Is Coronary Atherosclerosis One Disease or Many?: Setting Realistic Expectations for Precision Medicine
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The risk associated with a high polygenic score may not reflect a single underlying mechanism but rather the combined influence of multiple pathways.
“In both cases, it is important to recognize that the risk associated with a high polygenic score may not reflect a single underlying mechanism, but rather the combined influence of multiple pathways.28”
From Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (2018) · cites this paper as [28]
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- Authors
- Khera, A. V., & Kathiresan, S.
- Affiliations
- Broad Institute (US)
- Venue
- Circulation
- Published
- 2017-03-14
- Volume
- 135
- Issue
- 11
- Pages
- 1005-1007
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC5395046
- OpenAlex
- W2597294414
- Cited by
- 40
- References
- 5
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 9 · 2018: 8 · 2017: 2
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (U2COD023196, KL2TR001100)
- National Heart, Lung, and Blood Institute (R01HL127564)
- National Human Genome Research Institute (UM1HG008895)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
- Keywords
- coronary artery disease, disease classification
- MeSH terms
- Coronary Artery Disease, Humans, Atherosclerosis, Precision Medicine
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