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Bacteroides vulgatus and Bacteroides dorei Reduce Gut Microbial Lipopolysaccharide Production and Inhibit Atherosclerosis
Abstract
Background: It is increasingly recognized that gut microbiota play a pivotal role in the development of atherosclerotic cardiovascular disease. Previously, we have reported that the abundance of genus Bacteroides is lower in patients with coronary artery disease (CAD) than in patients without CAD with coronary risk factors or in healthy volunteers. However, it remains unclear which and how specific gut bacteria contribute to the progression of atherosclerosis. Methods: We recruited patients with CAD patients and controls without CAD with coronary risk factors. We then compared gut microbial composition using 16S ribosomal RNA gene sequencing in fecal samples to detect species with differential abundance between 2 groups. Subsequently, we used atherosclerosis-prone mice to study the mechanisms underlying the relationship between such species and atherosclerosis. Results: Human fecal 16S ribosomal RNA gene sequencing revealed a significantly lower abundance of Bacteroides vulgatus and Bacteroides dorei in patients with CAD. This significant differential abundance was confirmed by quantitative polymerase chain reaction. Gavage with live B. vulgatus and B. dorei attenuated atherosclerotic lesion formation in atherosclerosis-prone mice, markedly ameliorating endotoxemia followed by decreasing gut microbial lipopolysaccharide production, effectively suppressing proinflammatory immune responses. Furthermore, fecal lipopolysaccharide levels in patients with CAD were significantly higher and negatively correlated with the abundance of B. vulgatus and B. dorei . Conclusions: Our translational research findings identify a previously unknown link between specific gut bacteria and atherosclerosis. Treatment with live B. vulgatus and B. dorei may help prevent CAD. Clinical Trial Registration: URL: https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000018051 . Unique identifier: UMIN000015703.
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TL;DR
In patients with coronary artery disease (CAD), gut abundance of *Bacteroides vulgatus* and *Bacteroides dorei* was lower than in controls without CAD, and fecal lipopolysaccharide (LPS) levels were higher. In atherosclerosis-prone mice, oral gavage with live *B. vulgatus* and *B. dorei* reduced fecal and plasma LPS, dampened inflammation, and attenuated atherosclerotic plaque.
Key findings
- In 30 patients with CAD versus 30 age- and sex-matched controls without CAD but with coronary risk factors, 16S rRNA sequencing showed relative depletion of *B. vulgatus* and *B. dorei* in CAD; qPCR confirmed significantly decreased abundance of these species.
- Fecal LPS levels were significantly higher in patients with CAD than controls, and fecal LPS correlated negatively with *B. vulgatus*/*B. dorei* abundance in CAD (r=−0.541, P=0.002); genus *Bacteroides* showed a trend toward negative correlation (r=−0.227, P=0.0838).
- In apolipoprotein E-deficient mice, gavage with live *B. vulgatus* and *B. dorei* (2.5×10⁹ cfu/100 μL, 5 times/week) significantly reduced aortic root and en face atherosclerotic lesion size, macrophage and CD4⁺ T-cell accumulation, plasma LPS, and proatherogenic cytokines, without significant differences in body weight, plasma cholesterol, or plasma glucose.
- Live *Bacteroides* treatment decreased predicted microbial LPS biosynthesis genes *LpxA* and *LpxD* and dramatically lowered fecal LPS; heat-killed *Bacteroides* did not decrease fecal LPS, aortic sinus plaque, or plasma LPS compared with controls (reported P=0.92, P=0.74, and P=0.93, respectively).
Methods
- Human study: 30 patients with CAD and 30 controls without CAD with coronary risk factors were recruited at Kobe University Hospital between October 2014 and July 2015; fecal samples underwent 16S rRNA gene sequencing (V3–V4 region), qPCR, PICRUSt functional prediction, and limulus amebocyte lysate assay for LPS.
- Mouse study: 6-week-old female apolipoprotein E-deficient mice on C57BL/6 background were randomized to control, live *Bacteroides*, or heat-killed *Bacteroides* groups; mice were gavaged 5 times per week for 10 weeks and euthanized at 16 weeks for atherosclerosis, immune, gut permeability, and LPS analyses.
- Statistical analysis used R, JMP, and Prism; Shapiro-Wilk test, Student’s t test or Mann-Whitney U test, Fisher exact or χ² test, Spearman correlation, one-way ANOVA, and Benjamini-Hochberg adjustment for multiple comparisons.
Limitations
- The paper states that 16S rRNA sequencing has low phylogenetic power at the species level and poor discriminatory power for some genera, and that the human CAD gut microbial analysis was a single-center study with a relatively small number of patients.
- The paper states that controls without CAD did not all undergo coronary angiography, so subclinical CAD may have been present; the limulus amebocyte lysate assay could not measure LPS immunogenicity or the impact of *Bacteroides* on LPS structure/function; mechanisms of atherosclerosis protection by lower LPS were not completely elucidated; mouse and human dominant microbiota differ; and only *B. vulgatus* and *B. dorei* were tested, so more effective strains may exist.
- Evident from the text: the human findings are cross-sectional and cannot establish causality, and the causal evidence comes from a mouse gavage model rather than a human intervention.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“immunohistochemical staining followed by morphometric analysis of atherosclerotic lesions in the aortic sinus revealed a marked reduction in macrophage and CD4 + T-cell accumulation in mice gavaged with live Bacteroides compared with controls (Figure 2C and 2D).”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Gut Microbial Profile in Patients With CAD
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In the paper
“we observed significantly higher expression levels of ZO-1 (mRNA and protein) in HT29 cells stimulated with fecal supernatant from live Bacteroides-treated mice than in cells stimulated with fecal supernatant from control mice (Figure VD and VE in the online-only Data Supplement).”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Live Bacteroides Treatment Strengthened Tight Junction Formation In Vivo and In Vitro
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In the paper
“we found that the abundance of Bacteroides vulgatus and Bacteroides dorei was decreased in patients with CAD.”
- Also stated in: § Gut Microbial Profile in Patients With CAD · plain
“patients with CAD showed a relative depletion of B. vulgatus and B. dorei”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Abstract
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In the paper
“The mRNA expression of several proatherogenic immune cell markers and chemokines/ chemokine receptors was decreased in mice gavaged with live Bacteroides (Figure 2E).”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Gut Microbial Profile in Patients With CAD
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In the paper
“reflected in higher mean fluorescence intensity of ZO-1 in the colon (Figure VC in the online-only Data Supplement).”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Live Bacteroides Treatment Strengthened Tight Junction Formation In Vivo and In Vitro
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In the paper
“Although the expression of genes related to TMA synthesis (CutC, CutD) had no difference among the groups”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Gavage With Live Bacteroides Alters Gut Microbial LPS Production
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In the paper
“We found that the relative abundance of the genus Bacteroides was visibly lower in patients with CAD compared with controls (Figure 1G).”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Gut Microbial Profile in Patients With CAD
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In the paper
“The abundance of B. vulgatus and B. dorei was considerably higher in feces from live Bacteroides-gavaged mice (Figure IIIF in the online-only Data Supplement).”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Gavage With Live Bacteroides Alters Gut Microbial LPS Production
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In the paper
“the expression of genes involved in LPS biosynthesis, especially LpxA and LpxD, which are involved in lipid A biosynthesis and constitute the essential acyltransferases of the lipid A structure (Figure 3B), 38,39 was significantly decreased in mice gavaged with live Bacteroides (Figure 3A and 3C, Figure IV in the online-only Data Supplement).”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Gavage With Live Bacteroides Alters Gut Microbial LPS Production
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In the paper
“We also confirmed the significantly decreased abundance of B. vulgatus and B. dorei in patients with CAD by quantitative polymerase chain reaction (Figure 1J and Table II in the online-only Data Supplement).”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Gut Microbial Profile in Patients With CAD
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- It may state two separate claims as one. 29
- Probably not a substantial claim. 21
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“mice gavaged with Bacteroides exhibited decreased expression of major histocompatibility complex class II and costimulatory molecule CD86, as well as increased expression of the coinhibitory molecules programmed death ligand-1 and programmed death ligand-2 on splenic CD11c high dendritic cells (Figure IIB in the online-only Data Supplement).”
