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Cited by 530

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Pivotal Role of a gp91 phox -Containing NADPH Oxidase in Angiotensin II-Induced Cardiac Hypertrophy in Mice

Bendall, Jennifer K., Cave, Alison C., Heymes, Christophe, Gall, Nicholas, Shah, Ajay M.·2002·Circulation
DOI 10.1161/hc0302.103712
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Abstract

Background — Angiotensin II induces both cardiac and vascular smooth muscle (VSM) hypertrophy. Recent studies suggest a central role for a phagocyte-type NADPH oxidase in angiotensin II-induced VSM hypertrophy. The possible involvement of an NADPH oxidase in the development of cardiac hypertrophy has not been studied. Methods and Results — Mice with targeted disruption of the NADPH oxidase subunit gp91 phox (gp91 phox−/− ) and matched wild-type mice were subjected to subcutaneous angiotensin II infusion at a subpressor dose (0.3 mg/kg/day) for 2 weeks. Systolic blood pressure was unaltered by angiotensin II in either group. Angiotensin II significantly increased heart/body weight ratio, atrial natriuretic factor and β-myosin heavy chain mRNA expression, myocyte area, and cardiac collagen content in wild-type but not gp91 phox−/− mice. Angiotensin II treatment increased myocardial NADPH oxidase activity in wild-type but not gp91 phox−/− mice. Conclusions — A gp91 phox -containing NADPH oxidase plays an important role in the development of angiotensin II-induced cardiac hypertrophy, independent of changes in blood pressure.

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Metadata

Authors
Bendall, J. K., Cave, A. C., Heymes, C., Gall, N., & Shah, A. M.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2002-01-22
Volume
105
Issue
3
Pages
293-296
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/hc0302.103712
OpenAlex
W2090016088
Cited by
530
References
16
FWCI
17.02
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Pivotal Role of a gp91 phox -Containing NADPH Oxidase in Angiotensin II-Induced Cardiac Hypertrophy in Mice. https://app.cochat.ai/papers/10.1161/hc0302.103712
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Bendall, J. K., Cave, A. C., Heymes, C., Gall, N., & Shah, A. M. (2002). Pivotal Role of a gp91 phox -Containing NADPH Oxidase in Angiotensin II-Induced Cardiac Hypertrophy in Mice. Circulation. https://doi.org/10.1161/hc0302.103712

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.