The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Takotsubo Syndrome: Pathophysiology, Emerging Concepts, and Clinical Implications
Open accessAbstract
Takotsubo syndrome is a condition characterized by acute transient left ventricular systolic dysfunction, which at presentation can be challenging to distinguish from acute myocardial infarction. Although previously thought to be a benign, self-limiting condition, recent studies have confirmed that patients with takotsubo syndrome have persistent subtle ongoing cardiac dysfunction, and many continue to have limiting symptoms despite restoration of left ventricular ejection fraction. Moreover, these patients have a substantial burden of morbidity and mortality, as well, with high rates of subsequent major adverse cardiovascular events that approach those of patients with acute coronary syndrome. The mechanisms behind this condition remain elusive. Despite substantial research, the medical community continues to have an incomplete understanding of its underlying pathogenesis and pathophysiology. Catecholamine-induced myocardial injury is the most established and well-known theory, but this does not explain all the clinical features and presentations of the condition, and numerous other pathways and abnormalities are emerging. Because of the poor understanding of its underlying pathophysiology, there is a lack of evidence-based interventions to treat the acute episode, to avoid recurrences, and to prevent major adverse cardiovascular events. This highlights the need for further research to gain a better understanding of the underlying pathophysiology to inform appropriate randomized controlled trials of interventions targeting the causative pathways. Only then can evidence-based management strategies be established to improve clinical outcomes of this potentially lethal condition.
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Cites
Cardiovascular and renal outcomes with empagliflozin in heart failure
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Neurohumoral Features of Myocardial Stunning Due to Sudden Emotional Stress
Wittstein, I. S., Thiemann, D. R., Lima, J. A. C., Baughman, K. L., Schulman, S. P., Gerstenblith, G., Wu, K. C., Rade, J. J., Bivalacqua, T. J., & Champion, H. C. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043046 · Cited by 3,110
Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy
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ESC working group position paper on myocardial infarction with non-obstructive coronary arteries
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Cited by
Saha, D., Dutta, P., & Chakraborty, A. (2025) · Immuno · doi:10.3390/immuno5040045 · Cited by 3
Metadata
- Authors
- Singh, T., Khan, H., Gamble, D. T., Scally, C., Newby, D. E., & Dawson, D.
- Venue
- Circulation
- Published
- 2022-03-29
- Volume
- 145
- Issue
- 13
- Pages
- 1002-1019
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W4220726280
- Cited by
- 396
- References
- 70
- FWCI
- 46.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Takotsubo Syndrome: Pathophysiology, Emerging Concepts, and Clinical Implications. https://app.cochat.ai/papers/10.1161/circulationaha.121.055854
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- Singh, T., Khan, H., Gamble, D. T., Scally, C., Newby, D. E., & Dawson, D. (2022). Takotsubo Syndrome: Pathophysiology, Emerging Concepts, and Clinical Implications. Circulation. https://doi.org/10.1161/circulationaha.121.055854
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