- Also stated in: § ORIGINAL RESEARCH ARTICLE · plain
“Similar phenotypic changes along with increased expression of PD-L1 and PD-L2 in dendritic cells were observed in the spleen.”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > ORIGINAL RESEARCH ARTICLE
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- Also stated in: § ORIGINAL RESEARCH ARTICLE · plain
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In the paper
“the samples were clustered into 3 clusters at the genus level”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Gut Microbial Profile in Patients With CAD
Strength:plain· not yet calibratedn = 30Tests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
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In the paper
“mice gavaged with live Bacteroides showed significantly reduced lesion size in the aortic root and en face analysis of thoracoabdominal aortas (Figure 2A and 2B)”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Gut Microbial Profile in Patients With CAD
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In the paper
“The controls without CAD were significantly more likely to be categorized into cluster 1, whereas few patients with CAD were categorized into this cluster (Figure 1F).”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Gut Microbial Profile in Patients With CAD
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In the paper
“without significant difference in body weight (Figure 2F), plasma cholesterol levels (Figure 2G), or plasma glucose levels (data not shown).”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Gut Microbial Profile in Patients With CAD
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In the paper
“Each cluster was characterized by a high abundance of a specific genus as follows: Bacteroides in cluster 1, Prevotella in cluster 2, and Faecalibacterium, Ruminococcus, or Bifidobacterium in cluster 3 (Figure 1E).”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Gut Microbial Profile in Patients With CAD
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In the paper
“Mice gavaged with live Bacteroides had lower numbers of effector CD44 high CD62Llow CD4 + T cells and a significantly higher proportion of CD4 + CD25 + Foxp3 + regulatory T cells, with higher levels of intracellular CTLA4 (Figure IID and IIE in the online-only Data Supplement)”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > ORIGINAL RESEARCH ARTICLE
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In the paper
“patients with CAD showed a relative depletion of B. vulgatus and B. dorei and enrichment in Faecalibacterium prausnitzii and Prevotella copri (Figure 1H).”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Gut Microbial Profile in Patients With CAD
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In the paper
“The α diversity, Bacteroidetes/Firmicutes ratio, and Gram-positive to Gramnegative strain ratio did not differ significantly between the 2 groups (Figure 1A and 1C).”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Gut Microbial Profile in Patients With CAD
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“were the 2 most abundant species within the genus Bacteroides in 16S rRNA gene sequencing analysis (Figure 1I).”
- Also stated in: § DISCUSSION · plain
“B. vulgatus and B. dorei are the dominant species of genus Bacteroides in human gut microbiota.”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Gut Microbial Profile in Patients With CAD
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- Also stated in: § DISCUSSION · plain
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In the paper
“The Bacteroidetes/Firmicutes ratio, Gram-positive to Gram-negative strain ratio, and fecal water content did not differ significantly among the 3 groups”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Affiliations
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In the paper
“whereas the number of CD4 + T cells and several markers on CD4 + T cells did not significantly change (Figure VIC and VIF in the online-only Data Supplement).”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > ORIGINAL RESEARCH ARTICLE
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In the paper
“we found that fecal LPS levels were higher in patients with lower abundance of B. vulgatus and B. dorei.”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > DISCUSSION
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- Rests on an assumption: Fecal lipopolysaccharide levels reflect colon lipopolysaccharide concentrations produced by gut microbiota.
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In the paper
“Trimethylamine (TMA) and TMA N-oxide, which are gut microbiota metabolites of dietary phosphatidylcholine, are known to be associated with cardiovascular disease and with the atherosclerosis process in particular.3,4”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Abstract
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In the paper
“CAD remains the leading cause of morbidity and mortality worldwide, despite the widespread use of statin therapy in the last decade.12”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Abstract
What the sources say
- Not checked yetcites [12] source
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In the paper
“Endotoxemia is known to cause systemic inflammation leading to the disruption of innate and adaptive immunity and the development of atherosclerosis.[34][35][36]”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Gut Microbial Profile in Patients With CAD
What the sources say
- Not checked yetcites [34]
- Not checked yetcites [35] source
- Not checked yetcites [36]
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In the paper
“a recent clinical trial has shown contradictory results indicating that fish consumption drastically increases circulating TMA N-oxide levels”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Abstract
What the sources say
- Not checked yetcites [6] source
Strength:hedged· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
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In the paper
“This study was approved by the Ethics Committee of Kobe University (approval No. 1595) and registered with the University hospital Medical Information Network Clinical Trials Registry (trial registration No. UMIN000015703).”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Recruitment of Patients With CAD and Controls
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In the paper
“The success of the heat treatment was confirmed by the absence of growth of plated heat-killed bacteria.”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Animals
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In the paper
“All participants provided written informed consent on enrollment, and the study was conducted according to the guidelines of the Declaration of Helsinki.”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Recruitment of Patients With CAD and Controls
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In the paper
“All experiments were performed according to the Guidelines for Animal Experiments in effect at Kobe University School of Medicine (guideline No. P160701).”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Animals
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In the paper
“However, it remains unclear which specific Bacteroides species are involved and what their exact role is in CAD.11”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Abstract
What the sources say
- Not checked yetcites [11]
Load-bearingStrength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. It may state two separate claims as one.
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In the paper
“Six-week-old mice were randomly divided into 3 treatment groups”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Animals
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In the paper
“Because these 2 species share similar 16S rRNA sequencing patterns, 32 we were not able to distinguish them using our methodology.”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Gut Microbial Profile in Patients With CAD
What the sources say
- Not checked yetcites [32]
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In the paper
“The sample size was calculated using R software (power=0.9,significance level=0.05,mean difference=6, SD=7; n=30 per group.).”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Recruitment of Patients With CAD and Controls
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In the paper
“The genus Bacteroides includes some of the predominant gut bacteria in humans and is known to have an important role in maintaining a healthy gut ecosystem.7”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Abstract
What the sources say
- Not checked yetcites [7]
Strength:boosted· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
In the paper
“Because LPS stimulates cells through TLR4 and upregulates costimulatory molecules on antigen-presenting cells, 37”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Gut Microbial Profile in Patients With CAD
What the sources say
- Not checked yetcites [37]
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These results suggested that replenishment of live B. vulgatus and B. dorei by oral gavage reduced plaque inflammation, attenuating atherosclerotic lesion formation.”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > Gut Microbial Profile in Patients With CAD
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- Rests on an assumption: The effects of live B. vulgatus and B. dorei on atherosclerosis in apolipoprotein E-deficient mice are representative of human coronary artery disease.
