The influence of non-steroidal anti-inflammatory drugs on the gut microbiome

A Mathematical Theory of Communication

Shannon, C. E. (1948) · Bell System Technical Journal · doi:10.1002/j.1538-7305.1948.tb01338.x · Cited by 88,486 · see citing works

Comparing the Areas under Two or More Correlated Receiver Operating Characteristic Curves: A Nonparametric Approach

DeLong, E. R., DeLong, D. M., & Clarke-Pearson, D. L. (1988) · Biometrics · doi:10.2307/2531595 · Cited by 22,649 · see citing works

Measurement of Diversity

Simpson, E. (1949) · Nature · doi:10.1038/163688a0 · Cited by 14,328 · see citing works

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597 · see citing works

Reducing the Effects of PCR Amplification and Sequencing Artifacts on 16S rRNA-Based Studies

Schloss, P. D., Gevers, D., & Westcott, S. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027310 · Cited by 2,112 · see citing works

Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials

† (2013) · The Lancet · doi:10.1016/s0140-6736(13)60900-9 · Cited by 1,809 · see citing works

Long-term impacts of antibiotic exposure on the human intestinal microbiota

Jernberg, C., Löfmark, S., Edlund, C., & Jansson, J. K. (2010) · Microbiology · doi:10.1099/mic.0.040618-0 · Cited by 1,067 · see citing works

Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme

Craciun, S., & Balskus, E. P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215689109 · Cited by 701 · see citing works

Proton Pump Inhibitors Exacerbate NSAID-Induced Small Intestinal Injury by Inducing Dysbiosis

Wallace, J. L., Syer, S., Denou, E., de Palma, G., Vong, L., McKnight, W., Jury, J., Bolla, M., Bercik, P., Collins, S. M., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.075 · Cited by 460 · see citing works

Role of the Intestinal Microbiota in Resistance to Colonization by Clostridium difficile

Britton, R. A., & Young, V. B. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.059 · Cited by 446 · see citing works

Individual NSAIDs and Upper Gastrointestinal Complications

Castellsagué, J., Riera‐Guàrdia, N., Calingaert, B., Varas‐Lorenzo, C., Fourrier‐Réglat, A., Nicotra, F., Sturkenboom, M., Perez‐Gutthann, S., & Safety of Non-Steroidal Anti-Inflammatory Drugs (SOS) Project (2012) · Drug Safety · doi:10.1007/bf03261999 · Cited by 341 · see citing works

Resistance of germfree rats to indomethacin-induced intestinal lesions

Robert, A., & Asano, T. (1977) · Prostaglandins · doi:10.1016/0090-6980(77)90178-2 · Cited by 312 · see citing works

Individual NSAIDs and Upper Gastrointestinal Complications

Castellsagué, J., Riera‐Guàrdia, N., Calingaert, B., Varas‐Lorenzo, C., Fourrier‐Réglat, A., Nicotra, F., Sturkenboom, M., & Perez‐Gutthann, S. (2012) · Drug Safety · doi:10.2165/11633470-000000000-00000 · Cited by 309 · see citing works

Microbiome Data Distinguish Patients with Clostridium difficile Infection and Non-C. difficile-Associated Diarrhea from Healthy Controls

Schubert, A. M., Rogers, M. A. M., Ring, C., Mogle, J. A., Petrosino, J., Young, V. B., Aronoff, D. M., & Schloss, P. D. (2014) · mBio · doi:10.1128/mbio.01021-14 · Cited by 308 · see citing works

Trends in the use of aspirin and nonsteroidal anti‐inflammatory drugs in the general U.S. population

Zhou, Y., Boudreau, D. M., & Freedman, A. N. (2013) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.3463 · Cited by 302 · see citing works

Dose–response relationships between individual nonaspirin nonsteroidal anti‐inflammatory drugs (NANSAIDs) and serious upper gastrointestinal bleeding: a meta‐analysis based on individual patient data

Lewis, S. C., Langman, M. J. S., Laporte, J., Matthews, J. N. S., Rawlins, M. D., & Wiholm, B. (2002) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2002.01636.x · Cited by 250 · see citing works

Health, United States, 2013 : with special feature on prescription drugs

Holmes, J. S., & Arispe, I. E. (2014) · Cited by 246 · see citing works

NSAID gastropathy and enteropathy: distinct pathogenesis likely necessitates distinct prevention strategies

Wallace, J. L. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01509.x · Cited by 173 · see citing works

