, A. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.06.012 · Cited by 23
Martinez, C. S., Zheng, A., & Xiao, Q. (2024) · Antioxidants · doi:10.3390/antiox13111330 · Cited by 26
Update on novel targets and potential treatment avenues in pulmonary hypertension
Huetsch, J., Suresh, K. S., Bernier, M. L., & Shimoda, L. A. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00302.2016 · Cited by 21
Nitric oxide activates AMPK by modulating PDE3A in human pulmonary artery smooth muscle cells
Dillard, J., Meng, X., Nelin, L. D., Liu, Y., & Chen, B. (2020) · Physiological Reports · doi:10.14814/phy2.14559 · Cited by 21
Dietary nitrite extends lifespan and prevents age-related locomotor decline in the fruit fly
Moretti, C. H., Schiffer, T. A., Montenegro, M. F., Larsen, F. J., Tsarouhas, V., Carlström, M., Samakovlis, C., Weitzberg, E., & Lundberg, J. O. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.09.018 · Cited by 21
Skeletal muscle (dys)function in heart failure with preserved ejection fraction
Saw, E. L., Ramachandran, S., Valero‐Muñoz, M., & Sam, F. (2020) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000824 · Cited by 20
Elinoff, J. M., Agarwal, R., Barnett, C. F., Benza, R. L., Cuttica, M. J., Gharib, A. M., Gray, M. P., Hassoun, P. M., Hemnes, A. R., Humbert, M. J. C., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201710-2093pp · Cited by 20
Protection against Doxorubicin-Induced Cytotoxicity by Geniposide Involves AMPKα Signaling Pathway
Meng, Y., Yuan, Y., Zhang, X., Kong, C., Song, P. K., Ma, Z., & Tang, Q. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7901735 · Cited by 20
Zhang, D., Deng, J., Wu, Y.-G., Tang, T., Xiong, L., Zheng, Y., & Xu, X. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.801661 · Cited by 19
Yeo, Y. H., & Lai, Y. (2019) · Current Opinion in Physiology · doi:10.1016/j.cophys.2019.05.003 · Cited by 20
Lessons from Cancer Metabolism for Pulmonary Arterial Hypertension and Fibrosis
Han, S., & Chandel, N. S. (2021) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2020-0550tr · Cited by 18
Abdelazeem, H., Tu, L., Thuillet, R., Ottaviani, M., Boulfrad, A., Beck, T., Senbel, A. M., Mani, S., Castier, Y., Guyard, A., et al. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175579 · Cited by 18
Khorasani, V., Jeddi, S., Yaghmaei, P., Tohidi, M., & Ghasemi, A. (2019) · Nitric Oxide · doi:10.1016/j.niox.2019.02.003 · Cited by 19
Yang, Y., Zhao, M., Yu, X., Liu, L., He, X., Deng, J., & Zang, W. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00569.2018 · Cited by 18
Animal models of pulmonary hypertension due to left heart disease
Liu, S., & Yan, Y. (2022) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12214 · Cited by 17
Nie, C., Li, T., Fan, M., Wang, Y., Sun, Y., He, R., Zhang, X., Qian, H., Ying, H., Wang, L., et al. (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200225 · Cited by 17
Identification of Novel Therapeutic Targets for Pulmonary Arterial Hypertension
Satoh, K., Kikuchi, N., Satoh, T., Kurosawa, R., Sunamura, S., Siddique, M. A. H., Omura, J., Yaoita, N., & Shimokawa, H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19124081 · Cited by 18
Wang, H.-L., Tang, F., Jiang, Y., Zhu, Y., Zhao, J., & Xiao, Y. (2020) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-020-00742-4 · Cited by 16
Nutraceuticals in the Treatment of Pulmonary Arterial Hypertension