None of the sources cited for this claim have been checked yet.
In the paper
“Although LPS from E. coli increases intestinal permeability in a TLR4-dependent manner, 40,41”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > ORIGINAL RESEARCH ARTICLE
What the sources say
- Not checked yetcites [40]
- Not checked yetcites [41]
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“because we did not perform coronary angiography for all the controls without CAD, there might have been individuals with subclinical CAD in the control group”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > ORIGINAL RESEARCH ARTICLE
Strength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“These limitations imply that we did not fully elucidate the characteristics of gut microbial composition in CAD”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > ORIGINAL RESEARCH ARTICLE
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
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In the paper
“16S rRNA sequencing analysis helped to seek candidate and translate to animal experiments”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > ORIGINAL RESEARCH ARTICLE
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In the paper
“Given that gut microbiota-derived LPS and systemic endotoxemia are involved in the onset and progression of not only atherosclerosis but also many prevalent disorders, such as inflammatory bowel disease, obesity and related metabolic diseases, and nonalcoholic steatohepatitis, [47][48][49]”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > ORIGINAL RESEARCH ARTICLE
What the sources say
- Not checked yetcites [47][48][49]
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“the gut microbial analysis in patients with CAD was a single-center study with a relatively small number of patients”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > ORIGINAL RESEARCH ARTICLE
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“used a mouse model to clarify the causal relationship between B. vulgatus and B. dorei and atherosclerosis”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > ORIGINAL RESEARCH ARTICLE
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“the LPS compounds penta-and tetraacylated lipid A of these Bacteroides species are structur-ally distinct from the hexa-acylated LPS of E.scherichia coli and elicit reduced TLR4 responses.33”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > DISCUSSION
What the sources say
- Not checked yetcites [33] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These results strongly support the idea that B. vulgatus and B. dorei regulate gut microbial production of LPS and that their activity can influence the progression of atherosclerosis in patients with CAD.”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > ORIGINAL RESEARCH ARTICLE
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: Fecal lipopolysaccharide levels reflect colon lipopolysaccharide concentrations produced by gut microbiota.
- Rests on an assumption: The effects of live B. vulgatus and B. dorei on atherosclerosis in apolipoprotein E-deficient mice are representative of human coronary artery disease.
None of the sources cited for this claim have been checked yet.
In the paper
“we considered that augmentation of these tolerogenic dendritic cells' phenotype in MLNs or spleen was suspected to migrate into the blood and was closely associated with attenuated atherosclerotic lesion formation as previously reported.42,43,46”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > ORIGINAL RESEARCH ARTICLE
What the sources say
- Not checked yetcites [42]
- Not checked yetcites [43]
- Not checked yetcites [46]
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- The authors state this as an assumption: Decreased circulating lipopolysaccharide levels after live Bacteroides treatment may reduce expression of TLR4, CCR7, CCL17, and CCL21 in the aorta, resulting in less macrophage and CD4+ T cell accumulation in atherosclerotic plaque.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“we performed gavage only with B. vulgatus and B. dorei”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > ORIGINAL RESEARCH ARTICLE
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“we believe that B. vulgatus and B. dorei might improve the enteric environment, providing gut bacteria with good living conditions and having a beneficial effect on bacterial LPS production.”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > DISCUSSION
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“we did not completely elucidate the mechanisms of atherosclerosis protection by lower LPS concentrations in mice”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > ORIGINAL RESEARCH ARTICLE
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“it could not measure LPS immunogenicity and the impact of Bacteroides on the structure and function of LPS”
§ Live Bacteroides Treatment Ameliorated Endotoxemia and Systemic Inflammation > ORIGINAL RESEARCH ARTICLE
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
The authors state this as an assumption.
Decreased circulating lipopolysaccharide levels after live Bacteroides treatment may reduce expression of TLR4, CCR7, CCL17, and CCL21 in the aorta, resulting in less macrophage and CD4+ T cell accumulation in atherosclerotic plaque.
“it is intriguing to assume that decreased circulating LPS levels after live Bacteroides treatment may reduce the expression of TLR4, CCR7, CCL17, and CCL21 in the aorta, resulting in less macrophage and CD4 + T cell accumulation in atherosclerotic plaque.”
The paper relies on this without support.
Fecal lipopolysaccharide levels reflect colon lipopolysaccharide concentrations produced by gut microbiota.
“we measured fecal LPS levels as an indicator of colon LPS concentrations pro-duced by gut microbiota.”
The paper relies on this without support.
The effects of live B. vulgatus and B. dorei on atherosclerosis in apolipoprotein E-deficient mice are representative of human coronary artery disease.
“Bacteroides treatment may serve as a novel and attractive therapeutic strategy for suppressing lipopolysaccharide-induced inflammatory response in CAD.”
The paper relies on this without support.
The hospital diet consumed by participants did not confound the gut microbiome or fecal lipopolysaccharide measurements.
“Fecal samples were collected while participants were hospitalized and thus consuming a hospital diet for >1 day.”
The paper relies on this without support.
The impact of colon lipopolysaccharide concentrations on intestinal permeability has not been fully investigated to date.
“the impact of colon LPS concentrations on intestinal permeability has not been fully investigated to date.”
The paper relies on this without support.
A specific gut microbiota-based target to prevent coronary artery disease has yet to emerge.
“a specific gut microbiota-based target to prevent CAD has yet to emerge.”
The paper relies on this without support.
Gut microbial profiles depend on age, sex, local food or lifestyle, and many other factors, making it difficult to define dysbiosis in atherosclerosis.
“it is difficult to conclude the definition of dysbiosis in atherosclerosis because each gut microbial profile depends on age, sex, local food or lifestyle, and many other factors”
The paper relies on this without support.
16S rRNA sequencing analysis has low phylogenetic power at the species level and poor discriminatory power for some genera.
“It has low phylogenetic power at the species level and poor discriminatory power for some genera”
The paper relies on this without support.
The relative abundances of most of the dominant gut microbiota in mice and humans are quite different.
“the relative abundances of most of the dominant gut microbiota in mice and human are quite different”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“For instance, gavage with the gram-negative Bacteroides (vulgatus and dorei) that produce penta- and tetra-acylated lipid A – in contrast to the hexa-acylated lipid A of e. coli, reduced colonic inflammation, endotoxemia, and atherosclerosis in ApoE−/− mice31.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [31]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Two different articles are assigned the same DOI
MinorReferences 31 and 33 give the identical DOI for articles with different titles, journals, and page ranges. At least one DOI is incorrect.