Age and Sex Patterns of Drug Prescribing in a Defined American Population

Zhong, W., Maradit-Kremers, H., St. Sauver, J. L., Yawn, B. P., Ebbert, J. O., Roger, V. L., Jacobson, D. J., McGree, M. E., Brue, S. M., & Rocca, W. A. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.04.021 · Cited by 116 · see citing works

Role of Intestinal Bacteria in Ileal Ulcer Formation in Rats Treated with a Nonsteroidal Antiinflammatory Drug

Uejima, M., Kinouchi, T., Kataoka, K., Hiraoka, I., & Ohnishi, Y. (1996) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1996.tb01108.x · Cited by 110 · see citing works

Nonsteroidal Anti-inflammatory Drugs, Proton Pump Inhibitors, and Gastrointestinal Injury: Contrasting Interactions in the Stomach and Small Intestine

Marlicz, W., Łoniewski, I., Grimes, D. S., & Quigley, E. M. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2014.07.015 · Cited by 91 · see citing works

Nonsteroidal Anti-Inflammatory Drug-Induced Enteropathy: Case Discussion and Review of the Literature

Kwo, P. Y., & Tremaine, W. J. (1995) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)64666-1 · Cited by 83 · see citing works

Adverse drug reactions associated with the use of NSAIDs: a case/noncase analysis of spontaneous reports from the French pharmacovigilance database 2002–2006

Lapeyre‐Mestre, M., Grolleau, S., & Montastruc, J. (2011) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2011.00991.x · Cited by 70 · see citing works

[U.S. Food and Drug Administration (FDA) strengthens warning that non-aspirin non steroidal anti-inflammatory drugs (NSAIDs) can cause myocardial infarctions or strokes: the dentist's perspective].

Rosen, E., Tsesis, I., & Vered, M. (2015) · PubMed · Cited by 57 · see citing works

A randomized, double-blinded, placebo-controlled, multicenter trial, healing effect of rebamipide in patients with low-dose aspirin and/or non-steroidal anti-inflammatory drug induced small bowel injury

Kurokawa, S., Katsuki, S., Fujita, T., Saitoh, Y., Ohta, H., Nishikawa, K., Sato, Y., Sato, Y., Ohira, K., Yamada, M., et al. (2013) · Journal of Gastroenterology · doi:10.1007/s00535-013-0805-2 · Cited by 56 · see citing works

1H NMR-based metabolic profiling of naproxen-induced toxicity in rats

Jung, J., Park, M., Park, H. J., et al. (2010) · Toxicology Letters · doi:10.1016/j.toxlet.2010.09.020 · Cited by 44 · see citing works

NSAID enteropathy: could probiotics prevent it?

Montalto, M., Gallo, A., Gasbarrini, A., & Landolfi, R. (2012) · Journal of Gastroenterology · doi:10.1007/s00535-012-0648-2 · Cited by 30 · see citing works

Environmental and NSAID-Enteropathy: Dysbiosis as a Common Factor

Syer, S. D., & Wallace, J. L. (2014) · Current Gastroenterology Reports · doi:10.1007/s11894-014-0377-1 · Cited by 22 · see citing works

Extensive impact of non-antibiotic drugs on human gut bacteria

Maier, L., Pruteanu, M., Kuhn, M., Zeller, G., Telzerow, A., Anderson, E. E., Brochado, A. R., Fernandez, K. C., Dose, H., Mori, H., et al. (2018) · Nature · doi:10.1038/nature25979 · Cited by 1,905 · see citing works

The Human Gut Microbiome: From Association to Modulation

Schmidt, T. S. B., Raes, J., & Bork, P. (2018) · Cell · doi:10.1016/j.cell.2018.02.044 · Cited by 845 · see citing works

Mechanisms and consequences of intestinal dysbiosis

Weiss, G. A., & Hennet, T. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2509-x · Cited by 775 · see citing works

Gut microbiome interactions with drug metabolism, efficacy, and toxicity

Wilson, I. D., & Nicholson, J. K. (2017) · Translational Research · doi:10.1016/j.trsl.2016.08.002 · Cited by 656 · see citing works

Development of a gut microbe–targeted nonlethal therapeutic to inhibit thrombosis potential

Roberts, A. B., Gu, X., Buffa, J. A., Hurd, A. G., Wang, Z., Zhu, W., Gupta, N., Skye, S. M., Cody, D. B., Levison, B. S., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0128-1 · Cited by 552 · see citing works