Sánchez-Gloria, J. L., Osorio‐Alonso, H., Arellano-Buendía, A. S., Carbó, R., Hernández-Díazcouder, A., Guzmán-Martín, C. A., Rubio‐Gayosso, I., & Sánchez‐Muñoz, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144827 · Cited by 16
Systemic Interactions in HFpEF: A Multiorgan Perspective on Pathways and Therapeutic Targets
Cui, X., Hu, Y., Xu, Y., Yang, L., Chatterjee, E., Li, G., Crețoiu, D., Wang, L., & Xiao, J. (2025) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-025-10699-8 · Cited by 15
Halliday, S. J., Matthews, D. T., Talati, M. H., Austin, E. D., Su, Y. R., Absi, T., Fortune, N. L., Gailani, D., Matafonov, A., West, J. D., et al. (2020) · JRSM Cardiovascular Disease · doi:10.1177/2048004020906994 · Cited by 15
Cardiac Acetylation in Metabolic Diseases
Dubois‐Deruy, E., Masri, Y. E., Turkieh, A., Amouyel, P., Pinet, F., & Annicotte, J. (2022) · Biomedicines · doi:10.3390/biomedicines10081834 · Cited by 15
Advances in epigenetic modifications of autophagic process in pulmonary hypertension
Mao, M., Song, S., Li, X., Lu, J., Li, J., Zhao, W., Liu, H., Liu, J., & Zeng, B. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1206406 · Cited by 15
Cardiometabolic HFpEF: Mechanisms and Therapies
Schiattarella, G. G., & Hill, J. A. (2021) · CardioMetabolic Syndrome Journal · doi:10.51789/cmsj.2021.1.e18 · Cited by 14
Moral‐Sanz, J., Lewis, S. A., MacMillan, S., Meloni, M., McClafferty, H., Viollet, B., Foretz, M., del Pozo, J., & Evans, A. M. (2022) · Nature Communications · doi:10.1038/s41467-022-32568-7 · Cited by 14
Losartan improves renal function and pathology in obese ZSF-1 rats
Su, Z., Widomski, D. L., Nikkel, A. L., Leys, L. J., Namovic, M. T., Donnelly‐Roberts, D. L., Gopalakrishnan, M., & McGaraughty, S. (2018) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2017-0157 · Cited by 14
Kelly, N. J., & Chan, S. Y. (2022) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2311378 · Cited by 14
Nitric Oxide Formation From Inorganic Nitrate
Lundberg, J. O., & Weitzberg, E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804273-1.00012-0 · Cited by 13
Yang, L., Yang, J., Xiao, L., Huang, W., Zhang, X., & Li, R. (2021) · Bioengineered · doi:10.1080/21655979.2021.1954581 · Cited by 12
Aradhyula, V., Vyas, R., Dube, P. R., Haller, S. T., Gupta, R., Maddipati, K. R., Kennedy, D. J., & Khouri, S. J. (2024) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00068.2024 · Cited by 12
Protective Effect of Metformin on Sepsis Myocarditis in Zebrafish
Zhang, M., Sun, W., Du, J., Gou, Y., Liu, L., Wang, R., & Xu, X. (2020) · Dose-Response · doi:10.1177/1559325820938543 · Cited by 12
Rescue of Heart Failure by Mitochondrial Recovery
Marquez, J. C., Lee, S. R., Kim, N., & Han, J. (2006) · International Neurourology Journal · doi:10.5213/inj.1632570.285 · Cited by 12
From Diabetes to Degenerative Diseases: The Multifaceted Action of Metformin
Campagnoli, L. I. M., Varesi, A., Fahmideh, F., Hakimizad, R., Petkovic, P., Barbieri, A., Marchesi, N., & Pascale, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199748 · Cited by 15
Extrapulmonary manifestations of pulmonary arterial hypertension
Singh, N., Al‐Naamani, N., Brown, M. B., Long, G., Thenappan, T., Umar, S., Ventetuolo, C. E., & Lahm, T. (2024) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2024.2361037 · Cited by 10
Anti-oxidant effect of nitrite in the pancreatic islets of type 2 diabetic male rats.