“Variation in microbiome LPS immunogenicity contributes to autoim- munity in humans. Cell. 2016;165:842-853. doi: 10.1002/art.39783”
“Dysbio- sis contributes to arthritis development via activation of autoreactive T cells in the intestine. Arthritis Rheumatol. 2016;68:2646-2661. doi: 10.1002/art.39783”
Citations
Cites
Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887
Search and clustering orders of magnitude faster than BLAST
Edgar, R. C. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq461 · Cited by 21,098
Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 20,145
UPARSE: highly accurate OTU sequences from microbial amplicon reads
Edgar, R. C. (2013) · Nature Methods · doi:10.1038/nmeth.2604 · Cited by 16,770
UCHIME improves sensitivity and speed of chimera detection
Edgar, R. C., Haas, B. J., Clemente, J. C., Quince, C., & Knight, R. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr381 · Cited by 15,114
Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences
Langille, M. G. I., Zaneveld, J., Caporaso, J. G., McDonald, D., Knights, D., Reyes, J. A., Clemente, J. C., Burkepile, D. E., Vega Thurber, R. L., Knight, R., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2676 · Cited by 9,116
KEGG: new perspectives on genomes, pathways, diseases and drugs
Kanehisa, M., Furumichi, M., Tanabe, M., Sato, Y., & Morishima, K. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkw1092 · Cited by 8,865
Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548
Self-citationRosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein
Ridker, P. M., Danielson, E., Fonseca, F. A. H., Genest, J., Gotto, A. M., Kastelein, J. J. P., Koenig, W., Libby, P., Lorenzatti, A. J., MacFadyen, J. G., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0807646 · Cited by 6,674
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Items 201–300 of 625
Saha, A., Samadder, A., & Nandi, S. (2022) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026623666221201150933 · Cited by 25
Tintoré, M., Cuñé, J., Vu, L. D., Poppe, J., den Abbeele, P. V., Baudot, A., & de Lecea, C. (2024) · Biology · doi:10.3390/biology13010051 · Cited by 24
Variation in responses to incretin therapy: Modifiable and non-modifiable factors
Austin, G. O., & Tomás, A. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1170181 · Cited by 24
“After adjusting for baseline HbA1c and serum C-peptide, the bacteria Bacteroides dorei and Lachnoclostridium sp, both of which are associated with anti-inflammatory immunomodulation and improved gut barrier integrity (Yoshida et al., 2018), were positively associated with responders.”
MethodShe, J., Sun, L.-Z., Yu, Y., Fan, H., Li, X., Zhang, X., Zhuo, X.-Z., Guo, M., Liu, J.-H., Liu, P., et al. (2024) · Gut microbes · doi:10.1080/19490976.2024.2415487 · Cited by 21
“…a pivotal role in the pathogenesis of several diseases such as cardiovascular diseases (hypertension, atherosclerosis, and heart failure), 13,17–19 metabolic diseases (obesity, hyperlipidemia, and diabetes), 20–22 and gastrointestinal diseases (inflammatory bowel disease and colorectal cancer).”
BackgroundZaheen, M., Pender, P., Dang, Q., Sinha, E., Chong, J. J. H., Chow, C. K., & Zaman, S. J. (2025) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd12040148 · Cited by 27
“Studies suggest that microbiome-derived metabolites like trimethylamine N-oxide (TMAO), produced by bacteria such as Bacteroides, contribute to atherosclerosis and CAD [111,112].”
Cheng, G., Kong, W., Lin, R., Jiang, Z., Wang, X., Qin, X., Shi, Y., Yang, P., Chen, X., Xia, L., et al. (2025) · Microbiome · doi:10.1186/s40168-025-02124-8 · Cited by 23
“Consistent with previous studies, several bacterial communities with beneficial effects, including Prevotella spp., Akkermansia spp., Bacteroides spp., and Faecalibacterium spp., have been reported as core microbiota in mammals [9, 16–18].”
Multi-omics integration reveals functional signatures of gut microbiome in atherosclerosis
Shi, H., Wu, M., Wu, X., Liu, Z., Jiang, S., Li, G., Yang, Y., Fu, Y., Wang, Q., Zhang, G., et al. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2542384 · Cited by 22
The gut microbiota and its products: Establishing causal relationships with obesity related outcomes
Li, L., Zhang, Y., Speakman, J. R., Hu, S., Song, Y., & Qin, S. (2021) · Obesity Reviews · doi:10.1111/obr.13341 · Cited by 25
Chen, S.-L., Lundy, D. J., Ruan, S., Chen, H.-C., Chao, Y.-K., Cheng, Y., Prajnamitra, R. P., Liao, C.-C., Lin, C., Lai, J. J., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121807 · Cited by 21
Dynamics of the gut microbiota in rats after hypobaric hypoxia exposure
Han, Y., Xu, J., Yan, Y., & Zhao, X. (2022) · PeerJ · doi:10.7717/peerj.14090 · Cited by 26
“The abundance of Bacteroides vulgatus and Bacteroides dorei , reducing gut microbial lipopolysaccharide production and inhibiting atherosclerosis ( Yoshida et al., 2018 ), was significantly enriched in Inside group.”
Magadán‐Corpas, P., Pérez‐Valero, Á., Ye, S., Sordon, S., Huszcza, E., Popłoński, J., Villar, C. J., & Lombó, F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063236 · Cited by 22
“…were observed in the family Prevotellaceae in the xanthohumol cohort (Table 2, Supplementary Figure S3) [39,50], as well as in the species Bacteroides dorei and Bacteroides thetaiotaomicron , both being species reported with anti-inflammatory activity (Table 3, Supplementary Figure S5) [51,52].”
BackgroundAdvanced Bioinspired Multifunctional Platforms Focusing on Gut Microbiota Regulation
Li, M., Wang, L., Lin, D., Liu, Z., Wang, H., Yang, Y., Sun, C., Ye, J., & Liu, Y. (2024) · ACS Nano · doi:10.1021/acsnano.4c05013 · Cited by 24
Zhang, J., Yang, Y., Han, H., Zhang, L., & Wang, T. (2021) · Journal of Animal Science · doi:10.1093/jas/skab296 · Cited by 21
Guo, L., Wang, Y., Wang, J.-H., Zhao, H., Yu, Y., Wang, G.-D., Dai, K., Yan, Y., Yang, Y., & Lv, J. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i27.3455 · Cited by 24
Lee, A. H., Jha, A. R., Do, S., Scarsella, E., Shmalberg, J. W., Schauwecker, A., Steelman, A. J., Honaker, R. W., & Swanson, K. S. (2022) · Animal Microbiome · doi:10.1186/s42523-022-00213-9 · Cited by 21
“In addition, the relative abundance of Bacteroides vulgatus (name recently changed to Phocaeicola vulgatus), which has been shown to reduce liposaccharide in the GI tract, was elevated in cats fed the FPPB or iFPPB diets [65].”
BackgroundLi, X., Chen, Y., Song, L., Wang, J., Song, Z., Zhao, X., Zhou, C., & Wu, Y. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.124175 · Cited by 21
Gan, J., Chen, J., Ma, R., Deng, Y., Ding, X., Zhu, S., & Sun, A. (2023) · Gynecological Endocrinology · doi:10.1080/09513590.2023.2219342 · Cited by 21
“Anaerobutyricum can improve insulin sensitivity [41], and Phocaeicola can help host to utilize complex nutrients, thereby alleviating disease [42], inhibiting the colonization of pathogenic bacteria [43], and enhancing immunity [44].”
