The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
BG9719 (CVT-124), an A 1 Adenosine Receptor Antagonist, Protects Against the Decline in Renal Function Observed With Diuretic Therapy
Abstract
Background — Adenosine may adversely affect renal function via its effects on renal arterioles and tubuloglomerular feedback, but effects of adenosine blockade in humans receiving furosemide and ACE inhibitors is unknown. Methods and Results — This was a randomized, double-blind, ascending-dose, crossover study evaluating 3 doses of BG9719 in 63 patients with congestive heart failure. Patients received placebo or 1 of 3 doses of BG9719 on 1 day and the same medication plus furosemide on a separate day. Renal function and electrolyte and water excretion were assessed. BG9719 alone caused an increase in urine output and sodium excretion ( P <0.05). Although administration of furosemide alone caused a large diuresis, addition of BG9719 to furosemide increased diuresis, which was significant at the 0.75-μg/mL concentration. BG9719 alone improved glomerular filtration rate (GFR) at the 2 lower doses. Furosemide alone caused a decline in GFR. When BG9719 was added to furosemide, however, creatinine clearance remained at baseline at the 2 lower doses. Conclusions — In patients with congestive heart failure on standard therapy, including ACE inhibitors, BG9719 increased both urine output and GFR. In these same patients, furosemide increased urine output at the expense of decreased GFR. When BG9719 was given in addition to furosemide, urine volume additionally increased and there was no deterioration in GFR. A 1 adenosine antagonism might preserve renal function while simultaneously promoting natriuresis during treatment for heart failure.
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Cites
Renal Function, Neurohormonal Activation, and Survival in Patients With Chronic Heart Failure
Hillege, H. L., Girbes, A. R. J., de Kam, P. J., Boomsma, F., de Zeeuw, D., Charlesworth, A., Hampton, J. R., & van Veldhuisen, D. J. (2000) · Circulation · doi:10.1161/01.cir.102.2.203 · Cited by 1,045
Sun, D., Samuelson, L. C., Yang, T., Huang, Y., Paliege, A., Saunders, T., Briggs, J., & Schnermann, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171317998 · Cited by 404
Krumholz, H. M., Chen, Y.-T., Vaccarino, V., Wang, Y., Radford, M. J., Bradford, W. D., & Horwitz, R. I. (2000) · The American Journal of Cardiology · doi:10.1016/s0002-9149(00)00705-0 · Cited by 379
Juxtaglomerular cell complex in the regulation of renal salt excretion
Schnermann, J. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.2.r263 · Cited by 231
Plasma Adenosine Levels Increase in Patients With Chronic Heart Failure
Funaya, H., Kitakaze, M., Node, K., Minamino, T., Komamura, K., & Hori, M. (1997) · Circulation · doi:10.1161/01.cir.95.6.1363 · Cited by 218
Gottlieb, S. S., Skettino, S. L., Wolff, A. A., et al. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00532-x · Cited by 146
Self-citationNatriuretic and Diuretic Actions of a Highly Selective Adenosine A1 Receptor Antagonist
Wilcox, C. S., Welch, W. J., Schreiner, G. F., & Belardinelli, L. (1999) · Journal of the American Society of Nephrology · doi:10.1681/asn.v104714 · Cited by 131
Adenosine-induced renal vasoconstriction in man
Marraccini, P., Fedele, S., Marzilli, M., et al. (1996) · Cardiovascular Research · doi:10.1016/s0008-6363(96)00128-9 · Cited by 63
Renal Effects of Local Infusion of Adenosine in Man
EDLUND, A., Ohlsén, H., & Sollevi, A. (1994) · Clinical Science · doi:10.1042/cs0870143 · Cited by 41
CVT-124, a Novel Adenosine A1 Receptor Antagonist with Unique Diuretic Activity
Gellai, M., Schreiner, G. F., Ruffolo, R. R., Fletcher, T., DeWolf, R., & Brooks, D. P. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37711-0 · Cited by 39
Cited by
Adenosine Receptors as Therapeutic Targets
Jacobson, K. A., & Gao, Z.-G. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1983 · Cited by 1,431
Gheorghiade, M., & Pang, P. S. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.10.041 · Cited by 600
Cardiorenal Syndrome: New Perspectives
Bock, J. S., & Gottlieb, S. S. (2010) · Circulation · doi:10.1161/circulationaha.109.886473 · Cited by 455
Self-citationVallon, V., Mühlbauer, B., & Osswald, H. (2006) · Physiological Reviews · doi:10.1152/physrev.00031.2005 · Cited by 448
Peacock, W. F., Costanzo, M. R., De Marco, T., Lopatin, M., Wynne, J., Mills, R. M., & Emerman, C. L. (2009) · Cardiology · doi:10.1159/000164149 · Cited by 262
Metadata
- Authors
- Gottlieb, S. S., Brater, D. C., Thomas, I., Havranek, E., Bourge, R., Goldman, S., Dyer, F., Gomez, M., Bennett, D., Ticho, B., Beckman, E., & Abraham, W. T.
- Venue
- Circulation
- Published
- 2002-03-19
- Volume
- 105
- Issue
- 11
- Pages
- 1348-1353
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2140292987
- Cited by
- 369
- References
- 12
- FWCI
- 9.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gottlieb, S. S., Brater, D. C., Thomas, I., Havranek, E., Bourge, R., Goldman, S., Dyer, F., Gomez, M., Bennett, D., Ticho, B., Beckman, E., & Abraham, W. T. (2002). BG9719 (CVT-124), an A 1 Adenosine Receptor Antagonist, Protects Against the Decline in Renal Function Observed With Diuretic Therapy. Circulation. https://doi.org/10.1161/hc1102.105264
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