Secretory Products of the Human GI Tract Microbiome and Their Potential Impact on Alzheimer's Disease (AD): Detection of Lipopolysaccharide (LPS) in AD Hippocampus

Zhao, Y., Jaber, V., & Lukiw, W. J. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00318 · Cited by 379 · see citing works

Systematic review: human gut dysbiosis induced by non-antibiotic prescription medications

Le Bastard, Q., Al‐Ghalith, G. A., Grégoire, M., Chapelet, G., Javaudin, F., Dailly, E., Batard, E., Knights, D., & Montassier, E. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14451 · Cited by 263 · see citing works

Gut Microbe-Generated Trimethylamine <i>N</i> -Oxide From Dietary Choline Is Prothrombotic in Subjects

Zhu, W., Wang, Z., Tang, W. H. W., & Hazen, S. L. (2017) · Circulation · doi:10.1161/circulationaha.116.025338 · Cited by 274 · see citing works

Gut microbiota composition is associated with polypharmacy in elderly hospitalized patients

Ticinesi, A., Milani, C., Lauretani, F., Nouvenne, A., Mancabelli, L., Lugli, G. A., Turroni, F., Duranti, S., Mangifesta, M., Viappiani, A., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10734-y · Cited by 211 · see citing works

The esophageal microbiota in health and disease

Di Pilato, V., Freschi, G., Ringressi, M. N., Pallecchi, L., Rossolini, G. M., & Bechi, P. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13127 · Cited by 139 · see citing works

From taxonomy to metabolic output: what factors define gut microbiome health?

Wilmanski, T., Rappaport, N., Diener, C., Gibbons, S. M., & Price, N. D. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1907270 · Cited by 73 · see citing works

Targeting the Microbiota in Pharmacology of Psychiatric Disorders

Pascale, A., Marchesi, N., Govoni, S., & Barbieri, A. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104856 · Cited by 67 · see citing works

Effect of Concomitant Use of Proton Pump Inhibitors on Immunotherapy Clinical Response in Advanced Cancer Patients: Real-Life Setting

Cantarelli, L., Gutiérrez Nicolás, F., García Gil, S., Morales Barrios, J. A., Oramas Rodriguez, J., & Nazco Casariego, G. J. (2024) · Journal of Immunotherapy · doi:10.1097/cji.0000000000000494 · Cited by 4 · see citing works

Pharmacomicrobiomics of Non-Antibiotic Drugs: Mechanisms and Clinical Consequences of Gut Microbiota Alterations

Dumitru, C. N., Dumitru, A. O., Goroftei, L., Niculet, E., Ignat, M. D., Baroiu, L., Nechita, A., & Balan, G. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18060651 · Cited by 4 · see citing works

Fecal menaquinone profiles of overweight adults are associated with gut microbiota composition during a gut microbiota–targeted dietary intervention

Karl, J. P., Fu, X., Wang, X., Zhao, Y., Shen, J., Zhang, C., Wolfe, B. E., Saltzman, E., Zhao, L., & Booth, S. L. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.109496 · Cited by 53 · see citing works

Association of dietary patterns with the fecal microbiota in Korean adolescents

Jang, H. B., Choi, M.-K., Kang, J., Park, S. I., & Lee, H. (2017) · BMC Nutrition · doi:10.1186/s40795-016-0125-z · Cited by 31 · see citing works

Structure analysis of the gut microbiota in chronic functional constipation patients

Huang, L., Gao, R., Yan, X., Zhu, Q. R., Pan, C., Yin, M., Li, H., Kong, C., Zhang, P., Shen, T., et al. (2017) · Chin J Colorec Dis (Electronic Edition) · doi:10.3877/cma.j.issn.2095-3224.2017.02.008 · Cited by 8 · see citing works

Interpreting prevotella and bacteroides as biomarkers of diet and lifestyle

Gorvitovskaia, A., Holmes, S. P., & Huse, S. M. (2016) · Microbiome · doi:10.1186/s40168-016-0160-7 · Cited by 461 · see citing works

Investigation into the stability and culturability of Chinese enterotypes

Yin, Y., Fan, B., Liu, W. Y., Ren, R., Chen, H., Bai, S., Zhu, L., Sun, G., Yang, Y., & Wang, X. (2017) · Scientific Reports · doi:10.1038/s41598-017-08478-w · Cited by 41 · see citing works