BackgroundHe, Z., Wang, T., Zhang, S., Shi, K., Wang, F., Li, Y., Lin, C., & Chen, J. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1279996 · Cited by 22
Schwenger, K. J. P., Sharma, D., Ghorbani, Y., Xu, W., Lou, W. Y. W., Comelli, E. M., Fischer, S. E., Jackson, T. D., Okrainec, A., & Allard, J. P. (2024) · Liver International · doi:10.1111/liv.15864 · Cited by 22
“44 In NAFLD subjects with the presence of fibrosis versus no fibrosis, some factors were different such as higher E. coli and lower serum threonine and Alistipes Putredinis .”
BackgroundResultYunusbaeva, M. M., Borodina, L., Terentyeva, D., Bogdanova, A. A., Zakirova, A., Bulatov, S., Altinbaev, R., Bilalov, F. S., & Yunusbayev, B. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1331521 · Cited by 20
“Despite wide interest in the role of P. (B.) dorei in the intestinal microbiome, this bacterium is poorly studied, and there is little evidence of its direct involvement in the pathogenesis of Comparison of the intestinal microbiota diversity in untreated TB patients versus healthy controls.”
BackgroundEberhart, T., Stanley, F. U., Ricci, L., Chirico, T., Ferrarese, R., Sisti, S., Scagliola, A., Baj, A., Badurek, S., Sommer, A., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06483-2 · Cited by 20
“Importantly, the transplant of Acod1 -/- stools in wild-type mice decreased gut leakiness (Fig.”
Xia, T., Huang, F., Yun, F., Liu, Y., Wang, T., Wang, S., Jin, S., Ma, X., Wang, W., He, J., et al. (2024) · Current Research in Food Science · doi:10.1016/j.crfs.2024.100924 · Cited by 22
Huang, Y., Dhital, S., Liu, F., Fu, X., Huang, Q., & Zhang, B. (2021) · Food & Function · doi:10.1039/d1fo00488c · Cited by 21
Wang, Z., Hopson, L. M., Singleton, S. S., Yang, X., Jogunoori, W. S., Mazumder, R., Obias, V., Lin, P., Nguyen, B.-N. H., Yao, M. D., et al. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166179 · Cited by 20
“Among these bacteria, Bacteroides dorei is known to reduce LPS production and inhibit atherosclerosis [53], whereas Lachnoclostridium sp.”
BackgroundThe Types and Proportions of Commensal Microbiota Have a Predictive Value in Coronary Heart Disease
Chen, L., Ishigami, T., Doi, H., Arakawa, K., & Tamura, K. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10143120 · Cited by 21
“Tuomisto S, 2019 [13] Finland CHD 67 √ √ DNA Liu HH, 2019 [14] China CAD 201 √ V3-V4 of 16S rRNA Emoto T, 2016 [15] Japan CAD 119 √ 16S rDNA Cui L, 2017 [16] China CHD 64 √ V3-V5 of 16S rRNA Yoshida N, 2018 [17] Japan CAD 60 √ V3-V4 of 16S rRNA Amar J, 2019 [18] France MI 201 √ V3-V4 of 16S rDNA Emoto T, 2017 [19] Jap…”
Microbiota associations with inflammatory pathways in asthma
Wang, J., Chai, J., Zhang, L., Zhang, L., Yan, W., Sun, L., Chen, Y., Sun, Y., Zhao, J., & Chang, C. H. (2021) · Clinical & Experimental Allergy · doi:10.1111/cea.14089 · Cited by 20
Saji, N., Saito, Y., Yamashita, T., Murotani, K., Tsuduki, T., Hisada, T., Sugimoto, T., Niida, S., Toba, K., & Sakurai, T. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215653 · Cited by 23
“Theplasmawasdiluted 10-foldinpyrogen-freewaterandinactivatedfor15 minat90 ◦ C. LPS measurements were performed in pyrogen-free glass tubes, Eppendorf tubes, and plates [31].”
Self-citationMiyajima, Y., Karashima, S., Ogai, K., Taniguchi, K., Ogura, K., Kawakami, M., Nambo, H., Kometani, M., Aono, D., Demura, M., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.908997 · Cited by 20
Nakayama, K., Furuyama, T., Matsubara, Y., Morisaki, K., Onohara, T., Ikeda, T., & Yoshizumi, T. (2022) · PLoS ONE · doi:10.1371/journal.pone.0278995 · Cited by 20
“Additionally, gavage of some species of Bacteroidetes prevented the formation of atherosclerotic plaques [18].”
BackgroundWang, J., Dong, P., Zheng, S., Mai, Y.-Y., Ding, J., Pan, P., Tang, L., Wan, Y., & Liang, H. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1196967 · Cited by 21
“Yoshida N. et al. discovered the relationship between specific gastrointestinal bacteria: Bacteroides vulgatus and Bacteroides dorei and their metabolome with CAD (Yoshida et al., 2018).”
BackgroundInfluentialAlteration of gut microbiota in post-stroke depression patients with Helicobacter pylori infection
Sun, M., Chen, H., Dong, S., Zhang, G., Zhou, X., & Cheng, H. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106458 · Cited by 20
“Bacteroides dorei also plays an important role in maintaining intestinal homeostasis and suppressing inflammatory responses (Yoshida et al., 2018).”
BackgroundXue, B., Li, C., Wang, S., Chen, Z., Dai, K., Li, W., Xi, Z., Wang, J., Qiu, Z., & Shen, Z. (2019) · Journal of Water and Health · doi:10.2166/wh.2019.081 · Cited by 20
The Effect of Xylooligosaccharide, Xylan, and Whole Wheat Bran on the Human Gut Bacteria
Chen, M., Liu, S., Imam, K. M. S. U., Sun, L., Wang, Y., Gu, T., Wen, B., & Xin, F. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.568457 · Cited by 18
“Additionally, compared with the CK group (Figure 6), the relative abundance of probiotics (Burnet and Cowen, 2013; Yoshida et al., 2018; Vuillermin et al., 2020), such as Bifidobacterium, Prevotella_9, Lactobacillus, and Bacteroides, was increased by WB, X, and XO treatments.”
ResultZhao, X., Chen, Y., Li, L., Zhai, J., Yu, B., Wang, H., Yang, D., Wang, Q., Chang, Y., Li, J., et al. (2021) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000970 · Cited by 20
Hong, M., Liu, H., Chen, G., Zhu, J., Zheng, S., Zhao, D., Diao, J., Jia, H., Zhang, D., Chen, S., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/3259238 · Cited by 20
“vulgatus suppresses proinflammatory immune responses by decreasing gut microbial lipopolysaccharide production [34].”
BackgroundGut Microbiota and Adipose Tissue Microenvironment Interactions in Obesity
Wang, C., Yi, Z., Ye, J., Shen, Z., Yang, F., & Zhu, S. (2023) · Metabolites · doi:10.3390/metabo13070821 · Cited by 23
“The species Bacteroides vulgatus and Bacteroides dorei may provide benefits for T2DM patients by increasing Zonula occludens protein 1 (ZO-1) expression and enhancing epithelial barrier function [114].”