Ghasemi, A., Gheibi, S., Kashfi, K., & Jeddi, S. (2023) · PubMed Central · doi:10.22038/ijbms.2023.68245.14900 · Cited by 11
Ma, Y., Ma, J., Lu, L., Xiong, X., Shao, Y., Ren, J. T., Yang, J. Z., & Liu, J. (2023) · Antioxidants · doi:10.3390/antiox12091716 · Cited by 11
Nitrite Prevents Right Ventricular Failure and Remodeling Induced by Pulmonary Artery Banding
HU, J. L., Sharifi‐Sanjani, M., & Tofovic, S. P. (2016) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000446 · Cited by 12
Thapa, D., Zhang, M., Manning, J. R., Guimarães, D. A., Stoner, M. W., Lai, Y., Shiva, S., & Scott, I. (2019) · Physiological Reports · doi:10.14814/phy2.14054 · Cited by 9
McNair, B. D., Polson, S. M., Shorthill, S. K., Yusifov, A., Walker, L. A., Weiser‐Evans, M. C. M., Kovacs, E. J., & Bruns, D. R. (2023) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00124.2023 · Cited by 11
The Basic Science of Metabolism in Pulmonary Arterial Hypertension
Frump, A. L., & Lahm, T. (2018) · Advances in Pulmonary Hypertension · doi:10.21693/1933-088x-17.3.95 · Cited by 9
The future of group 2 pulmonary hypertension: Exploring clinical trials and therapeutic targets
Awada, C., Boucherat, O., Provencher, S., Bonnet, S., & Potus, F. (2023) · Vascular Pharmacology · doi:10.1016/j.vph.2023.107180 · Cited by 10
Myocardial Metabolic Reprogramming in HFpEF
Zhang, Z., Sun, M., Jiang, W., Yu, L., Zhang, C., & Ma, H. (2023) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-023-10433-2 · Cited by 10
McCabe, C., Oliveira, R. K. F., Rahaghi, F. N., Faria‐Urbina, M., Howard, L., Axell, R. G., Priest, A. N., Waxman, A. B., & Systrom, D. M. (2018) · European Journal of Applied Physiology · doi:10.1007/s00421-018-3873-4 · Cited by 10
Myeloid-Derived Suppressor Cells and Pulmonary Hypertension
Bryant, A. J., Mehrad, B., Brusko, T. M., West, J. D., & Moldawer, L. L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082277 · Cited by 10
George, M. P., Gladwin, M. T., & Graham, B. B. (2020) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2020-0099tr · Cited by 10
Skeletal myopathy in a rat model of postmenopausal heart failure with preserved ejection fraction
Kelley, R. C., Betancourt, L. G., Noriega, A. M., Brinson, S. C., Curbelo-Bermudez, N., Hahn, D., Kumar, R. A., Balazic, E., Muscato, D. R., RYAN, T. E., et al. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00170.2021 · Cited by 10
Endothelial SIRT3 deficiency predisposes brown adipose tissue to whitening in diet-induced obesity
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Ovchinnikov, A. G., Potekhina, A. V., Belyavskiy, E., & Ageev, F. T. (2022) · Pharmaceuticals · doi:10.3390/ph15081024 · Cited by 9
Current Understanding of Circulating Biomarkers in Pulmonary Hypertension Due to Left Heart Disease
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SIRT3/GLUT4 signaling activation by metformin protect against cisplatin-induced ototoxicity in vitro
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Paiva, B., Laranjinha, J. A. N., & Rocha, B. S. (2024) · FEBS Letters · doi:10.1002/1873-3468.14859 · Cited by 12
Jheng, J.-R., DesJardin, J. T., Chen, Y.-Y., Huot, J. R., Bai, Y., Cook, T. G., Hibbard, L. M., Rupp, J. M., Fisher, A. J., Zhang, Y., et al. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.320270 · Cited by 8
Kang, Z., Wu, Y., Ding, Y., Zhang, Y., Cai, X., Yang, H., & Wei, J. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118419 · Cited by 8
Exploring Sirtuins: New Frontiers in Managing Heart Failure with Preserved Ejection Fraction
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Hubesch, G., Dewachter, C., Chomette, L., Hupkens, E., Jespers, P., Vegh, G., Doppler, M., Mohammad, U. S., Thiriard, A., Remmelink, M., et al. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.032201 · Cited by 8
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Ławniczak, A., Wrońska, A., Wierzbicki, P., & Kmieć, Z. (2022) · Biogerontology · doi:10.1007/s10522-022-09965-y · Cited by 7
