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Prospective Multicenter Study of Pregnancy Outcomes in Women With Heart Disease
Open accessAbstract
Background The maternal and neonatal risks associated with pregnancy in women with heart disease receiving comprehensive prenatal care have not been well defined. Methods and Results We prospectively enrolled 562 consecutive pregnant women with heart disease and determined the outcomes of 599 pregnancies not ending in miscarriage. Pulmonary edema, arrhythmia, stroke, or cardiac death complicated 13% of pregnancies. Prior cardiac events or arrhythmia, poor functional class or cyanosis, left heart obstruction, and left ventricular systolic dysfunction independently predicted maternal cardiac complications; the cardiac event rate can be predicted using a risk index incorporating these predictors. Neonatal complications (20% of pregnancies) were associated with poor functional class or cyanosis, left heart obstruction, anticoagulation, smoking, and multiple gestations. Conclusions Pregnancy in women with heart disease is associated with significant cardiac and neonatal complications, despite state-of-the-art obstetric and cardiac care. Maternal cardiac risk can be predicted with the use of a risk index.
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Cited by
2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy
Authors/Task Force members, Elliott, P. M., Anastasakis, A., Borger, M. A., Borggrefe, M., Cecchi, F., Charron, P., Hagege, A. A., Lafont, A., Limongelli, G., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu284 · Cited by 4,332
Priori, S. G., Blomström-Lundqvist, C., Mazzanti, A., Blom, N., Borggrefe, M., Camm, J., Elliott, P. M., Fitzsimons, D., Hatala, R., Hindricks, G., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv316 · Cited by 3,893
Otto, C. M., Nishimura, R. A., Bonow, R. O., Carabello, B. A., Erwin, J. P., Gentile, F., Jneid, H., Krieger, E. V., Mack, M., McLeod, C., et al. (2021) · Circulation · doi:10.1161/cir.0000000000000923 · Cited by 3,686
2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease
Nishimura, R. A., Otto, C. M., Bonow, R. O., Carabello, B. A., Erwin, J. P., Guyton, R. A., O’Gara, P. T., Ruiz, C. E., Skubas, N. J., Sorajja, P., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.02.536 · Cited by 3,523
2023 ESC guidelines for the management of cardiomyopathies
Arbelo, E., Protonotarios, A., Gimeno, J. R., Arbustini, E., Barriales-Villa, R., Basso, C., Bezzina, C. R., Biagini, E., Blom, N. A., de Boer, R. A., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad194 · Cited by 2,844
Metadata
- Authors
- Siu, S. C., Sermer, M., Colman, J. M., Alvarez, A. N., Mercier, L.-A., Morton, B. C., Kells, C. M., Bergin, M. L., Kiess, M. C., Marcotte, F., Taylor, D. A., Gordon, E. P., Spears, J. C., Tam, J. W., Amankwah, K. S., Smallhorn, J. F., Farine, D., Sorensen, S., & on behalf of the Cardiac Disease in Pregnancy (CARPREG) Investigators
- Venue
- Circulation
- Published
- 2001-07-31
- Volume
- 104
- Issue
- 5
- Pages
- 515-521
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2053859746
- Cited by
- 1,402
- References
- 0
- FWCI
- 9.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Siu, S. C., Sermer, M., Colman, J. M., Alvarez, A. N., Mercier, L.-A., Morton, B. C., Kells, C. M., Bergin, M. L., Kiess, M. C., Marcotte, F., Taylor, D. A., Gordon, E. P., Spears, J. C., Tam, J. W., Amankwah, K. S., Smallhorn, J. F., Farine, D., Sorensen, S., & on behalf of the Cardiac Disease in Pregnancy (CARPREG) Investigators. (2001). Prospective Multicenter Study of Pregnancy Outcomes in Women With Heart Disease. Circulation. https://doi.org/10.1161/hc3001.093437
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