BackgroundLiu, Y., Li, K., Xu, J., Shen, W., Li, Y., Ma, J., Wang, T., Liu, J., Li, T., Zhang, X., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157214 · Cited by 19
Hu, M., He, F., Guo, Y.-X., Mo, L.-Z., & Zhu, X. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c02372 · Cited by 19
The gut microbiome and obstructive sleep apnea syndrome in children
Liu, W., Du, Q., Zhang, H., & Han, D. (2022) · Sleep Medicine · doi:10.1016/j.sleep.2022.09.022 · Cited by 21
Wang, J., Yu, C., Zhang, J., Liu, R., & Xiao, J. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-27051-9 · Cited by 19
Keivanlou, M., Amini‐Salehi, E., Hassanipour, S., Zare, R., Mohammadi‐Vajari, E., Hashemi, M., Salari, A., & Porteghali, P. (2024) · Current Diabetes Reviews · doi:10.2174/0115733998284844240102110559 · Cited by 20
Hassan, A., Luqman, A., Zhang, K., Ullah, M., Din, A. U., Xiaoling, L., & Wang, G. (2024) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-024-04010-1 · Cited by 19
“The measurement of mesenteric adipose tissue was conducted using the LAL assay, following a previously established protocol (Yoshida et al. 2018).”
Flynn, C. M., Omoluabi, T., Janes, A. M., Rodgers, E. J., Torraville, S. E., Negandhi, B. L., Nobel, T. E., Mayengbam, S., & Yuan, Q. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01674-1 · Cited by 26
Gut Microbiota and Heart, Vascular Injury
Zeng, C., & Tan, H. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-2385-4_8 · Cited by 19
Li, Q., Zhang, X., Du, Y., Liu, X., Chen, G., Xiang, P., Wu, H., Liu, C., & Wang, D. (2022) · Journal of Nutrition · doi:10.1093/jn/nxac103 · Cited by 19
Kashif, R. R., D'Cunha, N. M., Mellor, D. D., Alexopoulos, N. I., Sergi, D., & Naumovski, N. (2022) · Medicina · doi:10.3390/medicina58020300 · Cited by 18
“For example, while intestinal permeability-induced endotoxemia may contribute to the pathogenesis of T2DM, some bacterial species ( Bacteroides vulgatus and B. dorei ) have been reported to reduce gut permeability in animal models [55,56].”
BackgroundNeff, A., Lück, R., Hövels, M., & Deppenmeier, U. (2023) · Anaerobe · doi:10.1016/j.anaerobe.2023.102742 · Cited by 17
Noh, C., Jung, W., Yang, M. J., Kim, W., & Hwang, J. C. (2023) · International Journal of Surgery · doi:10.1097/js9.0000000000000518 · Cited by 18
“A recent study suggested that P. vulgatus could inhibit the production of colon microbial lipopolysaccharide, which is related to the immune response, in a mouse model [50] .”
Liu, D., Gao, X., Huang, X., Fan, Y., Wang, Y.-E., Zhang, Y., Chen, X., Wen, J., He, H., Hong, Y., et al. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.167016 · Cited by 20
Studies of peach gum polysaccharide on gut microbiota in vitro fermentation by human feces
Xu, B., Sun, P., Lu, J. F., Wang, Y., Lin, X., Chen, C., Zhu, J., Jia, H., Wang, X., Shen, J., et al. (2024) · Journal of Future Foods · doi:10.1016/j.jfutfo.2024.01.007 · Cited by 18
Seo, K., Kim, D., YOKOYAMA, W. H., & Kim, H. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c01240 · Cited by 18
Human Gut Microbiota in Cardiovascular Disease
Ronen, D., Rokach, Y., Abedat, S., Qadan, A., Daana, S., Amir, O., & Asleh, R. (2024) · Comprehensive physiology · doi:10.1002/cphy.c230012 · Cited by 28
“Interestingly, not all LPS are identical as gavage of Bacteroides ( vulgatus and dorei ), which produce penta-and tetraacylated lipid A of LPS, resulting in reduced endotoxemia and atherosclerosis in mice, while gavage of E. coli , which produces hexa-acylated lipid A, did not (586).”
Temporal Dynamics of the Intestinal Microbiome Following Short-Term Dietary Restriction
Anderson, E. M., Rozowsky, J. M., Fazzone, B. J., Schmidt, E., Stevens, B. R., O’Malley, K. A., Scali, S. T., & Berceli, S. A. (2022) · Nutrients · doi:10.3390/nu14142785 · Cited by 18
“However, the same species have been found to be decreased in patients with obesity, type 2 diabetes, and atherosclerotic disease, suggesting protective effects [71,73,74].”
BackgroundFrankfater, C., Sartorio, M. G., Valguarnera, E., Feldman, M. F., & Hsu, F. (2023) · Biochemistry · doi:10.1021/acs.biochem.2c00664 · Cited by 17
Olczak, T., Śmiga, M., Antonyuk, S. V., & Smalley, J. W. (2024) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00131-23 · Cited by 19
Siemińska, K., Cierpisz, P., Śmiga, M., & Olczak, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052237 · Cited by 17
“However, altered or disturbed mutualism between gut microbiome members results in dysbiosis with the subsequent development of intestinal and systemic diseases such as inflammatory bowel disease, intra-abdominal sepsis, endocarditis, and atherosclerosis [5,6].”
BackgroundThe Role of the Gut Microbiota in Complications among Hemodialysis Patients
Du, J., Zhao, X., Ding, X., Han, Q., Duan, Y., Ren, Q., Wang, H., Song, C., Wang, X., Zhang, D., et al. (2024) · Microorganisms · doi:10.3390/microorganisms12091878 · Cited by 16
“Bacteroides can prevent atherosclerosis through a reduction in microbial LPS production [70].”
BackgroundChoi, J., Choi, Y. R., Jeong, M. K., Song, H. H., Yu, J. S., Song, S. H., Park, J. H., Kim, M. J., Park, H., Ham, Y. L., et al. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2539448 · Cited by 16
“14 Given that Phocaeicola treatment strengthens the intestinal barrier and modulates inflammation-related pathways, it may ameliorate the onset and progression of obesity-related metabolic diseases and MASLD.”
Recent Advances on the Role and Therapeutic Potential of Regulatory T Cells in Atherosclerosis
Tanaka, T., Sasaki, N., & Rikitake, Y. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10245907 · Cited by 18
Self-citationVu, H., Muto, Y., Hayashi, M., Noguchi, H., Tanaka, K. Y., & Yamamoto, Y. (2022) · Microbiology Resource Announcements · doi:10.1128/mra.01124-21 · Cited by 17
Saito, Y., Yamashita, T., Yoshida, N., Emoto, T., Takeda, S., Tabata, T., Shinohara, M., Kishino, S., Sugiyama, Y., Kitamura, N., et al. (2022) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2022.08.009 · Cited by 16
Self-citationChen, L., Sun, M., Xu, D., Gao, Z., Shi, Y., Wang, S., & Zhou, Y. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1027188 · Cited by 18
Liuzijue training improves hypertension and modulates gut microbiota profile
Wu, S., Zheng, C., Liu, N., Deng, T., Wang, J., Qi, L., & Xia, L. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1075084 · Cited by 16
“As a beneficial microbial community, Bacteroides play an important role in the systemic immune response (46, 47).”