Bruns, D. R., McNair, B. D., Peelor, F. F., Borowik, A., Pranay, A., Yusifov, A., & Miller, B. F. (2023) · GeroScience · doi:10.1007/s11357-023-00777-7 · Cited by 7
Niu, T., Zhi, Y., Wei, L., Liu, W., Ju, X., Pi, W., Fu, Z., Tong, H., Hu, H., & Dong, J. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.05.031 · Cited by 7
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Tawa, M., Yano, Y., Yamanaka, M., Sawano, T., Iesaki, K., Murata, Y., Tanaka, R., Nakagawa, K., Ohkita, M., & Matsumura, Y. (2018) · American Journal of Hypertension · doi:10.1093/ajh/hpy144 · Cited by 7
Karimzadeh, L., Behrouz, V., Sohrab, G., Razavion, T., & Haji‐Maghsoudi, S. (2024) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2024.2395817 · Cited by 6
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Akhter, N., Contreras, J., Ansari, M. A., Ducruet, A. F., Hoda, M. N., Ahmad, A. S., Gangwani, L., Bhatia, K., & Ahmad, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413626 · Cited by 6
Cheng, Z., Wang, X., Jiang, Y., Li, X., Tang, Q., Qu, C., Yang, D., Li, Y., Xia, Y., & Guo, Y. (2025) · Advanced Science · doi:10.1002/advs.202513956 · Cited by 5
Chen, S., Hu, X., Wang, Q., Bakker, D., van der Made, I., Tebbens, A. M., Guan, Y., Lykidou, M., van Goor, F. K. J., Hollmann, M. W., et al. (2026) · Metabolism · doi:10.1016/j.metabol.2026.156568 · Cited by 6
Kozaily, E., Akdogan, R. E., Dorsey, N. S., & Tedford, R. J. (2024) · Current Hypertension Reports · doi:10.1007/s11906-024-01296-2 · Cited by 6
Metadata
- Authors
- Lai, Y.-C., Tabima, D. M., Dube, J. J., Hughan, K. S., Vanderpool, R. R., Goncharov, D. A., St. Croix, C. M., Garcia-Ocaña, A., Goncharova, E. A., Tofovic, S. P., Mora, A. L., & Gladwin, M. T.
- Affiliations
- University of Pittsburgh (US)
- From Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA (Y.-C.L., D.M.T., K.S.H., R.R.V., D.A.G., E.A.G., S.P.T., A.L.M., M.T.G.); Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, PA (J.J.D.); Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, University of Pittsburgh, Pittsburgh, PA (K.S.H.); Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA (C.M.St.C.); Diabetes, Obesity and...
- ORCID
- Venue
- Circulation
- Published
- 2016-02-23
- Volume
- 133
- Issue
- 8
- Pages
- 717-731
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC4766041
- OpenAlex
- W2274562896
- Cited by
- 270
- References
- 74
- Citations by year
- 2026: 15 · 2025: 20 · 2024: 26 · 2023: 25 · 2022: 26 · 2021: 24 · 2020: 31 · 2019: 21 · 2018: 37 · 2017: 26 · 2016: 17
- FWCI
- 30.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- University of Pittsburgh (UL1TR000005, UL1RR024153, RR024153)
- Hemophilia Center of Western Pennsylvania (T32 HL110849)
- National Institutes of Health (5t32dk007729-24, UL1TR000005, UL1-TR- 000005, RR024153, TR000005)
- National Heart, Lung, and Blood Institute (R01HL096973, P01HL103455, K23HL124051, HL110849, R01HL113178, R01HL098032, T32HL110849)
- National Institute of Diabetes and Digestive and Kidney Diseases (T32 DK-007729, P30DK020541)
- National Center for Research Resources (UL1RR024153)
- National Center for Advancing Translational Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12HD052892)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- pulmonary hypertension, heart failure with preserved ejection fraction, nitrite, nitrate, SIRT3, AMPK, metformin, hyperglycemia, metabolic syndrome, skeletal muscle, GLUT4, leptin receptor, SU5416, vascular remodeling, animal models
- MeSH terms
- Animals, Cells, Cultured, Enzyme Activation, Heart Failure, Humans, Hyperglycemia, Hypertension, Pulmonary, Male, Metformin, Rats, Zucker, Sodium Nitrite, Stroke Volume, Mice, Knockout, Muscle, Skeletal, Mice, Rats, AMP-Activated Protein Kinases, Sirtuin 3, Mice, 129 Strain
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