The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Gut Microbe-Generated Trimethylamine N -Oxide From Dietary Choline Is Prothrombotic in Subjects
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In the citing paper
“TMAO has been shown to directly interact with platelets (human and murine), increasing their responsiveness, and promoting a prothrombotic phenotype.4,5”
From Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women (2019) · cites this paper as [5]
In the citing paper
“recent human observational and interventional studies show that TMAO levels can increase substantially (>10 lM) with chronic supplementation.4,5”
From Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women (2019) · cites this paper as [5]
In the citing paper
“In a subsequent human feeding study, healthy volunteers (both omnivore and vegan/vegetarian) that were orally supplemented with choline exhibited higher levels of TMAO and concomitant enhanced platelet responsiveness and aggregation77, 118.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [118]
In the citing paper
“The TMAO pathway is an excellent example of this, given the nutrient precursors are more abundant in a Western diet, and diets rich in phosphatidylcholine and carnitine are associated with heightened levels of TMAO, whereas vegetarian or vegan diets have reduced nutrient precursors111, 118.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [118]
In the citing paper
“It was observed that although blood lipid levels in the mice remained similar between all diet groups, TMAO was significantly elevated in the fish protein group.”
From Dietary metabolism, the gut microbiome, and heart failure (2019) · cites this paper as [166]
In the citing paper
“a recent study supplementing fish protein to a western diet in Apolipoprotein E−/− mice showed increases in atherosclerotic plaque area and calcification when compared to the matched soy or casein protein fed counterparts166.”
From Dietary metabolism, the gut microbiome, and heart failure (2019) · cites this paper as [166]
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Citations
Cites
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597
Self-citationIntestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
Koeth, R. A., Wang, Z., Levison, B. S., Buffa, J. A., Org, E., Sheehy, B. T., Britt, E. B., Fu, X., Wu, Y., Li, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3145 · Cited by 4,386
Self-citationIntestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
Tang, W. H. W., Wang, Z., Levison, B. S., Koeth, R. A., Britt, E. B., Fu, X., Wu, Y., & Hazen, S. L. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1109400 · Cited by 3,400
Self-citationGut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk
Zhu, W., Gregory, J. C., Org, E., Buffa, J. A., Gupta, N., Wang, Z., Li, L., Fu, X., Wu, Y., Mehrabian, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.011 · Cited by 1,968
Self-citationThe influence of non-steroidal anti-inflammatory drugs on the gut microbiome
Rogers, M. A. M., & Aronoff, D. M. (2016) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2015.10.003 · Cited by 346
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Gut microbiota and cardiovascular disease.
Witkowski, M., Weeks, T. L., & Hazen, S. L. (2020) · Circulation Research · doi:10.1161/circresaha.120.316242 · Cited by 1,051
Self-citationDietary metabolism, the gut microbiome, and heart failure
Tang, W. H. W., Li, D. Y., & Hazen, S. L. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0108-7 · Cited by 789
Self-citationRole of gut microbiota-generated short-chain fatty acids in metabolic and cardiovascular health
Chambers, E. S., Preston, T., Frost, G., & Morrison, D. J. (2018) · Current Nutrition Reports · doi:10.1007/s13668-018-0248-8 · Cited by 691
Development of a gut microbe–targeted nonlethal therapeutic to inhibit thrombosis potential
Roberts, A. B., Gu, X., Buffa, J. A., Hurd, A. G., Wang, Z., Zhu, W., Gupta, N., Skye, S. M., Cody, D. B., Levison, B. S., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0128-1 · Cited by 552
Self-citationIntestinal Microbiota in Cardiovascular Health and Disease
Tang, W. H. W., Bäckhed, F., Landmesser, U., & Hazen, S. L. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.03.024 · Cited by 524
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Metadata
- Authors
- Zhu, W., Wang, Z., Tang, W. H. W., & Hazen, S. L.
- Affiliations
- Cleveland Clinic (US)
- Venue
- Circulation
- Published
- 2017-04-25
- Volume
- 135
- Issue
- 17
- Pages
- 1671-1673
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC5460631
- OpenAlex
- W2609064408
- Cited by
- 274
- References
- 5
- Citations by year
- 2026: 22 · 2025: 31 · 2024: 19 · 2023: 30 · 2022: 41 · 2021: 27 · 2020: 41 · 2019: 23 · 2018: 31 · 2017: 8
- FWCI
- 11.51
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL126827, R01HL103866)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK106000)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Keywords
- trimethylamine N-oxide, choline, gut microbiota, prothrombotic effects, thrombosis
- MeSH terms
- Vegans, Gastrointestinal Microbiome, Adult, Aspirin, Choline, Dietary Fats, Female, Humans, Male, Methylamines, Middle Aged, Thrombosis
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