BackgroundSong, N., Wang, M., Zhong, G., Zhu, K., Chen, P., Zhang, N., Liu, X., & Zhang, W. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1173856 · Cited by 16
“Some beneficial effects of Bacteroides have been reported in the literature, such as anti-obesity effects, reduced gut microbial LPS production, and inhibition of atherosclerosis (Yoshida et al., 2018; Lopez-Almela et al., 2021).”
BackgroundWang, N., Zhang, C., Li, H., Zhang, D., Wu, J., Li, Y., Li, Y., Zhang, N., & Wang, X. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.128993 · Cited by 16
Research development on gut microbiota and vulnerable atherosclerotic plaque
Zheng, S., Liu, Z., Liu, H., Lim, J. Y., Li, D. W. H., Zhang, S., Luo, F., Wang, X., Sun, C., Tang, R., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e25186 · Cited by 18
“…the 16SRNA gene, showing that the abundance of Bacteroides vulgatus, Bacteroides dorei, was significantly reduced, while increased concentrations of LPS, which in turn confirmed that inhibition of atherosclerotic formation is associated with decreased LPS production by gut microbes [101].”
BackgroundHMOs Impact the Gut Microbiome of Children and Adults Starting from Low Predicted Daily Doses
Bajic, D., Wiens, F., Wintergerst, E., Deyaert, S., Baudot, A., & den Abbeele, P. V. (2024) · Metabolites · doi:10.3390/metabo14040239 · Cited by 18
“In contrast, 6 ′ SL specifically increased other health-related species such as Phocaeicola dorei for adults [55,56] and Bacteroides fragilis for children [57–59].”
BackgroundWang, J., Chang, S.-Y., Jin, Z.-Y., Li, D., Zhu, J., Luo, Z., Han, S., Kang, J., & Quan, L. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c03818 · Cited by 16
Serrano, M. G., Srivastava, A., Buck, G. A., Zhu, B., Edupuganti, L., Adegbulugbe, E., Shankaranarayanan, D., Kopp, J. B., & Raj, D. S. (2022) · American Journal of Nephrology · doi:10.1159/000526957 · Cited by 15
Alteration in gut microbiota is associated with immune imbalance in Graves’ disease
Liu, Y., Tang, S., Feng, Y., Xue, B., Cheng, C., Su, Y., Wei, W., Zhang, L., Huang, Z., Shi, X., et al. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1349397 · Cited by 15
The Role of the Gut Microbiome in Inflammatory Bowel Disease: The Middle East Perspective
El-Sayed, A., Kapila, D., Taha, R. S. I., El-Sayed, S., Mahen, M. R. A., Taha, R., & Alrubaiy, L. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14060652 · Cited by 17
“Dis-ruptions in the gut microbiota may therefore result in a more pro-inflammatory state [19].”
BackgroundValles-Colomer, M., Manghi, P., Cumbo, F., Masetti, G., Armanini, F., Asnicar, F., Blanco-Miguez, A., Pinto, F., Punčochář, M., Garaventa, A., et al. (2024) · eBioMedicine · doi:10.1016/j.ebiom.2023.104917 · Cited by 14
“|) were found for Phocaeicola dorei (r = 0.39, Padj = 4.4e-05) (a species previously reported to reduce microbial LPS production 47 ), and Bi fi dobacte-rium bi fi dum (r = 0.36, Padj = 1.1e-04), both depleted in patients.”
BackgroundInfluentialTao, Z., Luo, Z., Zou, Z., Ye, W., Hao, Y., Li, X., Zheng, K., Wu, J., Xia, J., Zhao, Y., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1580369 · Cited by 14
Mylavarapu, M., Tiwari, A., Kaur, H., Vempati, R., Kumar, H., Kodali, L. S. M., Khan, K. G., Dadana, S., Garcia, I., Cabrera, F. E. P., et al. (2026) · Cardiology Research and Practice · doi:10.1155/crp/9920016 · Cited by 16
“Microbiota transfer from infammatory-prone mice to atherosclerosis-prone mice has been shown to accelerate atherosclerotic plaque formation, likely due to elevated systemic infammatory cytokines such as interleukin (IL)-1 β , IL-2, and interferon (IFN)- γ [48, 49].”
In silico insights into potential gut microbial modulation of NAD+ metabolism and longevity
Salekeen, R., Siam, M. H. B., Sharif, D. I., Lustgarten, M. S., Billah, M. M., & Islam, K. M. D. (2021) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22925 · Cited by 14
Gut-microbiome-based predictive model for ST-elevation myocardial infarction in young male patients
Liu, M., Wang, M., Peng, T., Ma, W., Wang, Q., Niu, X., Hu, L., Qi, B., Guo, D. S., Ren, G., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1031878 · Cited by 14
“The combination of clinical characteristics and gut microbiome could significantly enhance the diagnostic efficacy of CAD (Zheng et al., 2020).”
BackgroundInfluentialHu, J., Huang, K., Bao, F., Zhong, S., Fan, Q., & Li, W. (2023) · PeerJ · doi:10.7717/peerj.15919 · Cited by 14
“Recent studies have shown that LPS induces a strong immune response after interacting with its receptors on cell membranes ( Rathinam, Zhao & Shao, 2019 ; Yoshida et al., 2018 ).”
Zhang, W., Zhong, Y., Wang, Z., Tang, F., & Zheng, C. (2024) · Scientific Reports · doi:10.1038/s41598-024-67132-4 · Cited by 15
“Previous study has reported that Bacteroides vulga-tus and Bacteroides dorei can reduce the production of lipopolysaccharide in intestinal microorganisms and inhibit atherosclerosis 54 .”
Ji, Y., Hu, Q., Zhang, X., Ma, G., Zhao, R., & Zhao, L. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.140391 · Cited by 14
Zhuang, Y., Liu, S., Xiao, J., Chen, T., Gao, D., Xu, Y., Jiang, W., Wang, J., Hou, G., Li, S., et al. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.136005 · Cited by 14
Zebrafish Model for Screening Antiatherosclerosis Drugs
Han, J., Zhang, R., Zhang, X., Dong, J., Chen, M., Pan, Y., Liao, Z., Zhong, M., He, J., Wang, F., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9995401 · Cited by 14
“By detecting bacteria in AS plaques, bacteria were found to induce AS by releasing LPS [27, 28].”
