The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Vascular Smooth Muscle Growth: Autocrine Growth Mechanisms
Abstract
Vascular smooth muscle cells (VSMC) exhibit several growth responses to agonists that regulate their function including proliferation (hyperplasia with an increase in cell number), hypertrophy (an increase in cell size without change in DNA content), endoreduplication (an increase in DNA content and usually size), and apoptosis. Both autocrine growth mechanisms (in which the individual cell synthesizes and/or secretes a substance that stimulates that same cell type to undergo a growth response) and paracrine growth mechanisms (in which the individual cells responding to the growth factor synthesize and/or secrete a substance that stimulates neighboring cells of another cell type) are important in VSMC growth. In this review I discuss the autocrine and paracrine growth factors important for VSMC growth in culture and in vessels. Four mechanisms by which individual agonists signal are described: direct effects of agonists on their receptors, transactivation of tyrosine kinase-coupled receptors, generation of reactive oxygen species, and induction/secretion of other growth and survival factors. Additional growth effects mediated by changes in cell matrix are discussed. The temporal and spatial coordination of these events are shown to modulate the environment in which other growth factors initiate cell cycle events. Finally, the heterogeneous nature of VSMC developmental origin provides another level of complexity in VSMC growth mechanisms.
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Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420301 · Cited by 8,663
A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF
Higashiyama, S., Abraham, J. A., Miller, J., Fiddes, J. C., & Klagsbrun, M. (1991) · Science · doi:10.1126/science.1840698 · Cited by 1,127
Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice
Dickson, M. C., Martin, J. S., Cousins, F. M., Kulkarni, A. B., Karlsson, S., & Akhurst, R. J. (1995) · Development · doi:10.1242/dev.121.6.1845 · Cited by 1,029
Localization of PDGF-B Protein in Macrophages in All Phases of Atherogenesis
Ross, R., Masuda, J., Raines, E. W., Gown, A. M., Katsuda, S., Sasahara, M., Malden, L. T., Masuko, H., & Sato, H. (1990) · Science · doi:10.1126/science.2343305 · Cited by 574
Sato, Y., Tsuboi, R., Lyons, R., Moses, H., & Rifkin, D. B. (1990) · The Journal of cell biology · doi:10.1083/jcb.111.2.757 · Cited by 444
Isobe, T., Okuyama, T., Toyoda, H., Komurasaki, T., Uchida, D., Takayama, Y., & Hanada, K. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7495 · Cited by 269
Janat, M. F., & Liau, G. (1992) · Journal of Cellular Physiology · doi:10.1002/jcp.1041500203 · Cited by 66
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Bendall, J. K., Cave, A. C., Heymes, C., Gall, N., & Shah, A. M. (2002) · Circulation · doi:10.1161/hc0302.103712 · Cited by 530
Otterbein, L. E., Zuckerbraun, B. S., Haga, M., Liu, F., Song, R., Usheva, A., Stachulak, C., Bodyak, N., Smith, R. N., Csizmadia, E., et al. (2003) · Nature Medicine · doi:10.1038/nm817 · Cited by 526
TGF-β signaling in vascular fibrosis
RUIZORTEGA, M., RODRIGUEZVITA, J., SANCHEZLOPEZ, E., CARVAJAL, G., & EGIDO, J. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.02.008 · Cited by 492
Sturrock, A., Cahill, B., Norman, K., Huecksteadt, T. P., Hill, K., Sanders, K., Karwande, S. V., Stringham, J. C., Bull, D. A., Gleich, M., et al. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00269.2005 · Cited by 402
Function of cGMP-Dependent Protein Kinases as Revealed by Gene Deletion
Hofmann, F., Feil, R., Kleppisch, T., & Schlossmann, J. (2006) · Physiological Reviews · doi:10.1152/physrev.00015.2005 · Cited by 395
Metadata
- Authors
- Berk, B. C.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2001-07-01
- Volume
- 81
- Issue
- 3
- Pages
- 999-1030
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2134665522
- Cited by
- 383
- References
- 8
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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