BackgroundMa, T., Shen, L., Wen, Q., Lv, R., Hou, Q., Kwok, L. Y., Sun, Z., & Zhang, H. (2021) · Microbiology · doi:10.1099/mic.0.000968 · Cited by 14
Jin, Z., Fang, Z., Pei, Z., Wang, H., Zhu, J., Lee, Y. K., Zhang, H., Zhao, J., Lu, W., & Chen, W. (2021) · Food & Function · doi:10.1039/d1fo03024h · Cited by 14
Jiang, C., Li, X., Shen, W., Pan, L., Li, Q., Luo, J., & Zha, X. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14337 · Cited by 14
Oral and intravenous iron treatment alter the gut microbiome differentially in dialysis patients
Liu, H., Wu, W., & Luo, Y. (2022) · International Urology and Nephrology · doi:10.1007/s11255-022-03377-0 · Cited by 16
A 2 miRNAs-based signature for the diagnosis of atherosclerosis
Han, X., Wang, H., Li, Y., Liu, L., & Gao, S. (2021) · BMC Cardiovascular Disorders · doi:10.1186/s12872-021-01960-4 · Cited by 14
“In addition, several studies revealed that microbiota could influence the atherosclerosis by regulating lipopolysaccharide production and intestinal homeostasis [35, 36].”
BackgroundXie, L., Muralitharan, R. R., Dinakis, E., Antonacci, S., Leung, K. C., McArdle, Z., Colafella, K. M., Nakai, M. E., Paterson, M. R., Peh, A., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.17.516695 · Cited by 14
Gut microbiota: a novel strategy affecting atherosclerosis
Yang, L., Yang, J., Zhang, T., Xie, X., & Wu, Q. (2025) · Microbiology Spectrum · doi:10.1128/spectrum.00482-24 · Cited by 17
Chen, S., Xue, X., Zhang, H., Huang, X., Lin, X., He, J., Chen, L., Luo, S., & Gao, J. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156000 · Cited by 13
Ghannoum, M. A., Long, L. A., Bunick, C. G., Rosso, J. Q. D., Gamal, A., Tyring, S. K., McCormick, T. S., & Grada, A. A. (2022) · Antibiotics · doi:10.3390/antibiotics11030324 · Cited by 13
“, has reported an association between reduction of Bacteroides vulgatus and atherosclerosis [37].”
BackgroundLiu, Y., Dou, C., Wei, G., Zhang, L., Xiong, W., Wen, L., Xiang, C., Chen, C., Zhang, T., Altamirano, A. M., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1064872 · Cited by 12
“Gavage with live Bacteroides vulgatus and Bacteroides dorei inhibited the development of atherosclerotic lesions in AS-prone mice (Yoshida et al., 2018).”
BackgroundIto, E., Ohki, T., Toya, N., Nakagawa, H., Horigome, A., Odamaki, T., Xiao, J., Koido, S., Nishikawa, Y., Ohkusa, T., et al. (2022) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.2022-055 · Cited by 13
“In total, hundreds of species and 40 trillion microorganisms exist in the gut microbiota (GM) of the human intestinal tract, and they exert various effects on the host directly and indirectly through their metabolites [6-9].”
BackgroundLee, K., Kei, N., Yang, F., Lauw, S., Chan, P. L., Chen, L., & Cheung, P. C. K. (2023) · Foods · doi:10.3390/foods12214014 · Cited by 13
“B. dorei oral administration with B. vulgatus resulted in attenuated atherosclerotic lesion, endotoxemia, lipopolysaccharide production in gut microbes and pro-inflammatory immune responses [40].”
BackgroundChen, J., Wang, Q., Hao, Z., Li, Z., Sahu, S. K., Liu, H., & Xiao, L. (2019) · Applied and Environmental Microbiology · doi:10.1128/aem.02465-19 · Cited by 14
“vulgatus in DBS samples might also be risk factors for infection/inflammation and acute arterial events (24, 46).”
BackgroundZhou, M., Xu, Y., Ouyang, P., Ling, J., Cai, Q., Du, Q., & Zheng, L. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.138693 · Cited by 13
The Kobe University Human Intestinal Microbiota Model for gut intervention studies
Hoshi, N., Inoue, J., Sasaki, D., & Sasaki, K. (2021) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-021-11217-x · Cited by 13
Self-citationIntestinal aging-related immune dysfunction: mechanisms and interventions
Shen, X., Gao, X., & Wang, L. (2025) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2025157 · Cited by 13
“SCFAs derived from the intestinal microbiota can help regulate blood pressure through the olfactory receptor Olfr78 and G protein - coupled receptor, while LPS can affect the stability of atherosclerotic plaques [190,191].”
Li, J., Wang, Y., Shrestha, S., Gewirtz, A. T., Ding, Y., & Zou, J. (2025) · Nutrients · doi:10.3390/nu17172887 · Cited by 12
Wu, H., Wang, X., Fang, X., Lian, F., Li, M., Liao, J., Dai, D., & Tian, J. (2022) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2022-003149 · Cited by 12
Retracted: Gut microbiota and COVID‐19: A systematic review
SeyedAlinaghi, S., Afzalian, A., Pashaei, Z., Varshochi, S., Karimi, A., Mojdeganlou, H., Mojdeganlou, P., Razi, A., Ghanadinezhad, F., Shojaei, A., et al. (2023) · Health Science Reports · doi:10.1002/hsr2.1080 · Cited by 11
“Bacteroides dorei is a controversial bacterium because of the fact that they also can downregulate the ACE‐2 receptor but they are also linked to some proinflammatory cytokines.(107) One study reported a decrease in the levels of Blautia spp.”
BackgroundRetracted
Metadata
- Authors
- Yoshida, N., Emoto, T., Yamashita, T., Watanabe, H., Hayashi, T., Tabata, T., Hoshi, N., Hatano, N., Ozawa, G., Sasaki, N., Mizoguchi, T., Amin, H. Z., Hirota, Y., Ogawa, W., Yamada, T., & Hirata, K.-I.
- Affiliations
- Kobe University (JP)
- Tokyo Institute of Technology (JP)
- Technosuruga Laboratory Co., Ltd. (Japan) (JP)
- University of Indonesia (ID)
- Corresponding author
- Yoshida, Naofumi
- Emoto, Takuo
- ORCID
- Venue
- Circulation
- Published
- 2018-11-27
- Volume
- 138
- Issue
- 22
- Pages
- 2486-2498
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2886282415
- Cited by
- 619
- References
- 50
- Citations by year
- 2026: 52 · 2025: 105 · 2024: 112 · 2023: 113 · 2022: 101 · 2021: 75 · 2020: 47 · 2019: 13 · 2018: 1
- FWCI
- 12.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Kobe University Repository Kernel (Kobe University) (submittedVersion)
- Funders
- Japan Society for the Promotion of Science (16H06279)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- Bacteroides vulgatus, Bacteroides dorei, gut microbiota, atherosclerosis, coronary artery disease, lipopolysaccharide, endotoxemia, pro-inflammatory response, fecal microbiota transplantation, gut-heart axis
- MeSH terms
- Gastrointestinal Microbiome, Aged, Animals, Bacteroides, Feces, Female, Humans, Intestines, Lipopolysaccharides, Male, Mice, Inbred C57BL, Middle Aged, Risk Factors, RNA, Ribosomal, 16S, Sequence Analysis, RNA, Mice, Knockout, Immunity, Mucosal, Tight Junctions, Atherosclerosis, Mice
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